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公开(公告)号：US12012579B2
公开(公告)日：2024-06-18
申请号：US17962965
申请日：2022-10-10
IPC分类号： B01L3/00 , B01D5/00 , B01D47/05 , B01F23/231 , B01F23/233 , B01F27/2121 , B01F27/88 , B01F27/90 , B01F27/91 , B01F35/10 , B01F35/51 , B01F35/513 , B01F35/92 , C12M1/00 , C12M1/02 , C12M1/06 , C12M1/12 , C12M3/00 , C12N1/10 , C12N1/12 , C12N1/14 , C12N1/20 , C12N5/00 , C12N5/04 , F28B1/02 , F28F3/12 , F28F21/06 , B01F23/237 , B01F35/90 , B01F101/44 , C12N5/10 , F28D21/00
CPC分类号： C12M23/14 , B01D5/0072 , B01D47/05 , B01F23/23125 , B01F23/233 , B01F27/2121 , B01F27/88 , B01F27/90 , B01F27/91 , B01F35/146 , B01F35/51 , B01F35/513 , B01F35/92 , C12M23/26 , C12M23/34 , C12M27/02 , C12M29/00 , C12M29/06 , C12M29/24 , C12M37/00 , C12M41/14 , C12M41/18 , C12N1/10 , C12N1/12 , C12N1/14 , C12N1/20 , C12N5/00 , C12N5/04 , F28B1/02 , F28F3/12 , F28F21/06 , F28F21/065 , B01F23/231151 , B01F23/231262 , B01F23/23362 , B01F23/23761 , B01F23/237611 , B01F23/237612 , B01F23/23762 , B01F23/23765 , B01F2035/98 , B01F2101/44 , C12N5/10 , F28D2021/0063 , F28F2255/02
摘要： A bag assembly for use with a heat exchanger includes a flexible bag having of one or more sheets of polymeric material, the bag having a first end that bounds a first compartment and an opposing second end that bounds a second compartment, a support structure being disposed between the first compartment and the second compartment so that the first compartment is separated and isolated from the second compartment. A first inlet port, a first outlet port, and a first drain port are coupled with the flexible bag so as to communicate with the first compartment. A second inlet port, a second outlet port, and a second drain port are coupled with the flexible bag so as to communicate with the second compartment.
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公开(公告)号：US11945845B2
公开(公告)日：2024-04-02
申请号：US17595894
申请日：2020-05-30
发明人： Ben Waldman , Sebastian Lourido
CPC分类号： C07K14/45 , A61K39/002 , A61P33/02 , A61P37/04 , C12N1/10 , C12N15/74 , A61K2039/52 , A61K2039/523 , A61K2039/585
摘要： The present disclosure provides genetically altered protozoan parasites comprising a mutation in a bradyzoite formation deficient 1 (BFD1) gene, wherein the mutation inhibits differentiation of the parasite into a bradyzoite. The genetically altered protozoan parasites can be utilized in vaccine compositions and in methods of treating apicomplexan parasite infection.
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公开(公告)号：US11913051B2
公开(公告)日：2024-02-27
申请号：US16625579
申请日：2018-06-28
CPC分类号： C12P21/005 , C12N1/105 , C12N9/1029 , C12N9/1051 , C12N9/1081 , C07K2319/04 , C07K2319/05 , C12R2001/90 , C12Y203/01003 , C12Y204/01022 , C12Y204/01101 , C12Y204/01143 , C12Y204/99006
摘要： Described herein are compositions and methods of producing glycosylated proteins in vitro and in vivo. The methods include using host cells to produce glycosylated proteins. Also described herein are glycosylated proteins produced using such methods and uses thereof.
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公开(公告)号：US11779639B2
公开(公告)日：2023-10-10
申请号：US17054872
申请日：2019-05-10
CPC分类号： A61K39/002 , A61P33/02 , C12N1/10 , C12N1/36 , C12N9/1051 , C12N9/1205 , C12N9/16 , C12Y204/01015 , C12Y207/01001 , C12Y301/03012 , A61K2039/522 , A61K2039/523 , A61K2039/552
摘要： The present disclosure provides mutant parasites, in particular protozoan parasites comprising a mutation of the trehalose-6-phosphate synthase/6-phosphate phosphatase (TPS/TPP)-like gene of Toxoplasma gondii (herein referred to as ‘Toxoplasma’) or a homologue thereof as well as vaccines comprising same.
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公开(公告)号：US20230287327A1
公开(公告)日：2023-09-14
申请号：US17791011
申请日：2021-01-07
CPC分类号： C12N1/10 , C12N9/1048 , C12P21/005
摘要： The present application relates to Leishmania cells genetically engineered such that the formation of an O-linked GlcNAc on a polypeptide in the Leishmania cell is reduced or eliminated. The formation of the O-linked GlcNAc may be catalyzed in the Leishmania cell prior to said genetic engineering by at least one N-acetylglucosamine (GlcNAc)-transferase. Also provided herein are methods of making a polypeptide using a Leishmania cell described herein and polypeptides produced by the methods provided herein.
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公开(公告)号：US11692164B2
公开(公告)日：2023-07-04
申请号：US17367231
申请日：2021-07-02
申请人： Huvepharma Inc.
IPC分类号： C12N1/10 , C12N1/04 , A61K39/012 , A61K39/00 , A61K35/68
CPC分类号： C12N1/10 , A61K39/012 , C12N1/04 , A61K35/68 , A61K2039/51
摘要： Compositions are provided that contain sporulated coccidial oocysts, wherein the compositions are free of antibiotics and comprise formalin at a concentration sufficient to inhibit microbial growth for at least 12 months while maintaining oocyst viability. Methods of preparing such compositions are also provided.
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公开(公告)号：US20220257742A1
公开(公告)日：2022-08-18
申请号：US17529812
申请日：2021-11-18
申请人： Sanaria Inc.
IPC分类号： A61K39/015 , C12N1/10
摘要： The application is directed to in vitro-reared Plasmodium sporozoites of human host range wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. Provided herein are in vitro-reared infectious Plasmodium sporozoites (SPZ) of human host range, particularly P. falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi, wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same.
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公开(公告)号：US11154076B2
公开(公告)日：2021-10-26
申请号：US15889842
申请日：2018-02-06
申请人： DSM IP Assets B.V.
发明人： Kirk E. Apt , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer, III , Tracey Lynn Stahl , Ross Zirkle
IPC分类号： A23D9/00 , C12P7/64 , A61K31/202 , A23K20/158 , A61K8/36 , A61K31/201 , A61Q19/00 , A23L2/52 , A23C9/152 , A23D9/007 , C11B1/10 , C11B3/04 , A23L33/00 , A23L33/115 , A61K35/68 , A23K10/12 , A23K50/00 , A23K50/40 , A23K50/80 , C12N1/10 , C12N1/12 , C12R1/89 , C12R1/90
摘要： The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.
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公开(公告)号：US10889793B2
公开(公告)日：2021-01-12
申请号：US15639120
申请日：2017-06-30
申请人： Calysta, Inc.
IPC分类号： C12M1/02 , C12M1/04 , C12M1/08 , C12P5/02 , C12P7/16 , C12P7/18 , C12P7/40 , C12P7/42 , C12P17/02 , C12N1/08 , C12N1/10 , C12N1/12 , C12N1/20 , C12N13/00 , C02F3/32 , A01G33/00 , C12M1/00 , C12M1/12
摘要： A fermenter can have at least one hollow fluid conduit disposed at least partially within a vessel. An external circumference of the hollow fluid conduit and an interior circumference of the vessel can define a downward flow path through which a multi-phase mixture including a liquid media and compressed gas substrate bubbles flows. An interior circumference of the hollow fluid conduit can defined an upward flow path which is in fluid communication with the downward flow path. The multi-phase liquid can flow through the upward flow path and exit the fermenter. Cooling may be provided in the hollow fluid conduit or the vessel. One or more backpressor generators can be used to maintain a backpressure on the fermenter. One or more fluid movers can be used to variously create an induced and/or forced flow in the downward and upward flow paths.
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公开(公告)号：US10781418B2
公开(公告)日：2020-09-22
申请号：US16551414
申请日：2019-08-26
申请人： Huvepharma Inc.
IPC分类号： C12N1/10 , A61K39/012 , C12N1/04 , A61K39/00 , A61K35/68
摘要： Compositions are provided that contain sporulated coccidial oocysts, wherein the compositions are free of antibiotics and comprise formalin at a concentration sufficient to inhibit microbial growth for at least 12 months while maintaining oocyst viability. Methods of preparing such compositions are also provided.
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