公开(公告)号：US20240361213A1

公开(公告)日：2024-10-31

申请号：US18766072

申请日：2024-07-08

申请人： Ventana Medical Systems, Inc.

发明人： Sheelah Ching CHANGHO ,  Michael Allen GURNEY ,  Grishma KHANAL ,  Laurel Anne Katharine MCKEE ,  John Douglas PALTING ,  Woody Yuh-Fan PERNG

IPC分类号： G01N1/31 ,  G01N1/30

CPC分类号： G01N1/31 ,  G01N2001/302

摘要： A method of depigmenting melanin-pigmented samples is provided. The sample is incubated in the presence of a hydrogen peroxide-based solution at a temperature less than 65° C. for up to 180 minutes. Times, temperatures, and concentrations of hydrogen peroxide that appropriately balance extent of depigmentation with maintenance of cellular morphology and sample retention are also disclosed.

公开(公告)号：US20240344017A1

公开(公告)日：2024-10-17

申请号：US18444673

申请日：2024-02-17

申请人： S2 Genomics, Inc.

发明人： Stevan Bogdan Jovanovich ,  Kaiwan Chear ,  Bruce Leisz ,  David Eberhart ,  John Bashkin

IPC分类号： C12M1/33 ,  C12M1/00 ,  C12M1/34 ,  C12N1/06 ,  G01N1/28 ,  G01N1/31 ,  G01N1/40

CPC分类号： C12M45/02 ,  C12M41/12 ,  C12M45/06 ,  C12M45/09 ,  C12M45/20 ,  C12N1/066 ,  G01N1/286 ,  G01N1/31 ,  G01N1/4077 ,  G01N2001/4088

摘要： A system, methods, and apparatus are described to collect and prepare single cells, nuclei, subcellular components, and biomolecules from specimens including tissues and in some embodiments use the single cells to form organoids or microtissues. The system can perform enzymatic and/or physical disruption of the tissue to dissociate it into single-cells and then use a hanging droplet method to form organoids or microtissues.

公开(公告)号：US12066400B2

公开(公告)日：2024-08-20

申请号：US16549450

申请日：2019-08-23

申请人： Massachusetts Institute of Technology

发明人： Kwanghun Chung ,  Sung-Yon Kim ,  Kimberly Ohn ,  Evan Murray ,  Jae Hun Cho

IPC分类号： G01N27/447 ,  B01L3/00 ,  G01N1/31 ,  G01N27/26 ,  G01N33/561

CPC分类号： G01N27/44756 ,  B01L3/502 ,  B01L3/508 ,  G01N1/31 ,  G01N27/26 ,  G01N27/44704 ,  G01N27/44708 ,  G01N27/44713 ,  B01L2300/0609 ,  B01L2400/0421 ,  G01N33/561

摘要： Articles and methods for the active transport of molecules into, within, and/or from a matrix are generally described. In some embodiments, an electric field may be used to alter the position of the molecule with respect to the matrix. The electric field may be used to move the molecule to a new location within the matrix, remove the molecule from the matrix, or infuse the molecule into the matrix. For instance, the electric field may be used to move a molecule having a binding partner within the matrix into or away from the vicinity of the binding partner. In some embodiments, the position of the molecule may be altered by exposing the molecule to an electrodynamic field. In some such embodiments, the molecule exposed to the dynamic electric field may have enhanced mobility and minimal adverse matrix interactions relative to conventional molecular transport methods, and in some cases, a molecule exposed to an electrostatic field. The active transport methods and articles, described herein, may be particularly well-suited for a variety of applications including histological, biological, and pharmaceutical applications.

公开(公告)号：US12061138B2

公开(公告)日：2024-08-13

申请号：US16155723

申请日：2018-10-09

申请人： Cepheid

发明人： John L. Bishop

IPC分类号： G01N1/31 ,  C12Q1/6806 ,  C12Q1/6876 ,  G01N33/68 ,  G01N35/00

CPC分类号： G01N1/31 ,  C12Q1/6806 ,  C12Q1/6876 ,  G01N33/6845 ,  G01N35/00 ,  G01N35/00871 ,  C12Q2600/16

摘要： A biological sample processing apparatus having an enclosure. A plurality of sample processing modules are held by the enclosure. Each sample processing module is configured to hold a removable sample cartridge and to only perform sample processing on a sample within the corresponding removable sample cartridge. Each sample processing module is configured to perform at least one of a plurality of testing processes on the sample within the removable sample cartridge. At least one module in the apparatus is configured to perform nucleic acid amplification and detection.

公开(公告)号：US20240246085A1

公开(公告)日：2024-07-25

申请号：US18628036

申请日：2024-04-05

申请人： LEICA BIOSYSTEMS MELBOURNE PTY LTD.

发明人： Campbell RICHARDS ,  Matthew Struan KING ,  Cyril LIM

IPC分类号： B01L9/00 ,  G01N1/31 ,  G01N1/44

CPC分类号： B01L9/52 ,  G01N1/312 ,  G01N1/44 ,  B01L2300/043 ,  B01L2300/0877 ,  B01L2300/1805

摘要： A sample processing assembly for treatment of a sample on a substrate, the assembly including: a mounting surface for the substrate; and a cover member, the cover member being movable between an open position and a substantially closed position, wherein, when the substrate is placed in the assembly and the cover member is in the substantially closed position, a reaction chamber is formed for processing the sample between the cover member and the substrate, and wherein the mounting surface provides for an air gap between the substrate and the mounting surface. An instrument for treatment of a sample on a substrate including at least one sample processing assembly as provided herein. A method of placing a substrate in a sample processing assembly is also provided.

公开(公告)号：US20240230654A1

公开(公告)日：2024-07-11

申请号：US18404819

申请日：2024-01-04

申请人： Caleb Ericson

发明人： Caleb Ericson

IPC分类号： G01N33/574 ,  G01N1/30 ,  G01N1/31 ,  G01N33/543

CPC分类号： G01N33/57484 ,  G01N1/30 ,  G01N1/312 ,  G01N33/54386 ,  B01L2200/16 ,  B01L2300/0654 ,  G01N2001/302 ,  G01N2001/315

摘要： A surgical system for identifying cancerous tissue includes a dish configured to receive a tissue sample, a frame including a base defining a recess configured to receive the dish, an upright extending upward from the base, and an overhang extending over the base, and a light source coupled to the overhang and positioned to emit light toward the recess.

公开(公告)号：US11986831B2

公开(公告)日：2024-05-21

申请号：US16620303

申请日：2018-08-17

申请人： LEICA BIOSYSTEMS MELBOURNE PTY LTD

发明人： Campbell Richards ,  Matthew Struan King ,  Cyril Lim

IPC分类号： B01L9/00 ,  G01N1/31 ,  G01N1/44

CPC分类号： B01L9/52 ,  G01N1/312 ,  G01N1/44 ,  B01L2300/043 ,  B01L2300/0877 ,  B01L2300/1805

摘要： A sample processing assembly for treatment of a sample on a substrate, the assembly including: a mounting surface for the substrate; and a cover member, the cover member being movable between an open position and a substantially closed position, wherein, when the substrate is placed in the assembly and the cover member is in the substantially closed position, a reaction chamber is formed for processing the sample between the cover member and the substrate, and wherein the mounting surface provides for an air gap between the substrate and the mounting surface. An instrument for treatment of a sample on a substrate including at least one sample processing assembly as provided herein. A method of placing a substrate in a sample processing assembly is also provided.

公开(公告)号：US20240142486A1

公开(公告)日：2024-05-02

申请号：US18244638

申请日：2023-09-11

申请人： Gen-Probe Incorporated

发明人： Rolf SILBERT ,  David OPALSKY ,  David Aaron BUSE ,  Robert J. ROSATI ,  Olev TAMMER ,  Richard CAPELLA ,  Matthias MERTEN

IPC分类号： G01N35/10 ,  B67B7/00 ,  G01F23/263 ,  G01N1/28 ,  G01N1/31 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04

CPC分类号： G01N35/1004 ,  B67B7/00 ,  G01F23/265 ,  G01N1/28 ,  G01N1/31 ,  G01N35/00732 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/04 ,  G01N35/1002 ,  G01N35/1016 ,  G01N35/1079 ,  C40B60/12 ,  G01N2035/00524 ,  G01N2035/1018 ,  G01N2035/1046

摘要： A sample processing station includes two or more container holders on a platform that is rotatable about a central axis of rotation. Each holder is configured to rotate about a secondary axis of rotation. The station includes a capping/decapping mechanism to cap or decap a container held in one of the container holders and an elevator with a chuck guide that contact the container holder as the chuck is lowered by the elevator to positon the chuck with respect to the cap of the container held in the holder and to hold jaws of the container holder in a closed position. In embodiment, the chuck guide includes a yoke with opposed arms and spindles located near distal ends of the arms that engage beveled shoulders of the container holder.

公开(公告)号：US11959931B2

公开(公告)日：2024-04-16

申请号：US17326760

申请日：2021-05-21

申请人： Ventana Medical Systems, Inc.

发明人： Aaron Ewoniuk ,  Dylan Miller ,  Kevin Talucci

IPC分类号： G01N35/10 ,  B01L3/02 ,  G01F15/075 ,  G01F22/00 ,  G01N1/31 ,  G01N15/14 ,  G01N35/00 ,  G01N15/10

CPC分类号： G01N35/1016 ,  B01L3/0241 ,  G01F15/075 ,  G01F22/00 ,  G01N1/312 ,  G01N15/1459 ,  G01N35/00663 ,  G01N35/00722 ,  G01N35/1002 ,  B01L2200/061 ,  B01L2200/14 ,  B01L2200/143 ,  G01N2015/1075 ,  G01N2015/1493 ,  G01N2035/00673 ,  G01N2035/009

摘要： A system and method for dispense characterization is disclosed. According to particular embodiments of the dispense characterization system and method, volumes of dispensed liquids can be determined. In more particular embodiments, additional characteristics and combinations of characteristics of a liquid dispensing event can be determined. Examples of additional characteristics that can be determined include the shape of the dispensing event, the velocity of the dispensing event, and the trajectory of the dispensing event. The dispense characterization system and method can be employed in automated biological sample analysis systems, and are particularly suited for monitoring liquid reagent dispensing events that deliver liquid reagents to a surface of a microscope slide holding a biological sample.

公开(公告)号：US11959840B2

公开(公告)日：2024-04-16

申请号：US16721054

申请日：2019-12-19

申请人： Ventana Medical Systems, Inc.

发明人： Jefferson Curtis Taft ,  David Chafin ,  Michael Otter ,  Benjamin Stevens

IPC分类号： G01N1/30 ,  G01N1/31 ,  G01N29/07 ,  G01N29/44

CPC分类号： G01N1/30 ,  G01N29/07 ,  G01N29/4418 ,  G01N1/31 ,  G01N2291/02475 ,  G01N2291/02491

摘要： A tissue sample that has been removed from a subject can be evaluated. A change in speed of the energy traveling through the sample is evaluated to monitor changes in the biological sample during processing. The monitoring can detect movement of fluid with the sample and cross-linking. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy.