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1.发明申请APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开用于治疗癌症和免疫和自发性疾病的病毒诱导剂
公开(公告)号：WO2010083441A3
公开(公告)日：2010-09-10
申请号：PCT/US2010021243
申请日：2010-01-15
申请人： ABBOTT LAB , HEXAMER LAURA , DING HONG , ELMORE STEVEN W , KUNZER AARON R , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WENDT MICHAEL D
发明人： HEXAMER LAURA , DING HONG , ELMORE STEVEN W , KUNZER AARON R , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WENDT MICHAEL D
IPC分类号： C07D209/08 , A61K31/635 , A61P35/00 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D295/155 , C07D311/14
CPC分类号： C07D295/155 , C07D209/08 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D311/14
摘要： Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译： 公开了抑制抗凋亡Bcl-2蛋白活性的式（I）化合物，含有该化合物的组合物和治疗其中表达抗凋亡Bcl-2蛋白的疾病的方法。
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公开(公告)号：WO2008131000A2
公开(公告)日：2008-10-30
申请号：PCT/US2008/060472
申请日：2008-04-16
申请人： ABBOTT LABORATORIES , ELMORE, Steven, W. , SOUERS, Andrew, J. , BRUNCKO, Milan , SONG, Xiaohong , WANG, Xilu , HASVOLD, Lisa, A. , WANG, Le , KUNZER, Aaron, R. , PARK, Cheol-min , WENDT, Michael, D. , TAO, Zhi-fu
发明人： ELMORE, Steven, W. , SOUERS, Andrew, J. , BRUNCKO, Milan , SONG, Xiaohong , WANG, Xilu , HASVOLD, Lisa, A. , WANG, Le , KUNZER, Aaron, R. , PARK, Cheol-min , WENDT, Michael, D. , TAO, Zhi-fu
IPC分类号： C07D209/34 , C07D401/12 , C07D413/06 , C07D417/04 , A61P35/00 , A61K31/404
CPC分类号： C07D209/42 , A61K31/5377 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D491/113
摘要： Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
摘要翻译： 公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。
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公开(公告)号：WO2013185284A1
公开(公告)日：2013-12-19
申请号：PCT/CN2012/076748
申请日：2012-06-12
申请人： ABBOTT LABORATORIES , ABBOTT LABORATORIES TRADING (SHANGHAI)COMPANY, LTD. , HUBBARD, Robert Dale , MCDANIEL, Keith F. , PARK, Chang Hoon , PRATT, John K. , SOLTWEDEL, Todd , SUN, Chaohong , WANG, Le , WENDT, Michael D
发明人： HUBBARD, Robert Dale , MCDANIEL, Keith F. , PARK, Chang Hoon , PRATT, John K. , SOLTWEDEL, Todd , SUN, Chaohong , WANG, Le , WENDT, Michael D
IPC分类号： C07D401/02 , C07D401/06 , C07D401/12 , C07D401/14 , A61K31/351 , A61P35/00 , A61P37/00 , A61P3/10 , A61P3/04 , A61P29/00
CPC分类号： A61K31/541 , A61K31/4412 , A61K31/50 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D213/30 , C07D213/64 , C07D213/68 , C07D213/74 , C07D213/81 , C07D237/14 , C07D401/02 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D498/04
摘要： Compounds of formula (I) wherein A 1 , A 2 , A 3 , A 4 , J, L, G, and R 1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, diabetes, obesity, cancer, and AIDS are disclosed. Pharmaceutical compositions comprising one or more compounds of formula (I) also are disclosed.
摘要翻译： 其中A1，A2，A3，A4，J，L，G和R1具有说明书中定义的任何值及其药学上可接受的盐的式（I）化合物，其可用作治疗疾病和 公开了包括炎性疾病，糖尿病，肥胖症，癌症和AIDS的病症。 还公开了包含一种或多种式（I）化合物的药物组合物。
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4.发明申请SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES 审中-公开作为治疗癌症和免疫疾病的BCL-2-选择性病毒诱导剂的磺酰胺衍生物
公开(公告)号：WO2011068561A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/036919
申请日：2010-06-01
申请人： ABBOTT LABORATORIES , BRUNCKO, Milan , DING, Hong , DOHERTY, George A. , ELMORE, Steven, W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron , MANTEI, Robert, A. , McCLELLAN, William, J. , PARK, Chang, H. , PARK, Cheol-Min , PETROS, Andrew, M. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , TAO, Zhi-Fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael, D. , HANSEN, Todd, M.
发明人： BRUNCKO, Milan , DING, Hong , DOHERTY, George A. , ELMORE, Steven, W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron , MANTEI, Robert, A. , McCLELLAN, William, J. , PARK, Chang, H. , PARK, Cheol-Min , PETROS, Andrew, M. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , TAO, Zhi-Fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael, D. , HANSEN, Todd, M.
IPC分类号： C07D405/12 , A61K31/404 , A61P35/00 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D235/26 , C07D249/04 , C07D295/14 , C07D309/14 , C07D401/12 , C07D295/125 , C07D231/56 , C07D405/14
CPC分类号： C07D401/12 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D209/32 , C07D211/58 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D241/04 , C07D249/04 , C07D295/125 , C07D295/14 , C07D295/155 , C07D309/04 , C07D309/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Disclosed are compounds (I) which inhibit the activity of anti-apoptotic Bc1-2 or Bc1 xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti apoptotic Bc1-2 protein.
摘要翻译： 公开了抑制抗凋亡Bc1-2或Bc1 xL蛋白活性的化合物（I），含有该化合物的组合物和治疗其中表达抗凋亡Bc1-2蛋白的疾病的方法。
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5.发明申请
公开(公告)号：WO2010065824A3
公开(公告)日：2010-10-07
申请号：PCT/US2009066722
申请日：2009-12-04
申请人： ABBOTT LAB , BRUNCKO MILAN , DAI YUJIA , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
发明人： BRUNCKO MILAN , DAI YUJIA , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
IPC分类号： A61P35/00 , A61K31/496 , C07D403/12
CPC分类号： C07D405/12 , C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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6.发明申请APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开用于治疗癌症和免疫和自发性疾病的病毒诱导剂
公开(公告)号：WO2010083442A1
公开(公告)日：2010-07-22
申请号：PCT/US2010/021245
申请日：2010-01-15
申请人： ABBOTT LABORATORIES , KUNZER, Aaron, R. , ELMORE, Steven, W. , HEXAMER, Laura , PARK, Cheol-Min , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , WANG, Gary, T. , WANG, Xilu , WENDT, Michael, D.
发明人： KUNZER, Aaron, R. , ELMORE, Steven, W. , HEXAMER, Laura , PARK, Cheol-Min , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , WANG, Gary, T. , WANG, Xilu , WENDT, Michael, D.
IPC分类号： C07C311/51 , C07D207/36 , C07D211/96 , C07D231/18 , C07D261/10 , C07D275/03 , C07D277/36 , C07D333/34 , C07D285/135 , C07D295/155 , C07D285/125 , C07D295/26 , A61K31/18 , A61P35/00
CPC分类号： C07D277/54 , C07C311/00 , C07C311/51 , C07D207/36 , C07D211/96 , C07D231/18 , C07D261/10 , C07D275/03 , C07D277/36 , C07D277/60 , C07D285/125 , C07D285/135 , C07D295/155 , C07D295/26 , C07D333/34 , C07D333/36 , C07D333/42 , C07D333/62 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/14 , C07D487/04 , C07D513/04
摘要： Disclosed are compounds of Formula (1), in which A 1 , Z 1 , Z 1A , Z 2 , Z 2A , L 1 and Z 3 are as defined in the claims, which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and their use in treating diseases during which anti-apoptotic Bcl-2 protein is expressed.
摘要翻译： 公开了式（1）的化合物，其中A1，Z1，Z1A，Z2，Z2A，L1和Z3如权利要求中所定义，其抑制抗凋亡Bcl-2蛋白的活性，含有这些化合物的组合物及其 用于治疗抗凋亡Bcl-2蛋白表达的疾病。
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公开(公告)号：WO2007008627A3
公开(公告)日：2007-01-18
申请号：PCT/US2006/026424
申请日：2006-07-07
申请人： ABBOTT LABORATORIES , WENDT, Michael, D. , SHEN, Wang , DICKMAN, Daniel, A. , DING, Hong , THOMAS, Sheela, A. , AUGERI, David , ELMORE, Steven, W.
发明人： WENDT, Michael, D. , SHEN, Wang , DICKMAN, Daniel, A. , DING, Hong , THOMAS, Sheela, A. , AUGERI, David , ELMORE, Steven, W.
IPC分类号： A61K31/192 , C07C15/12 , A61P35/00
摘要： Compounds which inhibit the activity of anti-apoptotic Mcl-I protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl- 1 protein are disclosed.
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公开(公告)号：WO2007008627A2
公开(公告)日：2007-01-18
申请号：PCT/US2006026424
申请日：2006-07-07
申请人： ABBOTT LAB , WENDT MICHAEL D , SHEN WANG , DICKMAN DANIEL A , DING HONG , THOMAS SHEELA A , AUGERI DAVID , ELMORE STEVEN W
发明人： WENDT MICHAEL D , SHEN WANG , DICKMAN DANIEL A , DING HONG , THOMAS SHEELA A , AUGERI DAVID , ELMORE STEVEN W
IPC分类号： A61K31/192 , A61P35/00 , C07C15/12
CPC分类号： C07C311/41 , C07C63/48 , C07C63/49 , C07C65/26 , C07C65/28 , C07C205/58 , C07C229/52 , C07C229/56 , C07C233/81 , C07C311/13 , C07C311/18 , C07C311/21 , C07C311/37 , C07C311/44 , C07C323/20 , C07C323/25 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/18 , C07C2603/74 , C07D207/30 , C07D213/53 , C07D215/12 , C07D215/48 , C07D333/34
摘要： Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.
摘要翻译： 公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物和治疗疾病的方法，其表达为Mcl-1蛋白。
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公开(公告)号：WO2005049594A1
公开(公告)日：2005-06-02
申请号：PCT/US2004/037911
申请日：2004-11-12
申请人： ABBOTT LABORATORIES , BRUNCKO, Milan , DING, Hong , ELMORE, Steven , KUNZER, Aaron R. , LYNCH, Christopher L. , MCCLELLAN, William , PARK, Cheol-Min , PETROS, Andrew , SONG, Xiaohong , WANG, Xilu , TU, Noah , WENDT, Michael D.
发明人： BRUNCKO, Milan , DING, Hong , ELMORE, Steven , KUNZER, Aaron R. , LYNCH, Christopher L. , MCCLELLAN, William , PARK, Cheol-Min , PETROS, Andrew , SONG, Xiaohong , WANG, Xilu , TU, Noah , WENDT, Michael D.
IPC分类号： C07D295/14
CPC分类号： C07D277/74 , C04B35/632 , C07C323/25 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D295/13 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D409/12 , C07D487/04 , C07D487/08
摘要： Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein family member.
摘要翻译： 公开了抑制抗凋亡蛋白家族成员的活性的N-酰基磺酰胺化合物，含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生一种或多种抗凋亡蛋白家族成员的表达。
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公开(公告)号：WO2005049593A2
公开(公告)日：2005-06-02
申请号：PCT/US2004/036770
申请日：2004-11-03
申请人： ABBOTT LABORATORIES , BRUNCKO, Milan , ELMORE, Steven , KUNZER, Aaron, R. , LYNCH, Christopher, L. , WANG, Xilu , WENDT, Michael, D.
发明人： BRUNCKO, Milan , ELMORE, Steven , KUNZER, Aaron, R. , LYNCH, Christopher, L. , WANG, Xilu , WENDT, Michael, D.
IPC分类号： C07D295/14
CPC分类号： C07D277/74 , C04B35/632 , C07C323/25 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D295/13 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D409/12 , C07D487/04 , C07D487/08
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which are expressed one or more than one of an anti apoptotic protein family member.
摘要翻译： 公开了抑制抗凋亡蛋白质家族成员的活性的化合物，含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，在该疾病期间表达一种或多种抗 - 凋亡蛋白家族成员。
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