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公开(公告)号：US10781247B2
公开(公告)日：2020-09-22
申请号：US15886118
申请日：2018-02-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ray Camphausen , Brent Morse , Stuart Emanuel , David Fabrizio
Abstract: The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
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公开(公告)号：US10221232B2
公开(公告)日：2019-03-05
申请号：US15404749
申请日：2017-01-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ray Camphausen , David Fabrizio , Martin C. Wright , Patrick Gage , John Mendlein
IPC: C07K14/78 , C07K14/47 , C07K14/71 , A61K38/39 , A61K39/395 , C07K19/00 , C12N15/10 , C40B30/04 , C40B40/08 , A61K38/18 , C07K14/00 , C07K14/765 , C07K14/79 , C07K16/00 , A61K47/60 , A61K47/64 , A61K47/68 , C07K16/22 , C07K16/28 , A61K39/00 , C40B40/10
Abstract: The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins in pharmaceutical preparations and derivatives of such proteins and the uses of same in diagnostic, research and therapeutic applications. The invention further provides cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins.
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3.发明授权公开(公告)号：US11149077B2
公开(公告)日：2021-10-19
申请号：US16244851
申请日：2019-01-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ray Camphausen , David Fabrizio , Martin C. Wright , Patrick Gage , John Mendlein
IPC: C07K14/78 , C07K14/71 , C07K16/28 , A61K38/17 , A61K38/39 , A61K39/395 , A61K47/10 , A61K47/60 , A61K47/64 , A61K47/68 , C12N15/10 , C40B30/04 , C40B40/08 , A61K38/18 , C07K14/00 , C07K14/765 , C07K14/79 , C07K16/00 , C07K14/47 , A61K39/00 , C07K19/00 , C40B40/10
Abstract: The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins in pharmaceutical preparations and derivatives of such proteins and the uses of same in diagnostic, research and therapeutic applications. The invention further provides cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins.
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公开(公告)号：US10221438B2
公开(公告)日：2019-03-05
申请号：US15363724
申请日：2016-11-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael L. Gosselin , David Fabrizio , Joanna F. Swain , Tracy Mitchell , Ray Camphausen , Sharon T. Cload , Eric Furfine , Paul E. Morin , Ranjan Mukherjee , Simeon I. Taylor
IPC: A61K38/00 , A61K47/62 , A61K47/64 , C07K14/50 , C07K14/78 , C12N15/62 , C12P21/00 , C07K14/435 , C07K14/575
Abstract: The present invention relates to an antibody-like protein based on the tenth fibronectin type III domain (10Fn3) that binds to serum albumin. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
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公开(公告)号：US09540424B2
公开(公告)日：2017-01-10
申请号：US14552823
申请日：2014-11-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael L. Gosselin , David Fabrizio , Joanna F. Swain , Tracy Mitchell , Ray Camphausen , Sharon T. Cload , Eric Furfine , Paul E. Morin , Ranjan Mukerjee , Simeon I. Taylor
IPC: A61K38/00 , C07K14/435 , A61K47/48 , C07K14/78 , C12N15/62 , C07K14/50 , C07K14/575
CPC classification number: C12P21/005 , A61K38/00 , A61K47/62 , A61K47/643 , C07K14/435 , C07K14/50 , C07K14/575 , C07K14/78 , C07K2319/70 , C12N15/62
Abstract: The present invention relates to an antibody-like protein based on the tenth fibronectin type III domain (10Fn3) that binds to serum albumin. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
Abstract translation: 本发明涉及基于结合血清白蛋白的第十纤连蛋白III型结构域（10Fn3）的抗体样蛋白。 本发明还涉及包含与用于诊断和治疗应用的异源蛋白质连接的血清白蛋白结合10Fn3的融合分子。
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Patent Agency Ranking
公开(公告)号：US09234028B2
公开(公告)日：2016-01-12
申请号：US13956952
申请日：2013-08-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ray Camphausen , Brent Morse , Stuart Emanuel , David Fabrizio
IPC: A61K38/17 , A61K38/39 , C07K14/78 , C07K14/435 , C07K16/28 , C07K14/765 , C07K14/79 , C07K19/00
CPC classification number: C07K14/78 , A61K38/00 , C07K14/765 , C07K14/79 , C07K16/2863 , C07K19/00 , C07K2317/31 , C07K2318/20 , C07K2319/30
Abstract: The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
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公开(公告)号：US11203630B2
公开(公告)日：2021-12-21
申请号：US16549462
申请日：2019-08-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Tracy S. Mitchell , Michael L. Gosselin , Dasa Lipovsek , Rex Parker , Ray Camphausen , Jonathan H. Davis , David Fabrizio
IPC: C07H21/04 , C12P21/06 , C12N15/87 , C12N5/20 , C12N1/20 , C12N15/00 , C07K14/78 , A61K47/64 , A61K38/00
Abstract: The present invention relates to polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin, with south pole loop substitutions. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
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公开(公告)号：US09920108B2
公开(公告)日：2018-03-20
申请号：US14954596
申请日：2015-11-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ray Camphausen , Brent Morse , Stuart Emanuel , David Fabrizio
CPC classification number: C07K14/78 , A61K38/00 , C07K14/765 , C07K14/79 , C07K16/2863 , C07K19/00 , C07K2317/31 , C07K2318/20 , C07K2319/30
Abstract: The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
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公开(公告)号：US12194110B2
公开(公告)日：2025-01-14
申请号：US17483393
申请日：2021-09-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Paul E. Morin , David Donnelly , Dasa Lipovsek , Jochem Gokemeijer , Maria N. Jure-Kunkel , David Fabrizio , Martin C. Wright , Douglas Dischino , Samuel J. Bonacorsi, Jr. , Ralph Adam Smith , Virginie Lafont , Daniel Cohen
Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.
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公开(公告)号：US20220204589A1
公开(公告)日：2022-06-30
申请号：US17527238
申请日：2021-11-16
Applicant: Bristol-Myers Squibb Company
Inventor： Tracy S. MITCHELL , Michael L. Gosselin , Dasa Lipovsek , Rex Parker , Ray Camphausen , Jonathan H. Davis , David Fabrizio
Abstract: The present invention relates to polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin, with south pole loop substitutions. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
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