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    Illumination Systems
    1.
    发明申请
    Illumination Systems 审中-公开
    照明系统

    公开(公告)号：US20150185152A1

    公开(公告)日：2015-07-02

    申请号：US14420647

    申请日：2013-08-09

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Kevin Maher

    IPC: G01N21/64

    CPC classification number: G01N21/6486 ,  G01N21/6452 ,  G01N2021/6463 ,  G01N2201/0446 ,  G01N2201/062 ,  G01N2201/0631

    Abstract: A system for detecting emissions from a sample containing nucleotide molecules contains a sample holder, an optical illumination system, an optical sensor. The sample holder includes a plurality of spatially separated reaction sites configured to hold a sample containing nucleotide molecules. The optical illumination system comprising a radiant source configured to simultaneously illuminate two or more of the reaction sites. The illumination system includes a homogenizer. An output from the homogenizer has less variation in power, energy, irradiance, or intensity than the variation in power, energy, irradiance, or intensity of the source.

    Abstract translation: 用于检测含有核苷酸分子的样品的发射的系统包含样品架，光学照明系统，光学传感器。 样品架包括多个空间分离的反应位点，其配置成容纳含有核苷酸分子的样品。 光学照明系统包括被配置为同时照亮两个或更多个反应位点的辐射源。 照明系统包括均质器。 来自均化器的输出与功率，能量，辐照度或源的强度的变化相比，功率，能量，辐照度或强度的变化较小。

    Systems and methods for biological analysis
    3.
    发明授权
    Systems and methods for biological analysis 有权

    公开(公告)号：US10323274B2

    公开(公告)日：2019-06-18

    申请号：US14348504

    申请日：2012-09-28

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jacob K. Freudenthal ,  Kevin Maher ,  Ming Song Chen ,  Theodore E. Straub ,  Kuan Moon Boo ,  Soo Yong Lau

    IPC: C12Q1/686 ,  B01L3/00 ,  B01L7/00

    Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.

    Systems and methods for assessing of biological samples
    7.
    发明授权
    Systems and methods for assessing of biological samples 有权

    公开(公告)号：US11987840B2

    公开(公告)日：2024-05-21

    申请号：US16234287

    申请日：2018-12-27

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Kevin Maher

    IPC: C12Q1/686 ,  B01L3/00 ,  B01L7/00 ,  G02B5/00

    CPC classification number: C12Q1/686 ,  B01L3/50857 ,  B01L7/52 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0893 ,  B01L2300/0896

    Abstract: A system for determining the number of target nucleotide molecules in a sample includes a sample holder, an excitation optical system, an optical sensor, and an emission optical system. The sample holder is configured to receive an article comprising at least 20,000 separate reaction sites. The excitation optical system comprises a light source configured to simultaneously illuminate the at least 20,000 separate reaction sites. The optical sensor comprises a predetermined number of pixels, the predetermined number of pixels being at least 20 times the number of separate reaction sites. The emission optical system comprises a system working distance from the sample holder, wherein the working distance is less than or equal to 60 millimeters.

    Optical system for capillary electrophoresis
    8.
    发明授权
    Optical system for capillary electrophoresis 有权

    公开(公告)号：US11280759B2

    公开(公告)日：2022-03-22

    申请号：US15124013

    申请日：2015-03-06

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Kevin Maher

    IPC: G01N27/447 ,  G01N21/64

    Abstract: A system for conducting a capillary electrophoresis assay includes a light source, an interface, and an illumination optical system. The light source is configured to provide a source beam of electromagnetic radiation. The interface is configured to receive a plurality of capillaries containing one or more target molecules or sequence of molecules. The illumination optical system is configured in use to produce a plurality of output beams from the source beam and to direct each of the output beams to corresponding capillary of the plurality of capillaries.

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