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公开(公告)号：US08852952B2
公开(公告)日：2014-10-07
申请号：US12990815
申请日：2009-05-04
申请人： Michael G. Pollack , Prasanna Thwar , Vamsee K. Pamula , Allen Eckhardt , Alexander Shenderov , Dwayne Allen , Vijay Srinivasan
发明人： Michael G. Pollack , Prasanna Thwar , Vamsee K. Pamula , Allen Eckhardt , Alexander Shenderov , Dwayne Allen , Vijay Srinivasan
IPC分类号： G01N1/00
CPC分类号： B01L3/502784 , B01L3/502715 , B01L3/502761 , B01L7/52 , B01L2200/027 , B01L2200/0673 , B01L2300/022 , B01L2300/023 , B01L2300/024 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0415 , B01L2400/0424 , B01L2400/0427 , B01L2400/043 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0683 , G01N27/44704 , G01N35/0098 , G01N2035/1046 , Y10T436/25 , Y10T436/2575
摘要： The invention provides droplet actuators and droplet actuator cassettes including reagent storage capabilities, as well as methods of making and using the droplet actuators and cassettes. The invention also provides continuous flow channel elements and techniques for using electrodes to manipulate droplets in flowing streams. The invention also discloses methods of separating compounds on a droplet actuator. Various other aspects of the invention are also disclosed.
摘要翻译： 本发明提供了包括试剂储存能力的液滴致动器和液滴致动器盒，以及制造和使用液滴致动器和盒的方法。 本发明还提供了用于使用电极在流动流中操纵液滴的连续流动通道元件和技术。 本发明还公开了在液滴致动器上分离化合物的方法。 还公开了本发明的各种其它方面。
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公开(公告)号：US20110104816A1
公开(公告)日：2011-05-05
申请号：US12990815
申请日：2009-05-04
申请人： Michael G. Pollack , Prasanna Thwar , Vamsee K. Pamula , Vijay Srinivasan , Allen Eckhardt , Alexander Shenderov , Dwayne Allen
发明人： Michael G. Pollack , Prasanna Thwar , Vamsee K. Pamula , Vijay Srinivasan , Allen Eckhardt , Alexander Shenderov , Dwayne Allen
IPC分类号： G01N1/00
CPC分类号： B01L3/502784 , B01L3/502715 , B01L3/502761 , B01L7/52 , B01L2200/027 , B01L2200/0673 , B01L2300/022 , B01L2300/023 , B01L2300/024 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0415 , B01L2400/0424 , B01L2400/0427 , B01L2400/043 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0683 , G01N27/44704 , G01N35/0098 , G01N2035/1046 , Y10T436/25 , Y10T436/2575
摘要： The invention provides droplet actuators and droplet actuator cassettes including reagent storage capabilities, as well as methods of making and using the droplet actuators and cassettes. The invention also provides continuous flow channel elements and techniques for using electrodes to manipulate droplets in flowing streams. The invention also discloses methods of separating compounds on a droplet actuator. Various other aspects of the invention are also disclosed.
摘要翻译： 本发明提供了包括试剂储存能力的液滴致动器和液滴致动器盒，以及制造和使用液滴致动器和盒的方法。 本发明还提供了用于使用电极在流动流中操纵液滴的连续流动通道元件和技术。 本发明还公开了在液滴致动器上分离化合物的方法。 还公开了本发明的各种其它方面。
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公开(公告)号：US09675972B2
公开(公告)日：2017-06-13
申请号：US12921256
申请日：2009-03-09
申请人： Michael G. Pollack , Ramakrishna Sista , Zhishan Hua , Vamsee K. Pamula , Arjun Sudarsan , Vijay Srinivasan , Prasanna Thwar , Alexander Shenderov , Dwayne Allen
发明人： Michael G. Pollack , Ramakrishna Sista , Zhishan Hua , Vamsee K. Pamula , Arjun Sudarsan , Vijay Srinivasan , Prasanna Thwar , Alexander Shenderov , Dwayne Allen
CPC分类号： B01L3/0282 , B01F13/002 , B01F13/0023 , B01F13/0071 , B01F13/0076 , B01F13/0818 , B01L3/502753 , B01L2200/0621 , B01L2200/0631 , B01L2200/0652 , B01L2200/0668 , B01L2200/141 , B01L2300/0832 , B01L2300/0864 , B01L2300/0867 , B01L2400/043 , B03C1/01 , B03C1/284 , B03C1/286 , B03C2201/18 , B03C2201/26 , B03C2201/28 , Y10T436/25
摘要： Methods of concentrating beads in a droplet and/or loading beads on a fluidic device are provided, including among other things, a method of concentrating beads in a droplet, the method comprising: (a) providing a droplet actuator comprising: (i) an interior droplet operations volume; and (ii) a reservoir exterior to the interior volume; (iii) a droplet established in a liquid path extending from the reservoir into the interior volume; (b) providing magnetically responsive beads in the portion of the droplet which is in the reservoir; (c) magnetically attracting the magnetically responsive beads through the liquid path into the portion of the droplet which is in the interior volume; and (d) forming a droplet comprising one or more of the magnetically responsive beads in the interior volume.
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公开(公告)号：US20110104747A1
公开(公告)日：2011-05-05
申请号：US12921256
申请日：2009-03-09
申请人： Michael G. Pollack , Ramakrishna Sista , Zhishan Hua , Vamsee K. Pamula , Arjun Sudarsan , Vijay Srinivasan , Prasanna Thwar , Alexander Shenderov , Dwayne Allen
发明人： Michael G. Pollack , Ramakrishna Sista , Zhishan Hua , Vamsee K. Pamula , Arjun Sudarsan , Vijay Srinivasan , Prasanna Thwar , Alexander Shenderov , Dwayne Allen
IPC分类号： G01N1/40
CPC分类号： B01L3/0282 , B01F13/002 , B01F13/0023 , B01F13/0071 , B01F13/0076 , B01F13/0818 , B01L3/502753 , B01L2200/0621 , B01L2200/0631 , B01L2200/0652 , B01L2200/0668 , B01L2200/141 , B01L2300/0832 , B01L2300/0864 , B01L2300/0867 , B01L2400/043 , B03C1/01 , B03C1/284 , B03C1/286 , B03C2201/18 , B03C2201/26 , B03C2201/28 , Y10T436/25
摘要： Methods of concentrating beads in a droplet and/or loading beads on a fluidic device are provided, including among other things, a method of concentrating beads in a droplet, the method comprising: (a) providing a droplet actuator comprising: (i) an interior droplet operations volume; and (ii) a reservoir exterior to the interior volume; (iii) a droplet established in a liquid path extending from the reservoir into the interior volume; (b) providing magnetically responsive beads in the portion of the droplet which is in the reservoir; (c) magnetically attracting the magnetically responsive beads through the liquid path into the portion of the droplet which is in the interior volume; and (d) forming a droplet comprising one or more of the magnetically responsive beads in the interior volume.
摘要翻译： 提供了将珠子集中在流体装置上的液滴和/或负载珠粒中的方法，其中包括将珠粒集中在液滴中的方法，所述方法包括：（a）提供液滴致动器，其包括：（i） 内部液滴操作量; 和（ii）内部容积外部的储存器; （iii）建立在从储存器延伸到内部容积中的液体路径中的液滴; （b）在储存器中的液滴部分中提供磁响应珠; （c）通过所述液体路径将所述磁响应珠磁吸引到位于所述内部容积中的所述液滴的所述部分中; 和（d）在内部容积中形成包含一个或多个磁响应珠的液滴。
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公开(公告)号：US08460528B2
公开(公告)日：2013-06-11
申请号：US12681879
申请日：2008-10-14
IPC分类号： G01N27/26
CPC分类号： B01L3/5027 , B01J2219/00371 , B01J2219/00378 , B01J2219/00385 , B01J2219/00515 , B01J2219/00518 , B01J2219/0065 , B01J2219/00653 , B01L3/502715 , B01L3/502792 , B01L2200/027 , B01L2200/0605 , B01L2200/0668 , B01L2200/16 , B01L2300/0816 , B01L2300/0819 , B01L2300/0845 , B01L2300/089 , B01L2400/0427 , B01L2400/0478 , B01L2400/0487
摘要： On-board reagent storage, handling, and dispensing apparatuses and methods for droplet actuator systems are provided. In one embodiment, a fluidic analyzer is provided and includes a droplet actuator including a substrate including a plurality of electrodes configured to actuate a droplet and a reagent storage component in selective fluid communication with the droplet actuator and including a reagent configured to combine with a solvent at a time of use. In another embodiment, a method of conducting fluidic analysis is provided and includes storing a reagent within a reagent storage component in fluid communication with a droplet actuator including a plurality of electrodes configured to actuate a droplet and combining the reagent with a solvent at a time for use within the droplet actuator.
摘要翻译： 提供了用于液滴致动器系统的机载试剂储存，处理和分配装置和方法。 在一个实施例中，提供了一种流体分析器，其包括液滴致动器，该液滴致动器包括基底，该基底包括配置成致动液滴的多个电极和与液滴致动器选择性流体连通的试剂储存部件，并且包括配置成与溶剂组合的试剂 在使用时。 在另一个实施例中，提供了一种进行流体分析的方法，包括将试剂储存在与液滴致动器流体连通的液体致动器内，所述液滴致动器包括配置成致动液滴的多个电极并且一次将溶剂与溶剂组合 在液滴致动器内使用。
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公开(公告)号：US20100282609A1
公开(公告)日：2010-11-11
申请号：US12681879
申请日：2008-10-14
IPC分类号： B01J19/08
CPC分类号： B01L3/5027 , B01J2219/00371 , B01J2219/00378 , B01J2219/00385 , B01J2219/00515 , B01J2219/00518 , B01J2219/0065 , B01J2219/00653 , B01L3/502715 , B01L3/502792 , B01L2200/027 , B01L2200/0605 , B01L2200/0668 , B01L2200/16 , B01L2300/0816 , B01L2300/0819 , B01L2300/0845 , B01L2300/089 , B01L2400/0427 , B01L2400/0478 , B01L2400/0487
摘要： On-board reagent storage, handling, and dispensing apparatuses and methods for droplet actuator systems are provided. In one embodiment, a fluidic analyzer is provided and includes a droplet actuator including a substrate including a plurality of electrodes configured to actuate a droplet and a reagent storage component in selective fluid communication with the droplet actuator and including a reagent configured to combine with a solvent at a time of use. In another embodiment, a method of conducting fluidic analysis is provided and includes storing a reagent within a reagent storage component in fluid communication with a droplet actuator including a plurality of electrodes configured to actuate a droplet and combining the reagent with a solvent at a time for use within the droplet actuator.
摘要翻译： 提供了用于液滴致动器系统的机载试剂储存，处理和分配装置和方法。 在一个实施例中，提供了一种流体分析器，其包括液滴致动器，该液滴致动器包括基底，该基底包括配置成致动液滴的多个电极和与液滴致动器选择性流体连通的试剂储存部件，并且包括配置成与溶剂组合的试剂 在使用时。 在另一个实施例中，提供了一种进行流体分析的方法，包括将试剂储存在与液滴致动器流体连通的液体致动器内，所述液滴致动器包括配置成致动液滴的多个电极并且一次将溶剂与溶剂组合 在液滴致动器内使用。
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公开(公告)号：US08702938B2
公开(公告)日：2014-04-22
申请号：US12676384
申请日：2008-09-04
CPC分类号： B01L3/502792 , B01L2200/12 , B01L2300/0819 , B01L2300/089 , B01L2400/0415 , B01L2400/0421 , B01L2400/0427 , Y10T29/49826
摘要： The invention provides a droplet actuator comprising a base substrate and a top substrate separated to form a gap, wherein: (a) the base substrate comprises electrodes configured for conducting droplet operations in the gap; and (b) the top substrate comprises a first portion coupled to second portion, where the second portion comprises one or more openings establishing a fluid path extending from an exterior of the droplet actuator and into the gap. The invention also provides related methods of manufacturing the droplet actuator, methods of using the droplet actuator, and methods of loading the droplet actuator.
摘要翻译： 本发明提供了一种液滴致动器，其包括分离的基底基板和顶部基板以形成间隙，其中：（a）基底基板包括构造成用于在间隙中进行液滴操作的电极; 和（b）顶部衬底包括联接到第二部分的第一部分，其中第二部分包括建立从液滴致动器的外部延伸到间隙中的流体路径的一个或多个开口。 本发明还提供了制造液滴致动器的相关方法，使用液滴致动器的方法以及装载液滴致动器的方法。
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公开(公告)号：US20100282608A1
公开(公告)日：2010-11-11
申请号：US12676384
申请日：2008-09-04
CPC分类号： B01L3/502792 , B01L2200/12 , B01L2300/0819 , B01L2300/089 , B01L2400/0415 , B01L2400/0421 , B01L2400/0427 , Y10T29/49826
摘要： The invention provides a droplet actuator comprising a base substrate and a top substrate separated to form a gap, wherein: (a) the base substrate comprises electrodes configured for conducting droplet operations in the gap; and (b) the top substrate comprises a first portion coupled to second portion, where the second portion comprises one or more openings establishing a fluid path extending from an exterior of the droplet actuator and into the gap. The invention also provides related methods of manufacturing the droplet actuator, methods of using the droplet actuator, and methods of loading the droplet actuator.
摘要翻译： 本发明提供了一种液滴致动器，其包括分离的基底基板和顶部基板以形成间隙，其中：（a）基底基板包括构造成用于在间隙中进行液滴操作的电极; 和（b）顶部衬底包括联接到第二部分的第一部分，其中第二部分包括建立从液滴致动器的外部延伸到间隙中的流体路径的一个或多个开口。 本发明还提供了制造液滴致动器的相关方法，使用液滴致动器的方法以及装载液滴致动器的方法。
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公开(公告)号：US08734629B2
公开(公告)日：2014-05-27
申请号：US13101787
申请日：2011-05-05
申请人： Alexander Shenderov
发明人： Alexander Shenderov
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01L3/502792 , B01F13/0071 , B01F13/0076 , B01F2005/0017 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L2200/0673 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0819 , B01L2300/0867 , B01L2300/089 , B01L2400/0415 , B01L2400/0427 , F04B17/00 , F04B19/006 , F16K99/0001 , F16K99/0017 , G02B26/005
摘要： A series of microactuators for manipulating small quantities of liquids, and methods of using these for manipulating liquids, are disclosed. The microactuators are based on the phenomenon of electrowetting and contain no moving parts. The force acting on the liquid is a potential-dependent gradient of adhesion energy between the liquid and a solid insulating surface.
摘要翻译： 公开了一系列用于操作少量液体的微致动器以及使用它们来操纵液体的方法。 微致动器基于电润湿现象，不含运动部件。 作用在液体上的力是液体和固体绝缘表面之间的粘附能的电势梯度。
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公开(公告)号：US20100087012A1
公开(公告)日：2010-04-08
申请号：US12596902
申请日：2008-04-23
申请人： Alexander Shenderov
发明人： Alexander Shenderov
IPC分类号： G01N33/543 , B01L3/00 , G01N1/28
CPC分类号： G01N1/2202 , G01N2001/2217 , Y10T436/25375
摘要： An aerosol sample collector with an air flow path comprising: (i) at a first segment thereof, a particle charging device, and (i) at a second segment thereof, deflection plates configured to focus particles of a desired charge into a preselected cross-section of the air flow path. The air flow path also includes charged substrates arranged at an outflow portion of the air flow path to collect charged particles on a collection surface of the charged substrates; and an exit path for flowing particles not in the preselected cross-section of the air flow path away from the charged substrates. Related methods are also provided.
摘要翻译： 一种具有空气流动路径的气溶胶样品收集器，包括：（i）在其第一部分处具有颗粒充电装置，和（i）在其第二部分处，配置成将所需电荷的颗粒聚焦成预选交联的偏转板， 空气流路的截面。 空气流路还包括布置在空气流动路径的流出部分处的带电基板，以将带电粒子收集在带电基板的收集表面上; 以及用于使不在所述空气流路的预选横截面中的颗粒流过所述带电基板的出口路径。 还提供了相关方法。
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