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    MASS TAG ANALYSIS FOR RARE CELLS AND CELL FREE MOLECULES
    3.
    发明申请
    MASS TAG ANALYSIS FOR RARE CELLS AND CELL FREE MOLECULES 有权

    公开(公告)号：US20230115304A1

    公开(公告)日：2023-04-13

    申请号：US18075578

    申请日：2022-12-06

    Applicant: Purdue Research Foundation

    Inventor： Zane Baird ,  Robert Graham Cooks ,  Adam Hollerbach ,  Zheng Ouyang ,  Michael Pugia

    IPC: G01N33/53

    Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.

    METHODS FOR ANALYZING A TISSUE SAMPLE
    5.
    发明申请
    METHODS FOR ANALYZING A TISSUE SAMPLE 有权

    公开(公告)号：US20220093380A1

    公开(公告)日：2022-03-24

    申请号：US17231224

    申请日：2021-04-15

    Applicant: Purdue Research Foundation

    Inventor： Yu Xia ,  Zheng Ouyang ,  Xiaoxiao Ma

    IPC: H01J49/04 ,  G01N1/30 ,  G01N33/92 ,  G01N30/00 ,  G01N1/40 ,  G01N30/72 ,  G01N30/88 ,  H01J49/00

    Abstract: The invention generally relates to methods for analyzing a tissue sample. In certain aspects, the invention provides methods that involve obtaining a tissue sample including an unsaturated compound, conducting a radical reaction on the tissue sample that targets a carbon-carbon double bond within the unsaturated compound to thereby produce a plurality of compound isomers, subjecting the plurality of compound isomers to mass spectrometry analysis to identify a location of the carbon-carbon double bond within the unsaturated compound, and quantifying the plurality of compound isomers in order to distinguish normal tissue from diseased tissue.

    Mass spectrometry analysis of microorganisms in samples
    6.
    发明授权
    Mass spectrometry analysis of microorganisms in samples 有权

    公开(公告)号：US10811241B2

    公开(公告)日：2020-10-20

    申请号：US16809171

    申请日：2020-03-04

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Ahmed Mohamed Hamid ,  Alan Keith Jarmusch ,  Zheng Ouyang

    IPC: H01J49/04 ,  C12N13/00 ,  C12Q1/04 ,  H01J49/16

    Abstract: The invention generally relates to methods for analyzing an analyte in a sample. In certain embodiments, the methods involve providing a capture module, the module configured to capture an analyte in a sample in an ambient environment and generate ions of the analyte, wherein the capture module comprises a cartridge and a porous substrate within the cartridge that is connected to a voltage source, and wherein the porous substrate further comprises an internal standard; capturing the analyte in the sample to the porous substrate of the capture module; generating ions of the analyte and the internal standard held by the porous substrate via the voltage source that is coupled to the porous substrate; and analyzing the generated ions of the analyte and the internal standard in a mass analyzer that is operably coupled to the capture module.

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