公开(公告)号：US20110034964A1

公开(公告)日：2011-02-10

申请号：US12920086

申请日：2009-02-27

申请人： Yafei Bi ,  Haifeng Li ,  Mark Zdeblick ,  Todd Thompson ,  Robert Leichner

发明人： Yafei Bi ,  Haifeng Li ,  Mark Zdeblick ,  Todd Thompson ,  Robert Leichner

IPC分类号： A61N1/08 ,  A61N1/362 ,  A61N1/05 ,  A61N1/39

CPC分类号： A61N1/05 ,  A61N1/025 ,  A61N1/37 ,  A61N1/378

摘要： Apparatus and methods enable robust, reliable control for implantable medical devices, including cardiac pacemakers, defibrillators and cardiac resynchronization devices. Integrated circuits in the devices have minimized interfaces, can derive power from the interface signals, and have high voltage and latch-up protection. A device lead has a power generation circuit and a switching circuit using cascaded PMOS transistors for operating with a stable voltage despite fluctuations in the supplied voltage. The lead has control electronics that provide a very low impedance between an electrode and a lead conductor during most of the duration of a pacing pulse, but during a brief initial portion of the pacing pulse, provide a very high impedance to permit charging up a power supply that is local to the control electronics. A method of stabilizing the external impedance and a system for fault detection and fault recovery for an implantable device are also provided.

摘要翻译： 装置和方法能够对可植入医疗装置（包括心脏起搏器，除颤器和心脏再同步装置）进行可靠的，可靠的控制。 器件中的集成电路具有最小化的接口，可以从接口信号中获取功率，并具有高电压和闭锁保护。 器件引线具有发电电路和使用级联PMOS晶体管的开关电路，用于尽管工作电压的波动以稳定的电压工作。 引线具有控制电子学，其在起搏脉冲的大部分持续时间期间在电极和引线导体之间提供非常低的阻抗，但是在起搏脉冲的短暂初始部分期间，提供非常高的阻抗以允许充电电力 供应是本地控制电子产品。 还提供了一种稳定外部阻抗的方法和用于可植入装置的故障检测和故障恢复系统。

公开(公告)号：US07862608B2

公开(公告)日：2011-01-04

申请号：US10746668

申请日：2003-12-23

申请人： Michael Hogendijk ,  Todd Thompson

发明人： Michael Hogendijk ,  Todd Thompson

IPC分类号： A61F2/06 ,  A61M29/00

CPC分类号： A61F2/966 ,  A61F2/88 ,  A61F2/885 ,  A61F2/91 ,  A61F2/95 ,  A61F2002/068 ,  A61F2002/828 ,  A61F2220/0016 ,  A61F2230/0054 ,  A61F2250/0068

摘要： The present invention is directed to an implantable vascular prosthesis configured for use in a wide range of applications, such as treating aneurysms, maintaining patency in a vessel, and allowing for the controlled delivery of therapeutic agents to a vessel wall. The prosthesis comprises one or more helical sections coupled to one or more anchoring sections having a generally zig-zag or cell-like configuration. The prosthesis is configured to conform to a vessel wall without substantially remodeling the vessel, and further is configured to be precisely deployed in a vessel without shifting or foreshortening during deployment.

摘要翻译： 本发明涉及一种可植入血管假体，其被配置用于广泛的应用中，例如治疗动脉瘤，维持血管中的开放性，并允许将治疗剂控制递送到血管壁。 假体包括一个或多个螺旋部分，其联接到具有大致Z字形或细胞样构造的一个或多个锚定部分。 假体被配置成符合血管壁而不会基本上重塑血管，并且进一步构造成在展开期间精确地展开在容器中而不会移动或缩短。

公开(公告)号：US20100204766A1

公开(公告)日：2010-08-12

申请号：US12097959

申请日：2006-12-22

申请人： Mark Zdeblick ,  Robert Leichner ,  Behrad Aria ,  Nilay Jani ,  Haifeng Li ,  Todd Thompson ,  Lawrence Arne ,  Timothy Robertson ,  Yafei Bi ,  Vladimier Gelfandbein

发明人： Mark Zdeblick ,  Robert Leichner ,  Behrad Aria ,  Nilay Jani ,  Haifeng Li ,  Todd Thompson ,  Lawrence Arne ,  Timothy Robertson ,  Yafei Bi ,  Vladimier Gelfandbein

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61B5/0422 ,  A61N1/025 ,  A61N1/362 ,  A61N1/3686 ,  A61N1/372 ,  A61N1/37205 ,  A61N1/37276 ,  A61N1/37288 ,  A61N1/3756

摘要： Embodiments of the present invention enable robust, reliable control functionality for effectors present on intraluminal, e.g., vascular leads, as well as other types of implantable devices. Embodiments of the invention enable the required functionality for accurate long term control of effectors units, even ones present on multiplex carrier configurations, while provide for low power consumption. Aspects of the invention include implantable integrated circuits that have power extraction; energy storage; communication; and device configuration functional blocks, where these functional blocks are all present in a single integrated circuit on an intraluminal-sized support. Also provided by the invention are effector assemblies that include the integrated circuits, as well as implantable medical devices, e.g., pulse generators that include the same, as well as systems and kits thereof and methods of using the same, e.g., in pacing applications, including cardiac resynchronization therapy (CRT) applications.

摘要翻译： 本发明的实施例对存在于管腔内（例如血管引线）以及其它类型的可植入装置的效果器提供了鲁棒，可靠的控制功能。 本发明的实施例能够实现对效果器单元的准确的长期控制所需的功能，即使存在于多路载波配置上的单元也能提供低功耗。 本发明的方面包括具有功率提取的可植入集成电路; 储能; 通讯; 以及器件配置功能块，其中这些功能块都存在于腔内尺寸支持体上的单个集成电路中。 本发明还提供了包括集成电路的效应器组件以及可植入的医疗装置，例如包括其的脉冲发生器，以及其系统和套件，以及使用该装置的方法，例如在起搏应用中， 包括心脏再同步治疗（CRT）应用。

公开(公告)号：US20080183072A1

公开(公告)日：2008-07-31

申请号：US11664340

申请日：2007-03-30

申请人： Timothy L. Robertson ,  George M. Savage ,  Todd Thompson ,  Mark J. Zdeblick ,  Olivier Colliou ,  Benedict J. Costello

发明人： Timothy L. Robertson ,  George M. Savage ,  Todd Thompson ,  Mark J. Zdeblick ,  Olivier Colliou ,  Benedict J. Costello

IPC分类号： A61B5/05

CPC分类号： A61B5/1107 ,  A61B5/0031 ,  A61B5/686 ,  A61B8/12 ,  A61B8/488 ,  A61B8/56 ,  A61B2562/046 ,  A61N1/3627 ,  A61N1/365

摘要： Methods for evaluating motion of a tissue, such as of a cardiac location, e.g., heart wall, via continuous field tomography are provided. In the subject methods, a continuous field (e.g., an electrical, mechanical, electro-mechanical, or other field) sensing element is stably associated with the tissue location. A property of the applied continuous field is detected with the sensing element to evaluate movement of the tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.

摘要翻译： 提供了通过连续场断层摄影评估诸如心脏位置（例如心脏壁）的组织运动的方法。 在主题方法中，连续场（例如，电，机械，机电或其他场）感测元件与组织位置稳定地相关联。 使用感测元件检测所施加的连续场的属性，以评估组织位置的运动。 还提供了用于实践主题方法的系统，装置和相关组合物。 主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。

公开(公告)号：US20050246010A1

公开(公告)日：2005-11-03

申请号：US10836909

申请日：2004-04-30

申请人： Miles Alexander ,  Todd Thompson ,  Tim Huynh ,  Ray Betelia

发明人： Miles Alexander ,  Todd Thompson ,  Tim Huynh ,  Ray Betelia

IPC分类号： A61F2/06 ,  A61F2/84 ,  A61F2/88 ,  A61F2/90

CPC分类号： A61F2/95 ,  A61F2/88 ,  A61F2/91

摘要： The present invention is directed to a delivery catheter for use in deploying a vascular prosthesis having a self-expanding helical section for use in a wide range of interventional applications. The delivery catheter comprises an elongated member having a helical ledge with a pitch selected to impose a predetermined amount of foreshortening on the vascular prosthesis during deployment. Methods of making and using the delivery catheter of the present invention also are provided.

摘要翻译： 本发明涉及用于部署具有自扩张螺旋段的血管假体的输送导管，用于广泛的介入应用。 递送导管包括细长构件，该细长构件具有螺旋凸缘，所述螺旋凸缘具有间距，其在展开期间在血管假体上施加预定量的缩短。 还提供了制造和使用本发明的输送导管的方法。

公开(公告)号：US20050192342A1

公开(公告)日：2005-09-01

申请号：US10789835

申请日：2004-02-27

申请人： Todd Thompson ,  George Wilding

发明人： Todd Thompson ,  George Wilding

IPC分类号： A61K31/353

CPC分类号： C07D311/72 ,  A61K31/353

摘要： Methods for the prevention and/or alleviation of androgen-mediated disorders treatable by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer.

摘要翻译： 通过本发明提供了通过施用苯并二氢吡喃衍生的抗雄激素化合物可治疗的雄激素介导的疾病的预防和/或缓解方法。 本发明进一步提供了含有色氨酸衍生的抗雄激素化合物的药物和营养组合物，其用于预防和/或减轻雄激素介导的病症，特别是前列腺癌。

公开(公告)号：US5749387A

公开(公告)日：1998-05-12

申请号：US779445

申请日：1997-01-07

申请人： Todd Thompson

发明人： Todd Thompson

IPC分类号： E04H15/00 ,  E04H15/48

CPC分类号： E04H15/001 ,  Y10S135/901 ,  Y10T403/32409 ,  Y10T403/58

摘要： A portable ice fishing hut consisting of sturdy plastic roof and floor shells secured together by collapsible supports. The walls of the hut are manufactured from a flexible skin, and the entire structure can be collapsed together for convenient storage and transport.

摘要翻译： 一个由坚固的塑料屋顶和地板壳组成的便携式冰钓鱼小屋，由可折叠的支架固定在一起。 小屋的墙壁由柔软的皮肤制成，整个结构可以折叠在一起，方便储存和运输。

公开(公告)号：US09439599B2

公开(公告)日：2016-09-13

申请号：US14004399

申请日：2012-03-08

申请人： Todd Thompson ,  Olivier Colliou ,  Robert Duck ,  Yashar Behzadi

发明人： Todd Thompson ,  Olivier Colliou ,  Robert Duck ,  Yashar Behzadi

IPC分类号： A61B5/00 ,  A61B5/0408 ,  H04B13/00 ,  A61B5/04 ,  A61B5/01 ,  A61B5/021 ,  A61B5/024 ,  A61B5/042 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/08 ,  A61B5/11 ,  A61B5/145

CPC分类号： A61B5/6833 ,  A61B5/0006 ,  A61B5/0022 ,  A61B5/0024 ,  A61B5/01 ,  A61B5/021 ,  A61B5/02405 ,  A61B5/0408 ,  A61B5/04087 ,  A61B5/042 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0809 ,  A61B5/1116 ,  A61B5/1118 ,  A61B5/145 ,  A61B2560/0412 ,  A61B2562/0219 ,  G06F19/00 ,  G16H40/67 ,  H04B13/005

摘要： A body associated device comprises a housing, an adhesive layer configured to be applied to a body of a living subject, and at least one standoff located between the housing and the adhesive layer. An electronic module may be located within the housing of the body associated device. A personal communication system comprises a body associated device including an electronic module and further comprises a feedback portion coupled to the housing and to the electronic module. The feedback portion is configured to communicate information between the living subject and the body associated device. An external local node is operative to provide at least one of transmit communications to and receive communications from the body associated device.

摘要翻译： 身体相关装置包括壳体，被配置为施加到活体的身体的粘合剂层和位于壳体和粘合剂层之间的至少一个支座。 电子模块可以位于身体相关装置的壳体内。 个人通信系统包括主体相关设备，其包括电子模块，并且还包括耦合到壳体和电子模块的反馈部分。 反馈部分被配置为在活体和身体相关联的装置之间传递信息。 外部本地节点可操作以向身体相关联的设备提供发送通信和从主体相关联的设备接收通信中的至少一个。

公开(公告)号：US08730031B2

公开(公告)日：2014-05-20

申请号：US13180539

申请日：2011-07-11

申请人： Todd Thompson ,  Mark Zdeblick ,  Yashar Behzadi ,  Benedict Costello ,  Timothy Robertson ,  Hooman Hafezi ,  George Savage

发明人： Todd Thompson ,  Mark Zdeblick ,  Yashar Behzadi ,  Benedict Costello ,  Timothy Robertson ,  Hooman Hafezi ,  George Savage

IPC分类号： H04Q5/22

CPC分类号： A61B5/076 ,  A61B5/0028 ,  A61B5/073 ,  A61B5/14539 ,  A61B5/4839 ,  A61B2560/0214 ,  A61J3/007 ,  A61N1/37288 ,  G06F19/00 ,  G06F19/3418 ,  H01Q1/273

摘要： The system of the present invention includes an implantable device that can detect high and low frequency current signature. The implantable device can communicate with a communication device that includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, the communication device is activated.

摘要翻译： 本发明的系统包括可以检测高频和低频电流签名的可植入装置。 可植入装置可以与包括导电元件，电子部件和不同材料形式的部分电源的通信装置通信。 当与导电流体接触时，通信装置被激活。

公开(公告)号：US20130172690A1

公开(公告)日：2013-07-04

申请号：US13640699

申请日：2011-04-11

申请人： Lawrence Arne ,  Benedict Costello ,  Yuriy Mestman ,  Timothy Robertson ,  George Savage ,  Angela Strand ,  Todd Thompson ,  Mark Zdeblick ,  William McAllister

发明人： Lawrence Arne ,  Benedict Costello ,  Yuriy Mestman ,  Timothy Robertson ,  George Savage ,  Angela Strand ,  Todd Thompson ,  Mark Zdeblick ,  William McAllister

IPC分类号： A61B5/00 ,  A61B5/053

CPC分类号： A61B5/4833 ,  A61B5/053 ,  A61B5/6846 ,  A61B2562/0214 ,  A61M15/0016 ,  A61M15/008 ,  A61M15/0081 ,  A61M15/0083 ,  A61M15/009 ,  A61M2016/0024 ,  A61M2016/0039 ,  A61M2205/13 ,  A61M2205/331 ,  A61M2205/3317 ,  A61M2205/332 ,  A61M2205/3375 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/583 ,  A61M2205/6009 ,  A61M2205/6054 ,  A61M2230/63 ,  A61M2230/65

摘要： An apparatus is disclosed as part of a system for tracking and confirming delivery of a medicinal dose to a user. The apparatus includes a detector. The detector is secured to and communicatively coupled to the user and is capable of detecting a current flow through the user's body. The current flow is produced when the user makes contact with the apparatus. The apparatus includes at least two contact areas connected to a power source where a circuit and, hence, a current path is completed through the user's body as the user makes contact with the apparatus. The current flow is detected by the detector, which is coupled to the user. Also disclosed is an apparatus for tracking and confirming delivery of a medicinal dose to a user where the apparatus includes an acoustic detector. Upon loading the dose into a chamber an acoustic vibration is generated. The vibration is detected and correlated with a current flow that is produced when the user makes contact with the apparatus. The combined event of vibration detection and current flow detection confirms that the dose is loaded and the user is in contact with the apparatus and ready to receive the dose.

摘要翻译： 公开了一种用于跟踪并确认向用户传送药用剂量的系统的一部分的装置。 该装置包括检测器。 检测器被固定到并且通信地耦合到用户，并且能够检测通过用户身体的电流。 当用户与设备接触时产生电流。 该设备包括连接到电源的至少两个接触区域，其中当用户与设备接触时，电路和因此的电流路径通过用户的身体完成。 电流由检测器检测到，该检测器耦合到用户。 还公开了一种用于跟踪并确认药物剂量递送给用户的装置，其中该装置包括声学检测器。 当将剂量加载到室中时，产生声振动。 检测振动并与用户与设备接触时产生的电流相关联。 振动检测和电流检测的组合事件证实了剂量被加载并且使用者与设备接触并准备接收剂量。