公开(公告)号：US20080262359A1

公开(公告)日：2008-10-23

申请号：US12058279

申请日：2008-03-28

申请人： Guillermo J. Tearney ,  Seemantini N. Nadkarni ,  Brett Eugene Bouma

发明人： Guillermo J. Tearney ,  Seemantini N. Nadkarni ,  Brett Eugene Bouma

IPC分类号： A61B5/00

CPC分类号： G02B6/06 ,  A61B1/00096 ,  A61B1/00167 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/7285 ,  G02B6/32

摘要： Apparatus and method according to an exemplary embodiment of the present invention can be provided for analyzing tissue. For example, the apparatus can include at least one first arrangement configured to illuminate at least one anatomical structure with at least one of at least one electro-magnetic radiation. The apparatus can also include at least one second arrangement that may include at least two wave-guiding arrangements associated with one another that are configured to receive a further electro-magnetic radiation reflected from the tissue and transmit at least one speckle pattern associated with the further electro-magnetic radiation. The wave-guiding arrangements may be structured so as to reduce crosstalk therebetween.

摘要翻译： 可以提供根据本发明的示例性实施例的装置和方法来分析组织。 例如，该装置可以包括配置成用至少一个电磁辐射中的至少一个照射至少一个解剖结构的至少一个第一配置。 该装置还可以包括至少一个第二布置，其可以包括彼此相关联的至少两个波导装置，其被配置为接收从组织反射的另外的电磁辐射，并且传输与另外的相关联的至少一个散斑图案 电磁辐射。 波导装置可以被构造成减小它们之间的串扰。

公开(公告)号：US20080206804A1

公开(公告)日：2008-08-28

申请号：US12016051

申请日：2008-01-17

申请人： Guillermo J. Tearney ,  Brett E. Bouma ,  Leilei Peng ,  Tayyaba Hasan ,  Sarika Verma

发明人： Guillermo J. Tearney ,  Brett E. Bouma ,  Leilei Peng ,  Tayyaba Hasan ,  Sarika Verma

IPC分类号： C12Q1/02 ,  C12M1/34 ,  G01N21/63 ,  G01N21/76

CPC分类号： G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/6456 ,  G01N21/6489 ,  G01N33/582 ,  G01N2201/1296

摘要： Exemplary embodiments of arrangements and methods providing information associated with a sample are described. For example, using such exemplary arrangements and methods, it is possible to receive an unpartitioned electro-magnetic radiation from the sample. Further, first data associated with first luminescent characteristics of at least one first molecule of the sample and second data associated with second luminescent characteristics of at least one second molecule of the sample can be obtained based on the unpartitioned electro-magnetic radiation. At least two of the photo-luminescent properties of the sample may be measured simultaneously as a function of the first and second data. Further, the information regarding the molecules of the sample may be determined as a function of the photo-luminescent properties.

摘要翻译： 描述了提供与样本相关联的信息的布置和方法的示例性实施例。 例如，使用这样的示例性布置和方法，可以从样品接收未分割的电磁辐射。 此外，可以基于未分割的电磁辐射获得与样品的至少一个第一分子的第一发光特性相关联的第一数据和与样品的至少一个第二分子的第二发光特性相关的第二数据。 可以同时测量样品的至少两种光致发光性质作为第一和第二数据的函数。 此外，关于样品分子的信息可以根据光致发光性质来确定。

公开(公告)号：US20070171433A1

公开(公告)日：2007-07-26

申请号：US11624277

申请日：2007-01-18

申请人： Guillermo J. Tearney ,  Brett E. Bouma

发明人： Guillermo J. Tearney ,  Brett E. Bouma

IPC分类号： G01B11/14

CPC分类号： G01N21/3563 ,  G01J3/02 ,  G01J3/021 ,  G01J3/42 ,  G01N21/031 ,  G01N21/45 ,  G01N21/4795 ,  G01N2021/1787

摘要： Exemplary systems and processes for generating information associated with at least one portion of a sample are provided. In one exemplary embodiment, at least one electromagnetic radiation can be received from the at least one portion, whereas the electromagnetic radiation has a wavenumber that is between approximately 5,000 cm−1 and 600 cm−1. The information can be generated which includes structural data, molecular data and/or chemical data of the portion. The information can be generated based on (a) at least one phase of the at least one electromagnetic radiation, and/or (b) at least one refractive index of the at least one portion. According to another exemplary embodiment, the electromagnetic radiation having a first wavenumber can be transmitted to the portion which has at least two substances, whereas a refractive index of one of the substances at a second wavenumber is approximately the same as a refractive index of another one of the substances at the second wavenumber. The electromagnetic radiation can be controlled such that the first wavenumber substantially matches the first wavenumber to reduce scattering within the portion.

摘要翻译： 提供了用于产生与样本的至少一部分相关联的信息的示例性系统和过程。 在一个示例性实施例中，可以从至少一个部分接收至少一个电磁辐射，而电磁辐射具有介于约5000cm -1至600cm -1之间的波数 。 可以生成包括该部分的结构数据，分子数据和/或化学数据的信息。 可以基于（a）至少一个电磁辐射的至少一个相位和/或（b）至少一个部分的至少一个折射率来生成信息。 根据另一示例性实施例，具有第一波数的电磁辐射可以传输到具有至少两种物质的部分，而第二波数处的物质之一的折射率与另一物质的折射率近似相同 的物质在第二个波数。 可以控制电磁辐射使得第一波数基本上与第一波数匹配以减少该部分内的散射。

公开(公告)号：US06654630B2

公开(公告)日：2003-11-25

申请号：US09871578

申请日：2001-05-31

申请人： Andres F. Zuluaga ,  Brett Bouma ,  Simon M. Furnish ,  Guillermo J. Tearney ,  S. Eric Ryan ,  Jing Tang ,  Mark A. Griffin

发明人： Andres F. Zuluaga ,  Brett Bouma ,  Simon M. Furnish ,  Guillermo J. Tearney ,  S. Eric Ryan ,  Jing Tang ,  Mark A. Griffin

IPC分类号： A61B600

CPC分类号： A61B5/0084

摘要： A catheter based optical system for generating data as to the condition of a tissue sample of a mammalian vessel. The system includes an elongated catheter shaft having a tissue engaging distal end and a coupled proximal end and an elongated optical delivery fiber arrangement disposed through a lumen of said catheter, said optical delivery fiber arrangement having a distal end and a proximal end. The distal end of the delivery fiber arrangement has a re-director light emitter thereon for directing light against mammalian tissues. An elongated optical collection fiber arrangement is disposed through a lumen of the catheter, the optical collection fiber arrangement having a distal end and a proximal most end. The distal end of the collection fiber arrangement has a re-director light receiver thereon for receiving light reflected from the mammalian tissue by the light emitter. The light emitter and the light receiver are longitudinally spaced apart from one another in the distal end of the catheter. The catheter apparatus includes a light source in communication with the delivery fiber and a signal detector in communication with the receiving fiber for receiving and presenting data collected.

公开(公告)号：US06615062B2

公开(公告)日：2003-09-02

申请号：US09871759

申请日：2001-05-31

申请人： S. Eric Ryan ,  Brett Bouma ,  Guillermo J. Tearney ,  Simon Furnish ,  Jing Tang ,  Andres Zuluaga

发明人： S. Eric Ryan ,  Brett Bouma ,  Guillermo J. Tearney ,  Simon Furnish ,  Jing Tang ,  Andres Zuluaga

IPC分类号： A61B500

CPC分类号： A61B5/0084 ,  A61B5/14535 ,  A61B2560/0233 ,  G01N21/4785

摘要： The invention provides methods and apparatus to reference or normalize optical measurements, by removing or accounting for background factors and artifacts, such as motion artifacts, that arise during use of optical catheters.

摘要翻译： 本发明提供了通过去除或计算在使用光学导管时出现的背景因素和伪像（诸如运动伪像）来参考或归一化光学测量的方法和装置。

公开(公告)号：US10285568B2

公开(公告)日：2019-05-14

申请号：US13152784

申请日：2011-06-03

申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Michalina Gora ,  Melissa Suter ,  Hongki Yoo ,  Milen Shishkov

发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Michalina Gora ,  Melissa Suter ,  Hongki Yoo ,  Milen Shishkov

IPC分类号： A61B1/00 ,  A61B5/00

摘要： In accordance with exemplary embodiments of the present disclosure, device and method can be provided which can facilitate imaging of biological tissues, e.g., luminal organs in vivo, using optical techniques. The exemplary device can include different designs an features of one or more catheters, which can illuminate the tissues, and collect signals from the inside of the lumen. In another exemplary embodiment according to the present disclosure, a balloon-catheter can be provided with the flexible neck, which can absorb most of the bending. According to still another exemplary embodiments of the present disclosure, a balloon-catheter tethered capsule can be provided, and according a yet further exemplary embodiment, a structured balloon design can be provided with one or more protuberances, thus enabling imaging of the structures in close contact, e.g., without compressing of the tissue.

公开(公告)号：US10241028B2

公开(公告)日：2019-03-26

申请号：US14240938

申请日：2012-08-27

申请人： Steven M. Rowe ,  Guillermo J. Tearney ,  Brett Eugene Bouma ,  Linbo Liu ,  Eric J. Sorscher ,  Kengyeh Ken Chu ,  Bradford James Diephuis ,  Eric James Wilsterman ,  Gregory Andrew Dierksen

发明人： Steven M. Rowe ,  Guillermo J. Tearney ,  Brett Eugene Bouma ,  Linbo Liu ,  Eric J. Sorscher ,  Kengyeh Ken Chu ,  Bradford James Diephuis ,  Eric James Wilsterman ,  Gregory Andrew Dierksen

IPC分类号： G01B9/02 ,  G01N21/17 ,  G01N21/47 ,  G01N21/45 ,  G01J3/45 ,  G01J9/02 ,  G01N15/02 ,  G01N21/35 ,  G01N21/64 ,  G01N29/00 ,  G01N21/65 ,  G01N15/14

摘要： Exemplary apparatus and method can be provided for obtaining data regarding a plurality of samples. For example, using at least one arrangement, it is possible to receive interferometric information that is based on radiations provided from a reference and the samples that are provided in respective chambers. Alternatively and/or in addition, based on the interferometric information, it is possible to discriminate between agents to identify a particular agent that affects a particular function within at least one of the samples.

公开(公告)号：US09795301B2

公开(公告)日：2017-10-24

申请号：US13115332

申请日：2011-05-25

申请人： Christine Fleming ,  Brett Eugene Bouma ,  Joseph Gardecki ,  Guillermo J. Tearney

发明人： Christine Fleming ,  Brett Eugene Bouma ,  Joseph Gardecki ,  Guillermo J. Tearney

IPC分类号： G01B9/02 ,  G01J3/45 ,  A61B5/00 ,  A61B5/02 ,  G01N21/47 ,  G01N21/17

CPC分类号： A61B5/0066 ,  A61B5/02007 ,  A61B5/7264 ,  G01B9/02091 ,  G01N21/4795 ,  G01N2021/1787 ,  G01N2201/129 ,  G01N2201/1293

摘要： According to an exemplary embodiment of the present disclosure, apparatus and method can be provided for generating information for at least one structure. For example, using at least one first arrangement, it is possible to receive at least one first radiation from the at least one structure and at least one second radiation from a reference, and interfere the first and second radiations to generate at least one third radiation. Further, with at least one second arrangement, it is possible to generate spectroscopic data as a function of the at least one third radiation, and reduce at least one scattering effect in the spectroscopic data to generate the information. In addition or as an alternative, according to a further exemplary embodiment of the present disclosure, it is possible to classify a type of the structure based on the spectroscopic data to generate the information.

公开(公告)号：US09615748B2

公开(公告)日：2017-04-11

申请号：US12690686

申请日：2010-01-20

申请人： Guillermo J. Tearney ,  Brett E. Bouma ,  Dongkyun Kang ,  Melissa J. Suter

发明人： Guillermo J. Tearney ,  Brett E. Bouma ,  Dongkyun Kang ,  Melissa J. Suter

IPC分类号： A61B6/00 ,  A61B5/00 ,  A61B5/02

CPC分类号： A61B5/0066 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0086

摘要： Exemplary embodiments of apparatus, method and system for determining a position on or in a biological tissue can be provided. For example, using such exemplary embodiment, it is possible to control the focus of an optical imaging probe. In another exemplary embodiment, it is possible to implement a marking apparatus together with or into an optical imaging probe. According to one exemplary embodiment, it is possible (using one or more arrangements) to receive information associated with at least one image of at least one portion of the biological tissue obtained using an optical imaging technique. Further, it is possible to, based on the information, cause a visible change on or in at least location of the portion(s) using at least one electro-magnetic radiation.

公开(公告)号：US09557154B2

公开(公告)日：2017-01-31

申请号：US13114845

申请日：2011-05-24

申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

IPC分类号： A61B5/00 ,  G01B9/02 ,  G01N21/47 ,  G01N21/64 ,  G01N21/65

CPC分类号： A61B5/0084 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/6852 ,  G01B9/02029 ,  G01B9/0205 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/64 ,  G01N21/6456 ,  G01N21/65 ,  G01N2201/0866

摘要： Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

摘要翻译： 描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。 例如，一种布置可以向解剖结构提供至少一个电磁辐射。 这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。 光纤芯和包层之间的区域可以具有与光纤芯和包层的折射率不同的折射率。 该装置还可以包括至少一个被配置为经由光学核和包层传播辐射到解剖结构的装置。