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    SYSTEM AND METHOD PROVIDING INTRACORONARY LASER SPECKLE IMAGING FOR THE DETECTION OF VULNERABLE PLAQUE
    1.
    发明申请
    SYSTEM AND METHOD PROVIDING INTRACORONARY LASER SPECKLE IMAGING FOR THE DETECTION OF VULNERABLE PLAQUE 审中-公开
    系统和方法提供用于检测易受伤害的PLAQUE的激光雷射成像

    公开(公告)号：US20080262359A1

    公开(公告)日：2008-10-23

    申请号：US12058279

    申请日：2008-03-28

    申请人： Guillermo J. Tearney ,  Seemantini N. Nadkarni ,  Brett Eugene Bouma

    发明人： Guillermo J. Tearney ,  Seemantini N. Nadkarni ,  Brett Eugene Bouma

    IPC分类号： A61B5/00

    CPC分类号： G02B6/06 ,  A61B1/00096 ,  A61B1/00167 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/7285 ,  G02B6/32

    摘要： Apparatus and method according to an exemplary embodiment of the present invention can be provided for analyzing tissue. For example, the apparatus can include at least one first arrangement configured to illuminate at least one anatomical structure with at least one of at least one electro-magnetic radiation. The apparatus can also include at least one second arrangement that may include at least two wave-guiding arrangements associated with one another that are configured to receive a further electro-magnetic radiation reflected from the tissue and transmit at least one speckle pattern associated with the further electro-magnetic radiation. The wave-guiding arrangements may be structured so as to reduce crosstalk therebetween.

    摘要翻译： 可以提供根据本发明的示例性实施例的装置和方法来分析组织。 例如，该装置可以包括配置成用至少一个电磁辐射中的至少一个照射至少一个解剖结构的至少一个第一配置。 该装置还可以包括至少一个第二布置，其可以包括彼此相关联的至少两个波导装置，其被配置为接收从组织反射的另外的电磁辐射，并且传输与另外的相关联的至少一个散斑图案 电磁辐射。 波导装置可以被构造成减小它们之间的串扰。

    APPARATUS AND METHOD FOR OBTAINING AND PROVIDING IMAGING INFORMATION ASSOCIATED WITH AT LEAST ONE PORTION OF A SAMPLE, AND EFFECTING SUCH PORTION(S)
    3.
    发明申请
    APPARATUS AND METHOD FOR OBTAINING AND PROVIDING IMAGING INFORMATION ASSOCIATED WITH AT LEAST ONE PORTION OF A SAMPLE, AND EFFECTING SUCH PORTION(S) 有权
    用于获取和提供与至少一个样品部分相关的成像信息的装置和方法，以及影响这些部分

    公开(公告)号：US20130066215A1

    公开(公告)日：2013-03-14

    申请号：US13614459

    申请日：2012-09-13

    申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin

    发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin

    IPC分类号： A61B1/07

    CPC分类号： A61B1/07 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B18/22 ,  A61B2017/00061

    摘要： Exemplary apparatus and process can be provided for imaging information associated with at least one portion of a sample. For example, (i) first different wavelengths of at least one first electro-magnetic radiation can be provided within a first wavelength range provided on the portion of the sample so as to determine at least one first transverse location of the portion, and (ii) second different wavelengths of at least one second electro-magnetic radiation within a second wavelength range can be provided on the portion so as to determine at least one second transverse location of the portion. The first and second ranges can east partially overlap on the portion. Further, a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference can be obtained to determine a relative depth location of the portion.

    摘要翻译： 可以提供示例性装置和过程用于与样品的至少一部分相关联的成像信息。 例如，（i）可在提供在样品部分上的第一波长范围内提供至少一个第一电磁辐射的第一不同波长，以便确定该部分的至少一个第一横向位置，和（ii ）可以在该部分上提供在第二波长范围内的至少一个第二电磁辐射的第二不同波长，以便确定该部分的至少一个第二横向位置。 第一和第二范围可以在该部分上部分重叠。 此外，可以获得从样品返回的至少一个第三电磁辐射电磁辐射与从基准返回的至少一个第四电磁辐射之间的相对相位，以确定该部分的相对深度位置。

    APPARATUS CONFIGURED TO PROVIDE A WAVELENGTH-SWEPT ELECTRO-MAGNETIC RADIATION
    4.
    发明申请
    APPARATUS CONFIGURED TO PROVIDE A WAVELENGTH-SWEPT ELECTRO-MAGNETIC RADIATION 审中-公开
    配置提供波长扫描电磁辐射的装置

    公开(公告)号：US20110255561A1

    公开(公告)日：2011-10-20

    申请号：US13003983

    申请日：2009-07-14

    申请人： Brian Goldberg ,  Guillermo J. Tearney ,  Brett Eugene Bouma ,  Reza Motgahian-Nezam

    发明人： Brian Goldberg ,  Guillermo J. Tearney ,  Brett Eugene Bouma ,  Reza Motgahian-Nezam

    IPC分类号： H01S3/10

    CPC分类号： H01S5/141 ,  G01J3/10 ,  H01S3/105 ,  H01S5/02248 ,  H01S5/101 ,  H01S5/143

    摘要： Exemplary embodiments of apparatus according to the present disclosure are provided. For example, an apparatus for providing electromagnetic radiation to a structure can be provided. In one exemplary embodiment, the apparatus can provide at least one electromagnetic radiation, and include at least one first arrangement which can be configured to generate the electromagnetic radiation(s) having at least one wavelength that varies over time. The exemplary apparatus can also include at least one second arrangement which can be configured to power the first arrangement(s) independently from an external power source. In another exemplary embodiment the apparatus can include at least one particular arrangement which is configured to generate the electromagnetic radiation(s) having at least one wavelength that varies over time. The particular arrangement(s) can include a resonant cavity that has a roundtrip optical transit time of approximately less than 0.7 nsec.

    摘要翻译： 提供了根据本公开的装置的示例性实施例。 例如，可以提供用于向结构提供电磁辐射的装置。 在一个示例性实施例中，该装置可以提供至少一个电磁辐射，并且包括至少一个第一布置，其可被配置为产生具有随时间变化的至少一个波长的电磁辐射。 示例性装置还可以包括至少一个第二装置，其可被配置为独立于外部电源为第一装置供电。 在另一个示例性实施例中，装置可以包括至少一个特定布置，其被配置为产生具有随时间变化的至少一个波长的电磁辐射。 具体布置可以包括谐振腔，其具有大约小于0.7纳秒的往返光通过时间。

    Methods and systems for performing angle-resolved fourier-domain optical coherence tomography
    6.
    发明授权
    Methods and systems for performing angle-resolved fourier-domain optical coherence tomography 有权
    用于进行角度分辨的傅里叶变换光学相干断层扫描的方法和系统

    公开(公告)号：US07982879B2

    公开(公告)日：2011-07-19

    申请号：US11677278

    申请日：2007-02-21

    申请人： Adrien E. Desjardins ,  Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett Eugene Bouma

    发明人： Adrien E. Desjardins ,  Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett Eugene Bouma

    IPC分类号： G01B9/02

    CPC分类号： G01N21/4795 ,  A61B5/0066 ,  A61B5/0073 ,  G01B9/02043 ,  G01B9/02087 ,  G01B9/02091 ,  G01B2290/70 ,  G01N2021/4714

    摘要： Arrangements, apparatus and methods are provided according to exemplary embodiments of the present invention. In particular, at least one first electro-magnetic radiation may be received and at least one second electro-magnetic radiation within a solid angle may be forwarded to a sample. The second electro-magnetic radiation may be associated with the first electro-magnetic radiation. A plurality of third electro-magnetic radiations can be received from the sample which is associated with the second electro-magnetic radiation, and at least one portion of the third electro-magnetic radiation is provided outside a periphery of the solid angle. Signals associated with each of the third electro-magnetic radiations can be simultaneously detected, with the signals being associated with information for the sample at a plurality of depths thereof. The depths can be determined using at least one of the third electro-magnetic radiations without a need to utilize another one of the third electro-magnetic radiations.

    摘要翻译： 根据本发明的示例性实施例提供了安排，装置和方法。 特别地，可以接收至少一个第一电磁辐射，并且将立体角内的至少一个第二电磁辐射转发到样品。 第二电磁辐射可以与第一电磁辐射相关联。 可以从与第二电磁辐射相关联的样品接收多个第三电磁辐射，并且第三电磁辐射的至少一部分设置在立体角的外围。 可以同时检测与每个第三电磁辐射相关联的信号，其中信号与样品在其多个深度处的信息相关联。 可以使用第三电磁辐射中的至少一个来确定深度，而不需要利用第三电磁辐射中的另一个。

    Apparatus and method for ranging and noise reduction of low coherence interferometry (LCI) and optical coherence tomography (OCT) signals by parallel detection of spectral bands
    7.
    发明授权
    Apparatus and method for ranging and noise reduction of low coherence interferometry (LCI) and optical coherence tomography (OCT) signals by parallel detection of spectral bands 有权
    用于通过光谱带的并行检测的低相干干涉测量（LCI）和光学相干断层扫描（OCT）信号的测距和降噪的装置和方法

    公开(公告)号：US07903257B2

    公开(公告)日：2011-03-08

    申请号：US11954794

    申请日：2007-12-12

    申请人： Johannes F. de Boer ,  Guillermo J. Tearney ,  Brett Eugene Bouma

    发明人： Johannes F. de Boer ,  Guillermo J. Tearney ,  Brett Eugene Bouma

    IPC分类号： G01B11/02 ,  G01B9/02 ,  G01J3/45

    CPC分类号： G01B9/02007 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02008 ,  G01B9/0201 ,  G01B9/02032 ,  G01B9/02044 ,  G01B9/02045 ,  G01B9/02079 ,  G01B9/0209 ,  G01B9/02091 ,  G01B2290/45 ,  G01N21/4795

    摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.

    摘要翻译： 通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。 对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。 结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。 信号保持不变。 喷射噪声的降低增加了系统的动态范围和灵敏度。

    System and method for optical coherence imaging
    9.
    发明授权
    System and method for optical coherence imaging 有权
    光学相干成像系统和方法

    公开(公告)号：US07366376B2

    公开(公告)日：2008-04-29

    申请号：US11241907

    申请日：2005-09-29

    申请人： Milen Shishkov ,  Brett Eugene Bouma ,  Guillermo J. Tearney

    发明人： Milen Shishkov ,  Brett Eugene Bouma ,  Guillermo J. Tearney

    IPC分类号： G02B6/32 ,  G02B6/12 ,  G02B6/26 ,  G02B6/42 ,  G02B6/44 ,  G02B6/02 ,  G02B6/028 ,  G02B6/032 ,  G02B6/036

    CPC分类号： H04J14/0267 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  G02B6/2552 ,  G02B6/262 ,  G02B6/2856

    摘要： Apparatus and method are provided for transmitting at least one electro-magnetic radiation is provided. In particular, at least one optical fiber having at least one end extending along a first axis may be provided. Further, a light transmissive optical arrangement may be provided in optical cooperation with the optical fiber. The optical arrangement may have a first surface having a portion that is perpendicular to a second axis, and a second surface which includes a curved portion. The first axis can be provided at a particular angle that is more than 0° and less than 90° with respect to the second axis.

    摘要翻译： 提供了用于传送至少一个电磁辐射的装置和方法。 特别地，可以提供至少一个具有沿着第一轴线延伸的至少一个端部的光纤。 此外，可以与光纤光学协作地提供透光的光学装置。 光学装置可以具有第一表面，其具有垂直于第二轴线的部分，以及包括弯曲部分的第二表面。 第一轴可以相对于第二轴线以大于0°且小于90°的特定角度设置。

    System and method for optical coherence imaging
    10.
    发明授权
    System and method for optical coherence imaging 有权
    光学相干成像系统和方法

    公开(公告)号：US07365859B2

    公开(公告)日：2008-04-29

    申请号：US11225840

    申请日：2005-09-12

    申请人： Seok-Hyun Yun ,  Brett Eugene Bouma ,  Guillermo J. Tearney ,  Johannes F. deBoer

    发明人： Seok-Hyun Yun ,  Brett Eugene Bouma ,  Guillermo J. Tearney ,  Johannes F. deBoer

    IPC分类号： G01B11/02

    CPC分类号： G01B9/02014 ,  G01B9/02004 ,  G01B9/02044 ,  G01B9/02069 ,  G01B9/02077 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/4795

    摘要： A system and method for imaging of a sample, e.g., biological sample, are provided. In particular, at least one source electro-magnetic radiation forwarded to the sample and a reference may be generated. A plurality of detectors may be used, at least one of the detectors capable of detecting a signal associated with a combination of at least one first electro-magnetic radiation received from the sample and at least one second electro-magnetic radiation received from the reference. At least one particular detector may have a particular electrical integration time, and can receive at least a portion of the signal for a time duration which has a first portion with a first power level greater than a predetermined threshold and a second portion immediately preceding or following the first portion. The second portion may have a second power level that is less than the predetermined threshold, and extends for a time period which may be, e.g., approximately more than 10% of the particular electrical integration time.

    摘要翻译： 提供了用于成像样品例如生物样品的系统和方法。 特别地，可以产生转发到样品的至少一个源电磁辐射和参考。 可以使用多个检测器，所述检测器中的至少一个检测器能够检测与从样本接收的至少一个第一电磁辐射的组合相关联的信号和从参考接收的至少一个第二电磁辐射。 至少一个特定检测器可以具有特定的电积分时间，并且可以接收信号的至少一部分持续一段持续时间，该持续时间具有第一部分具有大于预定阈值的第一功率电平，以及紧接在之前或之后的第二部分 第一部分。 第二部分可以具有小于预定阈值的第二功率电平，并且延伸可以是例如大约超过特定电积分时间的10％的时间段。