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    ENCAPSULATION OF RAMAN ACTIVE NANOPARTICLES
    92.
    发明申请
    ENCAPSULATION OF RAMAN ACTIVE NANOPARTICLES 审中-公开
    拉曼活性纳米颗粒的包封

    公开(公告)号：US20080241569A1

    公开(公告)日：2008-10-02

    申请号：US11694293

    申请日：2007-03-30

    Applicant: Haoyu Qin ,  Jingwu Zhang ,  Claire E. Dentinger ,  Lei Sun ,  Xing Su

    Inventor： Haoyu Qin ,  Jingwu Zhang ,  Claire E. Dentinger ,  Lei Sun ,  Xing Su

    IPC: B32B5/16

    CPC classification number: G01N21/658 ,  B82Y15/00 ,  B82Y30/00 ,  Y10T428/12028 ,  Y10T428/2991

    Abstract: Embodiments of the present invention provide methods for coating nanoparticles with polymeric coatings and nanoparticles that are coated with polymeric coatings. The polymeric coatings typically comprise two or more layers wherein the first layer has a charge that is opposite to that of the second layer. In further embodiments, the nanoparticles that can act as labels or reporters are coated with polymeric coatings. Optionally, these reporter or label nanoparticles may be Raman-active, such that they provide a distinctive Raman signature upon excitation with electromagnetic radiation.

    Abstract translation: 本发明的实施方案提供了用聚合物涂层和纳米颗粒涂覆聚合物涂层的方法。 聚合物涂层通常包含两层或更多层，其中第一层具有与第二层相反的电荷。 在另外的实施方案中，可以用作标记或报告物的纳米颗粒涂覆有聚合物涂层。 任选地，这些报告物或标记纳米颗粒可以是拉曼活性的，使得它们在用电磁辐射激发时提供独特的拉曼特征。

    Enzymatic signal generation and detection of binding complexes in stationary fluidic chip
    94.
    发明申请
    Enzymatic signal generation and detection of binding complexes in stationary fluidic chip 有权
    在固定流体芯片中的酶信号产生和结合复合物的检测

    公开(公告)号：US20080160630A1

    公开(公告)日：2008-07-03

    申请号：US11647565

    申请日：2006-12-29

    Applicant: David J. Liu ,  Kai Wu ,  Xing Su

    Inventor： David J. Liu ,  Kai Wu ,  Xing Su

    IPC: G01N21/00 ,  G01N1/00

    CPC classification number: G01N21/658 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2300/0654 ,  B01L2400/043 ,  B01L2400/086 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/255 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/76 ,  G01N33/54333 ,  G01N33/587

    Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.

    Abstract translation: 本发明的一个实施例涉及用于检测样品中的分析物的装置。 该装置包括流体网络和集成电路部件。 流体网络包括样品区，清洁区和检测区。 流体网络包含磁性粒子和/或信号粒子。 引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。 微线圈阵列或机械可移动永磁体在功能上耦合到流体网络，流体网络可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。 存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。

    Method and device for bioanalyte quantification by on/off kinetics of binding complexes
    95.
    发明申请
    Method and device for bioanalyte quantification by on/off kinetics of binding complexes 审中-公开
    通过结合复合物的开/关动力学进行生物分析物定量的方法和装置

    公开(公告)号：US20080160623A1

    公开(公告)日：2008-07-03

    申请号：US11645814

    申请日：2006-12-27

    Applicant: Xing Su

    Inventor： Xing Su

    IPC: G01F1/00 ,  G01F1/56 ,  G01N27/06

    CPC classification number: G01F1/708 ,  G01F1/56 ,  G01F1/7086 ,  Y10T436/143333

    Abstract: An embodiment of the invention relates to a device and method for measuring small fluid volume and detecting an analyte in a sample. The device has a channel having a plurality of sensors in a wall of the channel, wherein the sensors are located along a length of the channel and are configured to detect a leading edge and a trailing edge of a volume of a fluid flowing though the channel. The sensors could be electrodes. The device could further have a binding surface on a portion of the wall of the channel and a detector in the vicinity of the wall of the channel, wherein the binding surface has molecules that bind to an analyte and the detector could be adapted to detect binding of the analyte to the binding surface.

    Abstract translation: 本发明的一个实施例涉及用于测量小流体体积并检测样品中分析物的装置和方法。 该装置具有在通道的壁中具有多个传感器的通道，其中传感器沿着通道的长度定位，并且构造成检测流过通道的流体体积的前缘和后缘 。 传感器可以是电极。 该装置还可以在通道的壁的一部分上具有结合表面，并且在通道的壁附近具有检测器，其中结合表面具有结合分析物的分子，并且检测器可适于检测结合 的分析物到结合表面。

    Complexity Management of Genomic DNA
    97.
    发明申请
    Complexity Management of Genomic DNA 有权
    基因组DNA的复杂性管理

    公开(公告)号：US20080070796A1

    公开(公告)日：2008-03-20

    申请号：US11874858

    申请日：2007-10-18

    Applicant: Hajime Matsuzaki ,  Xing Su ,  Sean Walsh ,  Giulia Kennedy ,  Rui Mei

    Inventor： Hajime Matsuzaki ,  Xing Su ,  Sean Walsh ,  Giulia Kennedy ,  Rui Mei

    IPC: C40B30/04 ,  C12Q1/68 ,  C40B40/08

    CPC classification number: C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/683 ,  C12Q1/6837 ,  C12Q1/6844 ,  C12Q2600/156

    Abstract: The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further provides for analysis of the above sample by hybridization to an array, which may be specifically designed to interrogate the collection of target sequences for particular characteristics, such as, for example, the presence or absence of one or more polymorphisms.

    Abstract translation: 本发明提供了用于分析核酸样品中靶序列的集合的新颖方法和试剂盒。 在富集包括靶序列集合的片段子集的条件下扩增样品。 本发明进一步提供了通过与阵列杂交来分析上述样品，其可以被特别设计成询问用于特定特征的靶序列的收集，例如存在或不存在一个或多个多态性。

    Methods for determining nucleotide sequence information
    99.
    发明申请
    Methods for determining nucleotide sequence information 审中-公开

    公开(公告)号：US20070128615A1

    公开(公告)日：2007-06-07

    申请号：US11414681

    申请日：2006-04-28

    Applicant: Xing Su

    Inventor： Xing Su

    IPC: C12Q1/68 ,  C12M3/00

    CPC classification number: C12Q1/6818 ,  C12Q1/6874 ,  C12Q2565/632

    Abstract: Provided herein, is a nucleic acid sequencing method based on detection of Raman signatures of oligonucleotide probes. Raman signatures of individually captured nucleic acid probes, optionally labeled by a Raman label or a positively charged enhancer, are detected. The sequences of captured probes are used to identify the nucleotide sequences of captured probes and complementary target nucleic acids, which are then aligned and used to obtain nucleic acid sequence information. In another embodiment, a method is provided for determining a nucleotide occurrence at a target nucleotide position of a target nucleic acid, that utilizes binding of the target nucleic acid to a labeled oligonucleotide probe that binds to the target nucleic acid, wherein the labeled oligonucleotide probe includes a first label and a second label, the first label being capable of affecting an optical property of the second label.

    Programmable molecular barcodes
    100.
    发明申请
    Programmable molecular barcodes 审中-公开
    可编程分子条形码

    公开(公告)号：US20070054288A1

    公开(公告)日：2007-03-08

    申请号：US11430612

    申请日：2006-05-08

    Applicant: Xing Su ,  Tae-Woong Koo ,  Andrew Berlin ,  Lei Sun ,  Narayanan Sundararajan ,  Mineo Yamakawa

    Inventor： Xing Su ,  Tae-Woong Koo ,  Andrew Berlin ,  Lei Sun ,  Narayanan Sundararajan ,  Mineo Yamakawa

    IPC: C12Q1/68 ,  C12M1/34 ,  G06K7/10

    CPC classification number: B82Y10/00 ,  B82Y5/00 ,  C12Q1/6816 ,  G06K19/06028 ,  C12Q2525/161 ,  C12Q2537/143 ,  C12Q2565/1025

    Abstract: The present disclosure concerns methods for producing and/or using molecular barcodes. In certain embodiments of the invention, the barcodes comprise polymer backbones that may contain one or more branch structures. Tags may be attached to the backbone and/or branch structures. The barcode may also comprise a probe that can bind to a target, such as proteins, nucleic acids and other biomolecules or aggregates. Different barcodes may be distinguished by the type and location of the tags. In other embodiments, barcodes may be produced by hybridization of one or more tagged oligonucleotides to a template, comprising a container section and a probe section. The tagged oligonucleotides may be designed as modular code sections, to form different barcodes specific for different targets. In alternative embodiments, barcodes may be prepared by polymerization of monomeric units. Bound barcodes may be detected by various imaging modalities, such as, surface plasmon resonance, fluorescent or Raman spectroscopy.

    Abstract translation: 本公开涉及用于生产和/或使用分子条形码的方法。 在本发明的某些实施方案中，条形码包含可包含一个或多个分支结构的聚合物主链。 标签可以附加到骨干和/或分支结构。 条形码还可以包含可以与靶标结合的探针，例如蛋白质，核酸和其他生物分子或聚集体。 可以通过标签的类型和位置区分不同的条形码。 在其它实施方案中，条形码可以通过将一个或多个标记的寡核苷酸与包含容器部分和探针部分的模板杂交来产生。 标记的寡核苷酸可以被设计为模块代码部分，以形成针对不同靶标的不同条形码。 在替代实施例中，条形码可以通过单体单元的聚合来制备。 可以通过各种成像方式，例如表面等离子体共振，荧光或拉曼光谱来检测结合条形码。

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