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    Method for cross-linking peptides
    92.
    发明授权
    Method for cross-linking peptides 有权
    交联肽的方法

    公开(公告)号：US09290537B2

    公开(公告)日：2016-03-22

    申请号：US13996583

    申请日：2011-12-23

    Applicant: Annemieke Madder ,  Kurt Hoogewijs ,  Annelies Deceuninck ,  Lieselot Carrette

    Inventor： Annemieke Madder ,  Kurt Hoogewijs ,  Annelies Deceuninck ,  Lieselot Carrette

    IPC: A61K38/00 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K1/107 ,  C07K1/00 ,  C07K1/13

    CPC classification number: C07K1/113 ,  C07K1/006 ,  C07K1/1075 ,  C07K1/1077 ,  C07K1/13 ,  C12N9/0051 ,  C12Y108/01009

    Abstract: The present invention relates to a method for cross-linking peptides using an activated furan-moiety. In particular, the present invention provides a method for cross-linking peptides comprising the steps of: a) providing a composition comprising furan-peptides, said furan-peptides comprising at least one amino acid comprising a furan-moiety; b) contacting said composition comprising furan-peptides with second peptides, thereby obtaining a mixture comprising furan-peptides and second peptides; c) adding an activation signal to said mixture of step b), thereby activating said furan-peptides to activated furan-peptides, and d) reacting said activated furan-peptides with said second peptides, thereby cross-linking said activated furan-peptides with said second peptides.

    Abstract translation: 本发明涉及使用活化的呋喃部分交联肽的方法。 特别地，本发明提供了交联肽的方法，包括以下步骤：a）提供包含呋喃肽的组合物，所述呋喃肽包含至少一个包含呋喃部分的氨基酸; b）使包含呋喃肽的所述组合物与第二肽接触，从而获得包含呋喃肽和第二肽的混合物; c）向步骤b）的所述混合物中加入活化信号，从而将所述呋喃肽激活成活化的呋喃肽，和d）使所述活化的呋喃肽与所述第二肽反应，从而将所述活化的呋喃肽与 所述第二肽。

    Reduction of endotoxin in polysialic acids
    97.
    发明授权
    Reduction of endotoxin in polysialic acids 有权
    降低唾液酸中的内毒素

    公开(公告)号：US09212232B2

    公开(公告)日：2015-12-15

    申请号：US13557149

    申请日：2012-07-24

    Applicant: Sanjay Jain ,  Peter Laing ,  Gregory Gregoriadis

    Inventor： Sanjay Jain ,  Peter Laing ,  Gregory Gregoriadis

    IPC: C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  A61K35/74 ,  C12P19/28 ,  C12P21/06 ,  C08B37/00

    CPC classification number: C08B37/0006 ,  B01D15/363 ,  C08B37/0003

    Abstract: The present invention relates to process for reducing the endotoxin content of a sample of fermentation broth containing polysialic acid and endotoxin comprising the sequential steps: (i) adding to the sample a base having a pKa of at least 12 to form a basic solution having a pH of at least 12, incubating the solution for a pre-determined time at a pre-determined temperature; and (ii) recovery of PSA, suitably by (iii) passing the sample through an anion-exchange column whereby polysialic acid is absorbed on the ion exchange resin; (iv) washing the column with one washing buffer, whereby polysialic acid remains absorbed on the ion exchange resin; and (v) eluting the polysialic acid from the column using an elution buffer to provide a product solution of polysialic acid having reduced endotoxin content.

    Abstract translation: 本发明涉及降低含有唾液酸和内毒素的发酵肉汤样品的内毒素含量的方法，其包括以下顺序步骤：（i）向样品中加入pKa至少为12的碱，以形成具有 pH至少为12，在预定温度下将溶液温育预定时间; 和（ii）PSA的回收，适当地通过（iii）使样品通过阴离子交换柱，由此唾液酸被吸收在离子交换树脂上; （iv）用一个洗涤缓冲液洗涤该柱，由此聚唾液酸保持吸收在离子交换树脂上; 和（v）使用洗​​脱缓冲液从柱洗脱聚唾液酸以提供具有降低的内毒素含量的聚唾液酸的产物溶液。

    Solid phase peptide synthesis processes and associated systems
    100.
    发明授权
    Solid phase peptide synthesis processes and associated systems 有权
    固相肽合成过程及相关系统

    公开(公告)号：US09169287B2

    公开(公告)日：2015-10-27

    申请号：US13833745

    申请日：2013-03-15

    Applicant: Massachusetts Institute of Technology

    Inventor： Mark David Simon ,  Bradley L. Pentelute ,  Andrea Adamo ,  Patrick Louis Heider ,  Klavs F. Jensen

    IPC: A61K38/00 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K1/06 ,  C07K1/04 ,  C07K1/08

    CPC classification number: C07K1/045 ,  C07K1/04 ,  C07K1/042 ,  C07K1/061 ,  C07K1/08

    Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.

    Abstract translation: 通常描述用于进行固相肽合成的系统和方法。 固相肽合成是将已经固定在固体支持物上的肽加入氨基酸残基的已知方法。 在某些实施方案中，本发明的系统和方法可用于快速进行固相肽合成，同时保持高产率。 某些实施方案涉及可用于以减少进行固相肽合成所需时间量的方式加热，运输和/或混合试剂的方法和系统。

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