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351 条记录 (耗时 0.052 秒)

    Uses And methods of making Microarrays of Polymeric biomaterials
    105.
    发明申请
    Uses And methods of making Microarrays of Polymeric biomaterials 审中-公开
    使用和制备聚合物生物材料微阵列的方法

    公开(公告)号：US20080182240A1

    公开(公告)日：2008-07-31

    申请号：US11676729

    申请日：2007-02-20

    申请人： Daniel G. Anderson ,  Robert S. Langer ,  David A. Putnam

    发明人： Daniel G. Anderson ,  Robert S. Langer ,  David A. Putnam

    IPC分类号： C12Q1/02 ,  C12Q1/68

    CPC分类号： B01J19/0046

    摘要： A microarray of polymeric biomaterials is provided. Specifically, a microarray of polymeric biomaterials that comprises a base with a cytophobic surface, and a plurality of discrete polymeric biomaterial elements bound to the cytophobic surface, is provided. Preferably said polymeric biomaterials comprise a synthetic polymer. Said polymeric biomaterials may also comprise other compounds covalently or non-covalently attached to said synthetic polymer. Methods of preparing the microarray of polymeric biomaterials of the present invention and uses of the microarray of polymeric biomaterials of the present invention are also provided.

    摘要翻译： 提供了聚合物生物材料的微阵列。 具体地，提供了包含具有细胞疏松表面的基底的聚合物生物材料的微阵列和与细胞积极表面结合的多个离散的聚合物生物材料。 优选地，所述聚合物生物材料包含合成聚合物。 所述聚合物生物材料还可以包含与所述合成聚合物共价或非共价连接的其它化合物。 还提供了制备本发明的聚合物生物材料的微阵列的方法和本发明的聚合物生物材料的微阵列的用途。

    Microchip reservoir devices using wireless transmission of power and data
    106.
    发明授权
    Microchip reservoir devices using wireless transmission of power and data 有权
    Microchip库设备使用无线传输电源和数据

    公开(公告)号：US07226442B2

    公开(公告)日：2007-06-05

    申请号：US09975672

    申请日：2001-10-10

    申请人： Norman F. Sheppard, Jr. ,  John T. Santini, Jr. ,  Stephen J. Herman ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello

    发明人： Norman F. Sheppard, Jr. ,  John T. Santini, Jr. ,  Stephen J. Herman ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello

    IPC分类号： A61K9/22

    CPC分类号： A61B1/041 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/14539 ,  A61K9/0009 ,  A61K9/0051 ,  A61K9/0097 ,  A61M5/14 ,  A61M5/14276 ,  A61M2205/0244 ,  A61M2205/3523 ,  A61M2210/0612 ,  A61M2210/1042 ,  G06F19/00

    摘要： Devices, systems, and methods are provided for wirelessly powering and/or communicating with microchip devices used for the controlled exposure and release of reservoir contents, such as drugs, reagents, and sensors. In one embodiment, the system includes (1) a microchip device comprising a substrate having a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a rechargeable or on-demand power source comprising a local component which can wirelessly receive power from a remote transmitter wherein the received power can be used, directly or following transduction, to activate said release or exposure of the reservoir contents. In another embodiment, the system comprises (1) a microchip device comprising a substrate a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a telemetry system for the wireless transfer of data between the microchip device and a remote controller.

    摘要翻译： 提供了设备，系统和方法，用于与用于受控地暴露和释放储存器内容物（例如药物，试剂和传感器）的微芯片装置的无线供电和/或通信。 在一个实施例中，系统包括（1）微芯片装置，其包括具有多个储存器的基板，所述储存器包含用于释放或曝光的储存器内容物; 和（2）可充电或点播电源，其包括本地组件，其可以从远程发射器无线地接收电力，其中可以直接或继续使用所接收的功率来激活所述储存器内容物的释放或暴露。 在另一个实施例中，系统包括（1）微芯片装置，其包括基板，多个储存器包含用于释放或曝光的储存器内容物; 和（2）用于在微芯片设备和遥控器之间无线传输数据的遥测系统。

    Medical device with array of electrode-containing reservoirs
    107.
    发明授权
    Medical device with array of electrode-containing reservoirs 有权
    带有电极储存器阵列的医疗器械

    公开(公告)号：US07070592B2

    公开(公告)日：2006-07-04

    申请号：US10886405

    申请日：2004-07-07

    申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer

    发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer

    IPC分类号： A61K9/22 ,  A61N1/30

    CPC分类号： A61K9/0097 ,  A61K9/0009 ,  A61K9/0024 ,  Y10T436/25

    摘要： Devices are provided for medical diagnostics comprising a substrate; an array of reservoirs; one or more electrodes located at least partially inside the reservoirs; a plurality of discrete reservoir caps covering openings in the plurality reservoirs; control circuitry for selectively disintegrating or permeabilizing the reservoir cap over a reservoir opening; and, optionally, a diagnostic reagent in the reservoirs. Devices also are provided for the controlled delivery of molecules comprising a substrate; an array of reservoirs; a release system in the reservoirs comprising molecules for release; one or more electrodes attached to the substrate inside the reservoirs or to a surface outside of the reservoirs, wherein the electrodes are not reservoir caps; and means for applying an electric current or potential across the electrodes effective to activate release of the molecules from the reservoirs. The devices can be adapted for implantation for in vivo diagnostics or drug delivery.

    摘要翻译： 提供用于医疗诊断的装置，包括基底; 一系列水库; 一个或多个电极至少部分地位于储存器内部; 多个分立储存器盖，覆盖多个储存器中的开口; 用于选择性地将储存器盖分解或渗透在储存器开口上的控制电路; 和任选地，在储存器中的诊断试剂。 还提供了用于受控输送包含基底的分子的装置; 一系列水库; 储存器中的释放系统包括用于释放的分子; 一个或多个电极附着到储存器内的基底或储存器外部的表面，其中电极不是储​​存器盖; 以及用于施加跨过电极的电流或电位的装置，有效地激活分子从储存器的释放。 该装置可适于植入用于体内诊断或药物递送。