公开(公告)号：US6161043A

公开(公告)日：2000-12-12

申请号：US255140

申请日：1999-02-22

申请人： Kelly H. McClure ,  Gabriel Mouchawar ,  Timothy J. Starkweather ,  James D. Causey, III

发明人： Kelly H. McClure ,  Gabriel Mouchawar ,  Timothy J. Starkweather ,  James D. Causey, III

IPC分类号： A61B5/00 ,  A61N1/365 ,  A61N1/37 ,  A01B5/0452

CPC分类号： A61B5/0006 ,  A61B5/7232 ,  A61N1/36542 ,  A61N1/3702

摘要： An implantable cardiac device is disclosed having a converter that provides a digital electrocardiogram signal to a controller which is stored in memory or transmitted via the telemetry circuit in an improved compressed fashion. The improved compression scheme comprises sampling the electrogram signal, transmitting the starting value in an uncompressed format followed by a plurality of delta signals in a compressed format. The delta signals may be determined by subtracting successive signals or by subtracting a predicted value from the current value. In either case, the delta signal is then transmitted in a truncated number of bits, e.g., 2 or 4 bits. When the delta signal is too large to be represented in the compressed number of bits, the controller then provides an indicator signal followed by the delta signal in the uncompressed format. In addition, whenever successive delta signals are below a minimum threshold (e.g., zero), they may be compressed into a count.

摘要翻译： 公开了一种可植入心脏装置，其具有向控制器提供数字心电图信号的转换器，该控制器存储在存储器中或者以经改进的压缩方式通过遥测电路传输。 改进的压缩方案包括对电描记图信号进行采样，以未压缩格式发送起始值，然后以压缩格式传送多个delta信号。 Δ信号可以通过减去连续信号或从当前值减去预测值来确定。 在任一种情况下，然后以截断的位数（例如2或4位）发送增量信号。 当增量信号太大而不能在压缩位数中表示时，控制器随后以未压缩格式提供指示符信号，后跟增量信号。 此外，每当连续的delta信号低于最小阈值（例如，零）时，它们可以被压缩成计数。

公开(公告)号：US5718242A

公开(公告)日：1998-02-17

申请号：US670946

申请日：1996-06-26

申请人： Kelly H. McClure ,  Gene A. Bornzin

发明人： Kelly H. McClure ,  Gene A. Bornzin

IPC分类号： A61N1/362 ,  A61N1/37 ,  A61B5/0456 ,  A61N1/365

CPC分类号： A61N1/3621 ,  A61N1/3704

摘要： A cardiac event and arrhythmia detection system and method detects arrhythmic cardiac activity or other information from an electrogram signal of a heart. The system senses the electrogram signal through an electrogram lead, preliminarily processes the signal, and converts it to a plurality of discrete digital signals, each of which represents the magnitude of the electrogram signal at a prescribed sample time. The discrete digital signals are applied to both a cardiac event detector and a morphology detector. The morphology detector detects selected changes in the morphology (shape) of the electrogram signal, wherein such changes automatically control the sensitivity (gain and/or threshold) used to detect cardiac events. The occurrence of a prescribed amount of change in the detected morphology over time indicates the occurrence of a prescribed arrhythmic cardiac condition.

公开(公告)号：US5560369A

公开(公告)日：1996-10-01

申请号：US310688

申请日：1994-09-22

申请人： Kelly H. McClure ,  Gene A. Bornzin

发明人： Kelly H. McClure ,  Gene A. Bornzin

IPC分类号： A61B5/0452 ,  A61N1/365 ,  A61N1/37 ,  A61B5/0402

CPC分类号： A61N1/3702 ,  A61N1/3704 ,  Y10S128/901

摘要： A cardiac event and arrhythmia detection system and method detects arrhythmic cardiac activity or other information from an electrogram signal of a heart. The system senses the electrogram signal through an electrogram lead, preliminarily processes the signal, and converts it to a plurality of discrete digital signals, each of which represents the magnitude of the electrogram signal at a prescribed sample time. The discrete digital signals are applied to both a cardiac event detector and a morphology detector. The morphology detector detects selected changes in the morphology (shape) of the electrogram signal, wherein such changes automatically control the sensitivity (gain and/or threshold) used to detect cardiac events. The occurrence of a prescribed amount of change in the detected morphology over time indicates the occurrence of a prescribed arrhythmic cardiac condition.

摘要翻译： 心脏事件和心律失常检测系统和方法从心脏的电描记图信号检测心律失常心脏活动或其他信息。 该系统通过电导线感测电描记图信号，预先处理信号，并将其转换为多个离散数字信号，每个离散数字信号表示规定采样时间的电描记图信号的幅度。 离散数字信号被应用于心脏事件检测器和形态检测器。 形态检测器检测电描记图信号的形态（形状）中的选择的变化，其中这种变化自动控制用于检测心脏事件的灵敏度（增益和/或阈值）。 随着时间的推移，检测到的形态的规定量的变化的发生表明规定的心律失常心脏病的发生。

公开(公告)号：US08401661B2

公开(公告)日：2013-03-19

申请号：US12783432

申请日：2010-05-19

申请人： George Vamos ,  Kelly H. McClure

发明人： George Vamos ,  Kelly H. McClure

IPC分类号： A61N1/08

CPC分类号： A61N1/37264 ,  A61N1/37217 ,  A61N1/37282 ,  G06F17/2247 ,  G06F19/00 ,  G06F19/3418 ,  G16H40/40 ,  H04L67/02 ,  H04L67/12 ,  H04L67/42

摘要： A system and method for modifying the parameters of an implantable medical device includes an implantable medical device that communicates with a remote control device that, in turn, communicates through the browser of a computer or any other device capable of using mark-up language protocol. The computer optionally communicates with other computers and/or devices through a network.

摘要翻译： 用于修改可植入医疗装置的参数的系统和方法包括与远程控制装置进行通信的可植入医疗装置，所述远程控制装置又通过计算机的浏览器或能够使用标记语言协议的任何其他装置进行通信。 计算机可选地通过网络与其他计算机和/或设备通信。

公开(公告)号：US08401634B2

公开(公告)日：2013-03-19

申请号：US12873170

申请日：2010-08-31

申请人： Todd K. Whitehurst ,  James P. McGivern ,  Kelly H. McClure

发明人： Todd K. Whitehurst ,  James P. McGivern ,  Kelly H. McClure

IPC分类号： A61N1/00

CPC分类号： A61M5/14276 ,  A61K9/0085 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2210/0693 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/325 ,  A61N1/36082 ,  A61N1/37205

摘要： Systems for treating a movement disorder include a system control unit configured to be implanted at least partially within a patient and to generate at least one stimulus in accordance with one or more stimulation parameters adjusted to treat the movement disorder. The systems further include a programmable memory unit in communication with the system control unit and programmed to store the one or more stimulation parameters to at least partially define the stimulus such that the stimulus is configured to treat the movement disorder. A means for applying the stimulus to one or more stimulation sites within the patient is operably connected to the system control unit.

摘要翻译： 用于治疗运动障碍的系统包括系统控制单元，该系统控制单元被配置为至少部分地植入患者体内，并根据被调整以治疗运动障碍的一个或多个刺激参数产生至少一个刺激。 系统还包括与系统控制单元通信的可编程存储器单元，并被编程为存储一个或多个刺激参数以至少部分地限定刺激，使得刺激被配置为治疗运动障碍。 将刺激施加到患者体内的一个或多个刺激部位的手段可操作地连接到系统控制单元。

公开(公告)号：US08165696B2

公开(公告)日：2012-04-24

申请号：US11066968

申请日：2005-02-25

申请人： Kelly H. McClure ,  Matthew I. Haller ,  Jay Daulton

发明人： Kelly H. McClure ,  Matthew I. Haller ,  Jay Daulton

IPC分类号： A61N1/04

CPC分类号： A61N1/37229 ,  A61N1/0534 ,  A61N1/0543 ,  A61N1/0551 ,  A61N1/36036 ,  A61N1/3605 ,  A61N1/36082 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3787

摘要： An implantable stimulator includes a base, two prongs extending from the base and an electrode disposed on each of the prongs. This stimulator may be part of a system that includes an external device for transcutaneously communicating with the implanted stimulator. A method of using the implantable stimulator includes generating a current gradient between the electrodes on the two prongs to stimulate a target site in a patient. A method of making the implantable stimulator includes coating electrode material on the prongs except where the electrode surfaces are to be formed.

摘要翻译： 植入式刺激器包括基座，从底座延伸的两个插脚和设置在每个插脚上的电极。 该刺激器可以是包括用于与植入的刺激器经皮通信的外部设备的系统的一部分。 使用可植入刺激器的方法包括在两个尖头上的电极之间产生电流梯度以刺激患者中的目标部位。 制造可植入刺激器的方法包括将电极材料涂覆在尖头上，除了要形成电极表面之外。

公开(公告)号：US20110184587A1

公开(公告)日：2011-07-28

申请号：US13011892

申请日：2011-01-22

申请人： George Vamos ,  Kelly H. McClure

发明人： George Vamos ,  Kelly H. McClure

IPC分类号： G06F1/26 ,  G06Q90/00

CPC分类号： G06Q99/00 ,  B60L50/16 ,  B60L53/11 ,  B60L53/14 ,  B60L53/30 ,  B60L53/305 ,  B60L53/63 ,  B60L53/64 ,  B60L53/65 ,  B60L53/665 ,  B60L55/00 ,  B60L2240/80 ,  B60L2260/58 ,  G06Q30/06 ,  H02J3/008 ,  Y02E60/721 ,  Y02T10/70 ,  Y02T10/7005 ,  Y02T10/7077 ,  Y02T10/7088 ,  Y02T90/121 ,  Y02T90/128 ,  Y02T90/14 ,  Y02T90/163 ,  Y02T90/169 ,  Y04S10/126 ,  Y04S30/14 ,  Y04S50/10

摘要： A method is disclosed. The method provides a user with access to a plurality of power providers, allows the user to purchase power from at least one power provider out of the plurality of power providers, and allows the user to charge a battery or operate equipment using the purchased power.

摘要翻译： 公开了一种方法。 该方法向用户提供对多个电力供应商的访问，允许用户从多个电力供应商中的至少一个电力供应商购买电力，并且允许用户使用购买的电力对电池充电或操作设备。

公开(公告)号：US20100280575A1

公开(公告)日：2010-11-04

申请号：US12836440

申请日：2010-07-14

申请人： Rafael Carbunaru ,  Kelly H. McClure ,  Jordi Parramon

发明人： Rafael Carbunaru ,  Kelly H. McClure ,  Jordi Parramon

IPC分类号： A61N1/08 ,  A61N1/36

CPC分类号： A61N1/36146 ,  A61N1/36103 ,  A61N1/36107 ,  A61N1/37247 ,  A61N1/37264

摘要： Systems of techniques for controlling charge flow during the electrical stimulation of tissue. In one aspect, a method includes receiving a charge setting describing an amount of charge that is to flow during a stimulation pulse that electrically stimulates a tissue, and generating and delivering the stimulation pulse in a manner such that an amount of charge delivered to the tissue during the stimulation pulse accords with the charge setting.

摘要翻译： 在电刺激组织期间控制电荷流动的技术系统。 一方面，一种方法包括接收描述在电刺激组织的刺激脉冲期间流动的电荷量的电荷设置，以及产生和递送刺激脉冲，使得递送到组织的电荷量 在刺激脉冲期间符合充电设置。

公开(公告)号：US20100228323A1

公开(公告)日：2010-09-09

申请号：US12783432

申请日：2010-05-19

申请人： George Vamos ,  Kelly H. McClure

发明人： George Vamos ,  Kelly H. McClure

IPC分类号： A61N1/08

CPC分类号： A61N1/37264 ,  A61N1/37217 ,  A61N1/37282 ,  G06F17/2247 ,  G06F19/00 ,  G06F19/3418 ,  G16H40/40 ,  H04L67/02 ,  H04L67/12 ,  H04L67/42

摘要： A system and method for modifying the parameters of an implantable medical device includes an implantable medical device that communicates with a remote control device that, in turn, communicates through the browser of a computer or any other device capable of using mark-up language protocol. The computer optionally communicates with other computers and/or devices through a network.

摘要翻译： 用于修改可植入医疗装置的参数的系统和方法包括与远程控制装置进行通信的可植入医疗装置，所述远程控制装置又通过计算机的浏览器或能够使用标记语言协议的任何其他装置进行通信。 计算机可选地通过网络与其他计算机和/或设备通信。

公开(公告)号：US07437193B2

公开(公告)日：2008-10-14

申请号：US10607963

申请日：2003-06-27

申请人： Jordi Parramon ,  Goran N. Marnfeldt ,  Kelly H. McClure ,  Matthew I. Haller

发明人： Jordi Parramon ,  Goran N. Marnfeldt ,  Kelly H. McClure ,  Matthew I. Haller

IPC分类号： A61N1/08

CPC分类号： A61N1/37276 ,  A61N1/36007 ,  A61N1/3605 ,  A61N1/37205 ,  A61N1/37217 ,  A61N1/37223 ,  A61N1/37229 ,  A61N1/37235 ,  A61N1/3727 ,  A61N1/375 ,  A61N1/3787 ,  H01L2224/45144 ,  H01L2224/45147 ,  H01L2224/48465 ,  H01L2224/49175 ,  H01L2924/00011 ,  H01L2924/1461 ,  H01L2924/19105 ,  H01L2924/19107 ,  H01L2924/3011 ,  H01L2924/30111 ,  H02J7/025 ,  H02J7/345 ,  H04B5/0037 ,  H04B5/0081 ,  H04L27/02 ,  H04L27/10 ,  Y10T29/4902 ,  Y10T29/49071 ,  Y10T29/49073 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49155 ,  Y10T29/49169 ,  Y10T29/49826 ,  Y10T29/49945 ,  Y10T29/49968 ,  Y10T428/12264 ,  Y10T428/12271 ,  Y10T428/12347 ,  Y10T428/12375 ,  Y10T428/12396 ,  Y10T428/12535 ,  Y10T428/12806 ,  H01L2924/00 ,  H01L2924/01005 ,  H01L2924/01033

摘要： An implantable microstimulator configured to be implanted beneath a patient's skin for tissue stimulation to prevent and/or treat various disorders, e.g., neurological disorders, uses a self-contained power source such as a primary battery, a rechargeable battery, or other energy sources. For the rechargeable battery, and other energy sources that may require a periodic or occasional replenishment, such recharging or replenishment is accomplished, for example, by inductive coupling with an external device. A suitable bidirectional telemetry link allows the microstimulator system to inform the patient or clinician regarding the status of the system, including the charge level of the power source, and stimulation parameter states. Processing circuitry within the microstimulator automatically controls the applied stimulation pulses to match a set of programmed stimulation parameters established for a particular patient. The microstimulator preferably has a cylindrical hermetically sealed case having a length no greater than about 27 mm and a diameter no greater than about 3.3 mm. A reference electrode is located on one end of the case and an active electrode is located on the other end of the case. Further, the case is externally coated on selected areas with conductive and non-conductive materials.

摘要翻译： 被配置为植入在患者皮肤下面用于组织刺激以防止和/或治疗各种疾病（例如神经障碍）的可植入微刺激器使用诸如一次电池，可再充电电池或其他能量源的独立电源。 对于可充电电池和可能需要定期或偶尔的补充的其他能量源，例如通过与外部设备的电感耦合来实现这种再充电或补充。 合适的双向遥测链路允许微刺激器系统通知患者或临床医生关于系统的状态，包括电源的充电水平和刺激参数状态。 微刺激器内的处理电路自动控制所施加的刺激脉冲，以匹配为特定患者建立的一组编程刺激参数。 微型激励器优选具有圆柱形气密密封的外壳，其长度不大于约27mm，直径不大于约3.3mm。 参考电极位于壳体的一端，有源电极位于壳体的另一端。 此外，外壳在导电和非导电材料的外围涂覆在选定的区域上。