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    Process and device for determining an analyte contained in a scattering matrix
    118.
    发明授权
    Process and device for determining an analyte contained in a scattering matrix 失效
    用于确定包含在散射矩阵中的分析物的方法和装置

    公开(公告)号：US5962852A

    公开(公告)日：1999-10-05

    申请号：US875349

    申请日：1997-07-28

    Applicant: Alexander Knuettel ,  Dirk Boecker ,  Matthias Essenpreis

    Inventor： Alexander Knuettel ,  Dirk Boecker ,  Matthias Essenpreis

    IPC: A61B5/00 ,  G01N21/49

    CPC classification number: A61B5/1455 ,  A61B5/0066 ,  A61B5/14532 ,  G01N21/49

    Abstract: Method for determining an analyte in a scattering matrix. In a detection step detection measurements are made in which light is irradiated into the matrix as primary light and light leaving the scattering matrix is detected as secondary light, in order to determine as a measurement quantity a measurable physical property of the light which is variable due to the interaction of the light with the matrix. Information on the presence of the analyte in the matrix is determined in an evaluation step. The determination of optically weakly absorbing analytes against a strongly absorbing interference background is improved by the use of two selection methods for the depth selective detection of the secondary light in combination with one another. Primary light is focused by means of a primary light optically focussing element onto a region of focus lying in the matrix at a predetermined measuring depth and the region of focus is imaged by means of a secondary light optically focusing element onto a light entry aperture arranged in the light path of the secondary light to the detector. In addition to this first depth selection by a confocal arrangement, a second depth selection device is used to detect light reflected from a defined measuring depth as secondary light, with the measuring depth coinciding with the depth of focus.

    Abstract translation: PCT No.PCT / DE97 / 00168 Sec。 371日期1997年7月28日第 102（e）1997年7月28日PCT PCT 1997年1月23日PCT公布。 公开号WO97 / 27469 日期1997年7月31日确定散射矩阵中的分析物的方法。 在检测步骤中，进行检测测量，其中将光作为初级光照射到基质中，并且离开散射矩阵的光被检测为次级光，以便将测量量确定为可变的光的可测量的物理性质 对光与基质的相互作用。 在评估步骤中确定基质中分析物存在的信息。 通过使用两种选择方法来对二次光的深度选择性检测相结​​合，可以改善光吸收弱吸收分析物的强吸收干涉背景的测定。 初级光通过初级光光聚焦元件聚焦在位于矩阵中的预定测量深度的焦点区域上，并且聚焦的区域通过次光光学聚焦元件成像到布置在 次级光到检测器的光路。 除了通过共焦排列的第一深度选择之外，使用第二深度选择装置来检测从限定的测量深度反射的光作为次级光，其测量深度与焦深一致。

    Method and apparatus for the analysis of glucose in a biological matrix
    119.
    发明授权
    Method and apparatus for the analysis of glucose in a biological matrix 失效
    用于分析生物基质中葡萄糖的方法和装置

    公开(公告)号：US5692504A

    公开(公告)日：1997-12-02

    申请号：US592303

    申请日：1996-02-09

    Applicant: Matthias Essenpreis ,  Dirk Boecker ,  Heinz-Michael Hein ,  Hans-Peter Haar

    Inventor： Matthias Essenpreis ,  Dirk Boecker ,  Heinz-Michael Hein ,  Hans-Peter Haar

    IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  G01N21/41 ,  G01N21/47 ,  G01N21/49 ,  A61B5/000

    CPC classification number: A61B5/1455 ,  A61B5/14532 ,  G01N21/41 ,  G01N21/47 ,  G01N21/49 ,  A61B2562/0242 ,  G01N2201/0696

    Abstract: Method and apparatus for the analytical determination of glucose concentration in a biological matrix, wherein in a detection step light from a light emitter is irradiated into the biological matrix as primary light via a boundary surface of the biological matrix and light emerging from the the biological matrix through a boundary surface is being detected by a light detector in order to determine a measurable physical light property which is changed by interaction with the biological matrix and which correlates with the glucose concentration of said matrix. The glucose concentration is ascertained in an evaluation step on the basis of said change of the physical light property determined in at least one detection step in comparison with a calibration. In order to achieve by such a method good analytical accuracy in reagent-free and non-invasive manner, for instance to observe the change of the concentration of the analyzed substance (monitoring) over an adequate time interval, a measurable parameter corresponding to the light transit-time within the biological matrix between a defined irradiation site and a defined detection site and correlating with the glucose concentration is determined in the detection step.

    Abstract translation: PCT No.PCT / DE94 / 01290 Sec。 371日期1996年2月9日 102（e）日期1996年2月9日PCT 1994年10月29日PCT PCT。 WO95 / 12348 PCT公开号 日期：1995年5月11日用于生物基质中葡萄糖浓度分析测定的方法和装置，其中在检测步骤中，来自发光体的光经由生物基质的边界表面作为主要光照射到生物基质中， 通过光检测器检测生物基质，以便确定通过与生物基质相互作用而改变并与所述基质的葡萄糖浓度相关的可测量的物理光特性。 基于与校准相比在至少一个检测步骤中确定的物理光特性的变化，在评估步骤中确定葡萄糖浓度。 为了通过这种方法实现无试剂和非侵入性的良好的分析精确性，例如在足够的时间间隔内观察分析物质（监测）浓度的变化，对应于光的可测量参数 在检测步骤中确定在确定的照射位点和限定的检测位点之间的生物学基质内的与葡萄糖浓度相关的转运时间。

    Method and apparatus for analyte measurement test time
    120.
    发明授权
    Method and apparatus for analyte measurement test time 有权
    用于分析物测量测试时间的方法和设备

    公开(公告)号：US08652831B2

    公开(公告)日：2014-02-18

    申请号：US12055973

    申请日：2008-03-26

    Applicant: Dirk Boecker

    Inventor： Dirk Boecker

    IPC: C12M1/34 ,  C12M3/00 ,  G01N35/00

    CPC classification number: A61B5/14532 ,  A61B5/1468 ,  A61B5/1486 ,  A61B5/151 ,  A61B5/157 ,  C12Q1/006 ,  G01N27/3273

    Abstract: A disposable biosensor test strip is provided that includes a plurality of penetrating members. Each penetrating member is associated with a capillary chamber that has a depth suitable for capillary flow of blood and holds a volume of less than about 1.0 .μl of the blood sample. A working electrode and a counter or reference electrode are disposed within the capillary chamber. A reagent is proximal to or in contact with at least the working electrode. The reagent includes an enzyme and a mediator. The reagent reacts with glucose to produce an electroactive reaction product. A blood sample, containing glucose, is applied into the capillary chamber. The capillary chamber directs capillary flow of the blood sample into contact with the reagent to cause the blood sample to at least partially solubilize or hydrate the reagent. The blood sample is detected in the capillary chamber. The electroactive reaction product is electro-oxidized or electro-reduced at the working electrode. Within 10 seconds after detecting, a determination is made of glucose concentration and a readout of the measurement is provided. The glucose determination is made by correlating the electro-oxidized or electro-reduced electroactive reaction product to the concentration of glucose in the blood sample.

    Abstract translation: 提供了包括多个穿透构件的一次性生物传感器测试条。 每个穿透构件与毛细管室相关联，毛细管腔具有适于血液毛细血管流动的深度并保持少于约1.0mL血液样本的体积。 工作电极和计数器或参比电极设置在毛细管腔内。 试剂与至少工作电极接近或接触。 试剂包括酶和介体。 试剂与葡萄糖反应产生电活性反应产物。 将含有葡萄糖的血液样品施加到毛细管腔中。 毛细管腔引导血液样品的毛细管流动与试剂接触，使血液样品至少部分溶解或水合试剂。 在毛细血管腔中检测血样。 电活性反应产物在工作电极处被电氧化或电还原。 在检测后10秒钟内，确定葡萄糖浓度，并提供测量的读数。 通过将电氧化或电还原的电活性反应产物与血液样品中的葡萄糖浓度相关联来进行葡萄糖测定。

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