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343 条记录 (耗时 0.035 秒)

    Method and apparatus for measuring and analyzing mass spectrum
    111.
    发明授权
    Method and apparatus for measuring and analyzing mass spectrum 失效
    测量和分析质谱的方法和装置

    公开(公告)号：US6008490A

    公开(公告)日：1999-12-28

    申请号：US48347

    申请日：1998-03-26

    申请人： Yoshiaki Kato

    发明人： Yoshiaki Kato

    IPC分类号： G01N27/62 ,  H01J49/04 ,  H01J49/26 ,  H01J49/00

    CPC分类号： H01J49/0036

    摘要： An analyzing portion searches a mass spectrum for a mass peak exceeding a threshold level and adds the mass corresponding to the searched peak to the mass differences listed in an adduct ion table stored in a table, thereby forming a quasi-mass spectrum. The analyzing portion compares the formed quasi-mass spectrum with a measured mass spectrum in terms of mass. If agreement in mass between both the spectra is found, an index S is incremented by one and finally a total value of the index S is calculated. The analyzing portion then searches for another mass peak exceeding the threshold level and executes a similar process. Resulting values of the indexes S are compared with each other and probabilities of m/z and adduct ions are output to a display portion. Emergence frequency is counted for each of detected ion types and stored in storage means. If the measurement is executed in a predetermined number of times, then a greater weight is allocated to the ion types having larger emergence frequency, followed by updating the adduct ion table stored in the table. That arrangement realizes a method and apparatus for measuring and analyzing a mass spectrum by which a quasi-molecular ion and hence the molecular weight of a sample can be quickly estimated with high accuracy while preventing an error from being mixed in the process of analysis.

    摘要翻译： 分析部分在质谱中搜索超过阈值的质量峰值，并将与搜索到的峰对应的质量与存储在表中的加合离子表中列出的质量差相加，从而形成准质谱。 分析部分将形成的准质谱与质量质量的测量质谱进行比较。 如果发现两个光谱之间的质量一致，则索引S增加1，最后计算索引S的总值。 然后，分析部分搜索超过阈值水平的另一个质量峰值，并执行类似的处理。 将指标S的所得值相互比较，并将m / z和加合离子的概率输出到显示部分。 对每个检测到的离子类型计数出现频率并存储在存储装置中。 如果以预定次数执行测量，则对具有较大出现频率的离子类型分配更大的权重，随后更新存储在表中的加合离子表。 该装置实现了用于测量和分析质谱的方法和装置，通过该方法和装置可以高精度快速估计样品的准分子量，从而在分析过程中防止误差混合。

    Mass spectrometry and mass spectrometer
    112.
    发明授权
    Mass spectrometry and mass spectrometer 失效

    公开(公告)号：US6002130A

    公开(公告)日：1999-12-14

    申请号：US15322

    申请日：1998-01-29

    申请人： Yoshiaki Kato

    发明人： Yoshiaki Kato

    IPC分类号： H01J49/04 ,  B01D54/44 ,  H01J49/00

    CPC分类号： H01J49/24 ,  H01J49/04

    摘要： Ions generated under an atmospheric pressure pass through vacuum chambers partitioned through first, second and third fine holes. The ions are led to an MS part where the ions are mass-analyzed. A first vacuum chamber adjacent to an atmospheric pressure part has not vacuum pump for independently pumping this chamber. The first vacuum chamber is evacuated by a common pump together with a second vacuum chamber via a bypass hole formed in the wall having the second aperture. A pressure of the first vacuum chamber can be set to several 100 Pa, while a pressure of the second vacuum chamber can be set to several 10 Pa. Sufficient desolvation has been attained by an ion acceleration voltage of approximately 100 V in the first vacuum chamber, while a speed spread can be restrained. The ions are accelerated by approximately 10 V in the second vacuum chamber, and the speed can be restrained as low as possible.

    Three dimensional quadrupole mass spectrometry and mass spectrometer
    113.
    发明授权
    Three dimensional quadrupole mass spectrometry and mass spectrometer 失效
    三维四极杆质谱和质谱仪

    公开(公告)号：US5789747A

    公开(公告)日：1998-08-04

    申请号：US859657

    申请日：1997-05-20

    申请人： Yoshiaki Kato ,  Tadao Mimura

    发明人： Yoshiaki Kato ,  Tadao Mimura

    IPC分类号： G01N27/62 ,  H01J49/26 ,  H01J49/42

    CPC分类号： H01J49/424 ,  H01J49/4265

    摘要： In a three dimensional quadrupole mass spectrometry, ions created in an ion source 1 are introduced into a three dimensional quadrupole field 7 formed in an ion introduction space and trapped therein. When one or more parameters of the three dimensional quadrupole field is scanned, the ions of which oscillation are instablized are successively discharged to the outside thereof and are detected by a detector 12. The signal representing the detected ions is processed by a data processing unit 13 to determine mass spectrum thereof. Prior to the above mass spectrometry, a preliminary measurement for the created ions is performed by detecting the ions passing through the ion introduction space as they are with no influences therefrom within a predetermined period by the detector 12 and a time interval during which the created ions are to be introduced into the ion introduction space for the mass spectrometry is determined based on the detected ion amount in the preliminary measurement. Thereby, the measurement time by the three dimensional quadrupole mass spectrometry is shortened while preventing ion saturation and space charge caused by the ions.

    摘要翻译： 在三维四极杆质谱中，在离子源1中产生的离子被引入形成在离子引入空间中并被捕获的三维四极场7中。 当扫描三维四极场的一个或多个参数时，振荡的离子被稳定地被排出到其外部并由检测器12检测。表示检测到的离子的信号被数据处理单元13处理 以确定其质谱。 在进行上述质谱分析之前，通过检测器12在预定时间内检测通过离子引入空间的离子而不受其影响，并且产生的离子的时间间隔 基于在初步测量中检测到的离子量来确定用于质谱的离子引入空间。 因此，通过三维四极杆质谱的测定时间缩短，同时防止由离子引起的离子饱和和空间电荷。

    Contact-type magnetic head having an integral control portion for generating negative pressure
    114.
    发明授权
    Contact-type magnetic head having an integral control portion for generating negative pressure 失效
    具有用于产生负压的整体控制部分的接触型磁头

    公开(公告)号：US5717551A

    公开(公告)日：1998-02-10

    申请号：US443678

    申请日：1995-05-18

    申请人： Kenji Negishi ,  Daisuke Mitsuhashi ,  Yoshiaki Kato ,  Akira Takimoto ,  Noboru Kawasaki

    发明人： Kenji Negishi ,  Daisuke Mitsuhashi ,  Yoshiaki Kato ,  Akira Takimoto ,  Noboru Kawasaki

    IPC分类号： G11B5/187 ,  G11B17/32 ,  G11B17/34

    CPC分类号： G11B5/1871 ,  G11B17/32

    摘要： A magnetic head having a control portion provided integrally with an opposing surface located opposing the recording surface of a magnetic disc or a head mount for generating a negative pressure between the control portion and the magnetic disc to attract the magnetic disc towards the magnetic head, thereby generating an adequate and sufficient negative pressure in the vicinity of the magnetic head and achieving a good head touch. This configuration enables compact design of the mechanism and an increased recording area of the magnetic disc compared with the case in which a magnetic head and a negative pressure generation type stabilizing plate to attract the magnetic disc towards the magnetic head are separately disposed, and eliminates the need for procedures for separate positioning of the individual magnetic head and stabilizing plate, thereby achieving a considerable reduction in manufacturing steps and production cost.

    摘要翻译： 一种磁头，其具有与位于与磁盘的记录表面相对的相对表面一体地设置的控制部分或头部安装件，用于在控制部分和磁盘之间产生负压以将磁盘吸向磁头，由此 在磁头附近产生足够的和足够的负压并实现良好的头部接触。 与使磁头朝向磁头吸引磁盘的磁头和负压产生型稳定板分别设置的情况相比，能够实现机构的紧凑设计和磁盘的增加的记录区域，并且消除 需要单独定位磁头和稳定板的程序，从而实现制造步骤和生产成本的显着降低。

    Cyclic amidinylthiocarbapenem derivatives
    120.
    发明授权
    Cyclic amidinylthiocarbapenem derivatives 失效
    环丙氨基噻吩衍生物

    公开(公告)号：US5100888A

    公开(公告)日：1992-03-31

    申请号：US549574

    申请日：1990-07-06

    申请人： Susumu Nakagawa ,  Yoshiaki Kato ,  Hiroshi Fukatsu

    发明人： Susumu Nakagawa ,  Yoshiaki Kato ,  Hiroshi Fukatsu

    IPC分类号： C07D477/00 ,  A61K31/397 ,  A61K31/40 ,  A61P31/04 ,  C07D207/24 ,  C07D477/20

    CPC分类号： C07D477/20 ,  C07D207/24 ,  Y02P20/55

    摘要： A compound represented by formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a methyl group; R.sup.2 and R.sup.3, which may be the same or different, each represents a hydrogen atom or a lower alkyl group; and R.sup.4 represents a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a di-lower alkylcarbamoyl group, or a carbonyl group substituted with a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidino group, a morpholino group, a thio-morpholino group, a piperazinyl group, and a 4-lower alkyl-1-piperazinyl group, or a pharmaceutically acceptable salt or ester thereof. The compound of formula (I) and their salts or esters exhibit excellent antibacterial activity.