公开(公告)号：US20140194808A1

公开(公告)日：2014-07-10

申请号：US14148524

申请日：2014-01-06

Applicant: SEARETE LLC, A limited liability corporation of the State of Delaware

Inventor： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Lowell L. Wood, JR.

IPC: A61K41/00 ,  A61K33/00 ,  A61N5/06

CPC classification number: A61N5/062 ,  A61K9/0034 ,  A61K31/095 ,  A61K31/198 ,  A61K31/5377 ,  A61K31/655 ,  A61K33/00 ,  A61K41/0042 ,  A61N5/0601

Abstract: The present disclosure relates to methods and systems for use of photolyzable nitric oxide donors for the treatment of sexual dysfunction.

Abstract translation: 本公开涉及使用可光致照射的一氧化氮供体用于治疗性功能障碍的方法和系统。

公开(公告)号：US20140163647A1

公开(公告)日：2014-06-12

申请号：US14101022

申请日：2013-12-09

Applicant: Searete LLC

Inventor： Ralph G. Dacey, JR. ,  Gregory J. Della Rocca ,  Colin P. Derdeyn ,  Joshua L. Dowling ,  Eleanor V. Goodall ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Michael A. Smith ,  Lowell L. Wood, JR. ,  Victoria Y. H. Wood ,  Gregory J. Zipfel

IPC: A61N1/36

CPC classification number: A61M5/14276 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/1118 ,  A61B5/14539 ,  A61B5/4035 ,  A61B5/4041 ,  A61B5/411 ,  A61B5/441 ,  A61B5/4821 ,  A61B5/4839 ,  A61F7/00 ,  A61F7/0085 ,  A61F2007/0075 ,  A61M5/14244 ,  A61M5/14248 ,  A61M5/16827 ,  A61M5/1723 ,  A61M35/00 ,  A61M37/00 ,  A61M37/0015 ,  A61M37/0092 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2037/0007 ,  A61M2205/0244 ,  A61M2210/1003 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/30 ,  A61N1/303 ,  A61N1/306 ,  A61N1/325 ,  A61N1/327 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/37252 ,  A61N2/002 ,  A61N2/006 ,  A61N7/00 ,  A61N2007/0026

Abstract: Methods and related systems for modulating neural activity by cyclical blocking of conduction in peripheral neural structures with electrical blocking stimuli are disclosed. In an aspect, neural activity is blocked cyclically with an electrical blocking stimulus source implanted adjacent a nerve. In an aspect, a conduction block is produced in a sensory nerve. Neural modulation may be used, for example, to modulate an immune or inflammatory response or process.

Abstract translation: 公开了通过具有电阻塞刺激的周围神经结构中的传导的循环阻断来调节神经活动的方法和相关系统。 在一个方面，神经活动被循环地阻挡，其中植入邻近神经的电阻塞刺激源。 在一方面，在感觉神经中产生传导阻滞。 神经调节可用于例如调节免疫或炎症反应或过程。

公开(公告)号：US08647596B1

公开(公告)日：2014-02-11

申请号：US13961551

申请日：2013-08-07

Applicant: Searete LLC

Inventor： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Thomas A. Weaver ,  Lowell L. Wood, Jr.

IPC: B01D53/62 ,  B01D53/92 ,  G05B21/00 ,  G05D9/00 ,  G06F17/00

CPC classification number: F01N3/00 ,  B01D53/1412 ,  B01D53/1475 ,  B01D53/1493 ,  B01D53/18 ,  B01D53/62 ,  B01D53/92 ,  B01D53/94 ,  B01D53/9495 ,  B01D2252/20478 ,  B01D2257/504 ,  B01D2258/01 ,  B23P6/00 ,  B60V3/00 ,  F01N3/0857 ,  F01N3/10 ,  F01N3/18 ,  F01N2570/10 ,  G05B21/00 ,  G06F17/00 ,  Y02C10/04 ,  Y02C10/06 ,  Y10T29/4973

Abstract: Disclosed embodiments include methods of removing carbon dioxide from combustion gas from an engine of a vehicle, systems for removing carbon dioxide from combustion gas from an engine of a vehicle, vehicles, methods of managing carbon dioxide emissions from an engine of a vehicle, and computer software program products for managing carbon dioxide emissions from an engine of a vehicle.

公开(公告)号：US20130301770A1

公开(公告)日：2013-11-14

申请号：US13863521

申请日：2013-04-16

Applicant: Searete LLC

Inventor： Charles E. Ahlfeld ,  John Rogers Gilleland ,  Roderick A. Hyde ,  David G. McAlees ,  Jon David McWhirter ,  Ashok Odedra ,  Clarence T. Tegreene ,  Joshua C. Walter ,  Kevan D. Weaver ,  Charles Whitmer ,  Lowell L. Wood, JR. ,  George B. Zimmerman

IPC: G21D3/08

CPC classification number: G21D3/08 ,  C21D1/26 ,  G21C19/207

Abstract: Illustrative embodiments provide systems, methods, apparatuses, and applications related to annealing nuclear fission reactor materials.

Abstract translation: 说明性实施例提供了与退火核裂变反应堆材料相关的系统，方法，装置和应用。

公开(公告)号：US20130289360A1

公开(公告)日：2013-10-31

申请号：US13857721

申请日：2013-04-05

Applicant: Searete LLC

Inventor： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Eric C. Leuthardt ,  Royce A. Levien ,  Robert W. Lord ,  Mark A. Malamud ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC: A61B5/00

CPC classification number: A61M5/1723 ,  A61B5/024 ,  A61B5/04 ,  A61B5/05 ,  A61B5/08 ,  A61B5/16 ,  A61B5/411 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/4266 ,  A61B5/48 ,  A61B5/4839 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2230/04 ,  A61M2230/10 ,  A61M2230/30 ,  A61M2230/65 ,  G06F3/011 ,  G06F17/30528 ,  G06F19/00 ,  G06F19/325

Abstract: Methods, computer program products, and systems are described that include measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual and/or modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect.

Abstract translation: 描述了方法，计算机程序产品和系统，其包括测量组合的生物活性剂和人造感觉经验对个体的至少一种效应和/或至少部分地基于以下方式修饰生物活性剂或人造感官体验中的至少一种： 至少一个效果。

公开(公告)号：US20130248580A1

公开(公告)日：2013-09-26

申请号：US13901888

申请日：2013-05-24

Applicant: Searete LLC

Inventor： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC: A61B17/068

CPC classification number: A61B17/068 ,  A61B17/00491 ,  A61B17/072 ,  A61B17/07207 ,  A61B17/115 ,  A61B2017/00022 ,  A61B2017/00221 ,  A61B2017/00398 ,  A61B2017/00402 ,  A61B2017/00871 ,  A61B2017/07214 ,  A61B2017/07278 ,  A61B2017/2905

Abstract: Embodiments include a surgical device and a method. An embodiment of the surgical instrument includes at least one grasping jaw, the at least one grasping jaw being adapted to deliver surgical staples by a force generated from a force generator mechanism that is contained within the at least one grasping jaw or is in a proximity to the at least one grasping jaw. Another embodiment includes at least one grasping jaw, at least one actuation mechanism adapted to deliver surgical fasteners, the actuation mechanism being located in a proximity to or contained within the at least one grasping jaw, the surgical fasteners containing at least one shape-transforming material, at least one sensor, at least one chemical tissue sealant and at least one cutter. A method includes: grasping a body organ/tissue with at least one grasping jaw, adjusting a configuration of the grasping in response to a signal or a datum or an image, and releasing a surgical staple/fastener in response to the signal, datum or image.

Abstract translation: 实施例包括手术装置和方法。 手术器械的一个实施例包括至少一个抓持爪，所述至少一个抓持爪适于通过由容纳在所述至少一个抓持爪内的力产生器机构产生的力来输送外科缝合钉，或者靠近 所述至少一个抓握爪。 另一个实施例包括至少一个抓持爪，至少一个致动机构，其适于递送手术紧固件，所述致动机构位于所述至少一个抓持爪附近或者包含在所述至少一个抓持爪内，所述手术紧固件包含至少一个形状转换材料 ，至少一个传感器，至少一个化学组织密封剂和至少一个切割器。 一种方法包括：用至少一个抓持爪抓住身体器官/组织，响应于信号或基准面或图像调节抓握的构型，以及响应于信号，基准或释放手术钉/紧固件 图片。

公开(公告)号：US20130224112A1

公开(公告)日：2013-08-29

申请号：US13853571

申请日：2013-03-29

Applicant: Searete LLC

Inventor： Edward S. Boyden ,  Daniel B. Cook ,  Roderick A. Hyde ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR.

IPC: A61K9/14

CPC classification number: A61K9/143 ,  A61K9/0019 ,  A61K9/501 ,  A61K51/1051 ,  A61K51/1251 ,  B82Y5/00

Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Abstract translation: 本文公开的某些实施方案涉及关于冷冻颗粒的组合物，方法，装置，系统和产品。 在某些实施方案中，冷冻颗粒包括低温下的材料。 在某些实施方案中，冷冻颗粒提供用于递送特定试剂的载体。 在某些实施方案中，将冷冻颗粒施用于至少一种生物组织。

公开(公告)号：US20130144919A1

公开(公告)日：2013-06-06

申请号：US13656288

申请日：2012-10-19

Applicant: Searete LLC

Inventor： Shawn P. Firminger ,  Jason Garms ,  Roderick A. Hyde ,  Edward K. Y. Jung ,  Chris D. Karkanias ,  Eric C. Leuthardt ,  Royce A. Levien ,  Richard T. Lord ,  Robert W. Lord ,  Mark A. Malamud ,  John D. Rinaldo, JR. ,  Clarence T. Tegreene ,  Kristin M. Tolle ,  Lowell L. Wood, JR.

IPC: G06F17/30

CPC classification number: G06F16/13 ,  G06Q10/10

Abstract: A computationally implemented method includes, but is not limited to: providing a plurality of relevant reported aspects associated with a plurality of source users that are relevant to achieving one or more target outcomes, the providing of the plurality of relevant reported aspects being based, at least in part, on relevancy of the plurality of relevant reported aspects with respect to the one or more target outcomes; and developing a template designed to facilitate one or more end users to achieve the one or more target outcomes when one or more emulatable aspects included in the template are emulated, the development of the template being based, at least in part, on the providing of the plurality of relevant reported aspects associated with the plurality of source users In addition to the foregoing, other method aspects are described in the claims, drawings, and text forming a part of the present disclosure.

Abstract translation: 计算实现的方法包括但不限于：提供与多个源用户相关联的与实现一个或多个目标结果相关的多个相关报告的方面，提供多个相关报告的方面基于 至少部分地是关于一个或多个目标结果的多个相关报告方面的相关性; 以及开发模板，其旨在促进一个或多个最终用户在模拟包括的一个或多个可模仿方面时实现一个或多个目标结果，模板的开发至少部分地基于提供 与多个源用户相关联的多个相关报告的方面除了上述之外，在构成本公开的一部分的权利要求，附图和文本中描述了其它方法方面。

公开(公告)号：US20130131575A1

公开(公告)日：2013-05-23

申请号：US13715296

申请日：2012-12-14

Applicant: Searete LLC

Inventor： Ralph G. Dacey, JR. ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC: A61N5/06 ,  A61M27/00

CPC classification number: A61N5/0601 ,  A61B5/0084 ,  A61B5/053 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/412 ,  A61B18/20 ,  A61L2/0011 ,  A61L2/08 ,  A61L2/14 ,  A61L2202/24 ,  A61M5/14276 ,  A61M27/006 ,  A61N1/205 ,  A61N1/37252 ,  A61N1/3785 ,  A61N1/3787 ,  A61N1/40 ,  A61N1/403 ,  A61N5/02 ,  A61N5/0624 ,  A61N5/10 ,  A61N7/00 ,  A61N2005/0651 ,  A61N2005/0652 ,  A61N2005/0661

Abstract: Systems, devices, methods, and compositions are described for providing an actively controllable shunt configured to, for example, monitor, treat, or prevent an infection.

Abstract translation: 描述了用于提供被配置为例如监视，治疗或预防感染的主动控制分路的系统，装置，方法和组合物。

公开(公告)号：US20130035591A1

公开(公告)日：2013-02-07

申请号：US13648861

申请日：2012-10-10

Applicant: SEARETE LLC

Inventor： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Michael A. Smith ,  Leif T. Stordal ,  Lowell L. Wood, Jr. ,  Victoria Y.H. Wood

IPC: A61B6/12

CPC classification number: A61M5/3287 ,  A61B5/150022 ,  A61B5/15003 ,  A61B5/150106 ,  A61B5/150167 ,  A61B5/150229 ,  A61B5/150748 ,  A61B5/15087 ,  A61B5/15109 ,  A61B5/15117 ,  A61B5/15121 ,  A61B5/15123 ,  A61B5/15125 ,  A61B5/153 ,  A61B6/00 ,  A61B10/0283 ,  A61B17/3403 ,  A61B34/30 ,  A61B90/11 ,  A61B90/361 ,  A61B2017/00199 ,  A61B2017/00398 ,  A61B2017/00402 ,  A61B2017/00539 ,  A61B2017/00544 ,  A61B2017/3409 ,  A61B2090/376 ,  A61B2090/378 ,  A61M5/427 ,  A61M2005/14252 ,  A61M2005/1585 ,  A61M2205/59

Abstract: Embodiments disclosed herein are directed to systems and methods for automatically inserting a needle into an insertion-target region of a living subject in response to a machine-vision system locating the insertion-target region. In an embodiment, a needle insertion system includes a moveable needle configured to be inserted into a living subject, a machine-vision system configured to locate an insertion-target region of the living subject, control electrical circuitry, and an actuator coupled to the control electrical circuitry. The control electrical circuitry may be coupled to the machine-vision system to receive location information therefrom about the insertion-target region, and configured to output needle targeting instructions. The actuator may be coupled to the control electrical circuitry to receive the needle targeting instructions therefrom and coupled to the moveable needle. The actuator may be configured to move the moveable needle to the insertion-target region automatically in response to receiving the needle targeting instructions from the control electrical circuitry.