公开(公告)号：US20160061848A1

公开(公告)日：2016-03-03

申请号：US14715153

申请日：2015-05-18

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Brett HOLMQUIST ,  Nigel CLARKE

IPC: G01N33/82 ,  H01J49/00

CPC classification number: G01N33/82 ,  G01N33/6848 ,  G01N33/6851 ,  G01N2560/00 ,  H01J49/00 ,  H01J49/0027 ,  Y10T436/212

Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.

公开(公告)号：US09236236B2

公开(公告)日：2016-01-12

申请号：US14333724

申请日：2014-07-17

Applicant: Thermo Fisher Scientific Oy

Inventor： Robert DeWitte ,  Juhani Siidorov ,  Vesa Nuotio ,  Jukka Saukkonen ,  John Edward Brann, III ,  Terry N. Olney

IPC: H01J49/26 ,  H01J49/10 ,  G01N30/06 ,  G01N30/72 ,  G01N30/86 ,  G01N35/00 ,  G01N35/02 ,  G01N35/08 ,  G01N27/62 ,  H01J49/04 ,  G01N30/88 ,  H01J49/00

CPC classification number: G01N30/7233 ,  G01N27/62 ,  G01N30/06 ,  G01N30/16 ,  G01N30/72 ,  G01N30/8658 ,  G01N30/88 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/026 ,  G01N35/08 ,  G01N2030/027 ,  G01N2030/067 ,  G01N2030/628 ,  G01N2030/8804 ,  G01N2030/8813 ,  G06F19/00 ,  H01J49/00 ,  H01J49/0031 ,  H01J49/0409 ,  H01J49/0413 ,  H01J49/0431 ,  H01J49/10 ,  Y10T436/24

Abstract: A sample preparation and analysis system. The system includes a housing with a sample preparation station and a sample analysis station positioned within the housing. The sample analysis station is spaced away from the sample preparation station. A transport assembly is configured to move at least one sample within the housing and between the sample preparation station and the sample analysis station.

Abstract translation: 样品制备和分析系统。 该系统包括具有样品制备站和位于壳体内的样品分析站的壳体。 样品分析站与样品制备站隔开。 运输组件被配置为移动壳体内的至少一个样本，并且在样品制备站和样品分析站之间移动。

公开(公告)号：US20160003836A1

公开(公告)日：2016-01-07

申请号：US14767685

申请日：2014-02-17

Applicant: IMABIOTECH ,  UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE - LILLE 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： JONATHAN STAUBER ,  JEAN-PHILIPPE EBRAN ,  OLEG MELNYK

IPC: G01N33/58 ,  H01J49/16 ,  H01J49/40 ,  H01J49/00

CPC classification number: G01N33/58 ,  G01N33/6848 ,  G01N2560/00 ,  H01J49/00 ,  H01J49/0027 ,  H01J49/164 ,  H01J49/40

Abstract: The present invention relates to the field of the detection of molecules of interest in a sample, preferably by mass spectrometry. The present invention concerns a label compound, a molecule labeled with said compound (a conjugate), a method of detection of a molecule of interest (a target molecule) in a sample involving said conjugate, a kit to implement said method and a process for the preparation of the label.

Abstract translation: 本发明涉及样品中目标分子的检测领域，优选通过质谱法进行。 本发明涉及标记化合物，用所述化合物（缀合物）标记的分子，检测涉及所述缀合物的样品中的目标分子（靶分子）的方法，实施所述方法的试剂盒和用于 标签的准备。

公开(公告)号：US20150348768A1

公开(公告)日：2015-12-03

申请号：US14655845

申请日：2013-12-26

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Kyoung-Seok Lee ,  In Jung Kim ,  Sung-pil Jo ,  Hyung Sik Min ,  Yong Hyeon Yim ,  Joung Hae Lee ,  Eui Jin Hwang

IPC: H01J49/04

CPC classification number: H01J49/0422 ,  G01N27/62 ,  G01N27/70 ,  H01J49/00

Abstract: Provided is a combustion pretreatment-isotope dilution mass spectrometry measuring concentration of a target element for detection contained in a target sample for detection by using an isotope dilution mass spectrometry, including: pretreating the target sample for detection by combustion during an isotope dilution mass spectrometry, to thereby stabilize an isotope and further improve analysis ability, and therefore, the present invention is expected to be utilized as an element analysis method surpassing accuracy of the existing mass spectrometry method.

Abstract translation: 本发明提供一种通过使用同位素稀释质谱法来测定用于检测的目标样品中所含检测用的检测对象元素的浓度的燃烧预处理同位素稀释质谱法，其包括：在同位素稀释质谱法中，通过燃烧预处理所述检测用样品， 从而稳定同位素，进一步提高分析能力，因此，本发明有望用作超过现有质谱法精度的元素分析方法。

公开(公告)号：US09063047B2

公开(公告)日：2015-06-23

申请号：US13102606

申请日：2011-05-06

Applicant: Gary Van Berkel ,  Thomas Covey

Inventor： Gary Van Berkel ,  Thomas Covey

IPC: H01J49/00 ,  G01N1/40 ,  B01L3/00 ,  G01N1/02

CPC classification number: G01N1/4055 ,  B01L3/502715 ,  G01N2001/028 ,  H01J49/00

Abstract: A system and method is disclosed for extracting a sample from a sample surface. A sample is provided and a sample surface receives the sample which is deposited on the sample surface. A hydrophobic material is applied to the sample surface, and one or more devices are configured to dispense a liquid on the sample, the liquid dissolving the sample to form a dissolved sample material, and the one or more devices are configured to extract the dissolved sample material from the sample surface.

Abstract translation: 公开了从样品表面提取样品的系统和方法。 提供样品并且样品表面接收沉积在样品表面上的样品。 将疏水性材料施加到样品表面，并且一个或多个装置构造成分配样品上的液体，溶解样品的液体以形成溶解的样品材料，并且一个或多个装置被配置为提取溶解的样品 材料从样品表面。

公开(公告)号：US09058967B2

公开(公告)日：2015-06-16

申请号：US14478529

申请日：2014-09-05

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Liang Gao ,  Robert Graham Cooks

IPC: H01J49/04 ,  H01J49/10 ,  H01J49/24 ,  H01J49/00 ,  H01J49/26 ,  H01J49/16

CPC classification number: H01J49/24 ,  H01J49/00 ,  H01J49/0013 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/04 ,  H01J49/0404 ,  H01J49/0422 ,  H01J49/0495 ,  H01J49/10 ,  H01J49/165 ,  H01J49/26

Abstract: A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample. The reduced duty cycle of sample introduction is offset by operation of the mass spectrometer under higher performance conditions and by ion accumulation at atmospheric pressure.

Abstract translation: 将大气压力离子源（包括电喷雾和解吸电喷雾离子源）与将其离子化样品不连续地引入质谱仪的质谱仪（例如微型质谱仪）进行接口的方法。 不连续的介绍改善了仪器的抽吸能力与含有电离样品的大气压气体的体积之间的匹配。 样品引入的减少的占空比通过质谱仪在较高性能条件下的操作和大气压下的离子积聚来抵消。

公开(公告)号：US09048076B2

公开(公告)日：2015-06-02

申请号：US14122534

申请日：2012-05-25

Applicant: William R. Stott ,  Gholamreza Javahery

Inventor： William R. Stott ,  Gholamreza Javahery

IPC: H01J49/04 ,  H01J49/00 ,  G01N1/22 ,  G01N1/24 ,  H01J49/02 ,  G01N1/02

CPC classification number: H01J49/0459 ,  G01N1/22 ,  G01N1/24 ,  G01N2001/022 ,  G01N2001/024 ,  H01J49/00 ,  H01J49/02 ,  H01J49/04

Abstract: Methods and devices for detecting a target substance on a subject without contacting the subject are disclosed. At least one air jet blows analyte from a surface of the subject into an airflow, the airflow entraining the analyte. A desorption channel desorbs molecules from analyte in a portion of the airflow travelling through the desorption channel. An ionizer forms ions from vapor molecules in the portion of the airflow. At least one mass spectrometer analyzes the ions to detect the target substance. The flow travels without interruption from the subject to the at least one mass spectrometer. The desorption channel causes a sufficient quantity of molecules to desorb from the analyte to enable the at least one mass spectrometer to detect the target substance.

Abstract translation: 公开了用于在不接触受试者的情况下检测被检物体上的目标物质的方法和装置。 至少一个空气喷射器将被分析物从受试者的表面吹入气流，夹带分析物的气流。 解吸通道在通过解吸通道行进的气流的一部分中从分析物解吸分子。 电离器在气流的一部分形成来自蒸气分子的离子。 至少一个质谱仪分析离子以检测目标物质。 该流动不间断地从受试者移动到至少一个质谱仪。 解吸通道导致足够数量的分子从分析物解吸，使得至少一个质谱仪能够检测目标物质。

公开(公告)号：US09034653B2

公开(公告)日：2015-05-19

申请号：US13514892

申请日：2010-12-09

Applicant: Brett Holmquist ,  Nigel Clarke

Inventor： Brett Holmquist ,  Nigel Clarke

IPC: G01N33/82 ,  G01N33/68 ,  G01N33/00 ,  H01J49/00

CPC classification number: G01N33/82 ,  G01N33/6848 ,  G01N33/6851 ,  G01N2560/00 ,  H01J49/00 ,  H01J49/0027 ,  Y10T436/212

Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.

Abstract translation: 本发明涉及通过质谱法定量测定甾族化合物。 在一个特定方面，本发明涉及通过质谱法从多个样品定量测量甾族化合物的方法。

公开(公告)号：US09006679B2

公开(公告)日：2015-04-14

申请号：US13909299

申请日：2013-06-04

Applicant: Hitachi High-Technologies Corporation

Inventor： Hidetoshi Morokuma ,  Koji Ishiguro ,  Shun Kumano

IPC: H01J49/04 ,  H01J49/26 ,  H01J49/24 ,  H01J49/00 ,  H01J49/10

CPC classification number: H01J49/0404 ,  H01J49/00 ,  H01J49/005 ,  H01J49/04 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/0431 ,  H01J49/0495 ,  H01J49/10 ,  H01J49/24

Abstract: Provided is a mass spectrometer capable of easy exchange of a measurement sample and suppressing a carryover. The mass spectrometer includes a mass spectrometry section, an ion source the internal pressure of which is reduced by a differential pumping from the mass spectrometry section and the ion source ionizes the sample gas, a sample container in which the sample gas is generated by vaporizing the measurement sample, a thin pipe that introduces the sample gas generated in the sample container into the ion source, an elastic tube of openable and closable that connects the sample container and the thin pipe, a pair of weirs that closes or opens the elastic tube so as to sandwich the elastic tube, and a cartridge that integrates the sample container, the thin pipe, and the elastic tube, and is detachable in a lump from a main body of the mass spectrometer.

Abstract translation: 提供能够容易地进行交换测定样品并抑制残留物的质谱仪。 质谱仪包括质谱分析部分，离子源的内部压力通过来自质谱分析部分的差分泵浦而被离子源离子化，离子源使样品气体离子化，其中样本气体通过汽化 测量样品，将样品容器中产生的样品气体引入离子源的细管，连接样品容器和细管的可打开和关闭的弹性管，一对关闭或打开弹性管的堰 夹着弹性管，以及将样品容器，细管和弹性管整合在一起的药筒，并且能够与质谱仪的主体一体地分离。

公开(公告)号：US08980637B2

公开(公告)日：2015-03-17

申请号：US12680655

申请日：2008-10-03

Applicant: Daniel M. Raftery ,  Zhengzheng Pan ,  Haiwei Gu

Inventor： Daniel M. Raftery ,  Zhengzheng Pan ,  Haiwei Gu

IPC: G01R33/44 ,  H01J49/00 ,  G01R33/465 ,  G06K9/00 ,  G01N24/08 ,  G01R33/46 ,  G01R33/48 ,  G01R33/56

CPC classification number: G01R33/465 ,  G01N24/08 ,  G01N2800/7028 ,  G01R33/44 ,  G01R33/4625 ,  G01R33/4808 ,  G01R33/5608 ,  G06K9/00543 ,  H01J49/00 ,  H01J49/004 ,  Y10S436/813

Abstract: A method for the parallel identification of one or more metabolite species within a biological sample is provided. The method comprises producing a first spectrum by subjecting the sample to a nuclear magnetic resonance analysis, the first spectrum containing individual spectral peaks representative of the one or more metabolite species contained within the sample; producing a second spectrum by subjecting the sample to a mass spectrometry analysis, the spectrum containing individual spectral peaks representative of the one or more metabolite species contained within the sample; subjecting each of the individual spectral peaks to a statistical pattern recognition analysis to identify the one or more metabolite species contained within the sample; and identifying the one or more metabolite species contained within the sample by analyzing the individual spectral peaks of the mass and nuclear magnetic resonance spectra.

Abstract translation: 提供了用于平行鉴定生物样品中一种或多种代谢物种的方法。 该方法包括通过对样品进行核磁共振分析来产生第一光谱，所述第一光谱包含代表样品中所含的一种或多种代谢物种类的单个光谱峰; 通过对样品进行质谱分析来产生第二光谱，所述光谱包含表示样品中所含的一种或多种代谢物种类的单个光谱峰; 使每个单个光谱峰进行统计模式识别分析，以鉴定样品中所含的一种或多种代谢物种; 并通过分析质量和核磁共振谱的各个光谱峰来鉴定样品中所含的一种或多种代谢物种类。