公开(公告)号：US20170115317A1

公开(公告)日：2017-04-27

申请号：US15309293

申请日：2015-05-07

Applicant: South Dakota Board of Regents ,  Rochester Institute of Technology

Inventor： Daniel Heglund ,  Andrew Olson ,  Scott Williams ,  Neal Hodges ,  Joseph A. Marshall

IPC: G01N33/94 ,  G01N21/78 ,  G01N33/52

CPC classification number: G01N33/94 ,  G01N21/78 ,  G01N31/22 ,  G01N33/52 ,  Y02A50/58

Abstract: The present invention relates to methods of testing medications to evaluate authenticity and identify counterfeits. The testing methods employ a reactive system comprising a solvent and an acid. Optionally, the reactive system can also comprise an organometallic agent. The testing methods can provide rapid results verifying the authenticity of an antimalarial medication. Further the test method can provide clear results that can be implemented and interpreted without special training, anywhere in the world. The test methods can offer quantitative and qualitative results. The test methods are based on reactions that yield different colors where the color can indicate the presence of an active ingredient, and the intensity of the color can indicate the concentration of the active ingredient.

公开(公告)号：US09556113B2

公开(公告)日：2017-01-31

申请号：US14699946

申请日：2015-04-29

Applicant: The South Dakota Board of Regents ,  Sanford Research

Inventor： Xiangming Guan ,  Chandrahar Dwivedi ,  Yinghong Li ,  Yang Yang ,  John H. Lee ,  Wilson Keith Miskimins

IPC: C07C235/74 ,  A61K45/06 ,  A61N5/10 ,  A61K31/225 ,  C07C233/56 ,  A61K33/24 ,  A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/26 ,  A61K9/06 ,  A61K47/32 ,  A61K9/08 ,  A61K47/38 ,  A61K47/44 ,  A61K9/20 ,  A61K9/48

CPC classification number: C07C235/74 ,  A61K9/0019 ,  A61K9/008 ,  A61K9/06 ,  A61K9/08 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/225 ,  A61K33/24 ,  A61K45/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61K47/44 ,  A61N5/10 ,  A61N2005/1098 ,  C07C233/56 ,  A61K2300/00

Abstract: The invention novel compounds, pharmaceutical compositions and methods useful for preventing or treating cancer in animals and humans. Also, the invention provides novel prodrugs useful for reducing tumor size, and inhibiting the growth of cancers, inhibiting tumor cell growth and tumor cell proliferation, and promoting apoptosis of tumor cells. When used in combination with chemoradiation therapy, the novel compounds, compositions and prodrugs provided herein can improve the effectiveness of chemoradiation therapy. The novel compounds, compositions and prodrugs of the invention inhibit PDK and LDH in unique and effective ways.

Abstract translation: 本发明的新颖化合物，药物组合物和可用于预防或治疗动物和人类癌症的方法。 此外，本发明提供了可用于减少肿瘤大小，抑制癌细胞生长，抑制肿瘤细胞生长和肿瘤细胞增殖以及促进肿瘤细胞凋亡的新型前体药物。 当与放化疗联合使用时，本文提供的新型化合物，组合物和前药可以提高放化疗方案的有效性。 本发明的新颖化合物，组合物和前药以独特和有效的方式抑制PDK和LDH。

公开(公告)号：US09478361B2

公开(公告)日：2016-10-25

申请号：US14477344

申请日：2014-09-04

Applicant: South Dakota Board of Regents

Inventor： Brian A. Logue ,  Mahdi Farrakh Baroughi ,  Venkataiah Mallam

IPC: H01G9/20 ,  B05D1/00 ,  C23C16/448 ,  C23C14/12 ,  B05D1/18

CPC classification number: H01G9/2059 ,  B05D1/185 ,  B05D1/60 ,  C23C14/12 ,  C23C16/4485 ,  H01G9/2031 ,  Y02E10/542

Abstract: Self-assembled monolayer hybrid materials having a modified carboxylic acid deposited from the gas-phase onto a metal oxide substrate, methods of using targeted α-carbon modified carboxylic acids to rapidly deposit activated organic molecules into a self-assembled monolayer on metal oxide substrates, and the self-assembled monolayer hybrid materials capable of being used in various industries, such as optoelectronics and separation science.

Abstract translation: 具有从气相沉积到金属氧化物基底上的改性羧酸的自组装单层混合材料，使用目标α-碳改性羧酸将激活的有机分子快速沉积到金属氧化物基底上的自组装单层中的方法， 以及能够用于各种行业的自组装单层混合材料，如光电子学和分离科学。

公开(公告)号：US20160153117A1

公开(公告)日：2016-06-02

申请号：US14900426

申请日：2014-06-20

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： Guojian Wang ,  Dongming Mei

IPC: C30B15/28 ,  C30B29/08 ,  C30B15/10

CPC classification number: C30B15/28 ,  C30B15/10 ,  C30B29/08

Abstract: In accordance with the present invention, taught is a high purity germanium crystal growth method utilizing a quartz shield inside a steel furnace. The quartz shield is adapted for not only guiding the flow of an inert gas but also preventing the germanium melt from contamination by insulation materials, graphite crucible, induction coil and stainless steel chamber. A load cell provides automatic control of crystal diameter and helps to ensure exhaustion of the germanium melt. The method is both convenient and effective at producing high purity germanium crystals by relatively low skilled operators.

Abstract translation: 根据本发明，教导了在钢炉内使用石英屏蔽的高纯度锗晶体生长方法。 石英屏蔽适用于不仅引导惰性气体的流动，而且还防止锗熔体受绝缘材料，石墨坩埚，感应线圈和不锈钢室的污染。 称重传感器可自动控制晶体直径，有助于确保锗熔体的耗尽。 该方法既方便又有效地通过相对低的熟练操作者生产高纯锗晶体。

公开(公告)号：US20160121027A1

公开(公告)日：2016-05-05

申请号：US14921531

申请日：2015-10-23

Applicant: South Dakota Board of Regents ,  SANFORD HEALTH

Inventor： Gopinath MANI ,  Sujan LAMICHHANE ,  Jordan ANDERSON ,  Tyler REMUND ,  Patrick W. KELLY

IPC: A61L29/08 ,  A61L29/16

CPC classification number: A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/02 ,  A61L2420/06 ,  A61L2420/08 ,  A61M25/10 ,  A61M2025/105

Abstract: The present invention provides formulations comprising polymers and therapeutics and methods for their manufacture. The present invention also provides medical devices coated with such formulations and methods for their manufacture. The drug-loaded polymer formulations, solutions, and films tailor the drug release characteristics for medical devices.

Abstract translation: 本发明提供包含聚合物和治疗剂的制剂及其制备方法。 本发明还提供涂覆有这些制剂的医疗装置及其制造方法。 负载药物的聚合物配方，溶液和膜定制医疗器械的药物释放特性。

公开(公告)号：US12233129B2

公开(公告)日：2025-02-25

申请号：US18192210

申请日：2023-03-29

Applicant: South Dakota Board of Regents

Inventor： Khosrow Rezvani ,  Grigoriy Sereda

IPC: A61K47/60 ,  A61K9/51 ,  A61K31/435 ,  A61K47/64 ,  A61P35/00

Abstract: Disclosed herein are compositions for treating cancer comprising a modified veratridine.
In certain aspects, the modified veratridine comprises a polyglutamic acid (PLE) or polyethylene glycol/polyglutamic acid (PEG-PLE) conjugated to the 4′ hemiketal thereof. Further disclosed is a method of treating colorectal cancer in a subject comprising administering to a subject an effective amount of the disclosed compositions.

公开(公告)号：US12122975B2

公开(公告)日：2024-10-22

申请号：US17713053

申请日：2022-04-04

Applicant: Novum Nano, LLC ,  South Dakota Board of Regents

Inventor： Craig Bailey ,  Greg Christensen ,  Haiping Hong

IPC: C10M169/04 ,  C10M125/02 ,  C10M125/26 ,  B82Y30/00 ,  B82Y40/00 ,  C10N20/06 ,  C10N40/25 ,  C10N70/00

CPC classification number: C10M169/04 ,  C10M125/02 ,  C10M125/26 ,  B82Y30/00 ,  B82Y40/00 ,  C10M2201/041 ,  C10M2201/082 ,  C10M2201/14 ,  C10M2203/003 ,  C10N2020/06 ,  C10N2040/25 ,  C10N2070/02

Abstract: An engine oil additive includes carbon nanotubes and boron nitride particulates dispersed within a fluid. The additive is configured to be mixed with a quantity of oil such that the quantity of oil has a concentration from 0.05 to 0.5 grams of carbon nanotubes and of boron nitride particulates per quart of oil to improve the lubricity of the oil. The additive improves the horsepower and torque of the engine while reducing fuel consumption. The carbon nanotubes have an —OH functionalized exterior surface. The carbon nanotubes have a diameter from 1 nanometer to 50 nanometers and have a length from 1 micron to 1000 microns. The boron nitride particulates are hex-boron nitride structures having an average size from 30 nanometers to 500 nanometers.

公开(公告)号：US11996222B2

公开(公告)日：2024-05-28

申请号：US16294656

申请日：2019-03-06

Applicant: South Dakota Board of Regents

Inventor： Rajesh V. Shende ,  Jan A. Puszynski ,  Vinod S. Amar

IPC: H01F1/36 ,  B82Y25/00 ,  B82Y40/00 ,  C01B3/06

CPC classification number: H01F1/36 ,  C01B3/06 ,  B82Y25/00 ,  B82Y40/00 ,  Y02E60/36

Abstract: The present disclosure addresses limitations in ferritic materials. In at least one aspect, the present disclosure provides core-shell nanoparticles exhibiting improved characteristics for implementations and adoptability in numerous applications. Further aspects of the disclosure provide core-shell nanoparticles for use in electronic, magnetic and electro-magnetic applications. Still, other aspects of the present disclosure provide core-shell nanoparticles for a thermochemical water-splitting reaction resulting in increased H2 volume generation during multiple thermochemical cycles.

公开(公告)号：US11992028B2

公开(公告)日：2024-05-28

申请号：US17953640

申请日：2022-09-27

Applicant: THE SOUTH DAKOTA BOARD OF REGENTS, AS GOVERNING BOARD FOR SOUTH DAKOTA STATE UNIVERSITY

Inventor： William Gibbons ,  Michael L Brown

IPC: A23K40/25 ,  A23J1/12 ,  A23J1/14 ,  A23K10/14 ,  A23K10/38 ,  A23K20/147 ,  A23K40/20 ,  A23K50/80

CPC classification number: A23J1/125 ,  A23J1/14 ,  A23J1/148 ,  A23K10/14 ,  A23K10/38 ,  A23K20/147 ,  A23K40/20 ,  A23K40/25 ,  A23K50/80 ,  Y02A40/818

Abstract: The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets.

公开(公告)号：US20240067843A1

公开(公告)日：2024-02-29

申请号：US18450891

申请日：2023-08-16

Applicant: South Dakota Board of Regents

Inventor： Ying Deng ,  Shahaboddin Saeedi ,  Victor Huber

IPC: C09D133/16 ,  C08F220/34 ,  C09D5/14 ,  C09D5/33 ,  C09D7/65

CPC classification number: C09D133/16 ,  C08F220/34 ,  C09D5/004 ,  C09D5/14 ,  C09D7/65

Abstract: The present disclosure is directed to compositions, methods, and treated surfaces that comprise a co-polymer composition comprising a rechargeable N-halamine moiety and one or more monomers. The compositions are pre-halogenated for providing a single step application for antimicrobial use without the need for a subsequent chlorine application for activation of antimicrobial properties. The copolymers provide for effective and rapid inactivation of bacteria and viruses, with improved solubility and stability.