公开(公告)号：US09767230B2

公开(公告)日：2017-09-19

申请号：US14236662

申请日：2012-08-03

Applicant: Tali Kimchi ,  Aharon Weissbrod ,  Genadiy Vasserman

Inventor： Tali Kimchi ,  Aharon Weissbrod ,  Genadiy Vasserman

IPC: G08B1/08 ,  G06F17/50 ,  A01K1/03 ,  A01K29/00 ,  G06K9/62 ,  G01S3/14 ,  G01S3/786

CPC classification number: G06F17/5009 ,  A01K1/031 ,  A01K29/005 ,  G01S3/14 ,  G01S3/7864 ,  G06K9/6282

Abstract: A method of identifying and classifying social complex behaviors among a group of model organisms, comprising implanting at least one RFID transponder in each model organism in said group of model organisms; enclosing said group of model organisms in a monitored space divided into RFID monitored segments; RFID tracking a position of each model organism by reading said at least one RFID transponder in each model organism over a period of time; capturing a sequence of images of each model organism over said period of time; and calculating at least one spatiotemporal model of each model organism based on time synchronization of said RFID tracked position of said model organism with said sequence of images.

公开(公告)号：US09738685B2

公开(公告)日：2017-08-22

申请号：US15017049

申请日：2016-02-05

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David Milstein ,  Chidambaram Gunanathan ,  Yehoshua Ben-David ,  Ekambaram Balaraman ,  Boopathy Gnanaprakasam ,  Jing Zhang

IPC: C07K5/12 ,  C07C209/50 ,  C07C213/00 ,  C07C231/00 ,  C07C231/02 ,  C07D307/52 ,  C08L79/02 ,  C07C67/03 ,  C07C45/00 ,  C07C51/235 ,  C07C67/28 ,  C07D241/12 ,  C07D295/185 ,  C07D487/14 ,  C07C29/136 ,  C07C67/39 ,  C07K1/02 ,  C07K1/10

CPC classification number: C07K5/12 ,  C07C29/136 ,  C07C45/002 ,  C07C51/235 ,  C07C67/03 ,  C07C67/28 ,  C07C67/39 ,  C07C209/50 ,  C07C213/00 ,  C07C231/00 ,  C07C231/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D241/12 ,  C07D295/185 ,  C07D307/52 ,  C07D487/14 ,  C07K1/02 ,  C07K1/10 ,  C08L79/02 ,  Y02P20/52 ,  C07C233/05 ,  C07C235/06 ,  C07C235/10 ,  C07C233/36 ,  C07C211/27 ,  C07C215/28 ,  C08L1/00 ,  C07C69/14 ,  C07C69/24 ,  C07C31/04 ,  C07C31/08 ,  C07C31/10 ,  C07C31/12

Abstract: A process for preparing amides by reacting a primary amine and a primary alcohol in the presence of a Ruthenium complex to generate the amide and molecular hydrogen. Primary amines are directly acylated by equimolar amounts of alcohols to produce amides and molecular hydrogen (the only byproduct) in high yields and high turnover numbers. Also disclosed are processes for hydrogenation of amides to alcohols and amines; hydrogenation of organic carbonates to alcohols; hydrogenation of carbamates or urea derivatives to alcohols and amines; amidation of esters; acylation of alcohols using esters; coupling of alcohols with water and a base to form carboxylic acids; dehydrogenation of beta-amino alcohols to form pyrazines and cyclic dipeptides; and dehydrogenation of secondary alcohols to ketones. These reactions are catalyzed by a Ruthenium complex which is based on a dearomatized PNN-type ligand of formula A1 or precursors thereof of formulae A2 or A3.

公开(公告)号：US20170233702A1

公开(公告)日：2017-08-17

申请号：US15498493

申请日：2017-04-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rony SEGER ,  Alexander PLOTNIKOV

IPC: C12N9/12

CPC classification number: C12N9/12 ,  A61K38/00 ,  A61K38/12 ,  A61K47/64 ,  C12N9/1205 ,  C12Y207/11 ,  C12Y207/11024

Abstract: An isolated peptide being no longer than 20 amino acids comprising a sequence at least 95% homologous to the sequence GQLNHILGILGX1PX2QED (SEQ ID NO: 4), wherein X1 and X2 are any amino acid, the peptide being capable of preventing extracellular signal-regulated kinase1/2 (ERK) translocation into the nucleus.

公开(公告)号：US09696310B2

公开(公告)日：2017-07-04

申请号：US14738894

申请日：2015-06-14

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David Margulies ,  Leila Motiei ,  Linor Unger

IPC: C07D417/14 ,  G01N33/573 ,  C07D417/06 ,  C09K11/06 ,  G01N33/58 ,  C07F9/6541 ,  C07K7/06 ,  G01N33/574

CPC classification number: G01N33/573 ,  C07D417/06 ,  C07D417/14 ,  C07F9/6541 ,  C07K7/06 ,  C09K11/06 ,  C09K2211/1029 ,  C09K2211/1037 ,  G01N33/574 ,  G01N33/582 ,  G01N2333/91177 ,  G01N2333/918 ,  G01N2333/96494

Abstract: The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.

公开(公告)号：US20170087190A1

公开(公告)日：2017-03-30

申请号：US15379528

申请日：2016-12-15

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michael WALKER ,  Yoav SOEN ,  Revital SHARIVKIN

IPC: A61K35/39 ,  G01N33/569 ,  C12N5/071

CPC classification number: A61K35/39 ,  C12N5/0676 ,  C12N2501/415 ,  C12N2501/50 ,  C12N2501/505 ,  C12N2501/585 ,  C12N2501/599 ,  G01N33/56966 ,  G01N2333/70596 ,  G01N2333/71 ,  G01N2500/10

Abstract: Methods of isolating distinct specific cell types within mixed populations of cells. Methods of isolating specific cell types among pancreatic cells, particularly from human islets of Langerhans. Markers and combinations thereof for use in methods of isolating insulin producing islet beta cells for treatment of diabetes.

公开(公告)号：US20170081682A1

公开(公告)日：2017-03-23

申请号：US15101097

申请日：2014-12-10

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Arren BAR-EVEN ,  Ron MILO ,  Elad NOOR ,  Lior ZELCBUCH

IPC: C12P7/40 ,  C12N1/20 ,  C12N9/10 ,  C12P7/26 ,  C12P7/16 ,  C12P5/02 ,  C12P5/00 ,  C12P7/64 ,  C12N15/52 ,  C12P7/06

CPC classification number: C12P7/40 ,  C12N1/20 ,  C12N9/1029 ,  C12N15/52 ,  C12P5/007 ,  C12P5/023 ,  C12P5/026 ,  C12P7/06 ,  C12P7/16 ,  C12P7/26 ,  C12P7/649 ,  C12Y203/01054 ,  Y02E50/343

Abstract: An isolated microorganism is disclosed being genetically modified to express pyruvate formate lyase (PFL) or 2-ketobutyrate formate lyase, wherein acetyl-CoA of the microorganism is converted to pyruvate in the presence of formate in a single step reaction, wherein the net flux of the reaction is in the direction of pyruvate synthesis.Uses of the microorganism and products comprising same are also disclosed.

公开(公告)号：US20170029508A1

公开(公告)日：2017-02-02

申请号：US15261945

申请日：2016-09-10

Applicant: Yeda Research and Development Co. Ltd

Inventor： Michal Eisenbach-Schwartz ,  Kuti Baruch ,  Neta Rosenzweig

IPC: C07K16/28

Abstract: The present specification discloses a pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS. The pharmaceutical composition is administered by a dosage regimen comprising at least one course of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session of non-treatment.

Abstract translation: 本说明书公开了一种药物组合物，其包含活性剂，其导致个体中降低全身免疫抑制水平用于治疗CNS的疾病，病症，病状或损伤。 药物组合物通过包含至少一疗程疗程的给药方案施用，每个治疗过程依次包括治疗会话，然后是间歇疗程的非治疗。

公开(公告)号：US09527735B2

公开(公告)日：2016-12-27

申请号：US14635345

申请日：2015-03-02

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  B. G. Negev Technologies and Applications Ltd.

Inventor： Reshef Tenne ,  Olga Brontvein ,  Jeffrey Gordon ,  Daniel Feuerman

IPC: H01B1/10 ,  C01B19/00 ,  H01B1/08 ,  C01G39/00 ,  C01G39/02 ,  C01G39/06 ,  C01G41/00 ,  C01G41/02 ,  C01B13/32 ,  C01B13/36 ,  B82Y30/00 ,  C10M125/22 ,  H01B1/06

CPC classification number: C01B19/007 ,  B82Y30/00 ,  C01B13/322 ,  C01B13/366 ,  C01G39/006 ,  C01G39/02 ,  C01G39/06 ,  C01G41/00 ,  C01G41/02 ,  C01P2002/54 ,  C01P2004/03 ,  C01P2004/04 ,  C01P2004/13 ,  C01P2004/16 ,  C01P2006/40 ,  C10M125/22 ,  C10M2201/065 ,  C10M2201/066 ,  H01B1/06 ,  H01B1/08 ,  H01B1/10

Abstract: The present invention concerns inorganic nanostructures comprising soft metals at low concentrations and catalytic processes utilizing soft metals for obtaining inorganic nanostructures.

Abstract translation: 本发明涉及包含低浓度的软金属和利用软金属获得无机纳米结构的催化方法的无机纳米结构。

公开(公告)号：US09526749B2

公开(公告)日：2016-12-27

申请号：US14627593

申请日：2015-02-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michael D. Walker ,  Yoav Soen ,  Revital Sharivkin

IPC: A61K35/39 ,  C12N5/071

CPC classification number: A61K35/39 ,  C12N5/0676 ,  C12N2501/415 ,  C12N2501/50 ,  C12N2501/505 ,  C12N2501/585 ,  C12N2501/599 ,  G01N33/56966 ,  G01N2333/70596 ,  G01N2333/71 ,  G01N2500/10

Abstract: Methods of isolating distinct specific cell types within mixed populations of cells. Methods of isolating specific cell types among pancreatic cells, particularly from human islets of Langerhans. Markers and combinations thereof for use in methods of isolating insulin producing islet beta cells for treatment of diabetes.

Abstract translation: 在混合细胞群中分离不同特定细胞类型的方法。 在胰腺细胞，特别是胰岛细胞中分离特异性细胞类型的方法。 用于分离产生胰岛素胰岛β细胞用于治疗糖尿病的方法的标记物及其组合。

公开(公告)号：US09499793B2

公开(公告)日：2016-11-22

申请号：US14237930

申请日：2012-08-09

Applicant: Eran Hornstein ,  Sharon Kredo-Russo

Inventor： Eran Hornstein ,  Sharon Kredo-Russo

IPC: C12N15/11 ,  C12N5/0775 ,  A61K31/7088 ,  C12N5/071 ,  C12N15/113 ,  A61K35/39

CPC classification number: C12N5/0676 ,  A61K31/7088 ,  A61K35/39 ,  C07K14/62 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0664 ,  C12N5/0665 ,  C12N5/0666 ,  C12N5/0667 ,  C12N5/0668 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/11 ,  C12N2501/65

Abstract: A method of ex-vivo increasing insulin content in beta cells or stem cells is disclosed. The method comprising contacting the beta cells or stem cells with an agent for downregulating an activity or expression of miR-7, thereby increasing the insulin content in the beta cells or stem cells.

Abstract translation: 公开了一种离体增加β细胞或干细胞中胰岛素含量的方法。 该方法包括使β细胞或干细胞与用于下调miR-7的活性或表达的试剂接触，从而增加β细胞或干细胞中的胰岛素含量。