公开(公告)号：US07724786B2

公开(公告)日：2010-05-25

申请号：US11867953

申请日：2008-04-11

申请人： Brett Eugene Bouma ,  Seok-Hyun (Andy) Yun ,  Wang-Yuhl (William) Oh ,  Johannes F. De Boer ,  Guillermo J. Tearney

发明人： Brett Eugene Bouma ,  Seok-Hyun (Andy) Yun ,  Wang-Yuhl (William) Oh ,  Johannes F. De Boer ,  Guillermo J. Tearney

IPC分类号： H01S3/10

CPC分类号： G01J3/10 ,  A61B5/0059 ,  A61B5/0066 ,  G01B9/02004 ,  G01B9/02091 ,  G01J3/12 ,  G01J9/0215 ,  G01N21/4795 ,  G02B27/48 ,  H01S3/08009 ,  H01S3/08063 ,  H01S3/105 ,  H01S5/141 ,  H01S5/146 ,  H01S5/4087

摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.

摘要翻译： 可以提供用于过滤电磁辐射的装置和源装置，其可以包括被配置为基于电磁辐射的频率物理地分离电磁辐射的一个或多个部件的至少一个光谱分离装置。 装置和源装置还可以具有至少一个连续旋转的光学布置，其被配置为接收与一个或多个部件相关联的至少一个信号。 此外，装置和源装置可以包括被配置为接收信号的至少一个波束选择装置。

公开(公告)号：US20100110414A1

公开(公告)日：2010-05-06

申请号：US12437392

申请日：2009-05-07

申请人： Christopher Max Colice ,  Brett E. Bouma ,  Guillermo J. Tearney ,  Jinyong Ha ,  Milen Shishkov

发明人： Christopher Max Colice ,  Brett E. Bouma ,  Guillermo J. Tearney ,  Jinyong Ha ,  Milen Shishkov

IPC分类号： G01P3/36 ,  G01P3/00

CPC分类号： A61B5/0084 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0097 ,  A61B5/1076 ,  A61B5/1114 ,  A61B5/489 ,  A61B5/6844 ,  A61B5/6852 ,  A61B8/08 ,  A61B8/0891 ,  A61B8/12 ,  A61B8/488 ,  A61B90/36 ,  A61B2090/364 ,  A61B2090/3782 ,  G01S15/50 ,  G01S15/60 ,  G01S15/87 ,  G01S17/50 ,  G01S17/87

摘要： Exemplary embodiments of apparatus, method and computer accessible medium can be provided which can facilitate a determination of at least one characteristic of a structure. For example, it is possible to use at least one first arrangement which can be structured to provide at least one first transmitted radiation along a first axis and at least one second transmitted radiation along a second axis. The first and second transmitted radiations can impact the structure and generate respective first and second returned radiation. The first and second axis can be provided at a predetermined angle with respect with one another which is greater than 0. Further, at least one second arrangement can be provided which can be configured to receive data associated with the first and second returned radiations, and determine at least one relative velocity between the structure and the first arrangement along the first and second axes.

摘要翻译： 可以提供装置，方法和计算机可访问介质的示例性实施例，其可以有助于确定结构的至少一个特征。 例如，可以使用至少一个第一布置，其可被构造成沿着第一轴线提供至少一个第一透射辐射以及沿着第二轴线提供至少一个第二透射辐射。 第一和第二透射辐射可以影响结构并产生相应的第一和第二反射辐射。 第一和第二轴线可以彼此相对于预定角度提供，该角度大于0.此外，可以提供至少一个第二布置，其可被配置为接收与第一和第二返回辐射有关的数据，以及 确定沿着第一和第二轴线的结构和第一布置之间的至少一个相对速度。

公开(公告)号：US20090131801A1

公开(公告)日：2009-05-21

申请号：US12250359

申请日：2008-10-13

申请人： Melissa J. Suter ,  Guillermo J. Tearney ,  Brett Eugene Bouma

发明人： Melissa J. Suter ,  Guillermo J. Tearney ,  Brett Eugene Bouma

IPC分类号： A61B6/00

CPC分类号： A61B5/6852 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6853 ,  A61B5/6858 ,  A61B5/6886

摘要： Exemplary embodiments of an apparatus for obtaining data for at least one portion within at least one luminal or hollow sample can be provided. For example, the exemplary apparatus can include a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the portion. A second arrangement may be provided that can at least partially enclose the first arrangement. At least one third arrangement may be provided which is configured to be actuated so as to expand, at least in part, beyond a periphery of the second arrangement. Such exemplary third arrangement can be structured to facilitate a fluid flow and/or a gas flow therethrough. Further, a fourth arrangement may be provided which can be structured to (i) actuate a particular number of the third arrangement and/or (ii) adjust a distance between at least two outer portions of the third arrangement. According to one exemplary embodiment, the third arrangement can be a plurality of the third arrangements.

摘要翻译： 可以提供用于获得至少一个管腔或中空样品中的至少一个部分的数据的装置的示例性实施例。 例如，该示例性装置可以包括被配置为向该部分收发至少一个电磁辐射的第一光学装置。 可以提供可以至少部分地包围第一布置的第二布置。 可以提供至少一个第三布置，其被配置为被致动以至少部分地扩展到超过第二布置的周边。 这种示例性的第三布置可以被构造成促进流体流动和/或气体流过其中。 此外，可以提供第四布置，其可以被构造为（i）启动特定数量的第三布置和/或（ii）调整第三布置的至少两个外部部分之间的距离。 根据一个示例性实施例，第三布置可以是多个第三布置。

公开(公告)号：US20090073439A1

公开(公告)日：2009-03-19

申请号：US12210979

申请日：2008-09-15

申请人： Guillermo J. Tearney ,  Brett E. Bouma ,  Jason T. Motz ,  Joseph A. Gardecki ,  Alexandra H. Chau

发明人： Guillermo J. Tearney ,  Brett E. Bouma ,  Jason T. Motz ,  Joseph A. Gardecki ,  Alexandra H. Chau

IPC分类号： G01N21/00 ,  G02B6/06 ,  G06G7/48

CPC分类号： A61B5/0075 ,  A61B5/0084 ,  A61B5/02007

摘要： Exemplary apparatus and method can be provided for controlling at least one electro-magnetic radiation. For example, it is possible to rotate and/or translate at least one optical waveguide. At least one of the optical waveguide(s) can receive a first radiation at a first wavelength and transmit the first radiation to at least one sample. Such optical waveguide and/or another optical waveguide may receive a second radiation at a second wavelength that is different from the first wavelength. For example, the second radiation may be produced based on an inelastic scattering of the first radiation. In addition, exemplary apparatus and method can be provided which can also be used to receive data associated with the second radiation, determine at least one characteristic of the at least one sample based on the data, and generate the image and/or the map of a portion of the arterial sample based on the at least one characteristic. Further, exemplary computer-accessible medium can be provided which includes a software arrangement thereon. When a processing arrangement executes the software arrangement, the processing arrangement is configured to modify at least one characteristic of an arrangement using certain procedures. These exemplary procedures include simulating at least one electro-magnetic radiation provided into and out of the arrangement, simulating an inelastic scattering radiation from at least one simulated sample, receiving the simulated inelastic scattering radiation into and out of the simulated arrangement, and determining a simulated characteristic of the simulated arrangement as a function of the simulated inelastic scattering radiation.

摘要翻译： 可以提供示例性的装置和方法来控制至少一个电磁辐射。 例如，可以旋转和/或平移至少一个光波导。 至少一个光波导可以接收第一波长的第一辐射并将第一辐射传输到至少一个样本。 这种光波导和/或另一光波导可以接收与第一波长不同的第二波长的第二辐射。 例如，可以基于第一辐射的非弹性散射来产生第二辐射。 此外，可以提供示例性的装置和方法，其还可以用于接收与第二辐射相关联的数据，基于数据确定至少一个样本的至少一个特性，并且生成图像和/或 基于至少一个特征的动脉样本的一部分。 此外，可以提供示例性的计算机可访问介质，其中包括其上的软件布置。 当处理装置执行软件装置时，处理装置被配置为使用某些程序来修改装置的至少一个特性。 这些示例性程序包括模拟提供入和排出的至少一个电磁辐射，模拟来自至少一个模拟样本的非弹性散射辐射，将模拟的非弹性散射辐射接收到模拟装置中和从模拟装置中取出，以及确定模拟 作为模拟非弹性散射辐射的函数的模拟布置的特征。

公开(公告)号：US20090043192A1

公开(公告)日：2009-02-12

申请号：US12188679

申请日：2008-08-08

申请人： Guillermo J. Tearney ,  Brett Eugene Bouma

发明人： Guillermo J. Tearney ,  Brett Eugene Bouma

IPC分类号： A61B5/05

CPC分类号： G01B9/02014 ,  A61B1/00165 ,  A61B5/0066 ,  A61B5/0084 ,  G01B9/02007 ,  G01B9/02072 ,  G01B9/02083 ,  G01B9/02088 ,  G01B9/02091 ,  G01B2290/70

摘要： Methods for diagnosing vulnerable atherosclerotic plaque using optical coherence tomography to measure tissue optical properties, including backreflectance of heterogeneous layers, such as plaque cap, lipid pool composition and macrophage presence. Methods also include measurement of spatially and temporally dependent reflectance, measurement of multiple wavelength reflectance, low coherence interferometry, polarization and quantification of macrophage content.

公开(公告)号：US20080262314A1

公开(公告)日：2008-10-23

申请号：US12104689

申请日：2008-04-17

申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Saumil Merchant ,  John Rosowski

发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Saumil Merchant ,  John Rosowski

IPC分类号： A61B1/00

CPC分类号： A61B1/227 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4504

摘要： An apparatus and method according to an exemplary embodiment of to the present invention can provide imaging information associated with at least one portion of a sample. For example, at least two first different wavelengths of at least one first electromagnetic radiation within a first wavelength range may be provided on the portion of the sample so as to determine at least one first transverse location of the portion. At least two second different wavelengths of at least one second electromagnetic radiation may also be provided within a second wavelength range provided on the portion so as to determine at least one second transverse location of the portion. It is possible to obtain a relative phase between at least one third electromagnetic radiation electromagnetic radiation being returned from the sample and at least one fourth electromagnetic radiation returned from a reference to determine a motion of the portion or of particles within or on the portion, whereas the motion is effectuated by at least one of a sound wave. Further, the imaging information of the portion can be provided based on the first transverse location, the second transverse location and the motion.

摘要翻译： 根据本发明的示例性实施例的装置和方法可以提供与样本的至少一部分相关联的成像信息。 例如，可以在样品的该部分上提供在第一波长范围内的至少一个第一电磁辐射的至少两个第一不同波长，以便确定该部分的至少一个第一横向位置。 还可以在设置在该部分上的第二波长范围内提供至少两个第二不同波长的至少一个第二电磁辐射，以便确定该部分的至少一个第二横向位置。 可以获得从样品返回的至少一个第三电磁辐射电磁辐射与从参考物返回的至少一个第四电磁辐射之间的相对相位，以确定该部分或该部分内部或之上的颗粒的运动，而 运动由声波中的至少一个来实现。 此外，可以基于第一横向位置，第二横向位置和运动来提供该部分的成像信息。

公开(公告)号：US20080234586A1

公开(公告)日：2008-09-25

申请号：US12051600

申请日：2008-03-19

申请人： Guillermo J. Tearney ,  George Velmahos ,  Brett E. Bouma

发明人： Guillermo J. Tearney ,  George Velmahos ,  Brett E. Bouma

IPC分类号： A61B5/02

CPC分类号： A61B5/0261 ,  A61B5/0059 ,  A61B5/02007 ,  A61B5/02028 ,  A61B5/103 ,  A61B5/4878 ,  A61B2562/0242 ,  G01N2021/479

摘要： Exemplary systems and methods can be provided for providing information associated with tissue. For example, it is possible to illuminate the tissue with at least one electromagnetic radiation which is a coherent light and/or a partially coherent light. The electromagnetic radiation reflected from the tissue can be received and speckle patterns may be formed associated with the electromagnetic radiation. In addition, changes can be analyzed in the speckle patterns at time intervals sufficient to measure motion of or within a fascial compartment of the tissue. For example, it is also possible that the electromagnetic radiation is an interfered radiation from a sample and a reference. Further, the speckle patterns can be measured at different depths within the sample by moving the reference.

摘要翻译： 可以提供示例性系统和方法来提供与组织相关联的信息。 例如，可以用至少一个作为相干光和/或部分相干光的电磁辐射照射组织。 可以接收从组织反射的电磁辐射，并且可以形成与电磁辐射相关联的斑点图案。 此外，可以以足以测量组织的筋膜室内或内部的时间间隔的斑点图案来分析变化。 例如，电磁辐射也可能是来自样品和参考物的干扰辐射。 此外，可以通过移动参考来在样本内的不同深度处测量斑点图案。

公开(公告)号：US20080234567A1

公开(公告)日：2008-09-25

申请号：US12051315

申请日：2008-03-19

申请人： Guillermo J. Tearney ,  George Velmahos ,  Brett E. Bouma ,  Benjamin J. Vakoc

发明人： Guillermo J. Tearney ,  George Velmahos ,  Brett E. Bouma ,  Benjamin J. Vakoc

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/0066 ,  A61B5/0095 ,  A61B5/416

摘要： Exemplary apparatus and process can be provided for determining at least one characteristic of an anatomical structure. For example, it is possible to generate an acoustic wave in the anatomical structure using an opto-accoustic arrangement It is then possible to detect the acoustic wave and determine whether at least one blood pool is present at or in the anatomical structure as a function of at least one property of the acoustic wave. Further, it is possible to forward at least one first electro-magnetic radiation to at least one tissue of the anatomical structure, detect at least one second electro-magnetic radiation provided from the at least one tissue based on a motion of or within the at least one tissue to generate detection data, and determine the at least one characteristic of the at least one portion based on the detection data.

摘要翻译： 可以提供示例性的装置和过程来确定解剖结构的至少一个特征。 例如，可以使用光声布置在解剖结构中产生声波。然后可以检测声波并确定至少一个血液池是否存在于解剖结构中或解剖结构中，作为 声波的至少一个属性。 此外，可以将至少一个第一电磁辐射转发到解剖结构的至少一个组织，基于在所述至少一个组织的运动或内部检测从所述至少一个组织提供的至少一个第二电磁辐射 至少一个组织以产生检测数据，并且基于检测数据确定至少一个部分的至少一个特性。

公开(公告)号：US20080232410A1

公开(公告)日：2008-09-25

申请号：US12052984

申请日：2008-03-21

申请人： Brett Eugene Bouma ,  Reza Motaghiannezam ,  Guillermo J. Tearney

发明人： Brett Eugene Bouma ,  Reza Motaghiannezam ,  Guillermo J. Tearney

IPC分类号： H01S3/10 ,  G02B26/08

CPC分类号： G02B26/12 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/06 ,  G01J3/10 ,  G01J3/18 ,  G01J3/4338 ,  G01J2003/1286 ,  G01N21/39 ,  G02B26/002 ,  H01S5/141 ,  H01S5/143 ,  H01S5/146

摘要： Exemplary systems and methods for filtering an electromagnetic radiation can be provided. For example, at least one first arrangement can be provided which is capable of receiving at least one first electro-magnetic radiation and forwarding at least one second electro-magnetic radiation at different angles with respect to a direction of incidence of the first electro-magnetic radiation. At least one second wavelength dispersion arrangement can be provided which is configured to receive the second electro-magnetic radiation, forward at least one third electro-magnetic radiation to the first arrangement and further receive at least one fourth electro-magnetic radiation. The third electro-magnetic radiation can be based on the second electro-magnetic radiation, and the fourth electro-magnetic radiation can be based on the third electro-magnetic radiation. For example, the second arrangement can be configured to forward the second electro-magnetic radiation at different angles with respect to a direction of incidence of the at least one particular electro-magnetic radiation. Exemplary embodiments of methods can be provided to implement such exemplary techniques.

摘要翻译： 可以提供用于过滤电磁辐射的示例性系统和方法。 例如，可以提供至少一个第一布置，其能够接收至少一个第一电磁辐射并且相对于第一电磁场的入射方向以不同的角度转发至少一个第二电磁辐射 辐射。 可以提供至少一个第二波长色散布置，其被配置为接收第二电磁辐射，将至少一个第三电磁辐射向前延伸到第一布置并进一步接收至少一个第四电磁辐射。 第三电磁辐射可以基于第二电磁辐射，第四电磁辐射可以基于第三电磁辐射。 例如，第二布置可以被配置为相对于至少一个特定电磁辐射的入射方向以不同的角度转发第二电磁辐射。 可以提供方法的示例性实施例来实现这种示例性技术。

公开(公告)号：US07418169B2

公开(公告)日：2008-08-26

申请号：US11670069

申请日：2007-02-01

申请人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc

发明人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc

IPC分类号： G02B6/26 ,  G02B6/06

CPC分类号： A61B18/24 ,  A61B1/00082 ,  A61B1/00096 ,  A61B1/00172 ,  A61B1/00183 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  A61B2017/00057 ,  A61B2017/22051 ,  A61B2018/2211 ,  A61B2018/2272 ,  G02B23/2423

摘要： An apparatus for controlling at least one of at least two sections of at least one fiber can be provided. The apparatus can include an arrangement which may be provided between the first and second sections of a particular continuous fiber of the fibers. A particular one of the first and second sections may be provided in a particular orientation that is perpendicular to an extension of the particular fiber. The arrangement is capable of controlling the particular fiber such that the particular one of the sections is capable of being rotated for at least 360° with respect to the particular orientation. The arrangement can include a further arrangement that is capable of at least partially wrapping the particular fiber around the second arrangement, and controlling the particular fiber such that the particular one of the sections is capable of being rotated with respect to the particular orientation during a transmission of the electro-magnetic radiation.

摘要翻译： 可以提供一种用于控制至少一个光纤的至少两个部分中的至少一个的装置。 该装置可以包括可以设置在纤维的特定连续纤维的第一和第二部分之间的装置。 第一和第二部分中的特定一个可以以垂直于特定纤维的延伸部的特定方向设置。 该装置能够控制特定光纤，使得特定的一个部分能够相对于特定取向旋转至少360°。 该布置可以包括能够至少部分地围绕第二布置包围特定纤维并且控制特定光纤的另外的布置，使得特定的一个部分能够在传输期间相对于特定取向旋转 的电磁辐射。