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274 条记录 (耗时 0.047 秒)

    Instrumentation for injection of therapeutic fluid into joints
    131.
    发明授权
    Instrumentation for injection of therapeutic fluid into joints 有权
    将治疗液注入关节的仪器

    公开(公告)号：US08083722B2

    公开(公告)日：2011-12-27

    申请号：US12605780

    申请日：2009-10-26

    申请人： William F. McKay

    发明人： William F. McKay

    IPC分类号： A61M5/00

    CPC分类号： A61B17/3478 ,  A61B2017/00247 ,  A61B2017/00261 ,  A61B2018/00392 ,  A61M5/32 ,  A61M5/3298 ,  A61M2025/0085

    摘要： Described are novel medical delivery devices that can be used to effectively distribute a medical agent to multiple sites within a tissue volume without requiring the device to be repositioned, including for example to distribute the medical agent within the nucleus pulposus tissue of a spinal disc. Also described are medical delivery devices configured to simultaneously remove fluid from the tissue volume into which a medical agent is being delivered, thus avoiding or otherwise decreasing any pressure build-up and facilitating an effective, uniform delivery of the therapeutic agent.

    摘要翻译： 描述了可用于有效地将药剂分配到组织体积内的多个部位而不需要重新定位装置的新型医疗输送装置，包括例如将药剂分配在脊髓盘的髓核组织内。 还描述了被配置为同时从组织体积中去除流体的医疗输送装置，医药剂被递送到其中，从而避免或以其他方式减少任何压力积聚并促进治疗剂的有效且均匀的输送。

    Methods and instruments for treating pseudoarthrosis
    133.
    发明授权
    Methods and instruments for treating pseudoarthrosis 有权
    治疗假性关节炎的方法和手段

    公开(公告)号：US08002775B2

    公开(公告)日：2011-08-23

    申请号：US10399836

    申请日：2001-10-24

    申请人： William F. McKay

    发明人： William F. McKay

    IPC分类号： A61B17/00 ,  A61M5/178

    CPC分类号： A61F2/446 ,  A61B17/1615 ,  A61B17/1671 ,  A61F2/442 ,  A61F2/4601 ,  A61F2002/2817 ,  A61F2002/30235 ,  A61F2002/30677 ,  A61F2002/4475 ,  A61F2230/0069 ,  A61K9/0024 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/414

    摘要： Methods, instruments, and kits for treating spinal pseudoarthrosis are provided. In one embodiment, a method includes delivering to a location of spinal pseudoarthrosis an effective amount of an osteoinductive composition that includes an injectible osteoinductive composition that includes an injectible osteoinductive composition in a pharmaceutically acceptable carrier. In other embodiments, cannulated drills 10, 10′, 10″ and surgical instrument assemblies, 50, 50′ including a drill and a syringe 60 and 60′ wherein the syringe has a distal end that is matingly engaged to a proximal end of the drill are provided. The drill and other instruments, instrument assemblies, and kits formed therefrom may advantageously be used in a method for treating pseudoarthrosis.

    摘要翻译： 提供了用于治疗脊柱假关节的方法，仪器和试剂盒。 在一个实施方案中，一种方法包括向脊椎假性关节的位置递送有效量的骨诱导性组合物，其包括可注射的骨诱导组合物，其包含可药用载体中的可注射的骨诱导组合物。 在其他实施例中，插管式钻头10,10'，10“和包括钻头和注射器60和60'的手术器械组件50,50'，其中注射器具有配合地接合到钻头的近端的远端 被提供。 由此形成的钻和其他仪器，仪器组件和试剂盒可有利地用于治疗假性关节的方法。

    CATHETER DEVICES AND DRAINAGE SYSTEMS FOR DELIVERING THERAPEUTIC AGENTS
    134.
    发明申请
    CATHETER DEVICES AND DRAINAGE SYSTEMS FOR DELIVERING THERAPEUTIC AGENTS 有权
    用于输送治疗剂的导管装置和排水系统

    公开(公告)号：US20110184338A1

    公开(公告)日：2011-07-28

    申请号：US12695899

    申请日：2010-01-28

    申请人： William F. McKay

    发明人： William F. McKay

    IPC分类号： A61M25/00 ,  A61M27/00

    CPC分类号： A61M27/00 ,  A61M1/0084 ,  A61M25/0026 ,  A61M25/003 ,  A61M25/007 ,  A61M2025/0031 ,  A61M2025/0036 ,  A61M2025/004

    摘要： A catheter for drainage of a wound and delivery of a therapeutic agent at or near the wound of a patient is provided. The catheter comprises: a proximal end configured to receive the therapeutic agent and permit passage of bodily fluid, the proximal end configured to be coupled to a drainage tube and/or a therapeutic agent delivery device; a distal end for insertion at or near the wound; and a body disposed between the proximal end and distal end of the catheter and configured to receive the therapeutic agent from the proximal end of the catheter, the body having a first set of holes configured to allow passage of the therapeutic agent from the proximal end to a site at or near the wound and the body having a second set of holes configured to allow drainage of bodily fluid from the wound into the catheter.

    摘要翻译： 提供了用于在患者的伤口处或伤口附近引导伤口和递送治疗剂的导管。 所述导管包括：近端构造成容纳所述治疗剂并允许体液通过，所述近端构造成联接到排液管和/或治疗剂递送装置; 用于插入伤口处或附近的远端; 以及设置在所述导管的所述近端和远端之间并且构造成从所述导管的近端接收所述治疗剂的主体，所述主体具有第一组孔，所述第一组孔构造成允许所述治疗剂从所述近端通过至 伤口处或附近的部位和身体具有第二组孔，其被配置为允许体液从伤口排出到导管中。

    NON-INVASIVE DEVICES AND METHODS TO DIAGNOSE PAIN GENERATORS
    135.
    发明申请
    NON-INVASIVE DEVICES AND METHODS TO DIAGNOSE PAIN GENERATORS 审中-公开
    非侵入性装置和诊断疼痛发生器的方法

    公开(公告)号：US20110184284A1

    公开(公告)日：2011-07-28

    申请号：US12695906

    申请日：2010-01-28

    申请人： William F. McKay

    发明人： William F. McKay

    IPC分类号： A61B8/00

    CPC分类号： A61B8/00 ,  A61B5/06 ,  A61B5/441 ,  A61B5/4514 ,  A61B5/4528 ,  A61B5/4824 ,  A61B6/12 ,  A61B8/4245 ,  A61B8/4254

    摘要： Devices and methods are provided that diagnose one or more pain generators at or near the spine in a patient suffering from pain. In one embodiment, a device is provided that includes: an external transducer probe having a proximal end, a distal end and a body therebetween wherein the probe is configured to be placed in contact with the skin of a patient near a pain generator or suspected pain generator; an energy source that supplies the probe with energy; and a conduit for engaging the energy source and the proximal end of the probe. The energy is transferred from the energy source to the distal end of the probe through the skin of the patient and has an intensity to deliver and produce a pain signal when at least the distal end of the probe is near the pain generator or suspected pain generator.

    摘要翻译： 提供了在患有疼痛的患者中诊断脊柱处或附近的一个或多个疼痛发生器的装置和方法。 在一个实施例中，提供了一种装置，其包括：具有近端，远端和其间的身体的外部换能器探针，其中所述探针被配置为与疼痛发生器附近的患者皮肤接触或怀疑疼痛 发电机; 为探头提供能量的能源; 以及用于接合探测器的能量源和近端的导管。 能量通过患者的皮肤从能量源传递到探头的远端，并且当至少探针的远端靠近疼痛发生器或怀疑的疼痛发生器时具有输送和产生疼痛信号的强度 。

    Methods of expressing LIM mineralization protein in non-osseous cells
    137.
    发明授权
    Methods of expressing LIM mineralization protein in non-osseous cells 有权
    在非骨细胞中表达LIM矿化蛋白的方法

    公开(公告)号：US07923250B2

    公开(公告)日：2011-04-12

    申请号：US10292951

    申请日：2002-11-13

    申请人： William F. McKay ,  Scott Boden ,  Sangwook T. Yoon

    发明人： William F. McKay ,  Scott Boden ,  Sangwook T. Yoon

    IPC分类号： C12N15/00

    CPC分类号： A61K48/005 ,  A61K35/12 ,  A61K35/13 ,  A61K48/00 ,  A61K2121/00 ,  A61L27/3804 ,  A61L27/3856 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/78 ,  C07K16/18 ,  C12N2799/022

    摘要： Methods of expressing LIM mineralization protein in non-osseous mammalian cells, such as stem cells or intervertebral disc cells (e.g., cells of the annulus fibrosus, or cells of the nucleus pulposus) are described. The methods involve transfecting the cells with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein operably linked to a promoter. Transfection may be accomplished ex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid. Expression of the LIM mineralization protein can stimulate proteoglycan and/or collagen production in cells capable of producing proteoglycyan and/or collagen. Methods for treating disc disease associated with trauma or disc degeneration are also described.

    摘要翻译： 描述了在非骨骼哺乳动物细胞中表达LIM矿化蛋白的方法，例如干细胞或椎间盘细胞（例如纤维环的细胞或髓核的细胞）。 所述方法涉及用分离的核酸转染细胞，所述分离的核酸包含可操作地连接到启动子的编码LIM矿化蛋白的核苷酸序列。 转染可以通过直接注射病毒或裸露DNA或非病毒载体如质粒在体内或体内完成。 LIM矿化蛋白的表达可以刺激能够产生蛋白多糖和/或胶原的细胞中的蛋白聚糖和/或胶原产生。 还描述了与创伤或椎间盘退变相关的椎间盘疾病的治疗方法。

    Methods of treating a trauma or disorder of the knee joint by local administration and sustained-delivery of a biological agent
    138.
    发明授权
    Methods of treating a trauma or disorder of the knee joint by local administration and sustained-delivery of a biological agent 有权
    通过局部施用和生物制剂的持续递送来治疗膝关节的创伤或障碍的方法

    公开(公告)号：US07910123B2

    公开(公告)日：2011-03-22

    申请号：US11850183

    申请日：2007-09-05

    申请人： William F. McKay

    发明人： William F. McKay

    IPC分类号： A61F2/02 ,  A61K38/16 ,  A61K38/20 ,  A61M31/00 ,  A61P21/00

    CPC分类号： A61M31/002 ,  A61K38/1841 ,  A61K38/1875 ,  A61K38/2026 ,  A61K38/2066

    摘要： Methods and apparatus of providing a subject with post-operative, sustained-release of a biological agent within a synovial joint is disclosed. These methods involve securing a depot containing the biological agent to a ligament, tendon, muscle within the joint to provide sustained-release of the agent while allowing for normal joint articulation. This methodology may be utilized to provide for sustained-release of a biological agent useful in treating various traumas and disorders of the joint. Such biological agents include antagonists of inflammation-related proteins, such as TNF-α, IL-1β, IL-6, IL-8, NF-κB, High Mobility Group Box 1 (HMG-B1), IL-2, IL-15 and steroidal and non-steroidal anti-inflammatories. Other biological agents include anti-inflammatory cytokines such as IL-10, IL-4, IL-13, and TGF-β. The biological agents also include osteogenic and cartilage producing growth factors such as, but not limited to, BMP-2, BMP-4, BMP-6, BMP-7, BMP-8, and MIA CD-RAP. Finally, the biological agents include siRNA and/or therapeutic antibodies.

    摘要翻译： 公开了在滑膜关节内为生物制剂提供术后，持续释放的方法和装置。 这些方法涉及将包含生物制剂的贮库固定在关节内的韧带，肌腱，肌肉中以提供试剂的持续释放，同时允许正常的关节连接。 该方法可用于提供可用于治疗关节的各种创伤和障碍的生物剂的持续释放。 这样的生物制剂包括TNF-α，IL-1和bgr，IL-6，IL-8，NF-κB，高迁移率组1（HMG-B1），IL-2 ，IL-15和类固醇和非甾体抗炎药。 其他生物制剂包括抗炎细胞因子如IL-10，IL-4，IL-13和TGF-β。 生物制剂还包括产生成骨和软骨的生长因子，例如但不限于BMP-2，BMP-4，BMP-6，BMP-7，BMP-8和MIA CD-RAP。 最后，生物制剂包括siRNA和/或治疗性抗体。

    MINIMALLY INVASIVE INSTRUMENT AND METHOD TO TREAT PERIODONTAL DISEASE
    140.
    发明申请
    MINIMALLY INVASIVE INSTRUMENT AND METHOD TO TREAT PERIODONTAL DISEASE 审中-公开
    微小的入侵仪器和治疗周围疾病的方法

    公开(公告)号：US20110033817A1

    公开(公告)日：2011-02-10

    申请号：US12909673

    申请日：2010-10-21

    申请人： William F. McKay

    发明人： William F. McKay

    IPC分类号： A61C17/26 ,  A61B1/24 ,  A61C17/28 ,  A61C17/00

    CPC分类号： A61C3/00 ,  A46D1/00 ,  A46D1/0261 ,  A61B1/24 ,  A61C1/088 ,  A61C17/08 ,  A61C19/043

    摘要： The invention provides an instrument and methods for minimally invasive surgical scaling and/or planning procedures, thus reducing patient recovery time. Furthermore, the present invention overcomes the shortcoming in the prior art of inadequately preparing the diseased site or creating an aerosol by providing a device that is more mechanically abrasive by way of utilizing a rotational mechanical action of a plurality of bristles.

    摘要翻译： 本发明提供了用于微创手术缩放和/或计划程序的仪器和方法，从而减少患者恢复时间。 此外，本发明通过提供通过利用多个刷毛的旋转机械作用更机械研磨的装置来克服现有技术中不充分准备病变部位或产生气溶胶的缺点。