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    Flowable composition that hardens on delivery to a target tissue site beneath the skin
    6.
    发明授权
    Flowable composition that hardens on delivery to a target tissue site beneath the skin 有权
    可流动的组合物在皮肤递送至目标组织部位时变硬

    公开(公告)号：US09161903B2

    公开(公告)日：2015-10-20

    申请号：US12262705

    申请日：2008-10-31

    申请人： Susan J. Drapeau ,  William F. McKay ,  Nelson Scarborough

    发明人： Susan J. Drapeau ,  William F. McKay ,  Nelson Scarborough

    IPC分类号： A61K51/00 ,  A61K9/00 ,  A61K9/14 ,  A61K47/34

    CPC分类号： A61K9/0024 ,  A61K9/0085 ,  A61K9/16 ,  A61K31/573 ,  A61K47/10 ,  A61K47/34 ,  A61K51/1213

    摘要： Flowable compositions and methods are provided for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient, the flowable composition comprising (i) a solvent and (ii) an effective amount of the therapeutic agent, the flowable composition being capable of hardening to form a drug depot at a physiological temperature or as solvent contacts bodily fluid at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutic agent over a period of at least one day and the target tissue site comprises at least one muscle, ligament, tendon, cartilage, spinal disc, spinal foraminal space near the spinal nerve root, facet or synovial joint, or spinal canal. In some embodiments, an implantable drug depot for delivering a therapeutic agent is provided, the implantable drug depot comprising (i) a chamber; and (ii) a flowable composition comprising an effective amount of a therapeutic agent disposed within the chamber of the drug depot, the flowable composition capable of hardening when the drug depot is delivered at or near the target tissue site.

    摘要翻译： 提供可流动的组合物和方法用于在患者皮肤下方的靶组织部位处或附近递送治疗剂，所述可流动组合物包含（i）溶剂和（ii）有效量的治疗剂，所述可流动组合物为 能够在生理温度下硬化形成药物贮库，或者作为溶剂与目标组织部位处或附近的体液接触，其中药物贮库能够在至少一天的时间内释放治疗剂，并且靶组织部位 包括至少一个肌肉，韧带，肌腱，软骨，脊椎盘，脊神经根附近的脊椎孔隙空间，小面或滑膜关节或椎管。 在一些实施方案中，提供了用于递送治疗剂的可植入药物贮库，所述可植入药物贮库包括（i）室; 和（ii）可流动组合物，其包含设置在所述药物贮库的所述室内的有效量的治疗剂，所述可流动组合物能够在所述药物贮库在所述靶组织部位处或附近递送时硬化。

    Osteoconductive matrices comprising statins
    7.
    发明授权
    Osteoconductive matrices comprising statins 有权
    包含他汀类的骨诱导性基质

    公开(公告)号：US09107983B2

    公开(公告)日：2015-08-18

    申请号：US12913237

    申请日：2010-10-27

    申请人： William F. McKay

    发明人： William F. McKay

    IPC分类号： A61L27/44 ,  A61L27/54 ,  A61K9/00 ,  A61K35/32

    CPC分类号： A61L27/446 ,  A61L27/54 ,  A61L2300/412 ,  A61L2430/02

    摘要： Osteoconductive matrices and methods are provided that have one or more statins disposed therein. The matrices may be injected into a fracture site. The osteoconductive matrices provided allow for sustain release of the statin and facilitate bone formation and repair of the fracture site.

    摘要翻译： 提供具有一个或多个他汀类药物的骨诱导性基质和方法。 可将基质注入骨折部位。 提供的骨传导性基质允许他汀类维生素的释放并促进骨形成部位的骨形成和修复。

    Catheter devices and drainage systems for delivering therapeutic agents
    8.
    发明授权
    Catheter devices and drainage systems for delivering therapeutic agents 有权
    用于输送治疗剂的导管装置和排水系统

    公开(公告)号：US08998854B2

    公开(公告)日：2015-04-07

    申请号：US12695899

    申请日：2010-01-28

    申请人： William F. McKay

    发明人： William F. McKay

    IPC分类号： A61M5/178 ,  A61M27/00 ,  A61M25/00 ,  A61M1/00

    CPC分类号： A61M27/00 ,  A61M1/0084 ,  A61M25/0026 ,  A61M25/003 ,  A61M25/007 ,  A61M2025/0031 ,  A61M2025/0036 ,  A61M2025/004

    摘要： A catheter for drainage of a wound and delivery of a therapeutic agent at or near the wound of a patient is provided. The catheter comprises: a proximal end configured to receive the therapeutic agent and permit passage of bodily fluid, the proximal end configured to be coupled to a drainage tube and/or a therapeutic agent delivery device; a distal end for insertion at or near the wound; and a body disposed between the proximal end and distal end of the catheter and configured to receive the therapeutic agent from the proximal end of the catheter, the body having a first set of holes configured to allow passage of the therapeutic agent from the proximal end to a site at or near the wound and the body having a second set of holes configured to allow drainage of bodily fluid from the wound into the catheter.

    摘要翻译： 提供了用于在患者的伤口处或伤口附近引导伤口和递送治疗剂的导管。 所述导管包括：近端构造成容纳所述治疗剂并允许体液通过，所述近端构造成联接到排液管和/或治疗剂递送装置; 用于插入伤口处或附近的远端; 以及设置在所述导管的所述近端和远端之间并且构造成从所述导管的近端接收所述治疗剂的主体，所述主体具有第一组孔，所述第一组孔构造成允许所述治疗剂从所述近端通过至 伤口处或附近的部位和身体具有第二组孔，其被配置为允许体液从伤口排出到导管中。

    Bone delivery systems including holding and filling devices and methods
    10.
    发明授权
    Bone delivery systems including holding and filling devices and methods 有权
    骨输送系统，包括保持和灌装装置和方法

    公开(公告)号：US08926622B2

    公开(公告)日：2015-01-06

    申请号：US13438590

    申请日：2012-04-03

    申请人： William F. McKay

    发明人： William F. McKay

    IPC分类号： A61B17/58 ,  A61B17/60 ,  A61F2/00

    CPC分类号： A61F2/2846 ,  A61F2002/2835 ,  A61F2002/30462 ,  A61F2002/30586 ,  A61F2002/30588 ,  A61F2002/30729 ,  A61F2210/0004

    摘要： A delivery system comprising a biodegradable single or multi compartment covering is provided. The covering can be a mesh bag including a pre-attached detachable holding member surrounding the opening of at least one compartment and a pre-attached removable filling member configured to fit within the opening of the at least one compartment. The opening of the bag can include a closing member. The pre-attached detachable holding member can be a collar including finger grips and is used to hold the bag in one position while filling it. In some embodiments, the pre-attached detachable filling member can be a funnel for loading the mesh bag with bone graft material. Once the covering is filled, the holding member and filling member can be removed and the covering is closed with a closing member such as a drawstring. A method of treatment utilizing the delivery system is also provided.

    摘要翻译： 提供包括可生物降解的单室或多隔室覆盖物的递送系统。 覆盖物可以是网袋，其包括围绕至少一个隔室的开口的预先附接的可拆卸保持构件和构造成装配在至少一个隔室的开口内的预先附接的可移除填充构件。 袋的开口可以包括封闭构件。 预先安装的可拆卸的保持构件可以是包括手指的衣领，并且用于在将袋子填充在一个位置时将其保持在一个位置。 在一些实施例中，预先附接的可拆卸填充构件可以是用于使用骨移植材料装载网袋的漏斗。 一旦覆盖物被填充，就可以移除保持构件和填充构件，并且用诸如束带的关闭构件封闭覆盖物。 还提供了利用递送系统的治疗方法。