公开(公告)号：US20240001260A1

公开(公告)日：2024-01-04

申请号：US18252331

申请日：2021-11-17

Applicant: CYTIVA SWEDEN AB

Inventor： Stefan K. Eriksson ,  Andreas Bergstrom ,  Andreas Sjolund ,  Gustav D. Andersson ,  Mikael C. Sjogren

IPC: B01D15/22 ,  C12M1/00 ,  G01N30/60 ,  C12M3/00

CPC classification number: B01D15/22 ,  C12M47/12 ,  G01N30/6052 ,  C12M23/48 ,  C12M23/52

Abstract: The present invention relates to an apparatus (200) for bio-product processing. The apparatus (200) comprise a processing column (201) comprising an upper column tube (202B) releasably coupled to a lower column tube (202A). The lower column tube (202A) has a processing chamber (218) provided therein. The apparatus (200) additionally comprises an adapter (222) for moving within the processing column (201) so as to vary the volume of the processing chamber (218) within the lower column tube (202A), and a column stand (214) for supporting the adapter (222).

公开(公告)号：US11801456B2

公开(公告)日：2023-10-31

申请号：US17156749

申请日：2021-01-25

Applicant: Cytiva Sweden AB

Inventor： Bjorn Markus Olovsson

IPC: B01D15/16 ,  G01N30/32 ,  G01N30/34 ,  B01F23/40 ,  B01F25/31 ,  B01F35/21 ,  B01F35/22 ,  B01D15/22 ,  G01N30/86 ,  B01F35/221 ,  B01F35/71

CPC classification number: B01D15/166 ,  B01D15/22 ,  B01F23/49 ,  B01F25/31 ,  B01F35/2132 ,  B01F35/2133 ,  B01F35/2211 ,  B01F35/7176 ,  G01N30/32 ,  G01N30/34 ,  B01D15/16 ,  G01N30/8658 ,  G01N2030/324 ,  G01N2030/347

Abstract: A system for preparing solutions for chromatography application is disclosed. The system comprises a T-joint for preparing a buffer solution by mixing at least one first solution and a second solution. The T-joint receives the second solution from a solution supply unit connected to the T-joint. Further one or more low pressure pumps supply the one or more first solutions into the T-joint. The high pressure pump collects the buffer solution and delivers it to a chromatography apparatus.

公开(公告)号：US11686712B2

公开(公告)日：2023-06-27

申请号：US17727375

申请日：2022-04-22

Applicant: CYTIVA SWEDEN AB

Inventor： Stefan Dargy ,  Olle Bjernulf ,  Mats Lundkvist

IPC: G01N30/80 ,  G01N35/10 ,  G01N35/02 ,  G01N30/02 ,  G01N35/04

CPC classification number: G01N30/80 ,  G01N35/025 ,  G01N35/1011 ,  G01N2030/027 ,  G01N2035/0439

Abstract: Disclosed is a fraction collector for dispensing liquids into plural receptacles (P1,P2) arranged in a two dimensional array. The fraction collector comprises a table (22) for supporting said receptacles, and an arm supported above the table, in tum supporting a liquid dispenser (35), the fraction collector arm is rotatable about an arm axis (C) and the liquid dispenser is movable along the arm on a carriage 34 (FIG. 2). Thereby, the dispenser is low cost and is repositionable simply above the receptacles as a result of said rotation and as a result of said movement along the arm, without occupying too much laboratory bench space.

公开(公告)号：US11650219B2

公开(公告)日：2023-05-16

申请号：US16788836

申请日：2020-02-12

Applicant: CYTIVA SWEDEN AB

Inventor： Johan Blomberg ,  Mats Lundkvist

IPC: G01N35/10 ,  B01D15/10 ,  G01N30/88 ,  B01D29/60 ,  G01N30/24 ,  G01N30/38 ,  B01D15/08 ,  B01D17/12 ,  G01N35/00 ,  G01N30/02

CPC classification number: G01N35/1097 ,  B01D15/10 ,  B01D29/60 ,  G01N30/24 ,  G01N30/38 ,  G01N30/88 ,  B01D15/08 ,  B01D17/12 ,  B01D2201/54 ,  G01N2030/027 ,  G01N2030/8804 ,  G01N2030/8881 ,  G01N2035/00326 ,  Y10T137/6416 ,  Y10T137/6525 ,  Y10T137/6851 ,  Y10T137/85986 ,  Y10T137/87885

Abstract: Automated fluid handling system comprising a housing and two or more fluid handling units arranged as interchangeable modular components with an external fluidics section and an internal non fluidics section, and wherein the housing comprises a liquid handling panel with two or more of component positions for receiving said interchangeable modular components such that the external fluidics section is separated from the non fluidics section by the liquid handling panel.

公开(公告)号：US11648523B2

公开(公告)日：2023-05-16

申请号：US17381588

申请日：2021-07-21

Applicant: Cytiva Sweden AB

Inventor： Johan Rosenquist ,  Daria Donati ,  Mia Margareta Elisabet Bennemo

IPC: B01J19/00 ,  B01J4/00 ,  B01J19/24

CPC classification number: B01J19/004 ,  B01J4/008 ,  B01J19/245 ,  B01J2219/0002 ,  B01J2219/00011 ,  B01J2219/00813

Abstract: The present disclosure relates to a volume tailorable manufacturing system for quality assured manufacturing of biosafety level classified biopharmaceutical products and a method for tailoring a production volume capability of a manufacturing system.
The volume tailorable manufacturing system comprises one or more multi-product suites and a control facility configured to control a unidirectional flow in a circulation system of the one or more multi-product suites. The circulation system is configured to interconnect the one or more multi-product suites and comprises separated supply and return systems. The supply system comprising at least one inlet, the return system comprising at least one outlet that is paired with the inlet and provided at a spatially predetermined position from the inlet, and each inlet/outlet pair comprises a seal when not connected to an adjacent multi-product suite.

公开(公告)号：US20230138356A1

公开(公告)日：2023-05-04

申请号：US18147546

申请日：2022-12-28

Applicant: Cytiva Sweden AB

Inventor： Key Hyckenberg ,  Kjell Karlsson ,  Stefan Willehadson ,  Orjan Bo Grelsson

IPC: G16H40/67 ,  G06F16/955 ,  G06F3/0483 ,  G06F3/04842 ,  H04L67/025 ,  H04L67/125

Abstract: A method, system, gateway and computer program for remote controlling and monitoring of at least one instrument, for example a bioprocessing instrument. The system can comprise: at least one instrument to be controlled and/or monitored; at least one instrument server connected to the at least one instrument, said instrument server comprising an instrument control software; at least one gateway connected to the at least one instrument server; a transferring means provided in the at least one instrument server, said transferring means being arranged to receive information from the at least one connected instrument and forward said information to the at least one gateway.

公开(公告)号：US11549091B2

公开(公告)日：2023-01-10

申请号：US14910824

申请日：2013-08-27

Applicant: Cytiva Sweden AB

Inventor： Andreas Castan ,  Klaus Gebauer

IPC: C12M1/00 ,  C12M1/06 ,  C12M3/00 ,  C12M3/06 ,  C12N1/16 ,  C12N1/20 ,  C12N5/04 ,  C12N5/07 ,  C12N5/071

Abstract: The invention discloses a bioreactor with a vessel defining an inner volume, agitation means and at least one addition tube, wherein a delivery orifice in the addition tube is located within the inner volume and a check valve is arranged in proximity of the delivery orifice for allowing flow of a fluid in the direction from the addition tube into the inner volume of the vessel and blocking flow in the reverse direction.

公开(公告)号：US11543344B2

公开(公告)日：2023-01-03

申请号：US16078727

申请日：2017-02-27

Applicant: Cytiva Sweden AB

Inventor： Hanno Ehring

IPC: G01N21/03 ,  G01N21/05 ,  G01N21/33 ,  G01N21/31

Abstract: An apparatus for measuring the absorbance of a substance in a solution, includes at least one sample cell arranged to contain the solution that is at least partially transparent to light of a predefined wavelength spectrum, at least two light passages through the at least one sample cell, each of the light passages having a known path length, an LED light source arrangement including at least two LEDs, each arranged to emit a light output with a wavelength within the predefined wavelength spectrum. A plurality of optical fibers, one for each light passage, is arranged at each LED for receiving the light output and guiding it to the light passages. A method for measuring the absorbance of a substance in a solution includes providing the LED light source arrangement with an associate fiber bundle for each LED.

公开(公告)号：US11499913B2

公开(公告)日：2022-11-15

申请号：US16078681

申请日：2017-02-23

Applicant: Cytiva Sweden AB

Inventor： Erik Nils Ostlund

IPC: G01N21/33 ,  G02B27/14 ,  G02B27/10 ,  G01N21/05

Abstract: A measuring device for measuring the absorbance of a substance in at least one solution provided in at least two flow cells of the measuring device, wherein said measuring device comprises: —a light source transmitting a first light ray; —said at least two flow cells; —an optical arrangement comprising at least two semi-transparent mirrors with different transmission properties, said optical arrangement being arranged for dividing the first light ray coming from the light source into separate light parts, one for passing each flow cell and one for entering directly after the optical arrangement a reference detector; and —one detector provided after each flow cell for detecting light having passed through the flow cells.

公开(公告)号：US20220349864A1

公开(公告)日：2022-11-03

申请号：US17764452

申请日：2020-10-07

Applicant: Cytiva Sweden AB

Inventor： Erik Bjerneld

IPC: G01N30/86 ,  G01N27/447

Abstract: Disclosed is a method 100 for classifying a fluid sample. The method comprises the steps of: a. at least partially separating 110 one or more of the chemical constituents of the fluid sample; b. measuring and recording 120 the amount of separated chemical constituents of the sample during, or after, the chemical separation; c. measuring and recording 130 the spatial or time separation profile of sample constituents, during or after separation, and providing a data set of the same; d. comparing 140 the amount of said separated constituents to one or more reference samples; e. comparing 150 the spatial or time separation profile to the corresponding profile of the or each reference sample; f. assigning 160 a similarity score to the sample based on the similarity of the amount or the profile comparisons of the separated constituents, as performed under steps d 140 and e 150 above, or both, with the equivalent amount and/or profile of the or each reference sample respectively; g. providing 170 a classification of the sample based on the similarity score.