公开(公告)号：US06716918B2

公开(公告)日：2004-04-06

申请号：US10023220

申请日：2001-12-20

申请人： Takahiro Saito ,  Osamu Nishizawa ,  Takeshi Fukuda

发明人： Takahiro Saito ,  Osamu Nishizawa ,  Takeshi Fukuda

IPC分类号： C08F238

CPC分类号： C08F20/12 ,  C08F293/005 ,  C08F2438/01 ,  C08L53/00 ,  C09D153/00 ,  C09J153/00

摘要： In accordance with the present invention, there is provided a process for producing a polymer by a living radical polymerization method which is also applicable to the polymerization of a methacrylate monomer, and a methacrylate-based polymer having a narrow molecular weight distribution which is produced by the above process. Specifically, the present invention relates to a process for producing a methacrylate-based polymer by a atom transfer radical polymerization method in which a polymerizable monomer containing at least one methacrylate monomer is polymerized in the presence of a redox catalyst comprising a metal complex containing at least one transition metal as a central metal selected from the group consisting of elements of Groups 7 to 11 of the Periodic Table, using an organohalogen compound or a halogenated sulfonyl compound as a polymerization initiator.

摘要翻译： 根据本发明，提供了一种通过活性自由基聚合法制备聚合物的方法，该方法也可应用于甲基丙烯酸酯单体的聚合和具有窄分子量分布的甲基丙烯酸酯聚合物，其由 上述过程。 具体地说，本发明涉及一种通过原子转移自由基聚合法生产甲基丙烯酸酯类聚合物的方法，其中含有至少一种甲基丙烯酸酯单体的可聚合单体在包含至少含有至少一种甲基丙烯酸酯的金属络合物的氧化还原催化剂的存在下聚合 一种过渡金属作为中心金属，使用有机卤素化合物或卤代磺酰化合物作为聚合引发剂，所述过渡金属选自元素周期表第7至11族的元素。

公开(公告)号：US20030171496A1

公开(公告)日：2003-09-11

申请号：US10319802

申请日：2002-12-13

发明人： Leonard Pinchuk ,  Sepideh Nott ,  Marlene Schwarz ,  Kalpana Kamath

IPC分类号： C08F002/00

CPC分类号： C08L53/00 ,  A61L27/16 ,  A61L27/54 ,  A61L31/048 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  C08F293/005 ,  C08F297/00 ,  C08F297/04 ,  C08L53/02 ,  C09D153/00 ,  C09D153/02 ,  C08L2666/02

摘要： A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic blocks and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. The block copolymer is preferably of the formula X-(AB)n, where A is an elastomeric block, B is a thermoplastic block, n is a positive whole number and X is a seed molecule. The elastomeric blocks are preferably polyolefin blocks, and the thermoplastic blocks are preferably selected from vinyl aromatic blocks and methacrylate blocks. According to another aspect of the invention, a medical device is provided, at least a portion of which is insertable or implantable into the body of a patient. The medical device comprises (a) the above biocompatible block copolymer and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. According to another aspect of the present invention, a method of treatment is provided in which the above device is implanted or inserted into a patient, resulting in the release of therapeutic agent in the patient over an extended period. According to yet another aspect of the invention, a coated medical device is provided which comprises: (a) an intravascular or intervascular medical device and (b) a coating over at least a portion of the intravascular or intervascular a medical device, wherein the coating comprises the above biocompatible block copolymer.

公开(公告)号：US06602975B2

公开(公告)日：2003-08-05

申请号：US10021508

申请日：2001-10-22

申请人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Jennifer L. Hill

发明人： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Neil P. Desai ,  Jennifer L. Hill

IPC分类号： C08G6308

CPC分类号： A61K9/0024 ,  A61K9/1635 ,  A61K9/1647 ,  A61K38/47 ,  A61K38/49 ,  A61K47/32 ,  A61K2035/128 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L27/34 ,  A61L27/36 ,  A61L27/38 ,  A61L27/3839 ,  A61L27/52 ,  A61L29/085 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/424 ,  A61L2300/602 ,  C08F290/00 ,  C08F290/06 ,  C08F291/00 ,  C09D153/00 ,  C09J153/00 ,  C12N5/0012 ,  C12N5/0677 ,  C12N11/04 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/40 ,  C12N2533/74 ,  C12Y302/01017 ,  C12Y304/21068 ,  Y10T428/29 ,  Y10T428/2913 ,  Y10T428/2967 ,  Y10T428/31786 ,  C08L71/02

摘要： Hydrogels of polymerized and crosslinked macromers comprising hydrophilic oligomers having biodegradable monomeric or oligomeric extensions, which biodegradable extensions are terminated on free ends with end cap monomers or oligomers capable of polymerization and cross linking are described. The hydrophilic core itself may be degradable, thus combining the core and extension functions. Macromers are polymerized using free radical initiators under the influence of long wavelength ultraviolet light, visible light excitation or thermal energy. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. Preferred applications for the hydrogels include prevention of adhesion formation after surgical procedures, controlled release of drugs and other bioactive species, temporary protection or separation of tissue surfaces, adhering of sealing tissues together, and preventing the attachment of cells to tissue surfaces.

公开(公告)号：US20030134976A1

公开(公告)日：2003-07-17

申请号：US10205996

申请日：2002-07-26

发明人： Ronald Metcalfe

IPC分类号： C08L053/00

CPC分类号： C09D153/00 ,  C08G59/12 ,  C08L53/00 ,  C09D163/00 ,  C08L2666/02 ,  C08L2666/18

摘要： A protective coating composition in an organic liquid carrier comrpising a polymeric film forming binder, the polymeric binder comprising by weight: (a) 50% to 100% of an epoxy-polyester block copolymer being the reaction product of a preformed epoxy resin and a preformed carboxyl functional, and (b) 0 to 50% of a crosslinker where the sum of (a) and (b) is 100%, characterised in that the carboxyl functional polyester prepolymer is the reaction product of one or more polyols with one or more dicarboxylic acids or their anhydrides, where the dicarboxylic acids or anhydrides comprise a mixture of (i) 20% to 45% of an aromatic dicarboxylic acid or its anhydride, (ii) 55% to 80% of cyclohexane dicarboxylic acid, and (iii) 0 to 10% other aliphatic dicarboxylic acid, where the sum of (i), (ii), and (iii) is 100% based on the weight of the dicarboxylic acid and anhydride components.

摘要翻译： 在聚合物成膜粘合剂中的有机液体载体中的保护性涂料组合物，所述聚合物粘合剂包含重量：（a）50％至100％的环氧 - 聚酯嵌段共聚物，其为预成型环氧树脂与预成型环氧树脂的反应产物 羧基官能团，和（b）0〜50％的（a）和（b）之和为100％的交联剂，其特征在于羧基官能聚酯预聚物是一种或多种多元醇与一种或多种多元醇的反应产物 二羧酸或其酸酐，其中二羧酸或酸酐包含（i）20％至45％的芳族二羧酸或其酸酐的混合物，（ii）55％至80％的环己烷二羧酸，和（iii） 0至10％的其它脂族二羧酸，其中（i），（ii）和（iii）的总和为二羧酸和酸酐组分的重量的100％。

公开(公告)号：US06592980B1

公开(公告)日：2003-07-15

申请号：US09711573

申请日：2000-11-13

申请人： James Edward MacDougall ,  Kevin Ray Heier ,  Scott Jeffrey Weigel ,  Timothy W. Weidman ,  Alexandros T. Demos ,  Nikolaos Bekiaris ,  Yunfeng Lu ,  Michael P. Nault ,  Robert Parkash Mandal

发明人： James Edward MacDougall ,  Kevin Ray Heier ,  Scott Jeffrey Weigel ,  Timothy W. Weidman ,  Alexandros T. Demos ,  Nikolaos Bekiaris ,  Yunfeng Lu ,  Michael P. Nault ,  Robert Parkash Mandal

IPC分类号： B32B326

CPC分类号： H01L21/02126 ,  C08L53/00 ,  C09D153/00 ,  H01L21/02203 ,  H01L21/02216 ,  H01L21/02282 ,  H01L21/31695 ,  Y10T428/249953 ,  Y10T428/249967

摘要： A process provides a ceramic film, such as a mesoporous silica film, on a substrate, such as a silicon wafer. The process includes preparing a film-forming fluid containing a ceramic precursor, a catalyst, a surfactant and a solvent, depositing the film-forming fluid on the substrate, and removing the solvent from the film-forming fluid on the substrate to produce the ceramic film on the substrate. The ceramic film has a dielectric constant below 2.3, a halide content of less than 1 ppm and a metal content of less than 500 ppm, making it useful for current and future microelectronics applications.

公开(公告)号：US06545097B2

公开(公告)日：2003-04-08

申请号：US09734639

申请日：2000-12-12

申请人： Leonard Pinchuk ,  Sepideh Nott ,  Marlene Schwarz ,  Kalpana Kamath

发明人： Leonard Pinchuk ,  Sepideh Nott ,  Marlene Schwarz ,  Kalpana Kamath

IPC分类号： C08L2300

CPC分类号： C08L53/00 ,  A61L27/16 ,  A61L27/54 ,  A61L31/048 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  C08F293/005 ,  C08F297/00 ,  C08F297/04 ,  C08L53/02 ,  C09D153/00 ,  C09D153/02 ,  C08L2666/02

摘要： A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic blocks and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. The block copolymer is preferably of the formula X—(AB)n, where A is an elastomeric block, B is a thermoplastic block, n is a positive whole number and X is a seed molecule. The elastomeric blocks are preferably polyolefin blocks, and the thermoplastic blocks are preferably selected from vinyl aromatic blocks and methacrylate blocks. According to another aspect of the invention, a medical device is provided, at least a portion of which is insertable or implantable into the body of a patient. The medical device comprises (a) the above biocompatible block copolymer and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. According to another aspect of the present invention, a method of treatment is provided in which the above device is implanted or inserted into a patient, resulting in the release of therapeutic agent in the patient over an extended period. According to yet another aspect of the invention, a coated medical device is provided which comprises: (a) an intravascular or intervascular medical device and (b) a coating over at least a portion of the intravascular or intervascular a medical device, wherein the coating comprises the above biocompatible block copolymer.

公开(公告)号：US06521732B2

公开(公告)日：2003-02-18

申请号：US09827221

申请日：2001-04-05

申请人： Mario Alberto Perez ,  Ahmed Salih Abuelyaman ,  Ikuko Ebihara ,  Lani S. Kangas

发明人： Mario Alberto Perez ,  Ahmed Salih Abuelyaman ,  Ikuko Ebihara ,  Lani S. Kangas

IPC分类号： C09J12910

CPC分类号： C08F220/32 ,  C09D153/00 ,  C08L2666/04

摘要： A (meth)acrylate terpolymer comprising 1-30% of total terpolymer weight epoxy-functional (meth)acrylate monomer units, 1-98% of total terpolymer weight tackifier (meth)acrylate monomer units, and 1-98% of total terpolymer weight compatibilizing (meth)acrylate monomer units, wherein the compatibilizing (meth)acrylate monomer unit is a (meth)acrylic ester derived from an aromatic alcohol containing 6-14 carbon atoms. Also provided are self-fixturing adhesive compositions comprising the acrylate terpolymer of the present invention and methods of their use.

摘要翻译： 包含总共三聚体重量环氧官能的（甲基）丙烯酸酯单体单元的1-30％的三（甲基）丙烯酸酯三元共聚物，总三元共聚物增粘剂（甲基）丙烯酸酯单体单元的1-98％和总三元共聚物重量的1-98％ 相容性（甲基）丙烯酸酯单体单元，其中相容性（甲基）丙烯酸酯单体单元为衍生自含有6-14个碳原子的芳族醇的（甲基）丙烯酸酯。 还提供了包含本发明的丙烯酸酯三元共聚物及其使用方法的自固化粘合剂组合物。

公开(公告)号：US20030012936A1

公开(公告)日：2003-01-16

申请号：US10134150

申请日：2002-04-29

发明人： Erica J. Draheim ,  Bettie C. Fong ,  Bruce D. Kluge ,  Junkang J. Liu ,  Pradnya V. Nagarkar ,  William K. Smyth

IPC分类号： B32B007/02 ,  B32B031/26

CPC分类号： C08F2/44 ,  C08F290/06 ,  C08G65/007 ,  C08L53/00 ,  C08L2666/02 ,  C09D4/00 ,  C09D4/06 ,  C09D153/00 ,  C09D171/02 ,  C09J7/22 ,  C09J7/30 ,  C09J153/00 ,  C09J2433/00 ,  G01N1/36 ,  G02B1/111 ,  G02B21/34 ,  G06F1/1609 ,  G06F1/1626 ,  G06F3/041 ,  H01J29/868 ,  H04N5/65 ,  H04N9/3141 ,  Y10T428/24975 ,  Y10T428/269 ,  Y10T428/28 ,  Y10T428/2848 ,  C08F222/1006 ,  C08F222/18 ,  C08F290/062 ,  C08L2666/04

摘要： An antireflection film and method of making same includes a substrate having a first surface and a second surface, an inorganic layer deposited on the first surface of the substrate, and an optically active polymer layer formed by curing a curable composition in situ on the inorganic layer, the polymer layer having a refractive index not greater than about 1.53 over the wavelength range of 400 nm to 700 nm and a thickness of from about 20 nm to about 200 nm, and an adhesive layer deposited on the second surface of the substrate.

摘要翻译： 防反射膜及其制造方法包括具有第一表面和第二表面的基材，沉积在基材的第一表面上的无机层和通过在无机层上原位固化可固化组合物而形成的光学活性聚合物层 所述聚合物层在400nm至700nm的波长范围内具有不大于约1.53的折射率和约20nm至约200nm的厚度，以及沉积在所述基板的第二表面上的粘合剂层。

公开(公告)号：US06482475B2

公开(公告)日：2002-11-19

申请号：US09934385

申请日：2001-08-21

申请人： Karen A. Barkac ,  Simion Coca ,  James R. Franks ,  Kurt A. Humbert ,  Paul H. Lamers ,  Roxalana L. Martin ,  James B. O'Dwyer ,  Kurt G. Olson ,  Daniela White

发明人： Karen A. Barkac ,  Simion Coca ,  James R. Franks ,  Kurt A. Humbert ,  Paul H. Lamers ,  Roxalana L. Martin ,  James B. O'Dwyer ,  Kurt G. Olson ,  Daniela White

IPC分类号： C08G1862

CPC分类号： C08G18/8074 ,  C08F293/00 ,  C08F293/005 ,  C08F2438/01 ,  C08G18/6229 ,  C08G2150/20 ,  C09D153/00 ,  Y10T428/31504 ,  C08L2666/02

摘要： A thermosetting composition comprising a co-reactable solid, particulate mixture of (a) capped polyisocyanate crosslinking agent, e.g., a trimer of 1-isocyanato-3,3,5 -trimethyl-5-isocyanatomethylcyclohexane capped with e-caprolactam or 1H-2,5-dimethyl pyrazole, and (b) hydroxy functional polymer, is described. The hydroxy functional polymer is prepared by atom transfer radical polymerization and has well defined polymer chain architecture and polydispersity index of less than 2.5. The thermosetting compositions of the present invention have utility as powder coatings compositions.

摘要翻译： 一种热固性组合物，其包含（a）封端的多异氰酸酯交联剂，例如用ε-己内酰胺或1H-2封端的1-异氰酸酯基-3,3,5-三甲基-5-异氰酸甲酯基环己烷的三聚体的可共反应的固体颗粒混合物 ，5-二甲基吡唑和（b）羟基官能聚合物。 羟基官能聚合物通过原子转移自由基聚合制备，并且具有明确的聚合物链结构和小于2.5的多分散指数。 本发明的热固性组合物可用作粉末涂料组合物。

公开(公告)号：US20020156188A1

公开(公告)日：2002-10-24

申请号：US09930912

申请日：2001-08-16

发明人： Jeffrey L. Anderson ,  Alan J. Pekarik ,  Edward Tokas

IPC分类号： C08F008/00

CPC分类号： C09J153/00 ,  C08F293/00 ,  C08G18/10 ,  C08G18/765 ,  C08G81/024 ,  C08L71/02 ,  C08L101/02 ,  C09D5/032 ,  C09D11/10 ,  C09D153/00 ,  C08G18/62 ,  C08L2666/04

摘要： A substantially non-gelled polymeric composition is disclosed and comprises the reaction product of an A polymer which is an addition polymer having 3.5 or more reactive functional groups per polymer chain and a B polymer having about 2 to about 3 functional groups per polymer chain that are co-reactive with the reactive functional groups of the A polymer. Also disclosed is a process for preparing such polymeric compositions, powder coatings and 100% solids ink resins prepared with such polymeric compositions, and a method for deglossing a powder coating using such polymeric compositions.

摘要翻译： 公开了一种基本上非凝胶的聚合物组合物，其包含A聚合物的反应产物，该聚合物是每个聚合物链具有3.5个或更多个反应性官能团的加成聚合物和每个聚合物链具有约2至约3个官能团的B聚合物， 与A聚合物的反应性官能团共反应。 还公开了制备这种聚合物组合物的方法，粉末涂料和用这种聚合物组合物制备的100％固体油墨树脂，以及使用这种聚合物组合物使粉末涂料脱粒的方法。