公开(公告)号：US20180279927A1

公开(公告)日：2018-10-04

申请号：US15989706

申请日：2018-05-25

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-Hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: A61B5/1477 ,  G01N33/483 ,  A61B10/00 ,  A61M11/00 ,  A61M25/00 ,  H01J49/00 ,  H01J49/04 ,  H01J49/16

CPC classification number: A61B5/1477 ,  A61B5/1405 ,  A61B5/145 ,  A61B5/150015 ,  A61B5/150992 ,  A61B5/157 ,  A61B10/0045 ,  A61M11/00 ,  A61M25/00 ,  A61M2202/0468 ,  G01N33/4833 ,  G01N2001/028 ,  H01J49/0022 ,  H01J49/0404 ,  H01J49/0445 ,  H01J49/167 ,  H01J49/34

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US10088461B2

公开(公告)日：2018-10-02

申请号：US15710072

申请日：2017-09-20

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang

IPC: H01J49/00 ,  G01N30/95 ,  G01N33/49 ,  G01N30/91

Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.

公开(公告)号：US20180204714A1

公开(公告)日：2018-07-19

申请号：US15920900

申请日：2018-03-14

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder

IPC: H01J49/42 ,  H01J49/00

CPC classification number: H01J49/4285 ,  H01J49/0013 ,  H01J49/4225

Abstract: The invention generally relates to systems and methods for ejection of ions from an ion trap. In certain embodiments, systems and methods of the invention sum two different frequency signals into a single summed signal that is applied to an ion trap. In other embodiments, an amplitude of a single frequency signal is modulated as the single frequency signal is being applied to the ion trap. In other embodiments, a first alternating current (AC) signal is applied to an ion trap that varies as a function of time, while a constant radio frequency (RF) signal is applied to the ion trap.

公开(公告)号：US10004440B2

公开(公告)日：2018-06-26

申请号：US15617013

申请日：2017-06-08

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-Hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: H01J49/00 ,  A61B5/1477 ,  H01J49/16 ,  H01J49/34 ,  A61M25/00 ,  G01N33/483 ,  H01J49/04 ,  A61M11/00

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US20180040464A1

公开(公告)日：2018-02-08

申请号：US15556401

申请日：2016-03-09

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Anyin Li ,  Adam Hollerbach

IPC: H01J49/04 ,  H01J49/16

CPC classification number: H01J49/0409 ,  H01J49/00 ,  H01J49/04 ,  H01J49/165 ,  H01J49/167

Abstract: The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.

公开(公告)号：US20180017535A1

公开(公告)日：2018-01-18

申请号：US15710072

申请日：2017-09-20

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang

IPC: G01N30/95 ,  G01N30/91 ,  G01N33/49 ,  H01J49/00

CPC classification number: G01N30/95 ,  G01N30/91 ,  G01N33/49 ,  H01J49/0031 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0431 ,  H01J49/167 ,  H01J49/168

Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.

公开(公告)号：US09786478B2

公开(公告)日：2017-10-10

申请号：US14957661

申请日：2015-12-03

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Michael Stanley Wleklinski ,  Soumabha Bag ,  Yafeng Li

IPC: H01J49/00 ,  H01J49/04

CPC classification number: H01J49/0436 ,  H01J49/0013

Abstract: The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.

公开(公告)号：US09719181B2

公开(公告)日：2017-08-01

申请号：US15412230

申请日：2017-01-23

Applicant: Purdue Research Foundation ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Inventor： Robert Graham Cooks ,  Anyin Li ,  Qingjie Luo

IPC: B01J19/08 ,  C25C7/06 ,  C25C1/20

CPC classification number: C25C7/06 ,  C25C1/20 ,  C25C1/22 ,  C25C7/00 ,  Y02P10/234

Abstract: The invention generally relates to systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions. In certain aspects, the invention provides methods that involve providing a metal and a solvent. The methods additionally involve applying voltage to the solvated metal to thereby produce solvent droplets including ions of the metal containing compound, and directing the solvent droplets including the metal ions to a target. In certain embodiments, once at the target, the metal ions can react directly or catalyze reactions.

公开(公告)号：US09704700B2

公开(公告)日：2017-07-11

申请号：US15317801

申请日：2015-06-16

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zane Baird ,  Pu Wei

IPC: H01J49/06 ,  H01J49/00 ,  H01J49/24 ,  H01J49/14

CPC classification number: H01J49/24 ,  G01N27/622 ,  H01J49/0013 ,  H01J49/061 ,  H01J49/142

Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.

公开(公告)号：US20170135613A1

公开(公告)日：2017-05-18

申请号：US15400358

申请日：2017-01-06

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-Hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: A61B5/1477 ,  A61M25/00 ,  H01J49/34 ,  H01J49/00 ,  H01J49/04 ,  H01J49/16 ,  A61M11/00 ,  G01N33/483

CPC classification number: A61B5/1477 ,  A61B5/1405 ,  A61B5/145 ,  A61B5/150015 ,  A61B5/150992 ,  A61B5/157 ,  A61B10/0045 ,  A61M11/00 ,  A61M25/00 ,  A61M2202/0468 ,  G01N33/4833 ,  G01N2001/028 ,  H01J49/0022 ,  H01J49/0404 ,  H01J49/0445 ,  H01J49/167 ,  H01J49/34

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.