公开(公告)号：US20220259623A1

公开(公告)日：2022-08-18

申请号：US17508400

申请日：2021-10-22

Applicant: Genomatica, Inc.

Inventor： Andreas W. SCHIRMER ,  Mathew A. RUDE ,  Shane A. BRUBAKER

IPC: C12P7/64 ,  C12N9/02 ,  C10L1/02 ,  C12N9/88 ,  C12P7/04 ,  C12P7/24 ,  C12P7/6409 ,  C12P7/6436 ,  C12P7/649 ,  C12P5/02

Abstract: Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein. The aldehydes, alkanes, and alkenes can be used in biofuels.

公开(公告)号：US11365432B2

公开(公告)日：2022-06-21

申请号：US16573796

申请日：2019-09-17

Applicant: Genomatica, Inc.

Inventor： Liang Wu ,  Axel Christoph Trefzer ,  Stefaan Marie Andre De Wildeman ,  Marco Alexander Van Den Berg

IPC: C12P7/44 ,  C12P7/62 ,  C12P17/10 ,  C12N15/70

Abstract: The present invention relates to a method for preparing an adipate ester or thioester. The invention further relates to a method for preparing adipic acid from said ester or thioester. Further the invention provides a number of methods for preparing an intermediate for said ester or thioester. Further the invention relates to a method for preparing 6-amino caproic acid (6-ACA), a method for preparing 5-formyl valeric acid (5-FVA), and a method for preparing caprolactam. Further, the invention relates to a host cell for use in a method according to the invention.

公开(公告)号：US20220127649A1

公开(公告)日：2022-04-28

申请号：US17427019

申请日：2020-01-30

Applicant: Genomatica, Inc.

Inventor： Michael A. Noble ,  Jonathan Moore ,  Jingyi Li ,  Anna Lechner

IPC: C12P7/42 ,  C12N1/20 ,  C12N15/52 ,  C12N15/70 ,  C12P7/22

Abstract: The invention provides non-natural microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing synthesis of olivetolic acid, olivetolic acid derivatives and/or cannabinoids.

公开(公告)号：US20220098133A1

公开(公告)日：2022-03-31

申请号：US17494303

申请日：2021-10-05

Applicant: Genomatica, Inc.

Inventor： Haibo WANG

IPC: C07C33/035 ,  C07H15/10

Abstract: The disclosure relates to the field of specialty chemicals. In particular, the disclosure provides novel 1,3-fatty-diol compounds and derivatives thereof which are useful e.g., in the production of personal care products, surfactants, detergents, polymers, paints, coatings, and as emulsifiers, emollients, and thickeners in cosmetics and foods, as industrial solvents and plasticizers, etc.

公开(公告)号：US20210355071A1

公开(公告)日：2021-11-18

申请号：US17308864

申请日：2021-05-05

Applicant: Genomatica, Inc.

Inventor： Zhihao HU ,  Fernando VALLE

IPC: C07C69/533 ,  C12N1/20 ,  C12N1/16 ,  C12N1/14 ,  C12N1/12 ,  C07C69/34 ,  C07C69/52 ,  C10L1/02 ,  C10L1/19 ,  C11C3/00 ,  C12P7/64 ,  C12N9/02 ,  C12N9/10 ,  C12N9/16 ,  C12N9/00

Abstract: Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as biofuels.

公开(公告)号：US20210324431A1

公开(公告)日：2021-10-21

申请号：US17169845

申请日：2021-02-08

Applicant: Genomatica, Inc.

Inventor： Grace J. LEE ,  John HALIBURTON ,  Zhihao HU ,  Andreas W. SCHIRMER ,  Kevin HOLDEN

IPC: C12P7/64 ,  C12N9/10 ,  C12N9/16 ,  C12N9/04 ,  C12N9/18 ,  C12N9/12 ,  C12N9/90 ,  C12N9/88 ,  C07C53/126 ,  C07C57/03

Abstract: Recombinant microbial cells are provided which have been engineered to produce fatty acid derivatives having linear chains containing an odd number of carbon atoms by the fatty acid biosynthetic pathway. Also provided are methods of making odd chain fatty acid derivatives using the recombinant microbial cells, and compositions comprising odd chain fatty acid derivatives produced by such methods.

公开(公告)号：US11142756B2

公开(公告)日：2021-10-12

申请号：US16802133

申请日：2020-02-26

Applicant: Genomatica, Inc.

Inventor： Derek L. Greenfield ,  Donald E. Trimbur ,  Andreas W. Schirmer ,  Cindy Chang ,  Behnaz Behrouzian ,  Jessica Winger

IPC: C12N15/63 ,  C12N15/70 ,  C12N9/88 ,  C12N1/21 ,  C07K14/245 ,  C12P7/64 ,  C12N9/00 ,  C12N15/67

Abstract: The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.

公开(公告)号：US11085015B2

公开(公告)日：2021-08-10

申请号：US15585078

申请日：2017-05-02

Applicant: Genomatica, Inc.

Inventor： Priti Pharkya ,  Anthony P. Burgard ,  Stephen J. Van Dien ,  Robin E. Osterhout ,  Mark J. Burk ,  John D. Trawick ,  Michael P. Kuchinskas ,  Brian Steer

IPC: C12P7/42 ,  C12P7/18 ,  C12N1/20 ,  C12N1/14 ,  C12N1/16 ,  C12N9/18 ,  C12N15/52 ,  C12N15/63 ,  C07C31/20 ,  C07C59/01 ,  C08G18/28 ,  C08G18/32 ,  C08G63/06 ,  C08G63/16 ,  C08G63/181 ,  C08G69/02

Abstract: The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate or related products using the microbial organisms.

公开(公告)号：US11053184B2

公开(公告)日：2021-07-06

申请号：US14773149

申请日：2014-03-07

Applicant: GENOMATICA, INC.

Inventor： Myong K. Ko ,  Haibo Wang ,  Patricia J. Cole ,  Perry Y. Liao ,  Simon Li

IPC: C07C29/88 ,  C07C29/17

Abstract: The disclosure relates to downstream processing of fatty alcohol (FALC) and provides a novel purification method that provides FALC at high purity and yield.

公开(公告)号：US11034937B2

公开(公告)日：2021-06-15

申请号：US16414550

申请日：2019-05-16

Applicant: Genomatica, Inc.

Inventor： Derek L. Greenfield ,  Elizabeth J. Clarke ,  Eli S. Groban ,  Vikranth Arlagadda ,  Sungwon Lee ,  Xuezhi Li ,  Zhihao Hu ,  Baolong Zhu

IPC: C12P7/04 ,  C12N9/02 ,  C12P7/64

Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.