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    DIGITAL IMAGING WITH MASKED PIXELS
    161.
    发明申请
    DIGITAL IMAGING WITH MASKED PIXELS 审中-公开

    公开(公告)号：US20170366768A1

    公开(公告)日：2017-12-21

    申请号：US15675494

    申请日：2017-08-11

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Boaz RAN ,  Steve SWIHART ,  Evan THRUSH ,  Itay BARAK

    IPC: H04N5/361 ,  H04N5/365

    CPC classification number: H04N5/361 ,  H04N5/365

    Abstract: In one application, an imaging device includes an image sensor having an array of pixels, and a mask coupled with the image sensor. The mask is configured to darken a plurality of isolated pixels or groups of pixels interspersed within the array of pixels. The imaging device also includes a processor coupled with the image sensor and configured to receive image data from the image sensor, and determine a dark current fixed pattern noise based on the image data received from the plurality of darkened pixels or groups of pixels.

    Calibration process and system
    164.
    发明授权
    Calibration process and system 有权

    公开(公告)号：US09810703B2

    公开(公告)日：2017-11-07

    申请号：US14883395

    申请日：2015-10-14

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Adam Darmstadt ,  Michael Waite ,  Theresa Forni

    IPC: G01N35/00 ,  G01N30/04

    CPC classification number: G01N35/00693 ,  G01N35/0095 ,  G01N2030/047 ,  G01N2035/00702

    Abstract: An improved calibration process for a medical testing machine. The machine automatically recognizes that a package of calibration material has been inserted into it, and performs a calibration sequence to ascertain a calibration parameter to be used in performing future tests with the medical testing machine. The calibration package may include machine-readable indicators that the package is to be used for calibration, and of a calibration setpoint of a calibration material in the package. A calibration material may be stored in a lyophilized state in the package, and the medical testing machine may automatically reconstitute the lyophilized material.

    miRNA TRANSCRIPTOME METHODS AND COMPOSITIONS
    165.
    发明申请
    miRNA TRANSCRIPTOME METHODS AND COMPOSITIONS 审中-公开

    公开(公告)号：US20170314017A1

    公开(公告)日：2017-11-02

    申请号：US15499734

    申请日：2017-04-27

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Rongdian FU

    IPC: C12N15/113 ,  C12Q1/68 ,  C12N15/10

    Abstract: Methods, polynucleotides, kits, and reaction mixtures are disclosed for the enriching of short polynucleotide molecules that have a length within a desired target length range. A Type IIS or Type III restriction enzyme is used to cleave polynucleotides at cleavage sites located at a distance from the restriction enzyme recognition sites. For example, a mixture of polynucleotides can be formed by inserting DNA molecules between a recognition site for the restriction enzyme and a region of non-naturally-occurring nucleotides that block cleavage by the restriction enzymes. If a polynucleotide contains a DNA molecule with a length within a target range, then the cleavage site will be within the blocking region, and cleavage will not occur. Polynucleotides containing DNA molecules with lengths outside the target range can be cleaved. By selectively enriching, through PCR or other means, polynucleotides that are intact, a concentrated population of polynucleotides of a target length can be formed.

    Systems and methods for biochemical data analysis
    166.
    发明授权
    Systems and methods for biochemical data analysis 有权

    公开(公告)号：US09792548B2

    公开(公告)日：2017-10-17

    申请号：US13625753

    申请日：2012-09-24

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Todd Yeck ,  Niels Kirk Thomsen ,  John Clopton Dunaway

    IPC: G06N5/02 ,  G06F19/26 ,  G06F19/28

    CPC classification number: G06N5/02 ,  G06F19/26 ,  G06F19/28

    Abstract: Methods and systems for biochemical data analysis are provided. A dataset can be received and a selection of a compare field can be used for creation of sub-groups of data to run statistical analysis on. The sub-groups of the dataset can be created based on the selection of the compare field. Statistical information about each sub-group of data can be calculated and displayed on a user display. Other information can be provided for further dataset refinements. A user may supply a control group selection, and such a selection may then result in an indication on the display of which population represents the control group. A user may supply information for further dataset filtering. Such information may be used to filter data, prior to creating the sub-groups for statistical analysis.

    MULTIPLE BEADS PER DROPLET RESOLUTION
    169.
    发明申请
    MULTIPLE BEADS PER DROPLET RESOLUTION 审中-公开

    公开(公告)号：US20170232417A1

    公开(公告)日：2017-08-17

    申请号：US15400756

    申请日：2017-01-06

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Ronald Lebofsky ,  Nicholas Heredia

    IPC: B01J19/00

    Abstract: Methods of generating a nucleic acid signature for identifying particles associated in a partition are provided. In one aspect, the method comprises: partitioning a sample into a plurality of partitions comprising a particle comprising a solid support surface, the solid support surface having a plurality of oligonucleotide primers conjugated thereon, wherein the oligonucleotide primers comprise a barcode sequence, and wherein the partitions have 0, 1, or more than 1 particles per partition; providing in a partition a substrate comprising a barcode sequence or repeating clonal barcode sequences; and in the partition, associating a first particle conjugated to oligonucleotide primers comprising a first barcode sequence and a second particle conjugated to oligonucleotide primers comprising a second barcode sequence to a barcode sequence from the substrate, thereby generating a nucleic acid signature for the particles in the partition.

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