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    Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
    184.
    发明授权
    Semi-synthetic terephthalic acid via microorganisms that produce muconic acid 有权

    公开(公告)号：US10041093B2

    公开(公告)日：2018-08-07

    申请号：US15383593

    申请日：2016-12-19

    Applicant: GENOMATICA, INC.

    Inventor： Mark J. Burk ,  Robin E. Osterhout ,  Jun Sun

    IPC: C12N1/20 ,  C12P7/44 ,  C12N9/88

    CPC classification number: C12P7/44 ,  C12N9/88 ,  C12Y402/01002

    Abstract: The invention provides a non-naturally occurring microbial organism having a muconate pathway having at least one exogenous nucleic acid encoding a muconate pathway enzyme expressed in a sufficient amount to produce muconate. The muconate pathway including an enzyme selected from the group consisting of a beta-ketothiolase, a beta-ketoadipyl-CoA hydrolase, a beta-ketoadipyl-CoA transferase, a beta-ketoadipyl-CoA ligase, a 2-fumarylacetate reductase, a 2-fumarylacetate dehydrogenase, a trans-3-hydroxy-4-hexendioate dehydratase, a 2-fumarylacetate aminotransferase, a 2-fumarylacetate aminating oxidoreductase, a trans-3-amino-4-hexenoate deaminase, a beta-ketoadipate enol-lactone hydrolase, a muconolactone isomerase, a muconate cycloisomerase, a beta-ketoadipyl-CoA dehydrogenase, a 3-hydroxyadipyl-CoA dehydratase, a 2,3-dehydroadipyl-CoA transferase, a 2,3-dehydroadipyl-CoA hydrolase, a 2,3-dehydroadipyl-CoA ligase, a muconate reductase, a 2-maleylacetate reductase, a 2-maleylacetate dehydrogenase, a cis-3-hydroxy-4-hexendioate dehydratase, a 2-maleylacetate aminoatransferase, a 2-maleylacetate aminating oxidoreductase, a cis-3-amino-4-hexendioate deaminase, and a muconate cis/trans isomerase. Other muconate pathway enzymes also are provided. Additionally provided are methods of producing muconate.

    Process of separating components of a fermentation broth
    185.
    发明授权
    Process of separating components of a fermentation broth 有权

    公开(公告)号：US09994505B2

    公开(公告)日：2018-06-12

    申请号：US14066598

    申请日：2013-10-29

    Applicant: Genomatica, Inc.

    Inventor： Warren Clark ,  Michael Japs ,  Mark J. Burk

    IPC: C12P7/18 ,  C07C29/76

    CPC classification number: C07C29/76 ,  C12P7/18 ,  C07C31/207

    Abstract: A process of isolating 1,4-butanediol (1,4-BDO) from a fermentation broth includes separating a liquid fraction enriched in 1,4-BDO from a solid fraction comprising cells, removing water from said liquid fraction, removing salts from said liquid fraction, and purifying 1,4-BDO. A process for producing 1,4-BDO includes culturing a 1,4-BDO-producing microorganism in a fermentor for a sufficient period of time to produce 1,4-BDO. The 1,4-BDO-producing microorganism includes a microorganism having a 1,4-BDO pathway having one or more exogenous genes encoding a 1,4-BDO pathway enzyme and/or one or more gene disruptions. The process for producing 1,4-BDO further includes isolating 1,4-BDO.

    Methods for synthesis of olefins and derivatives
    188.
    发明授权
    Methods for synthesis of olefins and derivatives 有权
    合成烯烃和衍生物的方法

    公开(公告)号：US09365874B2

    公开(公告)日：2016-06-14

    申请号：US13887140

    申请日：2013-05-03

    Applicant: Genomatica, Inc.

    Inventor： Mark J. Burk ,  Priti Pharkya ,  Stephen J. Van Dien ,  Anthony P. Burgard ,  Christophe H. Schilling

    IPC: C12P7/40 ,  C12P7/42 ,  C12P7/62 ,  C12N1/21 ,  C07C51/353 ,  C07C57/04 ,  C07C67/08 ,  C07C67/333 ,  C12P7/46 ,  C07C51/38 ,  C07C67/32

    CPC classification number: C07C51/353 ,  C07C51/38 ,  C07C57/04 ,  C07C67/08 ,  C07C67/32 ,  C07C67/333 ,  C12P7/40 ,  C12P7/46 ,  C12P7/62 ,  Y02P20/125 ,  C07C69/60 ,  C07C69/54

    Abstract: The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method includes contacting fumarate diester with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylate ester per mole of fumarate diester. An integrated process for process for producing acrylic acid or acrylate ester is provided which couples bioproduction of fumaric acid with metathesis transformation. An acrylic acid and an acrylate ester production also is provided.

    Abstract translation: 本发明提供了制备丙烯酸的方法。 该方法包括在交叉复分解转化催化剂存在下使富马酸与足够量的乙烯接触，以产生约2摩尔丙烯酸/摩尔富马酸。 还提供了丙烯酸酯。 该方法包括在交叉复分解转化催化剂存在下使富马酸二酯与足够量的乙烯接触，以产生每摩尔富马酸二酯约2摩尔丙烯酸酯。 提供了用于生产丙烯酸或丙烯酸酯的方法的综合方法，其将富马酸的生物生产与易位转化相结合。 还提供丙烯酸和丙烯酸酯生产。

    MICROORGANISMS AND METHODS FOR PRODUCING (3R)-HYDROXYBUTYL (3R)-HYDROXYBUTYRATE
    190.
    发明申请
    MICROORGANISMS AND METHODS FOR PRODUCING (3R)-HYDROXYBUTYL (3R)-HYDROXYBUTYRATE 审中-公开
    （3R） - 羟基丁酸（3R） - 羟基丁酸酯的微生物和方法

    公开(公告)号：US20160108442A1

    公开(公告)日：2016-04-21

    申请号：US14893510

    申请日：2014-05-23

    Applicant: Genomatica, Inc.

    Inventor： Benjamin ADELSTEIN ,  Robin E. OSTERHOUT ,  Mark J. BURK

    IPC: C12P7/62 ,  C07C69/675 ,  C12N15/52 ,  C12R1/01 ,  C12R1/645

    CPC classification number: C12P7/62 ,  A23L33/135 ,  A23V2002/00 ,  A61K31/22 ,  A61K35/66 ,  A61K36/064 ,  C07B2200/05 ,  C07C69/675 ,  C12N9/18 ,  C12N15/52 ,  C12P7/42 ,  C12R1/01 ,  C12R1/645 ,  C12Y101/01035 ,  C12Y101/011 ,  C12Y301/01067 ,  C12Y301/08001 ,  Y02P20/127

    Abstract: Provided herein are non-naturally occurring microbial organisms having a pathway for production of (3R)-hydroxybutyl (3R)-hydroxybutyrate, wherein the organism can further include a (R)-1,3-butanediol pathway, a (3R)-hydroxybutyrate pathway, a (3R)-hydroxybutyryl-CoA pathway, an acetoacetate pathway, an acetoacetyl-CoA pathway, a (3R)-hydroxybutyl-ACP pathway, or an acetoacetyl-ACP pathway. Additionally provided are methods and processes for producing and isolating (3R)-hydroxybutyl (3R)-hydroxybutyrate using the microbial organisms, and various compositions having the (3R)-hydroxybutyl (3R)-hydroxybutyrate. Still further provided are methods of treating or preventing a disease, disorder or condition using the (3R)-hydroxybutyl (3R)-hydroxybutyrate produced by the microbial organisms of the invention.

    Abstract translation: 本文提供了具有（3R） - （3R） - 羟基丁酸生产途径的非天然存在的微生物生物，其中生物体还可包含（R）-1,3-丁二醇途径，（3R） - 羟基丁酸酯 途径，（3R） - 羟基丁酰辅酶A途径，乙酰乙酸途径，乙酰乙酰辅酶A途径，（3R） - 羟基丁基ACP途径或乙酰乙酰-ACP途径。 另外提供了使用微生物生物体（3R） - 羟基丁酸（3R） - 羟基丁酸生产和分离（3R） - 羟基丁酸酯的方法和方法，以及具有（3R） - 羟基丁基（3R） - 羟基丁酸酯的各种组合物。 还提供了使用本发明的微生物生物体产生的（3R） - 羟基丁酸（3R） - 羟基丁酸酯来治疗或预防疾病，病症或病症的方法。

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