公开(公告)号：US10010605B2

公开(公告)日：2018-07-03

申请号：US14863181

申请日：2015-09-23

申请人： MERIAL, INC.

发明人： Jean-Christophe Audonnet ,  Zahia Hannas-Djebbara ,  Teshome Mebatsion ,  Yu-Wei Chiang ,  Justin Widener ,  Frédéric Reynard

IPC分类号： A61K39/135 ,  A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/135 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/55577 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10043 ,  C12N2710/14043 ,  C12N2770/32123 ,  C12N2770/32134

摘要： The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The invention also encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV.

公开(公告)号：US09981033B2

公开(公告)日：2018-05-29

申请号：US15190740

申请日：2016-06-23

申请人： MERIAL INC.

发明人： Teshome Mebatsion ,  Aemro Kassa ,  Taejoong Kim

IPC分类号： A61K39/12 ,  C12N7/00 ,  C07K14/08 ,  C12N15/86 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61K2039/5256 ,  A61K2039/552 ,  C07K14/082 ,  C07K2319/03 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10043 ,  C12N2770/10034 ,  C12N2770/10051 ,  C12N2840/203

摘要： The present invention encompasses recombinant porcine reproductive and respiratory syndrome virus (PRRSV) vaccines or compositions. In particular, the invention encompasses recombinant adenovirus vectors encoding and expressing PRRSV gp2, gp3, gp4, gp5a, gp5 and/or E antigens, proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals from PRRSV.

公开(公告)号：US09944904B2

公开(公告)日：2018-04-17

申请号：US15154028

申请日：2016-05-13

申请人： MERIAL INC.

发明人： Paulraj Lawrence ,  Frederic Dumas

IPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/00

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  C12N2750/10034 ,  C12N2750/10051

摘要： This invention relates to a method for rapid production of PCV2 such that an optimum yield of the virus can be obtained. This invention also relates to the vaccine useful against PCV2 which includes the PCV2 propagated using such a method.

公开(公告)号：US20180100135A1

公开(公告)日：2018-04-12

申请号：US15840701

申请日：2017-12-13

申请人： Merial Inc.

发明人： Hervé François Coupier

IPC分类号： C12M1/00 ,  C12M1/34 ,  A01N1/02 ,  C12M1/12 ,  A61J1/10 ,  B01L3/00 ,  B01L9/00 ,  A61J1/14

CPC分类号： C12M45/22 ,  A01N1/0268 ,  A61J1/10 ,  A61J1/1462 ,  A61J1/1475 ,  B01L3/505 ,  B01L9/00 ,  B01L2300/021 ,  B01L2300/0681 ,  B01L2300/0809 ,  B01L2300/1894 ,  C12M23/14 ,  C12M23/26 ,  C12M37/00 ,  C12M37/02 ,  C12M37/04 ,  C12M41/44

摘要： The disclosure provides a cell freezing and storage bag assembly and a method for using the assembly in banking eukaryotic cells for later seed train expansion. The bag is constructed principally of fluorinated ethylene propylene (FEP) fabric, and is designed to be filled such that the cell suspension has a very thin cross-section. The bag design includes at least an inlet conduit and an outlet or inoculation conduit, which can be sterilely welded to the source of the eukaryotic cells. The use of at least two sterile-weldable conduits allows for “closed system” filling of the bags, which significantly reduces the risk of contamination relative to other cell-banking methods. The bag also include a sleeve, which can be thermo-welded to form an enclosure, which protects the inlet and outlet conduits against contamination and mechanical damage during freezing, storage and subsequent thawing. In the method, once each bag is filled, its corresponding inlet conduit is sealed, and both the inlet and outlet conduits are enclosed within the bag's sleeve. This closed system method obviates the need for sterile environments (e.g. laminar flow unit).

公开(公告)号：US09931320B2

公开(公告)日：2018-04-03

申请号：US14977680

申请日：2015-12-22

申请人： MERIAL INC.

发明人： Mark David Soll ,  Diane Larsen ,  Susan Mancini Cady ,  Peter Cheifetz ,  Izabela Galeska ,  Saijun Gong

IPC分类号： A61K31/42 ,  A61K45/06 ,  A61K47/42 ,  A61K31/325 ,  A61K31/365 ,  A61K31/7048 ,  A61K31/4985 ,  A61K9/00 ,  A61K47/36 ,  C07D261/04 ,  A61K31/27 ,  A61K31/437 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/44 ,  A61K31/194 ,  A01N43/80 ,  A23K20/00

CPC分类号： A61K31/42 ,  A01N43/80 ,  A23K20/00 ,  A61K9/0056 ,  A61K9/0068 ,  A61K31/194 ,  A61K31/27 ,  A61K31/325 ,  A61K31/365 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/7048 ,  A61K45/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/36 ,  A61K47/42 ,  A61K47/44 ,  C07D261/04 ,  A61K2300/00

摘要： This invention relates to oral veterinary compositions for combating ectoparasites and endoparasites in animals, comprising at least one systemically-acting active agent in combination with a pharmaceutically acceptable carrier. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

公开(公告)号：US09901628B2

公开(公告)日：2018-02-27

申请号：US14699296

申请日：2015-04-29

申请人： MERIAL INC.

发明人： Laurent Bernard Fischer

IPC分类号： A61K39/00 ,  A61K48/00

CPC分类号： A61K39/0011 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/545

摘要： The application discloses therapeutic vaccines based upon the “pING” DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as an adjunct treatment for surgery, radiation and/or chemotherapy for dogs and cats with cancers that over express the Her2 antigen, and prolong the post-surgical disease free interval and/or survival time. Also included are therapeutically effective methods of immunization using said vaccines.

公开(公告)号：US09877950B2

公开(公告)日：2018-01-30

申请号：US14930690

申请日：2015-11-03

申请人： MERIAL, INC.

发明人： Mark D. Soll ,  Joseph K. Rosentel ,  Monica Tejwani-Motwani ,  Carol Belansky

IPC分类号： A61K31/42 ,  A61K31/4402 ,  A61K31/215 ,  A61K31/415 ,  A61K31/22 ,  A61K31/44 ,  A61K45/06 ,  A61K38/15 ,  A61K31/366 ,  A61K31/7048 ,  A61K9/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K9/06 ,  A01N43/40 ,  A01N43/80 ,  A01N49/00 ,  A61K31/231 ,  A61K31/4745 ,  A61K47/08 ,  A61K47/22

CPC分类号： A61K31/42 ,  A01N43/40 ,  A01N43/80 ,  A01N49/00 ,  A61K9/0017 ,  A61K9/06 ,  A61K31/215 ,  A61K31/22 ,  A61K31/231 ,  A61K31/366 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4745 ,  A61K31/7048 ,  A61K38/15 ,  A61K45/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K2300/00

摘要： This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

公开(公告)号：US09856295B2

公开(公告)日：2018-01-02

申请号：US14507455

申请日：2014-10-06

申请人： MERIAL LIMITED ,  Centre National De la Recherche Scientifique ,  Institut Gustave Roussy ,  Universite Paris-Sud

发明人： Herve Poulet ,  Thierry Heidmann

IPC分类号： C07K14/005 ,  C07K14/15 ,  C12N7/00 ,  C12N15/86 ,  A61K31/04 ,  A61K38/16 ,  A61K39/12 ,  A61K39/21 ,  A61K39/275 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K31/04 ,  A61K38/162 ,  A61K39/12 ,  A61K39/21 ,  A61K39/275 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/70 ,  A61K2300/00 ,  C07K14/15 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/24043 ,  C12N2710/24044 ,  C12N2740/13022 ,  C12N2740/13034 ,  C12N2800/22

摘要： The present invention provides vectors that contain and express in vivo or in vitro FeLV antigens that elicit an immune response in animal or human against FeLV, compositions comprising said vectors and/or FeLV polypeptides, methods of vaccination against FeLV, and kits for use with such methods and compositions.

公开(公告)号：US20170311601A1

公开(公告)日：2017-11-02

申请号：US15480316

申请日：2017-04-05

申请人： MERIAL INC.

发明人： Chunhua Yang ,  Loic Patrick Le Hir de Fallois ,  Charles Q. Meng ,  Alan Long ,  Roelof Johannes Gorter de Vries ,  Bruno Baillon ,  Sylvaine Lafont ,  Myriam Gay de Saint Michel ,  Stephane Kozlovic

IPC分类号： A01N43/80 ,  A01N43/42 ,  A61K31/42 ,  C07D261/04

CPC分类号： A01N43/80 ,  A01N43/42 ,  A61K31/42 ,  C07D261/04 ,  C07D453/04

摘要： This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.

公开(公告)号：US09776999B2

公开(公告)日：2017-10-03

申请号：US15191163

申请日：2016-06-23

申请人： MERIAL, INC.

发明人： Loic Patrick Le Hir de Fallois ,  Hyoung Ik Lee ,  Douglas Edward Wilkinson ,  Brent Christopher Beck

IPC分类号： A61K31/495 ,  A61K31/365 ,  C07D471/04 ,  A01N43/90 ,  A01N43/80 ,  A61K31/437 ,  A61K38/05 ,  A61K45/06 ,  C07K5/06

CPC分类号： C07D471/04 ,  A01N43/80 ,  A01N43/90 ,  A61K31/365 ,  A61K31/437 ,  A61K31/495 ,  A61K38/05 ,  A61K45/06 ,  C07K5/06 ,  A61K2300/00

摘要： The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R1, A1, A2, G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.