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公开(公告)号：US20090075933A1
公开(公告)日：2009-03-19
申请号：US11857878
申请日：2007-09-19
Applicant: Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
Inventor： Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
IPC: A61K31/715 , A61P9/00 , C07H1/00 , C12P19/04
CPC classification number: A61L27/52 , A61L27/20 , A61L27/3604 , A61L27/3641 , A61L27/365 , A61L27/3804 , A61L27/3839 , C08L5/04
Abstract: The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.
Abstract translation: 本发明涉及一种制备细胞相容性藻酸盐凝胶的方法及其在治疗心肌病中的应用。
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12.发明授权Drug delivery system and method of treatment of vascular diseases using photodynamic therapy 有权药物输送系统和使用光动力疗法治疗血管疾病的方法公开(公告)号：US09572795B2
公开(公告)日：2017-02-21
申请号：US13572507
申请日：2012-08-10
Applicant: Syed Hossainy , Dariush Davalian , Mikael Trollsas , John Stankus , Jinping Wan
Inventor： Syed Hossainy , Dariush Davalian , Mikael Trollsas , John Stankus , Yuet Mei Khong , Jinping Wan
IPC: A61M37/00 , A61K31/409 , A61K9/00 , A61K9/127 , A61K9/51 , A61L29/16 , A61K41/00 , A61M25/00 , A61M25/10
CPC classification number: A61K31/409 , A61K9/0009 , A61K9/0019 , A61K9/1272 , A61K9/5146 , A61K41/0071 , A61L29/16 , A61L2300/224 , A61L2300/626 , A61M25/0045 , A61M25/10 , A61M2025/105 , A61M2025/1086
Abstract: This invention relates to photodynamic therapy (PDT) of vulnerable plaque using two pluralities of nanoparticles, one plurality comprising a PDT agent that is sensitive to blue-green light wherein the nanoparticles are capable of penetrating only into the fibrous cap of the vulnerable plaque and one plurality comprising a PDT agent that is sensitive to red light wherein the nanoparticles are capable of penetrating into the core of the vulnerable plaque.
Abstract translation: 本发明涉及使用两种纳米颗粒的易损斑块的光动力疗法（PDT），其一个包括对蓝绿色光敏感的PDT剂，其中纳米颗粒仅能穿透易损斑块的纤维帽和一个 多个包含对红光敏感的PDT剂，其中纳米颗粒能够渗入易损斑块的核心。
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13.发明授权公开(公告)号：US08765162B2
公开(公告)日：2014-07-01
申请号：US12165173
申请日：2008-06-30
Applicant: Michael Huy Ngo , Mikael O. Trollsas , Thierry Glauser , Jinping Wan , Bozena Zofia Maslanka
Inventor： Michael Huy Ngo , Mikael O. Trollsas , Thierry Glauser , Jinping Wan , Bozena Zofia Maslanka
IPC: A61F2/02
CPC classification number: C08L77/12 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/62 , C08G69/44 , C08G69/48
Abstract: The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers.
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14.发明授权公开(公告)号：US08735344B2
公开(公告)日：2014-05-27
申请号：US13177476
申请日：2011-07-06
Applicant: Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
Inventor： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
CPC classification number: C07K14/775 , A61K38/00
Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.
Abstract translation: 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白A-I（Apo A-I）合成模拟肽的组合物引入所述特定区域的血管壁中，其中所述肽具有使所述肽在反向胆固醇转运中有效的性质。 一种包含载体载脂蛋白AI（Apo AI）合成肽或Apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列的顺序与各种Apo AI模拟肽或内源性Apo AI类似物的顺序相反，或内源Apo AI的螺旋1和螺旋9的嵌合体。
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15.发明授权Multiple growth factor compositions, methods of fabrication, and methods of treatment 失效多重生长因子组合物，制备方法和治疗方法公开(公告)号：US08703180B1
公开(公告)日：2014-04-22
申请号：US11877635
申请日：2007-10-23
Applicant: John J. Stankus , Florian N. Ludwig , Evgenia Mandrusov , Liangxuan Zhang , Hong Ma , Jinping Wan , Shubhayu Basu
Inventor： John J. Stankus , Florian N. Ludwig , Evgenia Mandrusov , Liangxuan Zhang , Hong Ma , Jinping Wan , Shubhayu Basu
CPC classification number: A61K38/30 , A61K9/06 , A61K9/127 , A61K35/34 , A61K38/18 , A61K38/1825 , A61K38/1833 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/193 , A61K38/57 , A61K45/06 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/604 , A61L2300/626 , A61L2430/20 , A61K2300/00
Abstract: Disclosed are compositions with sustained-release carriers associated with at least two different types of growth factors and methods of fabrication and treatments thereof. In some embodiments, simultaneous release of the growth factors may be preferred while in other embodiments, sequential release of the growth factors may be preferred. Application of at least two growth factors to an injury site, e.g., compromised cardiac tissue caused by, for example, myocardial infarction or ischemic heart failure, may better mimic and induce the complex growth factor signaling pathways necessary to improve cardiac function. When applied to a patient after a myocardial infarction or ischemic heart failure, multiple growth factors within a sustained-release carrier platform or platforms may cause a synergistic effect on injected cells intending to alleviate left ventricle remodeling. Methods of treatment include percutaneous, sub-xiphoid, and open chest methods using catheters and/or syringes.
Abstract translation: 公开了具有与至少两种不同类型的生长因子相关联的持续释放载体的组合物及其制备和处理方法。 在一些实施方案中，生长因子的同时释放可以是优选的，而在其它实施方案中，生长因子的顺序释放可能是优选的。 至少两个生长因子施加到损伤部位，例如由心肌梗塞或缺血性心力衰竭引起的受损的心脏组织可以更好地模拟和诱导改善心脏功能所必需的复合生长因子信号传导途径。 当在心肌梗死或缺血性心力衰竭后应用于患者时，持续释放载体平台或平台内的多个生长因子可能对旨在减轻左心室重塑的注射细胞产生协同效应。 治疗方法包括使用导管和/或注射器的经皮，亚剑虫和胸部开胸方法。
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Patent Agency Ranking
公开(公告)号：US20130122097A1
公开(公告)日：2013-05-16
申请号：US13518811
申请日：2010-12-22
Applicant: Corinne Bright , Jinping Wan , Martin Babler , Ayse Zamboglu
Inventor： Corinne Bright , Jinping Wan , Martin Babler , Ayse Zamboglu
CPC classification number: A61K9/16 , A61K9/0012 , A61K9/0014 , A61K9/0024 , A61K9/146 , A61K9/1641 , A61K9/1647 , A61K31/137 , A61K45/06
Abstract: Described here are various compositions for the delivery active agents, e.g., antifungal agents. The compositions may be beneficial due to the particular release kinetics associated with them. Various locations and methods for placement of the compositions into the tissues of the nail unit, as well as tissues surrounding the nail unit are also described.
Abstract translation: 这里描述了用于递送活性剂，例如抗真菌剂的各种组合物。 由于与它们相关的特定释放动力学，组合物可能是有益的。 还描述了将组合物放置在指甲单元的组织中以及围绕钉单元的组织的各种位置和方法。
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公开(公告)号：US08221744B2
公开(公告)日：2012-07-17
申请号：US11857878
申请日：2007-09-19
Applicant: Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
Inventor： Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
CPC classification number: A61L27/52 , A61L27/20 , A61L27/3604 , A61L27/3641 , A61L27/365 , A61L27/3804 , A61L27/3839 , C08L5/04
Abstract: The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.
Abstract translation: 本发明涉及一种制备细胞相容性藻酸盐凝胶的方法及其在治疗心肌病中的应用。
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18.发明申请公开(公告)号：US20110262530A1
公开(公告)日：2011-10-27
申请号：US13177476
申请日：2011-07-06
Applicant: KATSUYUKI MURASE , LI ZHAO , IRINA ASTAFIEVA , PAUL M. CONSIGNY , STEPHEN D. PACETTI , DARIUSH DAVALIAN , SYED FAYAIZ AHMED HOSSAINY , FLORIAN N. LUDWIG , JINPING WAN , JOHN STANKUS , RACHEL BRIGHT
Inventor： KATSUYUKI MURASE , LI ZHAO , IRINA ASTAFIEVA , PAUL M. CONSIGNY , STEPHEN D. PACETTI , DARIUSH DAVALIAN , SYED FAYAIZ AHMED HOSSAINY , FLORIAN N. LUDWIG , JINPING WAN , JOHN STANKUS , RACHEL BRIGHT
CPC classification number: C07K14/775 , A61K38/00
Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.
Abstract translation: 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白A-I（Apo A-I）合成模拟肽的组合物引入所述特定区域的血管壁中，其中所述肽具有使所述肽在反向胆固醇转运中有效的性质。 一种包含载体载脂蛋白AI（Apo AI）合成肽或Apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列的顺序与各种Apo AI模拟肽或内源性Apo AI类似物的顺序相反，或内源Apo AI的螺旋1和螺旋9的嵌合体。
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19.发明授权公开(公告)号：US08044021B2
公开(公告)日：2011-10-25
申请号：US11946029
申请日：2007-11-27
Applicant: Syed F. A. Hossainy , Jinping Wan , Dariush Davalian , Florian Ludwig , Katsuyuki Murase
Inventor： Syed F. A. Hossainy , Jinping Wan , Dariush Davalian , Florian Ludwig , Katsuyuki Murase
CPC classification number: A61K31/661 , A61K9/1647 , A61K9/5084 , A61K38/00
Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
Abstract translation: 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质 胆固醇运输。 包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。
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公开(公告)号：US20100100169A1
公开(公告)日：2010-04-22
申请号：US11809045
申请日：2007-05-30
Applicant: Syed F. A. Hossainy , Dariush Davalian , Jinping Wan , Troy Carter , Charles Silvis , Fozan El-Nounou
Inventor： Syed F. A. Hossainy , Dariush Davalian , Jinping Wan , Troy Carter , Charles Silvis , Fozan El-Nounou
CPC classification number: B05D1/18 , A61F2/82 , A61F2250/0067 , A61L31/022 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2300/624 , A61L2400/12 , B05D3/101 , B05D2401/32 , B05D2602/00
Abstract: A method of modifying a medical device such as a stent with nano-constructs is disclosed. The method comprises applying a first fluid to the stent; immersing the stent being wet from the first fluid into a second fluid having a suspension of nano-constructs; and removing the stent from the second fluid and allowing the first and second fluid to be removed such that the nano-constructs are carried by the stent for in vivo application of the constructs to a target location of a mammalian subject. The nano-constructs can be attached to the surface of the stent, can be attached to a surface of the coating of the stent, can be embedded into the stent, or can be embedded into the coating.
Abstract translation: 公开了一种用纳米结构修饰诸如支架的医疗装置的方法。 该方法包括将第一流体施加到支架上; 将从第一流体湿润的支架浸入具有纳米结构物悬浮液的第二流体中; 以及从所述第二流体移除所述支架并且允许所述第一和第二流体被移除，使得所述纳米构建体由所述支架携带，用于体内施用所述构建体到哺乳动物受试者的目标位置。 纳米结构可以连接到支架的表面，可以附着在支架的涂层表面，可以嵌入到支架中，或者可以嵌入到涂层中。
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