公开(公告)号：US20030100119A1

公开(公告)日：2003-05-29

申请号：US10269362

申请日：2002-10-11

Applicant: Symyx Technologies, Inc.

Inventor： W. Henry Weinberg ,  Eric McFarland ,  Isy Goldwasser ,  Thomas Boussie ,  Howard Turner ,  Johannes A.M. Van Beek ,  Vince Murphy ,  Tim Powers

IPC: G01N001/10

CPC classification number: G01N29/348 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/0075 ,  B01J2219/00754 ,  C07F15/0066 ,  C07F15/045 ,  C08F10/00 ,  C08F110/02 ,  C40B40/18 ,  C40B60/14 ,  G01N29/0681 ,  G01N29/2418 ,  G01N2291/106 ,  Y10T436/2575 ,  C08F4/7006 ,  C08F4/027 ,  C08F2500/03 ,  C08F4/7081

Abstract: The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.

Abstract translation: 本发明尤其涉及有机金属化合物和催化剂（例如均相催化剂）的合成，筛选和表征的方法。 本发明的方法提供了负载和未负载的有机金属化合物和催化剂（例如均相催化剂）的文库的组合合成，筛选和表征。 本发明的方法可用于大量有机金属化合物的制备和筛选，所述有机金属化合物不仅可用作催化剂（例如均相催化剂），而且可用作添加剂和治疗剂。

公开(公告)号：US20020155036A1

公开(公告)日：2002-10-24

申请号：US10134556

申请日：2002-04-29

Applicant: Symyx Technologies, Inc.

Inventor： Damian A. Hajduk ,  Ralph B. Nielsen ,  Adam Safir ,  Leonid Matsiev ,  Eric McFarland ,  Paul Mansky

IPC: B01J019/00

CPC classification number: B01F15/00207 ,  B01F13/065 ,  B01F13/08 ,  B01F15/00357 ,  B01F15/00396 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  F28D15/00 ,  F28D2021/0077 ,  F28F27/00 ,  G01K13/00 ,  G01N21/253 ,  Y10T436/10 ,  Y10T436/11 ,  Y10T436/25

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

Abstract translation: 公开了一种用于实施和监测多重反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的​​装置。 单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。

公开(公告)号：US20020137845A1

公开(公告)日：2002-09-26

申请号：US09992760

申请日：2001-11-06

Applicant: Symyx Technologies, Inc.

Inventor： Thomas R. Boussie ,  Gary M. Diamond ,  Christopher Goh ,  Keith A. Hall ,  Anne M. LaPointe ,  Margarete K. Leclerc ,  Cheryl Lund ,  Vince Murphy

IPC: C08F004/44

CPC classification number: C07D213/74 ,  B01J2219/00722 ,  C07B2200/11 ,  C07D213/38 ,  C07D213/61 ,  C07D213/68 ,  C07F7/00 ,  C07F7/003 ,  C07F9/58 ,  C08F4/65908 ,  C08F4/65912 ,  C08F10/00 ,  C08F110/06 ,  C08F210/02 ,  C08F210/16 ,  C40B40/14 ,  C08F4/659 ,  C08F4/65904 ,  C08F2500/15 ,  C08F2500/02 ,  C08F210/10 ,  C08F212/08 ,  C08F210/14 ,  C08F4/64144 ,  C08F4/64113 ,  C08F4/64044

Abstract: New ligands, compositions, metal-ligand complexes and arrays with pyridyl-amine ligands are disclosed that catalyze the polymerization of monomers into polymers. Certain of these catalysts with hafnium metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, isobutylene or styrene. Certain of the catalysts are particularly effective at polymerizing propylene to high molecular weight isotactic polypropylene in a solution process at a variety of polymerization conditions.

Abstract translation: 公开了新配体，组合物，金属 - 配体络合物和具有吡啶基 - 胺配体的阵列，其催化单体聚合成聚合物。 这些具有铪金属中心的这些催化剂中的某些具有高性能特征，包括较高的共聚单体引入到乙烯/烯烃共聚物中，其中这种烯烃是例如1-辛烯，异丁烯或苯乙烯。 某些催化剂在各种聚合条件下在溶液过程中将丙烯聚合成高分子量全同立构聚丙烯是特别有效的。

公开(公告)号：US20020127146A1

公开(公告)日：2002-09-12

申请号：US10092364

申请日：2002-03-06

Applicant: Symyx Technologies, Inc.

Inventor： H. Sam Bergh ,  Daniel M. Pinkas

IPC: B01J019/00 ,  G01N030/02 ,  B01L003/00

CPC classification number: F16K99/0001 ,  F15C5/00 ,  F16K7/14 ,  F16K27/003 ,  F16K99/0015 ,  F16K99/0059 ,  F16K2099/0076 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N30/20 ,  G01N2030/205 ,  Y10T436/2575

Abstract: A novel gas injection valve for injecting discrete charges of gas into a mobile phase or carrier stream is provided. Injection valves of the invention comprise a plurality of microvalves capable of receiving gas at different pressures and emitting discrete charges of gas at approximately the same pressure. The invention further provides for parallel injection valve arrays capable of injecting multiple samples substantially simultaneously and a method of injecting discrete gas samples at a controlled pressure to a high-resolution gas chromatograph.

Abstract translation: 提供了一种用于将离散的气体注入流动相或载流子的新颖的气体注入阀。 本发明的注射阀包括能够接收不同压力的气体并以大致相同的压力发射离散的气体的多个微型阀。 本发明还提供了能够基本上同时喷射多个样品的平行喷射阀阵列以及将受控压力的离散气体样品注入高分辨率气相色谱仪的方法。

公开(公告)号：US20020110493A1

公开(公告)日：2002-08-15

申请号：US10040988

申请日：2002-01-07

Applicant: Symyx Technologies , Inc

Inventor： G. Cameron Dales ,  Gary Diamond ,  Trevor G. Frank ,  J. Christopher Freitag ,  Kenneth S. Higashihara ,  Dave Huffman ,  Jonah R. Troth

IPC: B01L003/02

CPC classification number: B01F7/167 ,  B01F7/00258 ,  B01F7/00266 ,  B01F7/00291 ,  B01F7/00416 ,  B01F7/00575 ,  B01F13/065 ,  B01F13/08 ,  B01F15/00207 ,  B01F15/00357 ,  B01F15/00396 ,  B01F2215/0037 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00337 ,  B01J2219/00342 ,  B01J2219/00351 ,  B01J2219/00353 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00466 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00497 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  C40B60/14 ,  F28F27/00 ,  G01K13/00 ,  G01N1/2226 ,  G01N21/253 ,  G01N35/0099 ,  G01N35/1004 ,  G01N35/1079 ,  G01N2035/00514 ,  G01N2035/0406 ,  Y10T436/2575

Abstract: A cannula for use in transferring small volumes of fluid materials, such as in a parallel reaction process. The cannula comprises a long thin needle having various end (port) configurations, and an adapter for connecting the needle to a fluid line. The adapter may include the combination of a reservoir and transition, or simply a transition.

Abstract translation: 用于转移少量流体材料的插管，例如在平行的反应过程中。 套管包括具有各种端部（端口）构造的长细针，以及用于将针连接到流体管线的适配器。 适配器可以包括储存器和转换器的组合，或简单地转换。

公开(公告)号：US20010033375A1

公开(公告)日：2001-10-25

申请号：US09874758

申请日：2001-06-05

Applicant: Symyx Technologies, Inc.

Inventor： Eric W. McFarland ,  Earl Danielson ,  William Archibald

IPC: G01N021/21

CPC classification number: G01N21/6402 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00583 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00621 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00722 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/0075 ,  B01J2219/00754 ,  B82Y30/00 ,  C07F15/0066 ,  C07F15/045 ,  C08F10/00 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/14 ,  G01J4/00 ,  G01N21/6452 ,  G01N29/036 ,  G01N29/2418 ,  G01N29/348 ,  G01N29/4427 ,  G01N2291/106 ,  C08F4/70

Abstract: Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or optimize new materials with specific desired properties are provided. The substrate can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems and methods are provided for screening a library of magnetic materials for their bulk magnetization, saturation magnetization, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions. Optical or visible luminescence systems are also provided as well as their application to screening libraries of different materials.

Abstract translation: 提供了筛选各种材料阵列的方法和装置。 特别地，提供了用于快速表征材料阵列中的化合物以发现和/或优化具有特定期望性质的新材料的技术。 对于具有有用性质的材料，可以对基材进行筛选，和/或可以对所得到的材料进行相对于有用性质或其它特性的相对性能的评价或以其它方式比较。 特别地，提供了系统和方法，用于通过对其单独的光学克尔旋转进行成像来筛选磁性材料库的体积磁化，饱和磁化强度和矫顽力，通过对其介电系数进行成像来筛选介电材料库， 通过在各种激发条件下成像其各自的发光性质来旋转和筛选发光材料库。 还提供光学或可见发光系统以及其应用于筛选不同材料的文库。

公开(公告)号：US20040261897A1

公开(公告)日：2004-12-30

申请号：US10860113

申请日：2004-06-03

Applicant: Symyx Technologies, Inc.

Inventor： Eric Carlson ,  Li Song ,  Daniel M. Pinkas ,  Claus G. Lugmair

IPC: B67C003/00

CPC classification number: B01F15/0445 ,  B01F3/188 ,  B01F13/0272 ,  B01F13/1055 ,  B01F15/0258 ,  B01F2015/0221 ,  B01F2215/0037 ,  B65B1/16 ,  B65B1/30 ,  G01G13/24

Abstract: Method for preparing a mixed powder sample by mixing two or more different powders comprising transferring a quantity of a first powder to a mixing vessel and transferring a quantity of a second powder to the mixing vessel to form a powder bed in the mixing vessel comprising the first and second powders. The quantities of the powders are selected so the mixed sample has a predetermined ratio of first powder to second powder. The powder bed is fluidized to mix the powders and produce a mixed sample. The mixed sample weighs about 5 grams or less. The invention also includes apparatus for preparing mixed powder samples by mixing two or more different powders.

公开(公告)号：US20040250622A1

公开(公告)日：2004-12-16

申请号：US10804379

申请日：2004-03-19

Applicant: Symyx Technologies, Inc.

Inventor： Oleg Kolosov ,  Leonid Matsiev ,  John F. Varni ,  G. Cameron Dales

IPC: G01N024/00

CPC classification number: G01N29/222 ,  C09D5/008 ,  G01F23/2967 ,  G01F23/2968 ,  G01N9/002 ,  G01N11/16 ,  G01N29/036 ,  G01N2291/02836 ,  G01N2291/02872 ,  G01N2291/0427

Abstract: An improved method and assembly, wherein the method generally includes the steps of providing a coated or uncoated sensor element having an exposed sensing surface; attaching the sensor element to a platform so that the exposed sensing surface is spaced from the platform; and optionally applying a protective layer over the platform while maintaining the sensing surface as exposed. The assembly includes a resonator having a free portion with a sensing surface is incorporated onto a platform, components of the sensor are physically shielded from harsh operating conditions, the requisite space is maintained between the free portion of the resonator and the platform, and the sensing surface of the resonator remains exposed for sensing.

Abstract translation: 一种改进的方法和组件，其中所述方法通常包括以下步骤：提供具有暴露的感测表面的涂覆或未涂覆的传感器元件; 将传感器元件附接到平台，使得暴露的感测表面与平台间隔开; 并且可选地在平台上施加保护层，同时保持感测表面暴露。 该组件包括具有感测表面的自由部分的谐振器被并入到平台上，传感器的部件在物理上不受恶劣的操作条件的影响，在谐振器的自由部分和平台之间保持必要的空间，并且感测 谐振器的表面保持暴露以进行感测。

公开(公告)号：US20040177707A1

公开(公告)日：2004-09-16

申请号：US10811619

申请日：2004-03-29

Applicant: Symyx Technologies, Inc.

Inventor： Paul Mansky

IPC: C08L001/00

CPC classification number: G01N33/442 ,  B01J2219/00274 ,  B01J2219/00495 ,  B01J2219/00691 ,  B01J2219/00693 ,  B01J2219/00707 ,  B01J2219/00722 ,  C40B40/14 ,  C40B60/14 ,  G01N3/02 ,  G01N19/02 ,  G01N2203/0222 ,  G01N2203/0286

Abstract: A library of materials is screened for mechanical properties such as strength, tack or other properties. A library of materials is provided. A stimulus such as a stress or force is provided to each member of the library. A response (e.g., a strain) of each of the materials due to the stimulus is measured and the response, the stimulus or both are recorded and related to provide data. Thereafter, the data is analyzed to reach conclusions regarding properties of the material samples.

Abstract translation: 对材料库筛选机械性能，如强度，粘性或其他性能。 提供材料库。 向图书馆的每个成员提供诸如压力或力量的刺激。 测量由于刺激引起的每种材料的响应（例如，应变），并且响应，刺激或两者被记录并且相关以提供数据。 此后，分析数据以得出关于材料样品的性质的结论。

公开(公告)号：US20040123650A1

公开(公告)日：2004-07-01

申请号：US10663141

申请日：2003-09-16

Applicant: Symyx Technologies, Inc.

Inventor： Oleg Kolosov ,  Leonid Matsiev

IPC: G01N011/14 ,  G01N011/00

CPC classification number: G01N35/028 ,  G01N11/14

Abstract: The present invention provides systems and methods for screening a library of material samples for a rheological property such as viscosity or elasticity. Accordingly, a library of material samples is can be provided in a substantially liquid form. The library is contacted with at least one probe for applying a stimulus to the material samples such as by moving the at least one probe within the samples. A response such as resistance to the motion of the probe is monitored and can be related to a rheological property of the samples.

Abstract translation: 本发明提供用于筛选材料样品库的流变性质如粘度或弹性的系统和方法。 因此，材料样本库可以以基本上液体的形式提供。 将文库与至少一个探针接触，以对材料样品施加刺激，例如通过移动样品中的至少一个探针。 监测对诸如探针的运动的抵抗力的响应，并且可以与样品的流变性相关。