公开(公告)号：US20060257543A1

公开(公告)日：2006-11-16

申请号：US11349041

申请日：2006-02-06

Applicant: Catherine Tachdjian ,  Andrew Patron ,  Marketa Lebl-Rinnova ,  Xiao-Qing Tang ,  Vincent Darmohusodo ,  Chad Priest

Inventor： Catherine Tachdjian ,  Andrew Patron ,  Marketa Lebl-Rinnova ,  Xiao-Qing Tang ,  Vincent Darmohusodo ,  Chad Priest

IPC: A23L1/22

CPC classification number: A23L27/2056 ,  A23L27/20 ,  A23L27/2022 ,  A23L27/203 ,  A23L27/204 ,  A23L27/2052 ,  A23L27/2054

Abstract: The inventions disclosed herein relate to genuses of non-naturally occurring small molecule compounds which comprise two or optionally three organic moieties of limited size “linked” by certain structurally related “linker” functional groups. Suitable linker groups include ester, amine, ether, keto, imino, thioamide, thioether, sulfonamide, sulfonate ester, sulfone, guanidine, and thiourea groups. The compounds are capable, when contacted with comestible food or drinks or pharmaceutical compositions, at concentrations preferably on the order of about 100 ppm or lower, of serving as savory (“umami”) or sweet taste modifiers, savory or sweet flavoring agents and savory or sweet flavor enhancers, for use in foods, beverages, and other comestible or orally administered medicinal products or compositions, optionally in the presence of or in mixtures with conventional flavoring agents such as monosodium glutamate or known natural or artificial sweeteners.

Abstract translation: 本文公开的发明涉及非天然存在的小分子化合物的基因，其包含两个或任选的三个有限部分的有限部分，其通过某些结构相关的“连接体”官能团“连接”。 合适的连接基团包括酯，胺，醚，酮，亚氨基，硫代酰胺，硫醚，磺酰胺，磺酸酯，砜，胍和硫脲基团。 当与可食食品或饮料或药物组合物接触浓度优选为约100ppm或更低的浓度时，化合物能够作为咸味（“鲜味”）或甜味调味剂，美味或甜味调味剂和咸味 或甜味增味剂，用于食品，饮料和其它可食用或口服给药的药物产品或组合物中，任选在常规调味剂如谷氨酸钠或已知天然或人造甜味剂存在下或与之混合。

公开(公告)号：US06936638B2

公开(公告)日：2005-08-30

申请号：US10741595

申请日：2003-12-19

Applicant: Soumitra S. Ghosh ,  Yazhong Pei ,  Xiao-Qing Tang ,  Spiros J. Liras ,  Michael K. Ahlijanian

Inventor： Soumitra S. Ghosh ,  Yazhong Pei ,  Xiao-Qing Tang ,  Spiros J. Liras ,  Michael K. Ahlijanian

IPC: A61K31/185 ,  A61P25/00 ,  C07C65/24 ,  C07C65/30 ,  C07C65/40 ,  C07C69/94 ,  C07D263/56 ,  C07D263/57 ,  C07D277/66 ,  C07D307/80 ,  C07D333/16 ,  C07D333/24 ,  C07D333/56 ,  C07D333/60 ,  A61K31/19 ,  C07D313/04

CPC classification number: C07D263/57 ,  A61K31/185 ,  C07C65/24 ,  C07C65/30 ,  C07C65/40 ,  C07C69/94 ,  C07D277/66 ,  C07D307/80 ,  C07D333/16 ,  C07D333/24 ,  C07D333/56 ,  C07D333/60

Abstract: Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds have the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.

Abstract translation: 可用于治疗与改变的线粒体功能相关的病症的化合物。 所述化合物具有以下结构（I）：包括其立体异构体，前药和药学上可接受的盐，其中R 1，R 2，R 3， >，R 4，R 5和R 6如本文所定义。 还公开了含有结构（I）化合物的药物组合物以及与其用途有关的方法。

公开(公告)号：US20130041046A1

公开(公告)日：2013-02-14

申请号：US13572237

申请日：2012-08-10

Applicant: Catherine TACHDJIAN ,  Xiao Qing TANG ,  Donald S. KARANEWSKY ,  Guy SERVANT ,  Xiaodong LI ,  Feng ZHANG ,  Qing CHEN ,  Hong ZHANG ,  Timothy James DAVIS ,  Vincent DARMOHUSODO ,  Melissa Sue WONG ,  Victor SELCHAU

Inventor： Catherine TACHDJIAN ,  Xiao Qing TANG ,  Donald S. KARANEWSKY ,  Guy SERVANT ,  Xiaodong LI ,  Feng ZHANG ,  Qing CHEN ,  Hong ZHANG ,  Timothy James DAVIS ,  Vincent DARMOHUSODO ,  Melissa Sue WONG ,  Victor SELCHAU

IPC: A23L1/236 ,  A61K47/22 ,  A23L2/60 ,  C07D401/12 ,  C07D413/12 ,  C07D471/08 ,  C07D215/42 ,  C07D405/12

CPC classification number: C07D405/12 ,  A23L2/60 ,  A23L27/88 ,  A23V2002/00 ,  A61K47/22 ,  C07D215/42 ,  C07D215/54 ,  C07D401/12 ,  C07D451/06

Abstract: The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.

公开(公告)号：US20120201763A1

公开(公告)日：2012-08-09

申请号：US13336272

申请日：2011-12-23

Applicant: Catherine Tachdjian ,  Andrew P. Patron ,  Sara L. Adamski-Werner ,  Farid Bakir ,  Qing Chen ,  Vincent Darmohusodo ,  Stephen Terrence Hobson ,  Xiaodong Li ,  Ming Qi ,  Daniel H. Rogers ,  Marketa Rinnova ,  Guy Servant ,  Xiao-Qing Tang ,  Mark Zoller ,  Daivd Wallace ,  Amy Xing ,  Klaus Gubernator

Inventor： Catherine Tachdjian ,  Andrew P. Patron ,  Sara L. Adamski-Werner ,  Farid Bakir ,  Qing Chen ,  Vincent Darmohusodo ,  Stephen Terrence Hobson ,  Xiaodong Li ,  Ming Qi ,  Daniel H. Rogers ,  Marketa Rinnova ,  Guy Servant ,  Xiao-Qing Tang ,  Mark Zoller ,  Daivd Wallace ,  Amy Xing ,  Klaus Gubernator

IPC: A61K8/49 ,  C07D317/68 ,  C07F9/655 ,  C07C235/46 ,  C07D405/12 ,  C07D319/18 ,  C07D321/10 ,  C07D307/85 ,  C07D263/56 ,  C07D241/24 ,  A61K8/55 ,  A61K8/42 ,  A61K47/22 ,  A61K47/24 ,  A61K47/18 ,  A61Q11/00 ,  A23L1/226

CPC classification number: G01N33/543 ,  A23L2/56 ,  A23L27/202 ,  A23L27/203 ,  A23L27/2054 ,  A23L27/88 ,  A23V2002/00 ,  A61K8/4973 ,  A61K8/55 ,  A61K47/22 ,  A61K47/24 ,  C07C233/65 ,  C07C235/54 ,  C07C275/30 ,  C07C275/34 ,  C07D307/84 ,  C07D317/68 ,  C07D405/12 ,  C07F9/65517 ,  G01N33/5041 ,  G01N33/566 ,  G01N33/74 ,  G01N2333/726

Abstract: The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, —savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

Abstract translation: 本发明涉及某些非天然存在的非肽酰胺化合物和酰胺衍生物，例如草酰胺，脲和丙烯酰胺，是有用的风味或调味剂，例如调味剂或调味剂和风味或味道 增强剂，更特别地，用于食品，饮料和其它可食用或口服给药的药物产品或组合物的美味（味道味道）或甜味调节剂，美味或甜味调味剂和咸味或甜味增味剂。

公开(公告)号：US08124121B2

公开(公告)日：2012-02-28

申请号：US12257017

申请日：2008-10-23

Applicant: Catherine Tachdjian ,  Andrew P. Patron ,  Sara L. Adamski-Werner ,  Farid Bakir ,  Qing Chen ,  Vincent Darmohusodo ,  Stephen Terrence Hobson ,  Xiaodong Li ,  Ming Qi ,  Daniel H. Rogers ,  Marketa Rinnova ,  Guy Servant ,  Xiao-Qing Tang ,  Mark Zoller ,  David Wallace ,  Amy Xing ,  Klaus Gubernator

Inventor： Catherine Tachdjian ,  Andrew P. Patron ,  Sara L. Adamski-Werner ,  Farid Bakir ,  Qing Chen ,  Vincent Darmohusodo ,  Stephen Terrence Hobson ,  Xiaodong Li ,  Ming Qi ,  Daniel H. Rogers ,  Marketa Rinnova ,  Guy Servant ,  Xiao-Qing Tang ,  Mark Zoller ,  David Wallace ,  Amy Xing ,  Klaus Gubernator

IPC: A61K47/00 ,  A61K31/4965

CPC classification number: G01N33/543 ,  A23L2/56 ,  A23L27/202 ,  A23L27/203 ,  A23L27/2054 ,  A23L27/88 ,  A23V2002/00 ,  A61K8/4973 ,  A61K8/55 ,  A61K47/22 ,  A61K47/24 ,  C07C233/65 ,  C07C235/54 ,  C07C275/30 ,  C07C275/34 ,  C07D307/84 ,  C07D317/68 ,  C07D405/12 ,  C07F9/65517 ,  G01N33/5041 ,  G01N33/566 ,  G01N33/74 ,  G01N2333/726

Abstract: The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, —savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

Abstract translation: 本发明涉及某些非天然存在的非肽酰胺化合物和酰胺衍生物，例如草酰胺，脲和丙烯酰胺，是有用的风味或调味剂，例如调味剂或调味剂和风味或味道 增强剂，更特别地，用于食品，饮料和其它可食用或口服给药的药物产品或组合物的美味（味道味道）或甜味调节剂，美味或甜味调味剂和咸味或甜味增味剂。

公开(公告)号：US20120041078A1

公开(公告)日：2012-02-16

申请号：US13208594

申请日：2011-08-12

Applicant: Catherine TACHDJIAN ,  Donald S. Karanewsky ,  Xiao-Qing Tang ,  Hanghui Liu

Inventor： Catherine TACHDJIAN ,  Donald S. Karanewsky ,  Xiao-Qing Tang ,  Hanghui Liu

IPC: A61K47/22 ,  A23L1/236 ,  A61K47/30

CPC classification number: A23L1/22678 ,  A23L2/56 ,  A23L27/2054 ,  A23L27/88 ,  A23V2002/00 ,  A61K47/22 ,  A61K47/26

Abstract: The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.

Abstract translation: 本发明包括当一种或多种增甜剂暴露于光源时稳定一种或多种甜味增强剂的方法以及含有一种或多种甜味增强剂和一种或多种光稳定剂的液体组合物。

公开(公告)号：US20110230502A1

公开(公告)日：2011-09-22

申请号：US13051586

申请日：2011-03-18

Applicant: Catherine TACHDJIAN ,  Xiao-Qing Tang ,  Sara Werner ,  Marketa Rinnova ,  Qing Chen ,  Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Haitian Liu ,  Albert Zlotnik ,  Mark Zoller ,  Boris Klebansky ,  Richard Fine ,  Xinshan Kang

Inventor： Catherine TACHDJIAN ,  Xiao-Qing Tang ,  Sara Werner ,  Marketa Rinnova ,  Qing Chen ,  Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Haitian Liu ,  Albert Zlotnik ,  Mark Zoller ,  Boris Klebansky ,  Richard Fine ,  Xinshan Kang

IPC: A61K31/519 ,  A61K31/522 ,  A61K31/437 ,  A61K31/4355 ,  A61K31/4365 ,  A61P27/00

CPC classification number: C07D513/04 ,  A23L2/39 ,  A23L2/60 ,  A23L27/30 ,  A23L27/31 ,  A23L27/33 ,  A23L27/34 ,  A23L27/88 ,  C07D215/42 ,  C07D215/54 ,  C07D215/56 ,  C07D239/70 ,  C07D239/84 ,  C07D239/94 ,  C07D239/95 ,  C07D285/16 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/056 ,  C07D493/04 ,  C07D495/04 ,  C07D495/14 ,  C07D513/20 ,  G01N33/566

Abstract: The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

Abstract translation: 本发明提供了用于鉴定化学感受器及其配体的调节剂的筛选方法，例如通过确定测试实体是否适合与化学感应受体的金星蝇捕获结构域内的一个或多个相互作用位点相互作用，以及能调节 化学感受器及其配体。

公开(公告)号：US07842324B2

公开(公告)日：2010-11-30

申请号：US11455314

申请日：2006-06-15

Applicant: Catherine Tachdjian ,  Andrew P. Patron ,  Farid Bakir ,  Claudia Averbuj ,  Chad Priest ,  Sara L. Adamski-Werner ,  Qing Chen ,  Vincent Darmohusodo ,  Marketa Lebl-Rinnova ,  Rachel D. A. Kimmich ,  Xiao-Qing Tang ,  Rhondi Shigemura

Inventor： Catherine Tachdjian ,  Andrew P. Patron ,  Farid Bakir ,  Claudia Averbuj ,  Chad Priest ,  Sara L. Adamski-Werner ,  Qing Chen ,  Vincent Darmohusodo ,  Marketa Lebl-Rinnova ,  Rachel D. A. Kimmich ,  Xiao-Qing Tang ,  Rhondi Shigemura

IPC: A23L1/236

CPC classification number: A23L2/39 ,  A23G3/36 ,  A23G9/32 ,  A23L7/122 ,  A23L27/204 ,  A23L27/205 ,  A23L27/30 ,  A23V2002/00 ,  C07C233/11 ,  C07C233/22 ,  C07C235/34 ,  C07C235/78 ,  C07C237/20 ,  C07C255/57 ,  C07C271/22 ,  C07D213/30 ,  C07D213/85 ,  C07D239/26 ,  C07D241/24 ,  C07D307/52 ,  C07D307/54 ,  C07D333/24 ,  A23V2200/16

Abstract: The inventions disclosed herein relate to man-made bi-aromatic amide compounds that, when contacted with comestible food or drinks or pharmaceutical compositions at concentrations preferably on the order of about 100 ppm or lower, serve as sweet taste modifiers, sweet flavoring agents, or sweet flavor enhancers, for use in foods, beverages, and other comestible products, or orally administered medicinal products or compositions, optionally in the presence of or in mixtures with conventional flavoring agents such as known natural saccharide sweeteners and previously known artificial sweeteners.

Abstract translation: 本文公开的本发明涉及人造双芳族酰胺化合物，当与可食食品或饮料或药物组合物以优选约100ppm或更低的量级的浓度接触时，可用作甜味调味剂，甜味调味剂或 用于食品，饮料和其他可食用产品的甜味增味剂或任选在常规调味剂如已知天然糖甜味剂和先前已知的人造甜味剂存在下或与之混合的口服药物或组合物。

公开(公告)号：US20090111834A1

公开(公告)日：2009-04-30

申请号：US12257017

申请日：2008-10-23

Applicant: Catherine Tachdjian ,  Andrew P. Patron ,  Sara L. Adamski-Werner ,  Farid Bakir ,  Qing Chen ,  Vincent Darmohusodo ,  Stephen Terrence Hobson ,  Xiaodong Li ,  Ming Qi ,  Daniel Harry Rogers ,  Marketa Rinnova ,  Guy Servant ,  Xiao-Qing Tang ,  Mark Zoller ,  David Wallace ,  Amy Xing ,  Klaus Gubernator

Inventor： Catherine Tachdjian ,  Andrew P. Patron ,  Sara L. Adamski-Werner ,  Farid Bakir ,  Qing Chen ,  Vincent Darmohusodo ,  Stephen Terrence Hobson ,  Xiaodong Li ,  Ming Qi ,  Daniel Harry Rogers ,  Marketa Rinnova ,  Guy Servant ,  Xiao-Qing Tang ,  Mark Zoller ,  David Wallace ,  Amy Xing ,  Klaus Gubernator

IPC: A61K31/4965 ,  A23L1/22 ,  A61K31/44 ,  C07D213/56 ,  C07D241/00 ,  C07D239/02 ,  C07C237/00 ,  A61K31/505

CPC classification number: G01N33/543 ,  A23L2/56 ,  A23L27/202 ,  A23L27/203 ,  A23L27/2054 ,  A23L27/88 ,  A23V2002/00 ,  A61K8/4973 ,  A61K8/55 ,  A61K47/22 ,  A61K47/24 ,  C07C233/65 ,  C07C235/54 ,  C07C275/30 ,  C07C275/34 ,  C07D307/84 ,  C07D317/68 ,  C07D405/12 ,  C07F9/65517 ,  G01N33/5041 ,  G01N33/566 ,  G01N33/74 ,  G01N2333/726

Abstract: The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, —savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

Abstract translation: 本发明涉及某些非天然存在的非肽酰胺化合物和酰胺衍生物，例如草酰胺，脲和丙烯酰胺，是有用的风味或调味剂，例如调味剂或调味剂和风味或味道 增强剂，更特别地，用于食品，饮料和其它可食用或口服给药的药物产品或组合物的美味（味道味道）或甜味调节剂，美味或甜味调味剂和咸味或甜味增味剂。

公开(公告)号：US20080306053A1

公开(公告)日：2008-12-11

申请号：US11836074

申请日：2007-08-08

Applicant: Catherine Tachdjian ,  Xiao-Qing Tang ,  Sara Werner ,  Marketa Rinnova ,  Qing Chen ,  Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Haitian Liu ,  Albert Zlotnik ,  Mark Zoller ,  Boris Klebansky ,  Richard Fine ,  Xinshan Kang

Inventor： Catherine Tachdjian ,  Xiao-Qing Tang ,  Sara Werner ,  Marketa Rinnova ,  Qing Chen ,  Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Haitian Liu ,  Albert Zlotnik ,  Mark Zoller ,  Boris Klebansky ,  Richard Fine ,  Xinshan Kang

IPC: A61K31/549 ,  C07D491/04 ,  C07D239/78 ,  C07D487/04 ,  C07D285/16 ,  C07D471/04 ,  A61K31/47 ,  C07D239/00 ,  C07D215/20 ,  A61K31/519 ,  A61K31/517 ,  A61K31/4985

CPC classification number: C07D513/04 ,  A23L2/39 ,  A23L2/60 ,  A23L27/30 ,  A23L27/31 ,  A23L27/33 ,  A23L27/34 ,  A23L27/88 ,  C07D215/42 ,  C07D215/54 ,  C07D215/56 ,  C07D239/70 ,  C07D239/84 ,  C07D239/94 ,  C07D239/95 ,  C07D285/16 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/056 ,  C07D493/04 ,  C07D495/04 ,  C07D495/14 ,  C07D513/20 ,  G01N33/566

Abstract: The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

Abstract translation: 本发明提供了用于鉴定化学感应受体及其配体的改性剂的筛选方法，例如通过确定测试实体是否适合与化学感应受体的金星蝇捕获结构域内的一个或多个相互作用位点相互作用，以及能够调节 化学感受器及其配体。