公开(公告)号：US20190151499A1

公开(公告)日：2019-05-23

申请号：US16222918

申请日：2018-12-17

Applicant: University of Southern California ,  California Institute of Technology ,  The Regents of the University of California

Inventor： Mark S. Humayun ,  Ashish Ahuja ,  Yu-Chong Tai ,  David R. Hinton ,  Robert H. Grubbs ,  Dennis O. Clegg ,  Lincoln Vallance Johnson ,  Sherry T. Hikita

IPC: A61L27/18 ,  A61K47/34 ,  A61K35/30 ,  A61L27/38 ,  A61L27/56 ,  A61K35/545 ,  A61K9/00

Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

公开(公告)号：US10259831B2

公开(公告)日：2019-04-16

申请号：US15219710

申请日：2016-07-26

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Anton Toutov ,  Kerry Betz ,  Andrew M. Romine ,  Robert H. Grubbs

IPC: C07F7/21 ,  C07D235/08 ,  C07F7/18 ,  C07F7/08

Abstract: The present disclosure is directed to methods for dehydrogenatively coupled hydrosilanes and alcohols, the methods comprising contacting an organic substrate having at least one organic alcohol moiety with a mixture of at least one hydrosilane and sodium and/or potassium hydroxide, the contacting resulting in the formation of a dehydrogenatively coupled silyl ether. The disclosure further described associated compositions and methods of using the formed products.

公开(公告)号：US10232043B2

公开(公告)日：2019-03-19

申请号：US15240997

申请日：2016-08-18

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Melanie A. Yen ,  Dennis A. Dougherty ,  Robert H. Grubbs ,  Harry B. Gray ,  Robert H. Chow ,  Mark S. Humayun ,  Mark E. Thompson ,  Lionel E. Cheruzel

IPC: C12N13/00 ,  A61K41/00 ,  A61N5/06 ,  A61F9/007

Abstract: Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.

公开(公告)号：US20190001024A1

公开(公告)日：2019-01-03

申请号：US16020196

申请日：2018-06-27

Applicant: California Institute of Technology

Inventor： Robert H. Grubbs ,  Christopher B. Marotta

IPC: A61L27/44 ,  A61L27/52 ,  A61L27/04 ,  A61L27/14 ,  A61F2/16

Abstract: This disclosure relates compositions comprising upconverting core-shell nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable intraocular lenses.

公开(公告)号：US10149906B2

公开(公告)日：2018-12-11

申请号：US15199710

申请日：2016-06-30

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  The Regents of the University of California

Inventor： Robert H. Grubbs ,  Marshall L. Stoller ,  Hoyong Chung ,  Alissa M. Fitzgerald ,  Thomas W. Kenny ,  Renee M. Thomas

IPC: A61K41/00 ,  A61K9/00 ,  A61B17/22 ,  A61K47/24 ,  A61N7/00 ,  A61K9/107 ,  A61K31/663 ,  A61K47/69

Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

公开(公告)号：US10118976B2

公开(公告)日：2018-11-06

申请号：US15398682

申请日：2017-01-04

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  CORNELL UNIVERSITY

Inventor： Brett M. Savoie ,  Michael A. Webb ,  Robert H. Grubbs ,  Thomas F. Miller, III ,  Geoffrey W. Coates ,  Qi Zheng

IPC: C08F30/06 ,  C08K3/38 ,  C08K3/00 ,  C08L43/00 ,  C08L79/00 ,  C08L81/02 ,  C08L85/00 ,  C08L85/04 ,  C08L87/00 ,  C08K3/10 ,  C08G65/328 ,  H01M10/052 ,  H01M10/054 ,  H01M10/0565 ,  C08K3/08

Abstract: Anion-coordinating polymers comprising one or more anion-coordinating unit of Formula (I), optionally in combination with one or more cation-coordinating unit of Formula (II) and/or a linking unit of Formula (III) and related electrolytes, batteries, methods and system.

公开(公告)号：US10072030B2

公开(公告)日：2018-09-11

申请号：US15375716

申请日：2016-12-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Anton Toutov ,  Kerry Betz ,  Brian M. Stoltz ,  Wenbo Liu ,  Robert H. Grubbs

IPC: C07F7/08 ,  C07J1/00 ,  C07J51/00 ,  C07F17/02 ,  C07J7/00 ,  C07J75/00

CPC classification number: C07F7/0827 ,  C07F17/02 ,  C07J1/0096 ,  C07J7/0005 ,  C07J51/00 ,  C07J75/00

Abstract: The present invention is directed to a mild, efficient, and general direct C(sp)-H bond silylation. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal alkynyl C—H bond, with a mixture of at least one organosilane and an alkali metal hydroxide, alkali metal alkoxide, or alkali metal hydride under conditions sufficient to form a silylated terminal alkynyl moiety. The methods are operable in the presence or substantially absence of transition-metal compounds. The systems associated with these methods are also disclosed.

公开(公告)号：US09957383B2

公开(公告)日：2018-05-01

申请号：US14850178

申请日：2015-09-10

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Robert J. MacFarlane ,  Robert H. Grubbs

IPC: C08L25/06 ,  C09D125/06 ,  C08L53/00 ,  C09D153/00 ,  C08G81/02 ,  C09D5/00 ,  C09D5/33 ,  C08F8/00

CPC classification number: C08L25/06 ,  C08F8/00 ,  C08G81/024 ,  C08G2261/136 ,  C08G2261/3324 ,  C08G2261/35 ,  C08G2261/418 ,  C08G2261/90 ,  C08L53/00 ,  C09D5/004 ,  C09D125/06 ,  C09D153/00 ,  C08L65/00 ,  C08L25/04 ,  C09D165/00

Abstract: The present invention is directed to brush block copolymer compositions comprising first and second homopolymers or random copolymers whose presence provides access to photonic bandgaps in the infrared frequency range, their use in this capacity, and methods of making the same. The specific parameters associated with these compositions are described within the specification.

公开(公告)号：US09580451B2

公开(公告)日：2017-02-28

申请号：US14604917

申请日：2015-01-26

Applicant: California Institute of Technology ,  Children's Hospital of Los Angeles

Inventor： Carl M. Blumenfeld ,  Harry B. Gray ,  Robert H. Grubbs ,  Karn Sorasaenee

IPC: C07F7/28 ,  C07D487/22 ,  C07F5/00 ,  C07F5/06 ,  A61K49/00

CPC classification number: C07F7/28 ,  A61K49/0021 ,  A61K49/0065 ,  A61K49/0067 ,  B01J2531/025 ,  C07D487/22 ,  C07F5/003 ,  C07F5/069

Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:

Abstract translation: 本发明涉及包括式I和II的金属氧化物的磺酸酯：

公开(公告)号：US09421164B2

公开(公告)日：2016-08-23

申请号：US14254183

申请日：2014-04-16

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Hoyong Chung ,  Robert H. Grubbs ,  Daniel M. Schwartz

IPC: A61K9/00 ,  A61L24/00 ,  A61L24/06

CPC classification number: A61K9/0048 ,  A61L24/0015 ,  A61L24/06 ,  A61L2300/402 ,  C08L33/26

Abstract: The present inventions are directed to novel aqueous compositions comprising a copolymer having water-soluble units and pendant catechols, said composition adapted for use on mammalian tissue and having a lower critical solubility temperature (LCST) of less than a physiological temperature, and their use, for example, in removing foreign particles from tissue surfaces, including ocular surfaces.

Abstract translation: 本发明涉及新型含水组合物，其包含具有水溶性单元和侧基邻苯二酚的共聚物，所述组合物适用于哺乳动物组织并且具有小于生理温度的较低临界溶解度温度（LCST） 例如，从包括眼表面的组织表面去除异物。