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公开(公告)号：US20190282937A1
公开(公告)日：2019-09-19
申请号：US16427942
申请日：2019-05-31
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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12.发明授权公开(公告)号：US10287314B2
公开(公告)日：2019-05-14
申请号：US14747029
申请日：2015-06-23
Applicant: EMD Millipore Corporation
Inventor： Nanying Bian , Christopher Gillespie , Matthew T. Stone , Mikhail Kozlov , Jie Chen , Martin Siwak
IPC: B01D15/36 , B01D15/12 , B01D15/18 , B01D15/38 , B01J39/26 , B01J41/20 , C07K1/36 , C07K1/16 , B01J20/282 , C07K1/20 , B01J43/00 , B01J47/04 , C07K16/00 , B01J20/20
Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.
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公开(公告)号：US20180208624A1
公开(公告)日：2018-07-26
申请号：US15920995
申请日：2018-03-14
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , William Cataldo , Jeffrey Caron
IPC: C07K1/34 , C08F259/08 , C08J5/22 , B01D15/10 , B01D37/00 , B01J20/288 , B01J20/289 , C07K1/18 , C07K16/00 , C08F220/18 , C08F220/54 , B01J20/26 , C08F220/58 , C08F220/56 , B01J20/32 , B01J39/26
CPC classification number: C07K1/34 , B01D15/10 , B01D37/00 , B01J20/267 , B01J20/288 , B01J20/289 , B01J20/321 , B01J20/3212 , B01J20/327 , B01J20/3276 , B01J20/3291 , B01J39/26 , B01J2220/80 , C07K1/18 , C07K16/00 , C08F220/18 , C08F220/54 , C08F220/56 , C08F220/58 , C08F259/08 , C08F2220/1825 , C08F2220/1858 , C08J5/2243 , C08J2351/00
Abstract: Novel compositions for removing impurities such as, protein aggregates, from a sample containing a protein of interest, e.g., an antibody. Such compositions can be used prior to the virus filtration step during protein purification, to remove aggregates and protect the virus filter from fouling, therefore improving virus filter capacity. A porous solid support including a co-polymer having at least two monomers, wherein at least one of the monomers comprises acrylamide and at least a second monomer comprises a hydrophobic binding group, where the solid support selectively binds protein aggregates, thereby to separate the monomeric protein of interest from the protein aggregates. The method can be performed under neutral to high pH and high conductivity conditions.
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公开(公告)号：US20180085743A1
公开(公告)日：2018-03-29
申请号：US15677526
申请日：2017-08-15
Applicant: EMD Millipore Corporation
Inventor： David Yavorsky , John Amara , Joaquin Umana , William Cataldo , Mikhail Kozlov , Matthew Stone
IPC: B01J39/26 , B01D15/36 , B01D15/38 , B01J20/285 , B01J20/287 , B01J20/28 , B01J20/32 , B01J41/20 , B01J47/014 , B01J47/127 , C07K1/18 , C07K16/00 , C12N7/00 , C12N7/02 , B01D15/32
CPC classification number: B01J39/26 , B01D15/327 , B01D15/361 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/28023 , B01J20/28059 , B01J20/285 , B01J20/287 , B01J20/3244 , B01J41/20 , B01J47/014 , B01J47/127 , C07K1/18 , C07K16/00 , C12N7/00 , C12N7/02 , G01N2030/521 , Y10S502/52724 , Y10T428/2938 , Y10T428/2973
Abstract: Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
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15.发明申请公开(公告)号：US20160059159A1
公开(公告)日：2016-03-03
申请号：US14839779
申请日：2015-08-28
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
CPC classification number: B01D29/908 , B01D29/52 , B01D29/603 , B01D61/142 , B01D61/145 , B01D61/147 , B01D63/082 , B01D2313/105 , B01D2313/125 , B01D2313/21 , B01D2315/10 , B01D2315/16 , B01D2319/022
Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
Abstract translation: 描述了一种过滤液体进料的方法，包括使液体进料通过单程切向流过滤（SPTFF）系统，并在分离的容器中回收系统中的渗余物和渗透物。 还描述了过滤液体进料的方法，包括使液体进料通过切向流过滤（TFF）系统，在分离的容器中从系统中回收渗透物和一部分滞留物，而不通过TFF系统再循环，并将剩余物 的滞留物通过TFF系统至少一次。 本发明的方法可以使用包括歧管段的SPTFF或TFF系统来进行，以串行化进料和滞留物的流动路径，而不需要转向板。
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Patent Agency Ranking
公开(公告)号：US20150258540A1
公开(公告)日：2015-09-17
申请号：US14682456
申请日：2015-04-09
Applicant: EMD Millipore Corporation
Inventor： David Yavorsky , John Amara , Joaquin Umana , William Cataldo , Mikhail Kozlov , Matthew Stone
CPC classification number: B01J39/26 , B01D15/327 , B01D15/361 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/28023 , B01J20/28059 , B01J20/285 , B01J20/287 , B01J20/3244 , B01J41/20 , B01J47/014 , B01J47/127 , C07K1/18 , C07K16/00 , C12N7/00 , C12N7/02 , G01N2030/521 , Y10S502/52724 , Y10T428/2938 , Y10T428/2973
Abstract: Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
Abstract translation: 来自成形纤维的用于色谱的吸附介质，特别是离子交换层析。 在某些实施方案中，与普通纤维相比，官能化成形纤维呈现原纤化或脊状结构，其大大增加了纤维的表面积。 本文还公开了向高表面积纤维添加提供阳离子交换或阴离子交换官能团的表面侧基官能团的方法。 这种侧链官能团可用于生物分子的离子交换色谱纯化，如单克隆抗体（mAb）。
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17.发明授权公开(公告)号：US11634457B2
公开(公告)日：2023-04-25
申请号：US16358845
申请日：2019-03-20
Applicant: EMD Millipore Corporation
Inventor： Nanying Bian , Christopher Gillespie , Matthew T. Stone , Mikhail Kozlov , Jie Chen , Martin Siwak
IPC: B01D15/36 , C07K1/36 , C07K1/16 , B01D15/18 , C07K1/18 , C07K1/22 , C07K16/00 , B01J20/282 , C07K1/20 , B01D15/12 , B01J39/26 , B01J41/20 , B01J43/00 , B01J47/04 , B01J20/20 , B01D15/38
Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely affecting the yield of the desired protein product.
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公开(公告)号：US20220176278A1
公开(公告)日：2022-06-09
申请号：US17682221
申请日：2022-02-28
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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公开(公告)号：US11305271B2
公开(公告)日：2022-04-19
申请号：US15677526
申请日：2017-08-15
Applicant: EMD Millipore Corporation
Inventor： David Yavorsky , John Amara , Joaquin Umana , William Cataldo , Mikhail Kozlov , Matthew Stone
IPC: B01D15/36 , B01J20/28 , B01J47/12 , B01J39/26 , C12N7/02 , B01J47/014 , B01J47/127 , B01D15/38 , C07K1/18 , B01J41/20 , B01D15/32 , B01J20/285 , B01J20/287 , B01J20/32 , C07K16/00 , C12N7/00 , G01N30/52
Abstract: Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
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公开(公告)号：US20210260504A1
公开(公告)日：2021-08-26
申请号：US17315721
申请日：2021-05-10
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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