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11.发明授权公开(公告)号：US11028222B2
公开(公告)日：2021-06-08
申请号：US16202454
申请日：2018-11-28
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Brian M. Kelly , Marc Wisnudel
IPC: C08G63/08 , C08G63/89 , C08G63/90 , C08L67/04 , C08G63/66 , C08G63/78 , C08G63/85 , C08J3/12 , C08K5/18 , C08G63/664
Abstract: The present invention is directed methods of making absorbable poly(p-dioxanone) pellets by melt polymerization of p-dioxanone conducted in a single reactor with a temperature regulator by charging a melt reactor with a mixture of p-dioxanone (PDO) monomer, initiator, catalyst, and optionally a dye; melt polymerizing the mixture in the melt reactor with sufficient agitation of the mixture to allow complete mixing of the monomer and for sufficient time to form a PDO polymer product having an unreacted PDO monomer content of at least 65 mole percent; placing the PDO polymer product under a vacuum to remove at least portion of unreacted PDO; discharging the PDO polymer product from the melt reactor directly into an in-line, underwater pelletizer to produce undried PDO pellets, collecting the undried PDO pellets, and storing the collected PDO pellets in the freezer or a vacuum chamber prior to drying.
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12.发明申请公开(公告)号：US20200000958A1
公开(公告)日：2020-01-02
申请号：US16021322
申请日：2018-06-28
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Christopher DeFelice , Sasa Andjelic , Brian M. Kelly , Marc Wisnudel , Daniel Steiger , Gaoyuan Gavin Chen
Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.
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公开(公告)号：US20180079192A1
公开(公告)日：2018-03-22
申请号：US15267700
申请日：2016-09-16
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Dominick Egidio
IPC: B32B37/10 , B29C47/00 , B29C55/30 , B32B37/06 , B32B27/12 , B32B5/02 , A61L31/10 , A61L31/04 , A61L31/14 , A61F2/00
CPC classification number: B32B37/10 , A61F2/0063 , A61K9/7007 , A61L31/042 , A61L31/048 , A61L31/10 , A61L31/14 , A61L31/148 , A61L2420/02 , B29C47/0004 , B29C47/0021 , B29C47/0057 , B29C47/0064 , B29C47/0066 , B29C47/92 , B29C55/30 , B29C2947/92704 , B29C2947/92942 , B29C2947/92961 , B29K2995/004 , B29L2031/753 , B32B5/022 , B32B5/024 , B32B5/028 , B32B27/00 , B32B27/12 , B32B37/06 , B32B37/15 , B32B2037/0092 , B32B2305/10 , B32B2535/00 , C08L67/04
Abstract: The invention relates to novel processes for the lamination of semi-crystalline, high-melting point, low glass transition polymeric films, which are extruded and subsequently laminated on various thermally sensitive substrates to form laminated medical device constructs in a specific time interval to allow low processing temperatures to avoid polymer film and/or substrate degradation or heat-related distortions. Also disclosed are laminated medical device constructs made from such processes.
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公开(公告)号：US09873790B1
公开(公告)日：2018-01-23
申请号：US15345034
申请日：2016-11-07
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Kenneth Keilman
IPC: C08L67/04 , C08G63/664 , C08J3/00 , C08G63/08 , A61L27/26 , A61L27/18 , A61L31/04 , A61L31/06 , A61K47/34 , C08G63/02
CPC classification number: C08L67/04 , A61K47/34 , A61L17/105 , A61L17/12 , A61L27/18 , A61L27/26 , A61L31/041 , A61L31/06 , C08G63/08 , C08G63/664 , C08J3/005 , C08J2367/04 , C08J2467/04 , C08L101/16 , C08L2203/02 , C08L2205/025 , D01F6/625 , D01F6/92 , D01F6/94
Abstract: Novel absorbable, semi-crystalline, polymer blend compositions are disclosed exhibiting enhanced crystallization and nucleation rates. Also disclosed are medical device constructs, such as fibers made from such blends. The blends have a first absorbable polymeric component having a first molecular weight distribution and a second absorbable polymeric component which has an ultrahigh molecular weight distribution. The first and second polymeric components may be the same polymer.
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15.发明申请ABSORBABLE POLYMERIC BLEND COMPOSITIONS BASED ON COPOLYMERS PREPARED FROM MONO- AND DI-FUNCTIONAL POLYMERIZATION INITIATORS, PROCESSING METHODS, AND MEDICAL DEVICES THEREFROM 有权基于单功能和二功能聚合引发剂制备的共聚物的可吸收的聚合物组合物，其加工方法及其医疗设备公开(公告)号：US20150165096A1
公开(公告)日：2015-06-18
申请号：US14571371
申请日：2014-12-16
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Dennis D. Jamiolkowski , Brian M. Kelly , Christopher DeFelice , Daniel Steiger
CPC classification number: A61L31/041 , A61B17/064 , A61B17/0642 , A61B2017/00004 , A61B2017/00889 , A61B2017/00893 , A61L17/12 , A61L27/18 , A61L29/06 , A61L31/06 , A61L31/148 , C08G63/664 , C08L67/04 , C08L2205/025 , C08L2205/03
Abstract: Novel absorbable polymeric blends made from components wherein at least one of the components is synthesized using mixtures of mono- and di-functional initiators are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is either poly(p-dioxanone) homopolymer, or a poly(p-dioxanone-co-glycolide) copolymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
Abstract translation: 公开了由组分制成的新型可吸收聚合物共混物，其中使用单官能和二官能引发剂的混合物合成至少一种组分。 共混物具有第一组分，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，第二组分是聚（对二恶烷酮）均聚物或聚（对 - 二恶烷酮 - 共 - 乙交酯）共聚物。 新型聚合物共混物提供具有尺寸稳定性的医疗装置。 还公开了由这些新型聚合物共混物制成的新型可吸收医疗器件以及新颖的制造方法。
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Patent Agency Ranking
公开(公告)号：US20130089511A1
公开(公告)日：2013-04-11
申请号：US13691434
申请日：2012-11-30
Applicant: ETHICON, INC.
Inventor： Sasa Andjelic , Tara Zabrosky
CPC classification number: A61K8/85 , A61K2800/91 , A61L31/06 , A61Q19/00 , C08G63/60 , C08L67/00 , C08L67/04 , C08L2666/22
Abstract: A co-polyester which includes the reaction product of a polycondensation polyester and epsilon-caprolactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and a diol. The co-polyester is injectable and absorbable into animal, such as human, tissue and can be used for facial cosmetic or reconstructive surgery of soft tissue. Another embodiment is directed to a method for preventing adhesion using a co-polyester comprising the reaction product of a polycondensation polyester and epsilon-caprolactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and a diol, and the co-polyester comprises about 40 to 50% by weight of the polycondensation polyester based on the total weight of the co-polyester.
Abstract translation: 包括缩聚聚酯和ε-己内酯的反应产物的共聚酯，其中缩聚聚酯包括二甘醇酸和/或其衍生物与二醇的反应产物。 共聚酯是可注射的并且可吸收到动物中，例如人，组织，并且可以用于软组织的面部化妆品或重建手术。 另一个实施方案涉及使用包含缩聚聚酯和ε-己内酯的反应产物的共聚酯来防止粘合的方法，其中缩聚聚酯包括二甘醇酸和/或其衍生物与二醇的反应产物，和 共聚酯包含基于共聚酯总重量的约40至50重量％的缩聚聚酯。
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公开(公告)号：US12156650B2
公开(公告)日：2024-12-03
申请号：US17546386
申请日：2021-12-09
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Marc Wisnudel , Kenneth M. Keilman , Leo B. Kriksunov , Robert J. Tannhauser
Abstract: The present invention is directed to a length adaptive surgical suture comprising a monofilament or a braid of a plurality of filaments, the suture having an original length when implanted and a second length that is different from the original length within a first twenty-four (24) hour period of time after implantation to accommodate tissue swelling. The present invention is also directed to configurations and combinations that enable length adaptive results.
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18.发明申请公开(公告)号：US20210054141A1
公开(公告)日：2021-02-25
申请号：US17090192
申请日：2020-11-05
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Brian M. Kelly , Marc Wisnudel
Abstract: The present invention is directed methods of making absorbable poly(p-dioxanone) pellets by melt polymerization of p-dioxanone conducted in a single reactor with a temperature regulator by charging a melt reactor with a mixture of p-dioxanone (PDO) monomer, initiator, catalyst, and optionally a dye; melt polymerizing the mixture in the melt reactor with sufficient agitation of the mixture to allow complete mixing of the monomer and for sufficient time to form a PDO polymer product having an unreacted PDO monomer content of at least 65 mole percent; placing the PDO polymer product under a vacuum to remove at least portion of unreacted PDO; discharging the PDO polymer product from the melt reactor directly into an in-line, underwater pelletizer to produce undried PDO pellets, collecting the undried PDO pellets, and storing the collected PDO pellets in the freezer or a vacuum chamber prior to drying.
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公开(公告)号：US10300165B2
公开(公告)日：2019-05-28
申请号：US15001313
申请日：2016-01-20
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Kenneth Keilman
IPC: A61L17/10 , A61L17/00 , C08G81/00 , A61L31/06 , C08G63/664
Abstract: Novel semi-crystalline, p-dioxanone-rich ABA triblock copolymers of p-dioxanone and epsilon-caprolactone, where “B” block is a random copolymer of p-dioxanone and epsilon-caprolactone, and absorbable devices for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, and other medical devices.
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公开(公告)号：US20180326114A1
公开(公告)日：2018-11-15
申请号：US16042059
申请日：2018-07-23
Applicant: Ethicon,Inc.
Inventor： Sasa Andjelic , Dennis D. Jamiolkowski , JackIe Donners , Mark Timmer
IPC: A61L24/04 , A61L24/00 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/06 , A61L31/14 , C08J9/04 , C08J5/18 , C08L67/04 , C08G63/08 , C08J9/26 , C08G101/00
CPC classification number: A61L24/046 , A61L24/001 , A61L24/0036 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/06 , A61L31/146 , A61L31/148 , C08G63/08 , C08G2101/00 , C08J5/18 , C08J9/04 , C08J9/26 , C08J2201/03 , C08J2201/0482 , C08J2205/02 , C08J2300/16 , C08J2367/04 , C08L67/04
Abstract: Absorbable medical devices based on novel foams and films made from semi-crystalline, segmented copolymers of lactide and epsilon-caprolactone exhibiting long term absorption characteristics are disclosed. Also disclosed are methods of producing said foams and films, and useful polymer solutions.
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