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    CIRCUIT DESIGN TO APPLY DIFFERENT VOLTAGES IN A NANOPORE ARRAY
    12.
    发明申请
    CIRCUIT DESIGN TO APPLY DIFFERENT VOLTAGES IN A NANOPORE ARRAY 有权

    公开(公告)号：US20230070552A1

    公开(公告)日：2023-03-09

    申请号：US17930673

    申请日：2022-09-08

    Applicant: Illumina, Inc.

    Inventor： Mohsen Rezaei ,  Xu Liu ,  Arvin Emadi

    IPC: C12Q1/6869 ,  G01N33/487

    Abstract: In one aspect, the disclosed technology relates to systems and methods for sequencing polynucleotides. In one embodiment, the disclosed system for sequencing polynucleotides includes: a sequencing cell comprising a nanopore for sensing a polynucleotide; an electronic circuit configured to measure an electrical response in the sequencing cell, the electronic circuit comprising an operational amplifier; and a memory unit configured to store a state of the sequencing cell.

    FLOW CELL WITH SELECTIVE DEPOSITION OR ACTIVATION OF NUCLEOTIDES
    13.
    发明申请
    FLOW CELL WITH SELECTIVE DEPOSITION OR ACTIVATION OF NUCLEOTIDES 有权

    公开(公告)号：US20220410154A1

    公开(公告)日：2022-12-29

    申请号：US17898663

    申请日：2022-08-30

    Applicant: ILLUMINA, INC.

    Inventor： Ali Agah ,  Aathavan Karunakaran ,  Tarun Khurana ,  Stanley Hong ,  Merek Siu ,  Arvin Emadi ,  Craig Ciesla

    IPC: B01L3/00 ,  G11C13/02 ,  B01J19/00

    Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.

    FLOW CELL WITH ONE OR MORE BARRIER FEATURES
    14.
    发明申请
    FLOW CELL WITH ONE OR MORE BARRIER FEATURES 有权

    公开(公告)号：US20220317100A1

    公开(公告)日：2022-10-06

    申请号：US17846538

    申请日：2022-06-22

    Applicant: ILLUMINA, INC.

    Inventor： Tarun Khurana ,  Ali Agah ,  Aathavan Karunakaran ,  Stanley Hong ,  Merek Siu ,  Arvin Emadi ,  Craig Ciesla

    IPC: G01N30/74 ,  C12Q1/6874

    Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an imaging assembly, and one or more barrier features. The flow cell body defines one or more flow channels and a plurality of wells defined as recesses in the floor of each flow channel. Each well is fluidically coupled with the corresponding flow channel. The flow cell body further defines interstitial surfaces between adjacent wells. Each well defines a corresponding depth. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are to effect writing of polynucleotides in the wells. The imaging assembly is to capture images of polynucleotides written in the wells. The one or more barrier features are positioned in the wells, between the wells, or above the wells. The one or more barrier features contain reactions in each well, reduce diffusion between the wells, or reduce optical cross-talk between the wells.

    ENABLING SENSOR TOP SIDE WIREBONDING
    15.
    发明申请
    ENABLING SENSOR TOP SIDE WIREBONDING 有权

    公开(公告)号：US20220231068A1

    公开(公告)日：2022-07-21

    申请号：US17574358

    申请日：2022-01-12

    Applicant: Illumina, Inc.

    Inventor： Ludovic Vincent ,  Tara Bozorg-Grayeli ,  Arvin Emadi ,  Vanessa Montaño Machado

    IPC: H01L27/146 ,  H01L23/00 ,  G01N33/543 ,  G01N27/414

    Abstract: Provided herein include various examples of an apparatus, a sensor system and examples of a method for manufacturing aspects of an apparatus, a sensor system. The method may include forming bumps on a surface of one or more electrical contacts, where the one or more electrical contacts are accessible on an upper surface of a die, where the die is oriented on a substrate, and where the electrical contacts comprise bonding pads. The method may also include coupling one or more additional electrical contacts to the one or more electrical contacts, where the coupling comprises wire-bonding each additional electrical contact of the additional electrical contacts to one of the one or more electrical contacts accessible on the upper surface of the die, via a portion of the bumps on the surface of the one or more electrical contacts, thereby forming wire-bonded connections.

    NANOPORE SENSING SYSTEMS
    18.
    发明公开
    NANOPORE SENSING SYSTEMS 审中-公开

    公开(公告)号：US20230408439A1

    公开(公告)日：2023-12-21

    申请号：US18208834

    申请日：2023-06-12

    Applicant: ILLUMINA, INC.

    Inventor： Xu Liu ,  Lisa Savagian ,  Arvin Emadi

    IPC: G01N27/327 ,  G01N33/487 ,  G01N27/419

    CPC classification number: G01N27/3278 ,  G01N27/419 ,  G01N33/48721

    Abstract: An example of a nanopore sensing system includes an application specific integrated circuit (ASIC) sensor mounted on a printed circuit board having an electrical interface with the ASIC sensor; and a nanopore sequencer formed on the ASIC sensor. The nanopore sequencer includes a redox mediator chamber having a cis electrode positioned therein; a cis well; a membrane positioned between the cis well and the redox mediator chamber, the membrane to confine a redox mediator species in the redox mediator chamber and to allow an ionic species to pass between the redox mediator chamber and the cis well; a plurality of trans wells, each including a trans electrode positioned therein; and a plurality of nanopores respectively fluidically connecting the cis well to each of the plurality of trans wells.

    SENSOR HAVING AN ACTIVE SURFACE
    20.
    发明公开
    SENSOR HAVING AN ACTIVE SURFACE 审中-公开

    公开(公告)号：US20230146020A1

    公开(公告)日：2023-05-11

    申请号：US18051674

    申请日：2022-11-01

    Applicant: Illumina, Inc.

    Inventor： Ravi Billa ,  Arvin Emadi ,  Hai Tran

    IPC: B01L3/00

    CPC classification number: B01L3/502761 ,  G01N2021/6439

    Abstract: Examples herein include an apparatus having a substrate, a sensor over the substrate including an active surface and a sensor bond pad, a molding layer over the substrate and covering sides of the sensor, the molding layer having a lower portion with a first molding height relative to a top surface of the substrate and an upper portion with a second molding height relative to the top surface of the substrate, the first molding height and the second molding height each being greater than a height of the active surface, the second molding height being great than the first molding height; and a lidding layer over at least some of the lower portion of the molding layer and over the active surface. The lidding layer and the molding layer form a space over the active surface of the sensor that defines a flow channel.

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