公开(公告)号：US20100168072A1

公开(公告)日：2010-07-01

申请号：US12600240

申请日：2008-08-01

申请人： Graham Michael Wynne ,  Stephen Wren ,  Peter Johnson ,  Paul Price ,  Olivier De Moor ,  Gary Nugent ,  Richard Storer ,  Richard Joseph Pye ,  Colin Richard Dorgan

发明人： Graham Michael Wynne ,  Stephen Wren ,  Peter Johnson ,  Paul Price ,  Olivier De Moor ,  Gary Nugent ,  Richard Storer ,  Richard Joseph Pye ,  Colin Richard Dorgan

IPC分类号： A61K31/56 ,  A61K31/416 ,  A61K31/4192 ,  A61K31/454 ,  A61K31/5377

CPC分类号： A61K45/06 ,  A61K31/416 ,  A61K31/4192 ,  A61K2300/00

摘要： Combinations comprising (or consisting essentially of) one or more compounds of the formula (I) or (II) with one or more ancillary compounds, to processes for preparing the combinations, and to various therapeutic uses of the combinations. Also provided are pharmaceutical compositions containing the combinations as well as a method of treatment of Duchenne muscular dystrophy, Becker muscular dystrophy or cachexia using the combinations.

摘要翻译： 包含（或基本上由）一种或多种式（I）或（II）化合物与一种或多种辅助化合物组合的组合，以及组合的各种治疗用途。 还提供了含有组合的药物组合物以及使用这些组合治疗杜氏肌营养不良症，贝克肌营养不良症或恶病质的方法。

公开(公告)号：US20060286668A1

公开(公告)日：2006-12-21

申请号：US11450877

申请日：2006-06-12

申请人： Paul Price ,  Steve Gorfien ,  Douglas Danner ,  Mark Plavsic

发明人： Paul Price ,  Steve Gorfien ,  Douglas Danner ,  Mark Plavsic

IPC分类号： C12N5/06 ,  C12N5/02

CPC分类号： C12N5/0043 ,  C12N5/06 ,  C12N2500/12 ,  C12N2500/20 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/36 ,  C12N2500/40 ,  C12N2500/74 ,  C12N2500/76 ,  C12N2500/90 ,  C12N2500/92 ,  C12N2501/11

摘要： The present invention provides serum-free cell culture media formulations which are capable of supporting the in vitro cultivation or animal cells. The media comprise at least one nutrient of non-animal derivation, such as at least one plant peptide and/or at least one non-animal or plant lipid and/or fatty acid. The media may further optionally comprise an enzymatic digest or extract of yeast cells. The present invention also provides methods of cultivating animal cells in vitro using these cell culture media formulations. In addition, the media of the present invention can be used for growth of animal cells for virus production.

摘要翻译： 本发明提供能够支持体外培养或动物细胞的无血清细胞培养基制剂。 培养基包含至少一种非动物衍生营养素，例如至少一种植物肽和/或至少一种非动物或植物脂质和/或脂肪酸。 培养基还可以任选地包含酵母细胞的酶促消化或提取物。 本发明还提供了使用这些细胞培养基制剂在体外培养动物细胞的方法。 此外，本发明的培养基可以用于病毒生产的动物细胞的生长。

公开(公告)号：US09321996B2

公开(公告)日：2016-04-26

申请号：US13608803

申请日：2012-09-10

申请人： Stephen Gorfien ,  Richard Fike ,  Glenn Godwin ,  Joyce Dzimian ,  David Epstein ,  Dale Gruber ,  Don McClure ,  Paul Price

发明人： Stephen Gorfien ,  Richard Fike ,  Glenn Godwin ,  Joyce Dzimian ,  David Epstein ,  Dale Gruber ,  Don McClure ,  Paul Price

IPC分类号： C12N5/071 ,  C07K14/61 ,  C12N7/00 ,  C12N15/85 ,  C12N9/38 ,  C12N5/073 ,  C12N9/24 ,  C12N5/00

CPC分类号： C12N5/0682 ,  C07K14/61 ,  C12N5/0037 ,  C12N5/0043 ,  C12N5/005 ,  C12N5/0603 ,  C12N7/00 ,  C12N9/2402 ,  C12N9/2471 ,  C12N15/85 ,  C12N2500/14 ,  C12N2500/16 ,  C12N2500/22 ,  C12N2500/24 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/35 ,  C12N2500/38 ,  C12N2500/74 ,  C12N2500/76 ,  C12N2500/90 ,  C12N2500/95 ,  C12N2501/90 ,  C12N2501/91 ,  C12N2710/10051 ,  C12Y302/01023

摘要： The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.

公开(公告)号：US08053563B2

公开(公告)日：2011-11-08

申请号：US11817244

申请日：2006-02-16

申请人： Richard Bonnichsen ,  Paul Price

发明人： Richard Bonnichsen ,  Paul Price

IPC分类号： C07K16/00

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/73

摘要： The present invention relates to monoclonal anti-human YKL-antibodies which are capable to modulate biological processes in which YKL-40 plays a prominent role, e.g. inhibit the growth and/or inducing apoptosis of cells, in particular cancer cells. The invention also relates to pharmaceutical compositions comprising said antibodies and uses said antibodies and/or pharmaceutical compositions for treatment of a disease wherein inhibition of cell growth, cell differentiation, remodelling of extracellular matrix, metastasis and/or induction of cell death due to apoptosis is a prerequisite for successful curing. An antibody of the invention is capable of inhibiting biological function of YKL-40 in the above mentioned processes by binding to a specific epitope on YKL-40.

摘要翻译： 本发明涉及能够调节其中YKL-40起突出作用的生物学过程的单克隆抗人YKL-抗体。 抑制细胞，特别是癌细胞的生长和/或诱导细胞凋亡。 本发明还涉及包含所述抗体的药物组合物，并且使用所述抗体和/或药物组合物来治疗疾病，其中抑制细胞生长，细胞分裂，细胞外基质的重塑，转移和/或由细胞凋亡引起的细胞死亡的诱导是 成功治愈的先决条件。 本发明的抗体能够通过与YKL-40上的特异性表位结合而在上述方法中抑制YKL-40的生物学功能。

公开(公告)号：US20110258058A1

公开(公告)日：2011-10-20

申请号：US12760534

申请日：2010-04-14

申请人： Roger D. Carroll ,  Aaron Randall Ferber ,  Kathy Fox ,  Mark Alexander Jones ,  Stina Maria Jonsson ,  Hyun Jin Ko ,  Eleanor Elizabeth Luna ,  Jeff Pollard ,  Carley Rachel Price ,  Paul Price ,  Melody Roberts ,  Jon Vernon Wettersten

发明人： Roger D. Carroll ,  Aaron Randall Ferber ,  Kathy Fox ,  Mark Alexander Jones ,  Stina Maria Jonsson ,  Hyun Jin Ko ,  Eleanor Elizabeth Luna ,  Jeff Pollard ,  Carley Rachel Price ,  Paul Price ,  Melody Roberts ,  Jon Vernon Wettersten

IPC分类号： G06Q50/00 ,  G06Q30/00

CPC分类号： G06Q30/06 ,  G06Q50/12

摘要： A wireless mobile personal computer is provided for enabling a customer to generate a restaurant order on the wireless mobile personal computer. The wireless mobile personal computer includes a restaurant order generating application configured to generate restaurant item selecting interface screens for generating the restaurant order comprising at least one restaurant item, to generate a machine-readable representation of the generated restaurant order, a processor for executing the restaurant order generating application, a memory for storing the restaurant order generating application and selectable restaurant items, and a display for displaying the restaurant item selecting interface screens, and the at least one restaurant item.

摘要翻译： 提供一种无线移动个人计算机，用于使得客户能够在无线移动个人计算机上产生餐厅订单。 无线移动个人计算机包括餐厅订单生成应用，其被配置为生成餐馆项目选择界面屏幕，用于生成包括至少一个餐厅项目的餐厅订单，以生成所生成的餐厅订单的机器可读表示，用于执行餐厅的处理器 订单生成应用程序，用于存储餐厅订单生成应用程序和可选择餐厅项目的存储器，以及用于显示餐厅项目选择界面屏幕的显示器，以及至少一个餐厅项目。

公开(公告)号：US20090175870A1

公开(公告)日：2009-07-09

申请号：US11817244

申请日：2006-02-16

申请人： Richard Bonnichsen ,  Paul Price

发明人： Richard Bonnichsen ,  Paul Price

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K5/00 ,  C07K7/00 ,  C12N5/06 ,  A61K38/08

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/73

摘要： The present invention relates to monoclonal anti-human YKL-antibodies which are capable to modulate biological processes in which YKL-40 plays a prominent role, e.g. inhibit the growth and/or inducing apoptosis of cells, in particular cancer cells. The invention also relates to pharmaceutical compositions comprising said antibodies and uses said antibodies and/or pharmaceutical compositions for treatment of a disease wherein inhibition of cell growth, cell differentiation, remodelling of extracellular matrix, metastasis and/or induction of cell death due to apoptosis is a prerequisite for successful curing. An antibody of the invention is capable of inhibiting biological function of YKL-40 in the above mentioned processes by binding to a specific epitope on YKL-40.

摘要翻译： 本发明涉及能够调节其中YKL-40起突出作用的生物学过程的单克隆抗人YKL-抗体。 抑制细胞，特别是癌细胞的生长和/或诱导细胞凋亡。 本发明还涉及包含所述抗体的药物组合物，并且使用所述抗体和/或药物组合物来治疗疾病，其中抑制细胞生长，细胞分裂，细胞外基质的重塑，转移和/或由细胞凋亡引起的细胞死亡的诱导是 成功治愈的先决条件。 本发明的抗体能够通过与YKL-40上的特异性表位结合而在上述方法中抑制YKL-40的生物学功能。

公开(公告)号：US20060106700A1

公开(公告)日：2006-05-18

申请号：US11076310

申请日：2005-03-08

申请人： Michael Boren ,  David Boren ,  Douglas Bates ,  Christopher Growney ,  Charles Dunn ,  James Dunn ,  Jerek Anderson ,  Paul Price ,  Brian Hill ,  Justin Reed ,  James Price

发明人： Michael Boren ,  David Boren ,  Douglas Bates ,  Christopher Growney ,  Charles Dunn ,  James Dunn ,  Jerek Anderson ,  Paul Price ,  Brian Hill ,  Justin Reed ,  James Price

IPC分类号： G07F19/00 ,  G06Q40/00 ,  G07B17/00

CPC分类号： G06Q20/4016 ,  G06Q40/00 ,  G06Q40/06 ,  G06Q40/12

摘要： A method and system for analyzing and reporting institutional investments provides a single platform for daily investment accounting, compliance, performance, and risk reports for investment portfolios held at single or multiple custody/safekeeping locations. The method involves retrieving transaction data from multiple independent financial institutions and storing it in a database in a standardized format and retrieving security data from one or more security information service providers and storing it in the database. The method further involves applying a uniform set of customized accounting, compliance, risk and performance parameters to the transaction data and security data stored in the database and, in response to a user request, calculating and reporting selected data to the user in accordance with the uniform accounting, compliance, risk and performance parameters.

摘要翻译： 分析和报告机构投资的方法和系统为单一或多个保管/保管地点的投资组合的日常投资会计，合规性，绩效和风险报告提供了单一平台。 该方法包括从多个独立的金融机构检索交易数据，并将其以标准格式存储在数据库中，并从一个或多个安全信息服务提供商检索安全数据并将其存储在数据库中。 该方法还包括将统一的定制会计，合规性，风险和性能参数集合应用于存储在数据库中的交易数据和安全数据，并且响应于用户请求，根据用户请求计算和报告所选择的数据给用户 统一的会计，合规性，风险和绩效参数。

公开(公告)号：US20050136409A1

公开(公告)日：2005-06-23

申请号：US10741390

申请日：2003-12-19

申请人： Dana Jacobs ,  Paul Price ,  Nery Ortiz ,  Theodore Gerula

发明人： Dana Jacobs ,  Paul Price ,  Nery Ortiz ,  Theodore Gerula

IPC分类号： G01N33/96 ,  C12N5/078 ,  C12N5/10 ,  C12N15/09 ,  C12Q1/68 ,  C12N5/08

CPC分类号： C12N5/0641 ,  C12N5/0006 ,  G01N33/96 ,  G01N2496/10 ,  Y10T436/10 ,  Y10T436/101666

摘要： The present invention is drawn to a hematology control made from particles a particle having a biopolymer attached to a surface of the particle. The particle simulates a component of a blood sample, such as a reticulocyte or nucleated red blood cell component of a blood cell sample in a flow cytometer or hematology analysis instrument. The present invention is further drawn to methods of making and using the hematology control.

摘要翻译： 本发明涉及由具有附着于颗粒表面的生物聚合物的颗粒的颗粒制成的血液学控制。 颗粒模拟流式细胞仪或血液学分析仪器中的血液样品的组分，例如血细胞样品的网织红细胞或有核红细胞成分。 本发明进一步涉及制造和使用血液学控制的方法。

公开(公告)号：US20050065325A1

公开(公告)日：2005-03-24

申请号：US10648811

申请日：2003-08-25

申请人： Paul Price ,  Julia Johansen

发明人： Paul Price ,  Julia Johansen

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  A61P43/00 ,  C07K14/47 ,  C07K16/18 ,  G01N33/564 ,  G01N33/574 ,  G01N33/577 ,  G01N33/68 ,  C07K16/00

CPC分类号： C07K14/47 ,  C07K16/18 ,  G01N33/6887 ,  G01N2800/105 ,  Y10S435/975 ,  Y10S436/808 ,  Y10S436/811 ,  Y10S436/813

摘要： The invention is a method of identifying the presence of a disease state in a mammal which is associated with degradation of connective tissue in the mammal which contains the protein known as YKL-40. The method is a competitive immunoassay for YKL-40. It can be used, for example, to identify the presence of inflammatory or degenerative joint disease and tumor metastasis (to the extent it can be correlated to serum YKL-40 levels). Serum YKL-40 levels as detected and quantified by the inventive method are also suggestive of the prognosis for the length of survival in breast cancer patients following recurrence and/or metastasis of their cancers.

摘要翻译： 本发明是鉴定哺乳动物中存在与包含称为YKL-40的蛋白质的哺乳动物的结缔组织降解相关的疾病状态的方法。 该方法是YKL-40的竞争性免疫测定法。 例如，它可以用于鉴定炎性或退行性关节疾病和肿瘤转移的存在（其程度可以与血清YKL-40水平相关）。 通过本发明方法检测和定量的血清YKL-40水平也暗示了在其癌症复发和/或转移后乳腺癌患者的存活时间长度的预后。

公开(公告)号：US11721061B2

公开(公告)日：2023-08-08

申请号：US15441930

申请日：2017-02-24

申请人： Paul Price

发明人： Paul Price

IPC分类号： G06T15/08 ,  G06T19/20 ,  G06Q30/0601 ,  G06T15/20 ,  G03B35/02 ,  G03B37/02 ,  G06F3/04815 ,  G06F3/04817 ,  G06F3/04845 ,  G06F3/0488 ,  G06Q10/087

CPC分类号： G06T15/08 ,  G06Q30/0623 ,  G06Q30/0643 ,  G06T15/205 ,  G06T19/20 ,  G03B35/02 ,  G03B37/02 ,  G06F3/0488 ,  G06F3/04815 ,  G06F3/04817 ,  G06F3/04845 ,  G06Q10/087 ,  G06T2219/2016

摘要： A method and apparatus are provided to allow the viewing of an item from several virtual positions for evaluation and potential purchase. The information, including photographs, about the item is made available using the Internet.