公开(公告)号：US20180267031A1

公开(公告)日：2018-09-20

申请号：US15756012

申请日：2016-08-08

Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services

Inventor： Peter D. Burbelo

IPC: G01N33/543 ,  G01N33/58

CPC classification number: G01N33/54326 ,  G01N33/566 ,  G01N33/582 ,  G01N35/0098 ,  G01N2469/20

Abstract: Methods for detecting antigen-specific antibodies in a biological sample are described. The disclosed methods can be used for the diagnosis of a variety of autoimmune and infectious diseases. The methods use a neodymium magnet to efficiently isolate immune complexes. The disclosed methods are rapid, highly specific and sensitive, require very small volumes of biological sample, and do not require the use of radioactivity. With these advantageous features, the disclosed methods are amendable for point-of-care testing (POCT), which is currently not available for the detection of autoantibodies associated with autoimmune disease or for the detection of many pathogen-specific antibodies.

公开(公告)号：US20180257088A1

公开(公告)日：2018-09-13

申请号：US15908161

申请日：2018-02-28

Applicant: RITTER GMBH

Inventor： FRANK RITTER

IPC: B03C1/28 ,  B01L9/06

CPC classification number: B03C1/288 ,  B01L3/5025 ,  B01L9/06 ,  B01L2300/046 ,  B01L2300/0829 ,  B01L2400/043 ,  B03C1/0332 ,  B03C1/286 ,  B03C2201/18 ,  B03C2201/26 ,  G01N35/0098

Abstract: A magnetic separation rack made of a plastics material for performing automated magnetic separation processes comprises a base plate in which a matrix of m×n wells is formed, and a comb-like hollow rod plate with a matrix of m×n hollow rods each connected with its upper end to a horizontal carrier plate and having a radially outwardly protruding ring collar on its lower end region. The carrier plate has a recess on the position of placement of each hollow rod, the extension of the recess corresponding at least to the projection of the ring collar onto the carrier plate. Each hollow rod has on its outer circumference a plurality of radial ribs extending along the axis of the hollow rod towards the upper end starting from the ring collar, and their connecting the hollow rod to the carrier plate is in one piece while extending radially through the recess.

公开(公告)号：US10073109B2

公开(公告)日：2018-09-11

申请号：US15565105

申请日：2016-04-05

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Chuanbin Mao ,  Binrui Cao

IPC: G01N33/68 ,  G01N35/00 ,  G01N33/569 ,  G01N33/543 ,  C07K7/08 ,  A61K38/04

CPC classification number: G01N35/0098 ,  A61K38/00 ,  A61K38/04 ,  C07K7/08 ,  G01N33/54326 ,  G01N33/56983

Abstract: Disclosed are genetically-modified phages, comprising a first nucleic acid sequence encoding at least a first peptide able to bind to a magnetic nanoparticle, and a second nucleic acid sequence encoding at least a second peptide able to bind with high specificity to a predetermined biomarker, and a method for using the genetically-modified phage displaying the first peptide and second peptide in a method for analyzing a fluid sample for the predetermined biomarker.

公开(公告)号：USD825772S1

公开(公告)日：2018-08-14

申请号：US29591165

申请日：2017-01-17

Applicant: CUE INC.

Designer： Clinton Sever ,  Paul Nelson ,  Ayub Khattak

CPC classification number: B01L3/508 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/5029 ,  B01L3/523 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/047 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/0672 ,  B01L2300/069 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/1805 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0677 ,  C12Q1/6825 ,  G01N27/3273 ,  G01N33/54366 ,  G01N35/0098 ,  G01N35/10

Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

公开(公告)号：US20180203026A1

公开(公告)日：2018-07-19

申请号：US15565105

申请日：2016-04-05

Applicant: The Board of Regents of the University of Oklahom

Inventor： Chuanbin Mao ,  Binrui Cao

IPC: G01N35/00 ,  G01N33/569 ,  C07K7/08 ,  G01N33/543

CPC classification number: G01N35/0098 ,  A61K38/00 ,  A61K38/04 ,  C07K7/08 ,  G01N33/54326 ,  G01N33/56983

Abstract: Disclosed are genetically-modified phages, comprising a first nucleic acid sequence encoding at least a first peptide able to bind to a magnetic nanoparticle, and a second nucleic acid sequence encoding at least a second peptide able to bind with high specificity to a predetermined biomarker, and a method for using the genetically-modified phage displaying the first peptide and second peptide in a method for analyzing a fluid sample for the predetermined biomarker.

公开(公告)号：US20180180607A1

公开(公告)日：2018-06-28

申请号：US15854281

申请日：2017-12-26

Applicant: SYSMEX CORPORATION

Inventor： Takuya KUBO

IPC: G01N33/543 ,  G01N35/00

CPC classification number: G01N33/54326 ,  G01N35/00722 ,  G01N35/0098 ,  G01N2035/00564

Abstract: Disclosed is an analysis method including: a component to be analyzed being set; bringing a carrier and a complex that includes the component into contact with each other, to form the complex on the carrier; selecting a washing process in accordance with the component; and analyzing the component, with use of the washing process selected in accordance with the set component.

公开(公告)号：USD821602S1

公开(公告)日：2018-06-26

申请号：US29584030

申请日：2016-11-10

Applicant: CUE INC.

Designer： Clinton Sever ,  Paul Nelson ,  Ayub Khattak

CPC classification number: B01L3/508 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/5029 ,  B01L3/523 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/047 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/0672 ,  B01L2300/069 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/1805 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0677 ,  C12Q1/6825 ,  G01N27/3273 ,  G01N33/54366 ,  G01N35/0098 ,  G01N35/10

Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

公开(公告)号：US10007885B1

公开(公告)日：2018-06-26

申请号：US15650216

申请日：2017-07-14

Applicant: The United States of America, as Represented by the Secretary of Commerce

Inventor： Alexey V. Gorshkov ,  Michael S. Foss-Feig ,  Zachary Eldredge ,  Steven L. Rolston

IPC: H01L29/06 ,  G06N99/00 ,  G01N24/00 ,  G01N35/00 ,  H04B10/70 ,  G01N29/44 ,  G06F17/10

CPC classification number: G06N10/00 ,  G01N24/00 ,  G01N24/008 ,  G01N29/4472 ,  G01N35/0098 ,  G01R33/24 ,  G06F17/10 ,  H04B10/70

Abstract: Determining a modal amplitude of an inhomogeneous field includes: preparing an initial entangled state of a quantum sensor; subjecting the quantum sensor to the inhomogeneous field of the analyte; subjecting a first qudit sensor of the quantum sensor to a first perturbation pulse; receiving the first perturbation pulse by the first qudit sensor to prepare a first intermediate entangled state of the quantum sensor, the first intermediate entangled state comprising a first intermediate linear superposition; changing the initial linear superposition to the first intermediate linear superposition in response to receiving the first perturbation pulse by the quantum sensor; and determining a final entangled state of the quantum sensor after applying the first perturbation pulse to determine the modal amplitude of the inhomogeneous field of the analyte.

公开(公告)号：US20180172597A1

公开(公告)日：2018-06-21

申请号：US15127119

申请日：2015-03-20

Applicant: UNIVERSAL BIO RESEARCH CO., LTD.

Inventor： Hideji Tajima

IPC: G01N21/78 ,  H01L31/167 ,  F21V8/00 ,  G01N21/03 ,  G01N21/64 ,  G01N21/76 ,  G01N35/10

CPC classification number: G01N21/78 ,  G01N21/0332 ,  G01N21/64 ,  G01N21/76 ,  G01N35/0098 ,  G01N35/10 ,  G01N2035/1062 ,  G01N2201/0833 ,  G02B6/0036 ,  H01L31/167

Abstract: A lightguide aggregate inspection device includes a reaction spot array including multiple reaction spot array elements having at least one reaction spot, a light-receiving element array having a light-receiving surface provided with multiple light-receiving regions each having at least one light-receiving element corresponding to each of the reaction spot array elements, and receiving light obtained based on an optical state resulting from reaction in each of the reaction spots, multiple lightguide paths provided to correspond to the reaction spot array elements, and each having a measurement end provided close to or in contact with, or to be movable close to or into contact with 1 reaction spot, and a connection end provided close to or in contact with the light-receiving region, and a digital data conversion unit configured to convert image region data obtained from the light-receiving elements corresponding to the light-receiving regions, into digital data.

公开(公告)号：US09999889B2

公开(公告)日：2018-06-19

申请号：US15336739

申请日：2016-10-27

Applicant: CUE INC.

Inventor： Ayub Khattak ,  Clinton Sever ,  Paul Nelson ,  Ryan Cooper ,  Thomas Congdon ,  Justin Demartino ,  Raphael Shapiro ,  Mark Duncan

IPC: B01L3/00 ,  G01N27/327 ,  G01N35/10 ,  G01N35/00 ,  G01N33/543 ,  C12Q1/68

CPC classification number: B01L3/508 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/5029 ,  B01L3/523 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/047 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/0672 ,  B01L2300/069 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/1805 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0677 ,  C12Q1/6825 ,  G01N27/3273 ,  G01N33/54366 ,  G01N35/0098 ,  G01N35/10

Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.