公开(公告)号：US08698494B2

公开(公告)日：2014-04-15

申请号：US13776580

申请日：2013-02-25

Applicant: STC.UNM

Inventor： Laurel Sillerud ,  Todd M. Alam ,  Andrew F. McDowell

IPC: G01V3/00

CPC classification number: G01R33/32 ,  B82Y15/00 ,  G01N24/08 ,  G01N33/54326 ,  G01N33/553 ,  G01R33/281 ,  G01R33/302 ,  G01R33/34007 ,  G01R33/34046 ,  G01R33/34092 ,  G01R33/341 ,  G01R33/465 ,  G01R33/5601

Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

Abstract translation: 生物检测器包括用于接收含有一个或多个待纳入检测体的磁性纳米颗粒标记的生物体的流体的导管，以及一个用于建立其中设置导管的低磁场的永磁体或电磁体。 微线圈靠近导管设置，以允许通过NMR光谱法检测流体中是否存在一个或多个磁性标记的生物体的频率。

公开(公告)号：US20140086795A1

公开(公告)日：2014-03-27

申请号：US14092409

申请日：2013-11-27

Applicant: STC.UNM ,  University of Florida Research Foundation, Inc.

Inventor： Kirk S. Schanze ,  Motokatsu Ogawa ,  Jonathan Robert Sommer ,  David G. Whitten ,  Thomas S. Corbitt

IPC: A01N25/28 ,  A61L2/23

CPC classification number: A01N25/28 ,  A01N25/00 ,  A01N25/10 ,  A01N25/34 ,  A01N43/90 ,  A61L2/23 ,  Y10S977/712 ,  Y10S977/903 ,  Y10T428/2982 ,  A01N41/04 ,  A01N2300/00

Abstract: Hollow conjugated polyelectrolyte (HCPE) microcapsules contain at least one conjugated polyelectrolyte and at least one other polyelectrolyte of complementary charge and the microcapsule has a hollow core. The conjugated polyelectrolyte is a polymer with a multiplicity of charged repeating units where a portion of the charged repeating units form a pi-conjugated sequence. The complementary polyelectrolyte is a polymer with a complementary charged repeating unit to the charged repeating units of the conjugated polyelectrolyte. The HCPE microcapsules can be formed by successively coating a sacrificial core with alternating layers of complementary polyelectrolytes, at least one of which is a conjugated polyelectrolyte. The sacrificial core can be removed to form the hollow center of a HCPE microcapsule. The HCPE microcapsules can be contacted with a medium containing microbes where the HCPE microcapsules associate with the microbes and efficiently kill the microbes when irradiated with light or other electromagnetic radiation.

Abstract translation: 中空共轭聚电解质（HCPE）微胶囊含有至少一种共轭聚电解质和至少一种其他互补电荷的聚电解质，微胶囊具有中空芯。 共轭聚电解质是具有多个带电重复单元的聚合物，其中一部分带电重复单元形成π-共轭序列。 互补聚电解质是与共轭聚电解质的带电重复单元具有互补的带电重复单元的聚合物。 HCPE微胶囊可以通过连续地涂覆具有互补聚电解质交替层的牺牲芯形成，其中至少一种是共轭聚电解质。 可以去除牺牲芯以形成HCPE微胶囊的中空中心。 HCPE微胶囊可以与含有微生物的培养基接触，其中HCPE微胶囊与微生物结合，并在用光或其他电磁辐射照射时有效杀死微生物。

公开(公告)号：US08666180B2

公开(公告)日：2014-03-04

申请号：US13512951

申请日：2010-12-03

Applicant: Pradeep Sen ,  Aliakbar Darabi

Inventor： Pradeep Sen ,  Aliakbar Darabi

IPC: G06K9/36 ,  G06T1/00

CPC classification number: H04N19/85 ,  H04N19/59 ,  H04N19/63 ,  H04N19/80

Abstract: Compressed sensing can be mapped to a more general set of problems in computer graphics and computer imaging. Representation of a rendered scene in the formulation y=A{circumflex over (x)} produces higher-quality rendering with less samples than previous approaches. A filter formulation Φ makes point samples compatible with wavelet and therefore allows reconstruction of 2-D images from a set of measured pixels (point samples).

Abstract translation: 压缩感测可以映射到计算机图形学和计算机成像中更一般的问题集。 在制定中，渲染场景的表示y = A {在（x）}中生成比以前的方法更少的样本的更高品质的渲染。 滤波器公式Phi使点样本与小波兼容，因此允许从一组测量像素（点样本）重建2-D图像。

公开(公告)号：US08658734B2

公开(公告)日：2014-02-25

申请号：US13320454

申请日：2010-05-11

Applicant: Gabriel Lopez ,  Nick Carroll ,  Kevin Cushing ,  Dimiter N Petsev

Inventor： Gabriel Lopez ,  Nick Carroll ,  Kevin Cushing ,  Dimiter N Petsev

IPC: C08L83/04

CPC classification number: C08L83/04 ,  A61K9/0009 ,  A61K9/1641 ,  A61K9/1682 ,  A61K47/34 ,  A61K49/225 ,  G01N33/538 ,  G01N33/54313

Abstract: We describe methods for synthesis and formulations of stable elastomeric negative acoustic contrast particles with controllable compressibility and density. These elastomeric negative acoustic contrast particles have a density/compressibility ratio that is less than that of water and therefore exhibit negative acoustic contrast under acoustic radiation exposure. This negative acoustic contrast allows our elastomeric negative acoustic contrast particles to be acoustically manipulated (e.g. separated) differently from other components (e.g. cells) within an aqueous solution. This disclosure also describes methods for biofunctionalization of the elastomeric negative acoustic contrast particles and as an example their use as platforms for bioassays. Potential applications of these elastomeric negative acoustic contrast particles include sensitive bioassays based on acoustic flow cytometry and other types of techniques that utilize acoustic fields, including ultrasound imaging and ultrasound triggered drug delivery.

Abstract translation: 我们描述了具有可压缩性和密度的稳定的弹性体负型声学造影颗粒的合成方法和配方。 这些弹性体负声学对比颗粒的密度/压缩比小于水的密度/压缩比，因此在声辐射暴露下呈现负的声学对比度。 这种负声学对比度允许我们的弹性体负声学对比粒子与水溶液中的其它组分（例如细胞）不同地被声学操纵（例如分离）。 本公开还描述了弹性体负声学对比粒子的生物功能化的方法，并且作为其用作生物测定平台的实例。 这些弹性体负声学对比粒子的潜在应用包括基于声流式细胞术的敏感生物测定和利用声场的其他类型的技术，包括超声成像和超声触发药物递送。

公开(公告)号：US20130302371A1

公开(公告)日：2013-11-14

申请号：US13820891

申请日：2011-09-13

Applicant: Bryce C. Chackerian ,  David S. Peabody

Inventor： Bryce C. Chackerian ,  David S. Peabody

IPC: A61K39/155

CPC classification number: A61K39/155 ,  A61K39/12 ,  A61K39/295 ,  A61K47/69 ,  A61K47/6901 ,  A61K47/6929 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/55566 ,  A61K2039/6075 ,  C07K14/005 ,  C07K2319/40 ,  C12N7/00 ,  C12N2760/18523 ,  C12N2760/18534 ,  C12N2795/00023

Abstract: The invention provides immunotherapeutic and prophylactic bacteriophage viral-like particle (VLPs) which are useful in the treatment and prevention of Respiratory Syncytial Virus (RSV) infections and related disorders, including bronchiolitis and viral pneumonia. Related compositions (e.g. vaccines), nucleic acid constructs, and therapeutic methods are also provided. VLPs and related compositions of the invention induce high titer antibody responses against RSV. VLPs, VLP-containing compositions, and therapeutic methods of the invention induce an immunogenic response against RSV infection, confer immunity against RSV infection, protect against RSV infection, and reduce the likelihood of infection by RSV infection.

Abstract translation: 本发明提供了可用于治疗和预防呼吸道合胞病毒（RSV）感染和相关疾病（包括细支气管炎和病毒性肺炎）的免疫治疗和预防性噬菌体病毒样颗粒（VLP）。 还提供了相关组合物（例如疫苗），核酸构建体和治疗方法。 本发明的VLP和相关组合物诱导针对RSV的高效价抗体应答。 VLP，含VLP的组合物和本发明的治疗方法诱导针对RSV感染的免疫原性应答，赋予针对RSV感染的免疫，防止RSV感染，并降低RSV感染感染的可能性。

公开(公告)号：US08557622B2

公开(公告)日：2013-10-15

申请号：US13223580

申请日：2011-09-01

Applicant: Seung Chang Lee ,  Steven R. J. Brueck

Inventor： Seung Chang Lee ,  Steven R. J. Brueck

IPC: H01L21/00 ,  H01L21/20 ,  H01L21/36 ,  H01L29/06 ,  H01L31/00

CPC classification number: H01L21/02603 ,  B82Y10/00 ,  B82Y40/00 ,  B82Y99/00 ,  H01L21/0237 ,  H01L21/02439 ,  H01L21/02507 ,  H01L21/02521 ,  H01L21/02639 ,  H01L29/0665 ,  H01L29/0673 ,  H01L29/127 ,  H01L29/158 ,  H01L29/7783 ,  H01L29/7853 ,  H01L33/06 ,  H01L33/18 ,  H01S5/32 ,  Y10S977/951 ,  Y10S977/962

Abstract: Exemplary embodiments provide semiconductor nanowires and nanowire devices/applications and methods for their formation. In embodiments, in-plane nanowires can be epitaxially grown on a patterned substrate, which are more favorable than vertical ones for device processing and three-dimensional (3D) integrated circuits. In embodiments, the in-plane nanowire can be formed by selective epitaxy utilizing lateral overgrowth and faceting of an epilayer initially grown in a one-dimensional (1D) nanoscale opening. In embodiments, optical, electrical, and thermal connections can be established and controlled between the nanowire, the substrate, and additional electrical or optical components for better device and system performance.

Abstract translation: 示例性实施例提供用于其形成的半导体纳米线和纳米线器件/应用和方法。 在实施例中，平面内纳米线可以在图案化衬底上外延生长，其比用于器件处理和三维（3D）集成电路的垂直纳米线更有利。 在实施方案中，可以通过使用最初在一维（1D）纳米尺度开口中生长的外延层的横向过生长和刻面的选择性外延来形成平面内纳米线。 在实施例中，可以在纳米线，衬底和附加电气或光学部件之间建立和控制光学，电气和热连接，以获得更好的器件和系统性能。

公开(公告)号：US08526105B2

公开(公告)日：2013-09-03

申请号：US13345267

申请日：2012-01-06

Applicant: Steven R. J. Brueck ,  Yuliya Kuznetsova ,  Alexander Neumann

Inventor： Steven R. J. Brueck ,  Yuliya Kuznetsova ,  Alexander Neumann

IPC: G02B21/06 ,  G02B21/00

CPC classification number: G02B21/0032 ,  G02B21/00 ,  G02B21/365 ,  G06T3/4061 ,  G06T2207/10056 ,  G06T2207/20056 ,  G06T2207/20221 ,  G06T2207/30148

Abstract: In accordance with the invention, there are imaging interferometric microscopes and methods for imaging interferometric microscopy using structural illumination and evanescent coupling for the extension of imaging interferometric microscopy. Furthermore, there are coherent anti-Stokes Raman (CARS) microscopes and methods for coherent anti-Stokes Raman (CARS) microscopy, wherein imaging interferometric microscopy techniques are applied to get material dependent spectroscopic information.

Abstract translation: 根据本发明，存在成像干涉显微镜和用于使用结构照明和ev逝耦合来成像干涉显微镜的成像干涉显微镜成像的方法。 此外，还有相干的反斯托克斯拉曼（CARS）显微镜和相干反斯托克斯拉曼（CARS）显微镜的方法，其中应用成像干涉显微技术获得材料依赖的光谱信息。

公开(公告)号：US20130210672A1

公开(公告)日：2013-08-15

申请号：US13585165

申请日：2012-08-14

Applicant: Larry A. Sklar ,  Bruce S. Edwards ,  Frederick W. Kuckuck

Inventor： Larry A. Sklar ,  Bruce S. Edwards ,  Frederick W. Kuckuck

IPC: G01N21/64

CPC classification number: G01N15/1436 ,  B01L3/5085 ,  G01N15/1404 ,  G01N15/1459 ,  G01N21/6428 ,  G01N21/6486 ,  G01N35/0099 ,  G01N35/085 ,  G01N35/1095 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1413 ,  G01N2015/1477 ,  G01N2015/149 ,  G01N2021/6439 ,  G01N2201/06113 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.

Abstract translation: 本发明提供了一种用于检测多个样品中的颗粒的流式细胞仪装置，包括：用于将包含多个相应源阱的颗粒的多个样品移动到流体流动流中的装置; 用于在所述流体流动流中的所述多个样品中的每一个之间引入分离气体的装置; 以及用于选择性地分析所述多个样品中的每个所述颗粒的装置。 本发明还提供了使用这种装置的流式细胞术方法。

公开(公告)号：US20130150415A1

公开(公告)日：2013-06-13

申请号：US13760605

申请日：2013-02-06

Applicant: Graham TIMMINS ,  Sharon Masters ,  Vojo P. Deretic ,  William Bishai

Inventor： Graham TIMMINS ,  Sharon Masters ,  Vojo P. Deretic ,  William Bishai

IPC: C07D213/81

CPC classification number: C07D213/81 ,  A61K9/0019 ,  A61K9/0073 ,  A61K31/44 ,  A61K31/4409 ,  C07D213/83 ,  C07D213/86

Abstract: The present invention relates to the use of isotopically labeled derivatives of isoniazid, ethionamide and related compounds as effective therapy for the treatment of mycobacterial diseases, including Mycobacterium tuberculosis.

Abstract translation: 本发明涉及异烟肼，乙硫异烟胺和相关化合物的同位素标记衍生物在治疗分枝杆菌疾病（包括结核分枝杆菌）中的有效疗法。

公开(公告)号：US08431041B2

公开(公告)日：2013-04-30

申请号：US12386503

申请日：2009-04-17

Applicant: Marek A. Osinski ,  Nathan J. Withers ,  Brian A. Akins ,  Gennady A. Smolyakov ,  Krishnaprasad Sankar

Inventor： Marek A. Osinski ,  Nathan J. Withers ,  Brian A. Akins ,  Gennady A. Smolyakov ,  Krishnaprasad Sankar

IPC: C09K11/08 ,  C09K11/61

CPC classification number: C09K11/7773 ,  C09K11/664 ,  C09K11/7772 ,  G01T1/20 ,  G01T1/202 ,  Y10T428/256 ,  Y10T428/2982

Abstract: Scintillator material comprising nanoparticles (nanocrystals) comprising lead (Pb), iodine (I), and optionally one or both of oxygen (O) and hydrogen (H) wherein the nanoparticles exhibit room-temperature scintillation under gamma irradiation. The scintillator nanoparticles can comprise Pb3O2I2. The scintillator nanoparticles can comprise PbIOH in generally equiatomic proportions or non-equiatomic variants thereof that exhibit scintillation under gamma irradiation. The scintillator nanoparticles have a particle dimension in the range of about 5 to about 100 nm. Microparticles (microcrystals) also are provided comprising lead (Pb), iodine (I), and optionally one or both of oxygen (O) and hydrogen (H) grown in a nanoparticle colloidal solution over time to a particle dimension greater than 0.1 μm, such as about 2 microns. A heterogeneous scintillator material is provided comprising core/shell nanoparticles having a highly hygroscopic or deliquescent halide-based core activated with trivalent Ln3+ or divalent Ln2+ lanthanide ions (Ln=La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) and a stable non-hygroscopic shell thereon. The heterogeneous nanoparticles can comprise highly hygroscopic lanthanide halide (LaBr3, LuI3) cores protected with stable non-hygroscopic LaF3 shells. The heterogeneous nanoparticles can comprise deliquescent alkaline earth halide (SrI2, BaI2) cores protected with stable non-hygroscopic (SrF2, BaF2) shells.

Abstract translation: 包含包含铅（Pb），碘（I）和任选的氧（O）和氢（H）中的一种或两者的纳米颗粒（纳米晶体）的闪烁体材料，其中纳米颗粒在γ照射下呈现室温闪烁。 闪烁体纳米颗粒可以包含Pb 3 O 2 I 2。 闪烁体纳米颗粒可以包含通常等原子比例的PbIOH或在γ照射下显示闪烁的非等摩尔变体。 闪烁体纳米颗粒具有在约5至约100nm范围内的粒子尺寸。 还提供包含铅（Pb），碘（I）以及任选的在纳米颗粒胶体溶液中生长的氧（O）和氢（H）中的一种或两种随时间变化至大于0.1μm的颗粒尺寸的微颗粒（微晶） 例如约2微米。 提供了一种异质闪烁体材料，其包括具有由三价Ln3 +或二价Ln2 +镧系元素离子（Ln = La，Ce，Pr，Nd，Pm，Sm，Eu，Gd，Tb）活化的高吸湿性或潮解性卤化物基核心的核/壳纳米颗粒 ，Dy，Ho，Er，Tm，Yb，Lu）和稳定的非吸湿性外壳。 非均相纳米颗粒可以包含用稳定的非吸湿性LaF 3壳保护的高吸湿性镧系元素卤化物（LaBr 3，LuI 3）。 非均相纳米颗粒可以包含用稳定的非吸湿性（SrF 2，BaF 2）壳保护的潮解性碱土卤​​化物（SrI 2，BaI 2）。