-
21.
公开(公告)号:US20240173720A1
公开(公告)日:2024-05-30
申请号:US18401140
申请日:2023-12-29
Applicant: Gen-Probe Incorporated
Inventor: Julian GROELI , Jin CHEN
Abstract: A scissors actuator is configured to translate a support platform in either of opposed lateral directions with respect to a base frame and includes a first arm, a second arm, wherein the first and second arms are rotatably connected at intermediate positions between their respective first and second ends, the first arm is pivotably attached at its first end to the base frame, and the second arm and is pivotably attached at its second end to the support platform. A first slide is disposed within a first linear track formed in the support platform and includes a bearing protruding from a side of the first slide for rolling contact with a side of the first linear track formed in the support platform. The first arm is pivotably and translatably attached at its second end to the support platform by the first slide. A second slide is disposed within a second linear track formed in the base frame and includes a bearing protruding from a side of the second slide for rolling contact with a side of the second linear track formed in the base frame. The second arm is pivotably and translatably attached at its first end to the base frame by the second slide.
-
22.
公开(公告)号:US20240150823A1
公开(公告)日:2024-05-09
申请号:US18544053
申请日:2023-12-18
Applicant: Gen-Probe Incorporated
Inventor: David BUSE , David Howard COMBS , Norbert D. HAGEN , David OPALSKY , Bruce RICHARDSON , Anita PRASAD , Keith MORAVICK , Tyler MOORE , Byron J. Knight
CPC classification number: C12Q1/686 , B01L7/52 , G01N21/6452 , B01L9/06 , B01L2200/142 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , B01L2300/1822 , G01N2021/6484
Abstract: An apparatus for incubating a plurality of receptacles includes one or more thermally-conductive receptacle holders, each comprising a plurality of receptacle wells. A thermally-conductive support is associated with each of the receptacle holders, and a thermal element is positioned between the associated support and the receptacle holder. A heat sink is in thermal communication with the support and comprises a plurality of spaced-apart fins. An optical fiber associated with each receptacle well has a first end positioned adjacent to or within a through-hole formed in the receptacle well and extends through through-holes formed in the support and the heat sink aligned with the through-hole of the receptacle well. Each of the optical fibers is positioned between two adjacent fins of the plurality of fins.
-
公开(公告)号:US20240044928A1
公开(公告)日:2024-02-08
申请号:US18489516
申请日:2023-10-18
Applicant: GEN-PROBE INCORPORATED
Inventor: Rolf SILBERT , HongRan PENG , David Aaron BUSE , David H. COMBS
CPC classification number: G01N35/04 , B01L3/5453 , B01L9/06 , B65G43/08 , B65G47/902 , G01N35/00584 , G01N35/0099 , G01N35/1079 , B01L2300/021 , B65G2201/0235 , B65G2203/044 , G01N2035/00752 , G01N2035/0406 , G01N2035/0494 , G01N2035/103
Abstract: A receptacle delivery system that includes a rail extending between first and second locations of an instrument and a carriage configured to move on the rail between the first and second locations of the instrument. The carriage includes a bracket having opposed first and second sidewalls and a base extending between the first and second sidewalls, where the carriage is configured to support a receptacle. The carriage further includes a pair of opposed support pads, where the pair of support pads are configured to (a) move toward a receptacle supported by the carriage as the carriage moves from the first location toward the second location, and (b) move away from a receptacle supported by the carriage as the carriage moves from the second location toward the first location. The carriage also includes a pair of meshed cam gears rotatably coupled to the first sidewall, where each cam gear is coupled to a different one of the support pads.
-
公开(公告)号:US20240043916A1
公开(公告)日:2024-02-08
申请号:US18361786
申请日:2023-07-28
Applicant: GEN-PROBE INCORPORATED
Inventor: Jennifer L. TIDD , Ann-Laure SHAPIRO , Ankur H. SHAH , James T. TUGGLE , David OPALSKY , Alberto A. LIO , Timothy J. SCHEER , Jason F. RHUBOTTOM , David Aaron BUSE
IPC: C12Q1/6844
CPC classification number: C12Q1/6844 , C12Q2523/32 , C12Q2527/101 , C12Q2531/113 , C12Q2565/629
Abstract: A method of performing a lab developed test for detecting a nucleic acid analyte on an automated analyzer. The method includes a first step of using a computer to select, define or modify one or more user-defined parameters of a protocol for performing the lab developed test on the analyzer, where each user-defined parameter of the protocol defines a step to be performed by the analyzer during the lab developed test. The method further includes a second step of performing the lab developed test with the protocol of the first step, where the analyzer stores one or more system-defined parameters for performing the lab developed test, the one or more system-defined parameters being installed on the analyzer prior to performing first step.
-
公开(公告)号:US20240011109A1
公开(公告)日:2024-01-11
申请号:US18458047
申请日:2023-08-29
Applicant: Gen-Probe Incorporated
Inventor: Kui GAO , Jeffrey M. LINNEN
IPC: C12Q1/70
CPC classification number: C12Q1/701 , C12Q2600/16 , C12Q2600/158
Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
-
公开(公告)号:US11859238B2
公开(公告)日:2024-01-02
申请号:US16241778
申请日:2019-01-07
Applicant: GEN-PROBE INCORPORATED
Inventor: Norman C. Nelson , Lyle J. Arnold, Jr. , Lizhong Dai , Steven Phelps , Jijumon Chelliserry
IPC: C12Q1/68 , C12Q1/6806 , C12Q1/6848 , C12Q1/70 , C12P19/34 , C12Q1/6865 , C12Q1/6825
CPC classification number: C12Q1/6806 , C12P19/34 , C12Q1/68 , C12Q1/6825 , C12Q1/6848 , C12Q1/6865 , C12Q1/70 , C12Q1/6865 , C12Q2537/101 , C12Q2545/10
Abstract: Improved methods for use in nucleic acid amplification, including multiplex amplification, where the amplification is carried out in two or more distinct phases are disclosed. The first phase amplification reaction preferably lacks one or more components required for exponential amplification. The lacking component is subsequently provided in a second, third or further phase(s) of amplification, resulting in a rapid exponential amplification reaction. The multiphase protocol results in faster and more sensitive detection and lower variability at low analyte concentrations. Compositions for carrying out the claimed methods are also disclosed.
-
公开(公告)号:US20230383335A1
公开(公告)日:2023-11-30
申请号:US18345861
申请日:2023-06-30
Applicant: GEN-PROBE INCORPORATED
Inventor: Norman C. NELSON , Jijumon CHELLISERRY
IPC: C12Q1/6811 , C07H21/00 , C12Q1/6844 , C12Q1/6848 , C12Q1/6853 , C12Q1/6869
CPC classification number: C12Q1/6811 , C07H21/00 , C12Q1/6844 , C12Q1/6848 , C12Q1/6853 , C12Q1/6869
Abstract: The invention provides compositions and methods for making closed nucleic acid structures in which one or both strands are continuous. The closed nucleic acid structures can be used as sequencing templates among other applications.
-
公开(公告)号:US11821046B2
公开(公告)日:2023-11-21
申请号:US17032310
申请日:2020-09-25
Applicant: GEN-PROBE INCORPORATED
Inventor: Kui Gao , Jeffrey M. Linnen
IPC: C12Q1/70
CPC classification number: C12Q1/701 , C12Q2600/158 , C12Q2600/16
Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
-
公开(公告)号:US11815522B2
公开(公告)日:2023-11-14
申请号:US18111865
申请日:2023-02-20
Applicant: Gen-Probe Incorporated
Inventor: Rolf Silbert , David Opalsky , David Aaron Buse , Robert J. Rosati , Olev Tammer , Richard Capella , Matthias Merten
IPC: G01N1/28 , G01N1/31 , G01N35/10 , G01N35/02 , G01N35/00 , G01F23/263 , G01N35/04 , B67B7/00 , C40B60/12
CPC classification number: G01N35/1004 , B67B7/00 , G01F23/265 , G01N1/28 , G01N1/31 , G01N35/0099 , G01N35/00732 , G01N35/025 , G01N35/04 , G01N35/1002 , G01N35/1016 , G01N35/1079 , C40B60/12 , G01N2035/00524 , G01N2035/00752 , G01N2035/00811 , G01N2035/00831 , G01N2035/00861 , G01N2035/0405 , G01N2035/1018 , G01N2035/1046 , G01N2035/1048 , G01N2035/1051 , G01N2035/1062
Abstract: A sample processing station includes two or more container holders on a platform that is rotatable about a central axis of rotation. Each holder is configured to rotate about a secondary axis of rotation. The station includes a capping/decapping mechanism to cap or decap a container held in one of the container holders and an elevator with a chuck guide that contact the container holder as the chuck is lowered by the elevator to positon the chuck with respect to the cap of the container held in the holder and to hold jaws of the container holder in a closed position. In embodiment, the chuck guide includes a yoke with opposed arms and spindles located near distal ends of the arms that engage beveled shoulders of the container holder.
-
30.
公开(公告)号:US11788128B2
公开(公告)日:2023-10-17
申请号:US17029930
申请日:2020-09-23
Applicant: Gen-Probe Incorporated
Inventor: David Buse , David Howard Combs , Norbert D. Hagen , David Opalsky , Bruce Richardson , Anita Prasad , Keith Moravick , Tyler Moore
CPC classification number: C12Q1/686 , B01L7/52 , G01N21/6452 , B01L9/06 , B01L2200/141 , B01L2200/142 , B01L2300/042 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , B01L2300/1822 , G01N2021/6482 , G01N2021/6484
Abstract: An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder with front and back surfaces. The front surface includes a row of receptacle wells, and an outer surface of each well has a frustoconical shape, an inner surface of each well receives a receptacle, and each well has a through-hole extending between the inner and outer surfaces thereof. One or more thermal elements in contact with the back surface of the holder alter a temperature(s) of the holder. The apparatus includes multiple optical fibers, and each optical fiber provides optical communication between one of the wells and an excitation signal source and/or an emission signal detector. A first end of each optical fiber is disposed outside, within, or extends through the through-hole of a corresponding well, and a second end of each optical fiber is in optical communication with the excitation signal source and/or the emission signal detector.
-
-
-
-
-
-
-
-
-