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    DIFFERENTIATION OF ISOBARIC AMINO ACIDS AND OTHER SPECIES
    22.
    发明申请
    DIFFERENTIATION OF ISOBARIC AMINO ACIDS AND OTHER SPECIES 有权
    ISOBARIC氨基酸和其他物种的差异

    公开(公告)号：US20130109578A1

    公开(公告)日：2013-05-02

    申请号：US13386333

    申请日：2009-07-22

    Applicant: James R. Heath ,  Su Seong Lee ,  Jaehong Lim ,  Junhoe Cha ,  Sylvia Tan ,  Shi Yun Yeo

    Inventor： James R. Heath ,  Su Seong Lee ,  Jaehong Lim ,  Junhoe Cha ,  Sylvia Tan ,  Shi Yun Yeo

    IPC: G01N33/68 ,  C07K1/13

    CPC classification number: G01N33/6848 ,  C07B2200/11 ,  C07K1/047 ,  C07K1/13 ,  C07K7/06 ,  C40B50/16 ,  G01N33/6812 ,  G01N33/6818

    Abstract: Techniques for differentiating isobaric species are described. An isobaric species may be substituted with a tagging species identified using mass spectrometry. The isobaric species may be a subunit of a first polymer having a defined sequence, e.g., the isobaric species may be an amino acid in a protein or a peptide sequence. A tagging species may be substituted for the isobaric species in a second polymer having an otherwise identical sequence as the first polymer. The second polymer may have the same number of sequences as the first polymer, and substantially the same sequence of subunits, with a few exceptions such as the tagging species for the isobaric species. The first polymer and the second polymer may be prepared in the same reaction vessel. A polymer/protein of defined subunit sequence containing an isobaric species or a tagging species may be analyzed by mass spectrometry to determine the sequence.

    Abstract translation: 描述了用于区分等压物种的技术。 同量异位物质可以用用质谱鉴定的标记物种代替。 等压异构物可以是具有确定的序列的第一聚合物的亚单位，例如，同量异位物质可以是蛋白质或肽序列中的氨基酸。 在具有与第一聚合物相同的序列的第二聚合物中，标记物质可以代替同量异位物质。 第二聚合物可以具有与第一聚合物相同数量的序列，以及基本上相同的亚基序列，只有少数例外，例如同量异序物种的标记物种。 第一聚合物和第二聚合物可以在相同的反应容器中制备。 可以通过质谱分析含有等压物种或标记物质的限定亚单位序列的聚合物/蛋白质来确定序列。

    Methods and systems for detecting and/or sorting targets
    23.
    发明授权
    Methods and systems for detecting and/or sorting targets 有权
    用于检测和/或排序目标的方法和系统

    公开(公告)号：US08354231B2

    公开(公告)日：2013-01-15

    申请号：US12652000

    申请日：2010-01-04

    Applicant: Gabriel A. Kwong ,  Ryan C. Bailey ,  Rong Fan ,  James R. Heath

    Inventor： Gabriel A. Kwong ,  Ryan C. Bailey ,  Rong Fan ,  James R. Heath

    IPC: C12Q1/68 ,  G01N33/53

    CPC classification number: G01N33/6845 ,  C12Q1/6834 ,  C12Q2563/131

    Abstract: Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate polynucleotide, wherein the substrate polynucleotide is attached to a substrate.

    Abstract translation: 本文提供了用于基于多核苷酸编码的蛋白质和底物多核苷酸的组合使用来检测和/或分选样品中靶标的方法和系统。 所述多核苷酸编码的蛋白质由特异性结合预定靶标的蛋白质和特异性结合底物多核苷酸的编码多核苷酸组成，其中所述底物多核苷酸附着于底物。

    SCREENING OF BIOPOLYMERS
    24.
    发明申请
    SCREENING OF BIOPOLYMERS 审中-公开
    生物聚合物筛选

    公开(公告)号：US20120122711A1

    公开(公告)日：2012-05-17

    申请号：US13384510

    申请日：2010-07-15

    Applicant: James R. Heath ,  Su Seong Lee ,  Jaehong Lim ,  Junhoe Cha ,  Sylvia Tan ,  Shi Yun Yeo ,  Yi Li Ang ,  Yiran Zhang

    Inventor： James R. Heath ,  Su Seong Lee ,  Jaehong Lim ,  Junhoe Cha ,  Sylvia Tan ,  Shi Yun Yeo ,  Yi Li Ang ,  Yiran Zhang

    IPC: C40B30/00 ,  C40B50/18 ,  C40B40/12 ,  C40B40/06 ,  C40B40/10

    CPC classification number: G01N33/6845

    Abstract: Described herein are inventive compositions and methods relating to sampling of biopolymers and, in particular, to fractional sampling of biopolymers. In one aspect, embodiments are generally related to unique biopolymer species where a fraction of each biopolymer species contains a cleavable linker. The biopolymer species may, in some embodiments, be attached to a surface. For example, the biopolymer species may be attached to beads. In some embodiments, a portion of a unique biopolymer species may be sampled by cleaving the cleavable linker. In some cases, the sample may be analyzed to determine the sequence of the biopolymer.

    Abstract translation: 本文描述了与生物聚合物的取样有关的本发明组合物和方法，特别是生物聚合物的分数取样。 在一个方面，实施方案通常涉及独特的生物聚合物种类，其中每个生物聚合物种类的一部分含有可切割的连接体。 在一些实施方案中，生物聚合物物质可附着于表面。 例如，生物聚合物物质可以连接到珠粒上。 在一些实施方案中，可以通过切割可切割接头来采样一部分独特的生物聚合物种类。 在一些情况下，可以分析样品以确定生物聚合物的顺序。

    LATERAL FLOW MICROFLUIDIC ASSAYING DEVICE AND RELATED METHOD
    25.
    发明申请
    LATERAL FLOW MICROFLUIDIC ASSAYING DEVICE AND RELATED METHOD 有权
    侧流微流体测定装置及相关方法

    公开(公告)号：US20120070833A1

    公开(公告)日：2012-03-22

    申请号：US13240347

    申请日：2011-09-22

    Applicant: Jun WANG ,  James R. HEATH

    Inventor： Jun WANG ,  James R. HEATH

    IPC: C12Q1/68 ,  G01N33/566 ,  G01N1/18 ,  G01N30/00 ,  C12M1/34

    CPC classification number: G01N33/54386 ,  B01L3/502753 ,  B01L3/502776 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0633 ,  B01L2400/086

    Abstract: Provided herein is a microfluidic device and related method for controlling flow of different fluid components of a fluid. The microfluidic device comprises an input channel, focusing channel and an assaying channel. The microfluidic device is adapted to separate a fluid into at least two fluid components, and is further adapted to detect a target material comprised within one of the fluid components. The method comprises providing a channel, the channel having a dimension which is a function of a dimension of one of the fluid components and deliver the fluid through the channel at a set flow rate.

    Abstract translation: 本文提供了用于控制流体的不同流体组分的流动的微流体装置和相关方法。 微流体装置包括输入通道，聚焦通道和测定通道。 微流体装置适于将流体分离成至少两个流体组分，并且还适于检测包含在流体组分之一内的目标材料。 该方法包括提供通道，通道具有作为流体部件中的一个的尺寸的函数的尺寸，并以设定的流速输送通过通道的流体。

    Superlattice nanopatterning of wires and complex patterns
    27.
    发明申请
    Superlattice nanopatterning of wires and complex patterns 有权
    电线和复杂图案的超晶格纳米图案

    公开(公告)号：US20100258785A1

    公开(公告)日：2010-10-14

    申请号：US11633043

    申请日：2006-12-04

    Applicant: James R. Heath ,  Pierre M. Petroff ,  Nicholas A. Melosh

    Inventor： James R. Heath ,  Pierre M. Petroff ,  Nicholas A. Melosh

    IPC: H01L29/12 ,  H01L21/02 ,  H01L21/71

    CPC classification number: B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  G03F7/0002 ,  H01L21/0337 ,  H01L21/76802 ,  H01L21/76838 ,  Y10S977/755 ,  Y10S977/76 ,  Y10S977/762 ,  Y10S977/847 ,  Y10S977/938

    Abstract: Fabrication of metallic or non-metallic wires with nanometer widths and nanometer separation distances without the use of lithography. Wires are created in a two-step process involving forming the wires at the desired dimensions and transferring them to a planar substrate. The dimensions and separation of the wires are determined by the thicknesses of alternating layers of different materials that are in the form of a superlattice. Wires are created by evaporating the desired material onto the superlattice that has been selectively etched to provide height contrast between layers. The wires thus formed upon one set of superlattice layers are then transferred to a substrate.

    Abstract translation: 制造具有纳米宽度和纳米分离距离的金属或非金属线，无需光刻。 电线是以两步法制成的，包括以所需尺寸形成电线并将其转移到平面衬底。 导线的尺寸和间距由超晶格形式的不同材料的交替层的厚度决定。 通过将期望的材料蒸发到已经被选择性蚀刻以提供层之间的高度对比度的超晶格上来产生电线。 然后将由此形成在一组超晶格层上的电线转移到基底。

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