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192 条记录 (耗时 0.034 秒)

    Displays and Sensors Integrated with Multi-State Cholesteric Liquid Crystal Devices
    21.
    发明申请
    Displays and Sensors Integrated with Multi-State Cholesteric Liquid Crystal Devices 有权
    与多态胆固醇液晶器件集成的显示器和传感器

    公开(公告)号：US20120293733A1

    公开(公告)日：2012-11-22

    申请号：US13453655

    申请日：2012-04-23

    申请人： Le Li ,  Yongxin Tang ,  Haiping Yu ,  Jie Yang ,  Jiangbin Zhao

    发明人： Le Li ,  Yongxin Tang ,  Haiping Yu ,  Jie Yang ,  Jiangbin Zhao

    IPC分类号： G02F1/1335

    CPC分类号： G02F1/13718

    摘要： A sensing device may include a cholesteric crystal device including two optically transparent substrates; a liquid crystal having portions adapted for producing a plurality of optical states, said liquid crystal being arranged between the two optically transparent substrates; an optical sensor for changing optical states of respective portions of said liquid crystal to produce a range of respective optical states including all optical states produced by said liquid crystal ranging from one state to any combination of broadband reflection, tunable narrow band reflection, light scattering, and transparency in accordance with an amount of voltage applied across said cholesteric crystal device for changing optical states.

    摘要翻译： 感测装置可以包括胆甾醇晶体装置，其包括两个光学透明基板; 具有适于产生多种光学状态的部分的液晶，所述液晶布置在两个光学透明基板之间; 一种光学传感器，用于改变所述液晶的各部分的光学状态，以产生包括由所述液晶产生的所有光学状态的范围，所述光学状态从一种状态到宽带反射，可调窄带反射，光散射， 并且根据用于改变光学状态的所述胆甾型晶体装置两端施加的电压量的透明度。

    Wideband Frequency Tunable Ring Resonator
    22.
    发明申请
    Wideband Frequency Tunable Ring Resonator 有权
    宽带可调谐振铃谐振器

    公开(公告)号：US20120256710A1

    公开(公告)日：2012-10-11

    申请号：US13239426

    申请日：2011-09-22

    申请人： Jian Xin CHEN ,  Li Heng Zhou ,  Hui Tang ,  Zhi Hua Bao ,  Yong Jie Yang ,  Quan Xue

    发明人： Jian Xin CHEN ,  Li Heng Zhou ,  Hui Tang ,  Zhi Hua Bao ,  Yong Jie Yang ,  Quan Xue

    IPC分类号： H01P7/08

    CPC分类号： H01P7/088

    摘要： The present invention provides a wideband frequency tunable ring resonator, wherein, comprises a closed λg/2 transmission line and two variable capacitors with tunable capacitance, the λg/2 transmission line is axisymmetric around a central line, first ends of the two variable capacitors are respectively connected to two intersection points of the λg/2 transmission line and the central line, the second ends of the two variable capacitors are respectively grounded. By implementing the technical solution of present invention, following technical effects are obtained. The fundamental resonant frequency (ffund) can be shifted up and down by controlling the respective values of the two loading capacitors, resulting in a bi-directional tuning of ffund. As a result, the tuning range of this invention can be approximately doubled as compared with the conventional tunable ring resonator.

    摘要翻译： 本发明提供一种宽带频率可调环形谐振器，其中包括一个闭合的λg/ 2传输线和两个具有可调电容的可变电容器，λg/ 2传输线围绕中心线是轴对称的，两个可变电容器的第一端 分别连接到λg/ 2传输线和中心线的两个交点，两个可变电容器的第二端分别接地。 通过实施本发明的技术方案，获得以下技术效果。 通过控制两个负载电容器的相应值，基本谐振频率（ffund）可以上下移动，从而导致ffund的双向调谐。 结果，与传统的可调环谐振器相比，本发明的调谐范围可以大致加倍。

    PROTEIN AGENT FOR DIABETES TREATMENT AND BETA CELL IMAGING
    23.
    发明申请
    PROTEIN AGENT FOR DIABETES TREATMENT AND BETA CELL IMAGING 有权
    用于糖尿病治疗和细胞成像的蛋白剂

    公开(公告)号：US20120244080A1

    公开(公告)日：2012-09-27

    申请号：US13503194

    申请日：2010-10-20

    申请人： Zhi-Ren Liu ,  Jie Yang ,  Bing Xu ,  Wangda Zhou ,  Shenghui Xue

    发明人： Zhi-Ren Liu ,  Jie Yang ,  Bing Xu ,  Wangda Zhou ,  Shenghui Xue

    IPC分类号： C07K19/00 ,  G01N21/75 ,  A61K49/14 ,  C12N5/071

    CPC分类号： A61K38/26 ,  A61K38/00 ,  A61K47/60 ,  A61K49/085 ,  C07K14/605 ,  C07K2319/00

    摘要： Glucagon-like peptide-1 (GLP-1) is a member of a large family of incretin hormones secreted in nutrient-dependent response. GLP-1 acts on GLP-1 receptor (GLP-1 R) that is highly expressed on pancreatic β-cells. The peptide has great potential for development of diabetes treatment and diagnosis. However, the pharmaceutical effects of the peptide suffer from in vivo instability and short life due to degradation by Dipeptidylpeptidase-1 (DPP-4). The 30 amino acid peptide GLP-1 has been integrated into a stable host protein human calbindin D9k. The fusion protein binds to GLP-1 R as demonstrated by immunostaining analyses of GLP-1 R expressing cells. The fusion protein agents can be useful for both diabetes treatment and GLP-1 R receptor targeting MR imaging. The fusion protein has a size about 14 kDa, which enables efficient tissue penetration and retention, and an extended circulation time, is stable, remaining intact and retaining activity after 48 hours incubation with 75% human serum. The protein retains its native folded structure after boiling for ten minutes forming the basis of an experimental protocol for large scale production of the fusion protein (>30 mg/l bacterial culture). No toxicity has been observed with tests on mice. One aspect of the disclosure, therefore, provides a fusion protein comprising a first peptide characterized by selectively binding to a site of a target cell and linked to a second peptide, where the fusion protein is more stable than the first peptide alone. In embodiments of this aspect of the disclosure, the fusion protein may further comprise a detectable label attached thereto. In some embodiments of this aspect of the disclosure, the first peptide of the fusion protein may be glucagon-like peptide-1 (GLP-1), glucagon-like peptide-1 (GLP-1)(7-36), or glucagon-like peptide-1 (GLP-1) (9-36), or a conservative variant thereof.

    摘要翻译： 胰高血糖素样肽-1（GLP-1）是营养依赖性反应中分泌的大肠激素的成员之一。 GLP-1作用于在胰腺细胞上高度表达的GLP-1受体（GLP-1R）。 该肽具有发展糖尿病治疗和诊断的巨大潜力。 然而，由于二肽基肽酶-1（DPP-4）的降解，肽的药物作用遭受体内不稳定性和短寿命。 30个氨基酸的肽GLP-1已经被整合到稳定的宿主蛋白人类calbindin D9k中。 如通过GLP-1R表达细胞的免疫染色分析所证明的，融合蛋白与GLP-1R结合。 融合蛋白剂可用于糖尿病治疗和靶向MR-1的受体受体。 融合蛋白具有约14kDa的大小，其能够有效的组织穿透和保留，并且延长的循环时间是稳定的，在75％人血清孵育48小时后保持完整和保留活性。 蛋白质在煮沸10分钟后保持其天然折叠结构，形成用于大规模生产融合蛋白（> 30mg / l细菌培养物）的实验方案的基础。 在小鼠试验中没有观察到毒性。 因此，本公开的一个方面提供了包含第一肽的融合蛋白，其特征在于选择性结合靶细胞的位点并连接到第二个肽，其中融合蛋白比单独的第一个肽更稳定。 在本公开的该方面的实施方案中，融合蛋白还可包含附着于其上的可检测标记。 在本公开的该方面的一些实施方案中，融合蛋白的第一肽可以是胰高血糖素样肽-1（GLP-1），胰高血糖素样肽-1（GLP-1）（7-36）或胰高血糖素 样肽-1（GLP-1）（9-36）或其保守变体。

    3-Pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives and uses thereof
    27.
    发明授权
    3-Pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives and uses thereof 有权
    3-吡咯并[b]环己基-2-二氢吲哚啉酮衍生物及其用途

    公开(公告)号：US08084621B2

    公开(公告)日：2011-12-27

    申请号：US12517351

    申请日：2007-12-03

    申请人： Feng Tang ,  Han Shen ,  Qiu Jin ,  Lei Ding ,  Jie Yang ,  Xiaojin Yin ,  Shiyue Lu

    发明人： Feng Tang ,  Han Shen ,  Qiu Jin ,  Lei Ding ,  Jie Yang ,  Xiaojin Yin ,  Shiyue Lu

    IPC分类号： C07D209/02 ,  A61K31/40

    CPC分类号： C07D209/42 ,  C07D401/14 ,  C07D403/14

    摘要： 3-pyrrolo[b]cyclohexylene-2-dihydro-indolinone derivatives of formula (I) or their pharmaceutically acceptable salts and uses thereof. The intermediates of formula (II) for preparing the above compounds. The bioassay shows that the above compounds and their pharmaceutically acceptable salts can modulate the activity of protein kinases (PKs), inhibit the activity of tyrosine kinases (PTKs) and inhibit many kinds of tumor cells as well as.

    摘要翻译： 式（I）的3-吡咯并[b]亚环己基-2-二氢 - 二氢吲哚酮衍生物或其药学上可接受的盐和用途。 用于制备上述化合物的式（II）的中间体。 生物测定显示，上述化合物及其药学上可接受的盐可调节蛋白激酶（PK）的活性，抑制酪氨酸激酶（PTK）的活性并抑制多种肿瘤细胞。

    SEMI-PERMANENT VEHICLE COUPLER FOR LIGHT RAIL
    28.
    发明申请
    SEMI-PERMANENT VEHICLE COUPLER FOR LIGHT RAIL 有权
    用于轻轨的半永久车辆联轴器

    公开(公告)号：US20110253663A1

    公开(公告)日：2011-10-20

    申请号：US13172811

    申请日：2011-06-29

    申请人： Fenggang Liu ,  Jie Yang ,  Minggang Li

    发明人： Fenggang Liu ,  Jie Yang ,  Minggang Li

    IPC分类号： B61G9/04

    CPC分类号： B61G9/06

    摘要： The present invention relates to a semi-permanent vehicle coupler for a light rail, which comprises a buffer end and a buffer-free end. The buffer end comprises a buffer, a joint bearing connected with the buffer and a mounting seat, wherein the joint bearing is connected with the mounting seat through a coupler yoke key; the buffer-free end comprises a left pull ring, a joint bearing connected with the left pull ring and a mounting seat, wherein the joint bearing is connected with the mounting seat through a coupler yoke key; the buffer is a double-acting buffer and comprises a shell, a left end cover, a right pull ring, elastic bodies, a central shaft and a middle partition plate, wherein the central shaft passes through the centers of the left end cover and the right pull ring and is glidingly contacted with the left end cover and the right pull ring, one end of the central shaft extends out of the left end cover, the middle partition plate is fixedly arranged on the central shaft and divides the inner part of the shell into two elastic body accommodating cavities, and the elastic bodies are positioned in the two elastic body accommodating cavities; and the other end of the left pull ring is provided with a lug boss, one end of the central shaft extending out of the left end cover is also provided with a lug boss, and the two lug bosses are connected through a connecting ring.

    摘要翻译： 本发明涉及一种用于轻轨的半永久性车辆耦合器，其包括缓冲端和无缓冲端。 缓冲端包括缓冲器，与缓冲器连接的关节轴承和安装座，其中关节轴承通过联接器轭扣与安装座连接; 无缓冲端包括左拉环，与左拉环连接的关节轴承和安装座，其中，关节轴承通过联接器轭扣与安装座连接; 缓冲器是双作用缓冲器，包括外壳，左端盖，右拉环，弹性体，中心轴和中间隔板，其中中心轴穿过左端盖的中心和 右拉环与左端盖和右拉环滑动接触，中心轴的一端从左端盖延伸出来，中间隔板固定地布置在中心轴上， 弹性体位于两个弹性体容纳腔中， 并且左拉环的另一端设置有凸耳凸起，从左端盖延伸出的中心轴的一端还设置有凸耳凸台，并且两个凸耳凸起通过连接环连接。

    Methods for Controlling a Main Clock Source Shared Between Different Wireless Communication Modules and Apparatuses Using the Same
    30.
    发明申请
    Methods for Controlling a Main Clock Source Shared Between Different Wireless Communication Modules and Apparatuses Using the Same 审中-公开
    用于控制不同无线通信模块之间共享的主时钟源的方法和使用其的设备

    公开(公告)号：US20110076945A1

    公开(公告)日：2011-03-31

    申请号：US12844411

    申请日：2010-07-27

    申请人： Liang-Cheng Chang ,  Ming-Jie Yang ,  Wei-Lun Wan ,  Juei-Ting Sun ,  Hong-Kai Hsu ,  Wei-Ning Chien

    发明人： Liang-Cheng Chang ,  Ming-Jie Yang ,  Wei-Lun Wan ,  Juei-Ting Sun ,  Hong-Kai Hsu ,  Wei-Ning Chien

    IPC分类号： H04B7/00

    CPC分类号： H04J3/0685 ,  G06F1/06 ,  G06F1/10

    摘要： A wireless communications module coexisting with a wireless telephony communications module includes a radio frequency (RF) module, a MODEM, a clock generator and distributor and a system control logic. The system control logic issues an external interrupt (EINT) signal to the wireless telephony communications module for activating a clock source via the wireless telephony communications module. When the clock source is activated, the clock generator and distributor receives a reference clock from the activated clock source, converts the reference clock into one or more internal clocks and drives the internal clock or clocks to the RF module and the MODEM for synchronization therebetween.

    摘要翻译： 与无线电话通信模块共存的无线通信模块包括射频（RF）模块，MODEM，时钟发生器和分配器以及系统控制逻辑。 系统控制逻辑向无线电话通信模块发出外部中断（EINT）信号，用于通过无线电话通信模块激活时钟源。 当时钟源被激活时，时钟发生器和分配器从激活的时钟源接收参考时钟，将参考时钟转换成一个或多个内部时钟，并将内部时钟或时钟驱动到RF模块和MODEM以在其间进行同步。