公开(公告)号：US20230322862A1

公开(公告)日：2023-10-12

申请号：US18165809

申请日：2023-02-07

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION ,  UNIVERSITY OF CONNECTICUT

Inventor： Ajit Vikram ,  Kaikobad Irani ,  Ravinder Reddy Gaddam ,  Raman Bahal ,  Karishma Dhuri

IPC: C07K14/00 ,  C12N15/113 ,  A61K38/00

CPC classification number: C07K14/003 ,  C12N15/113 ,  A61K38/00

Abstract: Disclosed are compounds and methods for the treatment of diseases or disorders associated with expression of miR-122. More specifically, γ peptide nucleic acid (γPNA) inhibitors of miR-122 and methods of using the same are disclosed.

公开(公告)号：US20230302433A1

公开(公告)日：2023-09-28

申请号：US18143559

申请日：2023-05-04

Applicant: University of Connecticut

Inventor： Pu-Xian Gao ,  Son Hoang

IPC: B01J21/06 ,  B01D53/86 ,  B01J23/42 ,  B01J35/00 ,  B01J35/02 ,  B01J35/04 ,  B01J35/06 ,  B01J37/02 ,  B01J37/10 ,  B01J37/34

CPC classification number: B01J21/063 ,  B01D53/865 ,  B01J23/42 ,  B01J35/0006 ,  B01J35/0013 ,  B01J35/023 ,  B01J35/04 ,  B01J35/06 ,  B01J37/0217 ,  B01J37/10 ,  B01J37/344 ,  B01D2255/1021 ,  B01D2255/20707 ,  B01D2258/012 ,  B01D2259/4566 ,  B82Y30/00

Abstract: Metal oxide nanoarrays, such as titanium oxide nanoarrays, having a platinum group metal dispersed thereon and methods of making such nanoarrays are described. The platinum group metal can be dispersed on the metal oxide nanoarray as single atoms. The nanoarrays can be used to catalyze oxidation of combustion exhaust.

公开(公告)号：US20230272405A1

公开(公告)日：2023-08-31

申请号：US18012143

申请日：2021-06-22

Applicant: University of Connecticut

Inventor： Paulo Henrique Verardi ,  Brittany Jasperse ,  Caitlin M. O’Connell ,  Yuxiang Wang

IPC: C12N15/62 ,  C07K14/005 ,  C12N15/86 ,  A61K39/12 ,  A61P31/14

CPC classification number: C12N15/625 ,  A61K39/12 ,  A61P31/14 ,  C07K14/005 ,  C12N15/86 ,  A61K2039/5258

Abstract: Disclosed herein are flavivirus signal peptide mutants useful for enhancing the production and secretion of flavivirus envelope (E) viral proteins or virus-like proteins. Also disclosed herein are methods of vaccinating subjects (e.g., human subjects) against a flavivirus comprising administering an expression vector, wherein the expression vector comprises a polynucleotide, and a fusion polypeptide comprising an engineered signal peptide and a flavivirus envelope (E) protein

公开(公告)号：US20230270554A1

公开(公告)日：2023-08-31

申请号：US18142238

申请日：2023-05-02

Applicant: University of Connecticut

Inventor： Thanh Duc Nguyen ,  Ritopa Das

IPC: A61F2/28 ,  A61L27/58 ,  A61L27/34 ,  A61L27/18 ,  A61L27/54 ,  A61L27/38

CPC classification number: A61F2/28 ,  A61L27/58 ,  A61L27/34 ,  A61L27/18 ,  A61L27/54 ,  A61L27/3847 ,  A61L2430/02 ,  A61F2002/2864 ,  A61F2002/2821 ,  A61F2002/30062

Abstract: A scaffold comprised of a plurality of PLLA layers, which may include stem cells, for regenerating bone or tissue. The PLLA layers are separated by a plurality of hydrogel layers. The PLLA layers comprise a nanofiber mesh having a piezoelectric constant to apply an electrical charge to the bone or tissue upon application of ultrasound energy.

公开(公告)号：US20230257271A1

公开(公告)日：2023-08-17

申请号：US17674389

申请日：2022-02-17

Applicant: University of Connecticut

Inventor： Douglas H. Adamson ,  Richard Parnas ,  Prabodha Abeykoon

IPC: C01B32/19 ,  C03C25/44

CPC classification number: C01B32/19 ,  C03C25/44 ,  C03C2218/328

Abstract: Systems and methods are provided that may utilize a glass substrate to selectively withdraw exfoliated graphene from a high-energy interface between immiscible solvents. The exfoliated graphene preferentially adheres to the surface of the glass substrate for withdrawal from the noted high energy interface, leaving behind the graphite (which is too large to be effectively adsorbed relative to the glass substrate). The disclosed systems and methods are easily implemented and offer significant advantages for graphene production relative to conventional systems and methods, e.g., the disclosed systems/methods do not require the input of heat or mechanical energy which translates to processes that are both cheaper to run and do not result in damage to the graphene. Still further, the disclosed systems/methods do not require chemical modification of the graphene, again lowering the cost considerably and not damaging the graphene structure.

公开(公告)号：US20230256052A1

公开(公告)日：2023-08-17

申请号：US18012288

申请日：2021-07-07

Applicant: University of Connecticut

Inventor： Tannin Avery Schmidt ,  Joseph Lorenzo ,  Sun-Kyeong Lee ,  Adam Tanguay

IPC: A61K38/17 ,  A61P19/10 ,  A61K47/69

CPC classification number: A61K38/1709 ,  A61P19/10 ,  A61K47/6903

Abstract: An anti-osteoclastic composition containing a proteoglycan 4 in a pharmaceutically acceptable carrier is administered to a human or animal suffering from a pathological bone condition such as osteoporosis in a sufficient amount to reduce, delay onset of or prevent excessive bone resorption in which the rate of bone resorption exceed the rate of bone formation. Excessive bone resorption is inhibited by preventing the formation or activity of osteoclasts. Osteoporosis is linked to bone fracture, a debilitation condition often resulting in the need for risky, invasive surgery, and the possible consequence of permanent immobilization, especially in elderly populations.

公开(公告)号：US20230248311A1

公开(公告)日：2023-08-10

申请号：US18125394

申请日：2023-03-23

Applicant: University of Connecticut

Inventor： Gregory Allen Sotzing ,  Ki Chon

IPC: A61B5/00 ,  A61B5/024 ,  A61B5/08 ,  A61B5/25 ,  A61B5/291 ,  A61B5/296

CPC classification number: A61B5/6804 ,  A61B5/6807 ,  A61B5/6803 ,  A61B5/02438 ,  A61B5/0816 ,  A61B5/7203 ,  A61B5/6802 ,  A61B5/25 ,  A61B5/291 ,  A61B5/296 ,  A61B2562/0209 ,  A61B2562/125 ,  B05D3/144

Abstract: Disclosed herein are conductive polymer electrodes and wiring elements for use as the conductive element in health monitoring applications, and more specifically to conductive polymer fabric electrodes or conductive polymer fabric wiring elements for use as the conductive element in pads for health monitoring applications and other wearable monitoring systems.

公开(公告)号：US20230241591A1

公开(公告)日：2023-08-03

申请号：US18166577

申请日：2023-02-09

Applicant: University of Connecticut

Inventor： Pu-Xian Gao ,  Wenxiang Tang

IPC: B01J23/889 ,  B01D53/86 ,  B01J23/00 ,  B01J23/78 ,  B01J35/00 ,  B01J35/04 ,  B01J37/02 ,  C01G51/00

CPC classification number: B01J23/8892 ,  B01D53/864 ,  B01J23/005 ,  B01J23/78 ,  B01J35/0013 ,  B01J35/04 ,  B01J37/0215 ,  C01G51/40 ,  B01D2255/2073 ,  B01D2255/20746 ,  B01D2255/405 ,  B01D2255/9202 ,  B01D2255/9205 ,  B01D2255/9207 ,  C01P2002/32

Abstract: Manganese-cobalt (Mn—Co) spinel oxide nanowire arrays are synthesized at low pressure and low temperature by a hydrothermal method. The method can include contacting a substrate with a solvent, such as water, that includes Mn04- and Co2 ions at a temperature from about 60° C. to about 120° C. The method preferably includes dissolving potassium permanganate (KMn04) in the solvent to yield the Mn04- ions. the substrate is The nanoarrays are useful for reducing a concentration of an impurity, such as a hydrocarbon, in a gas, such as an emission source. The resulting material with high surface area and high materials utilization efficiency can be directly used for environment and energy applications including emission control systems, air/water purifying systems and lithium-ion batteries.

公开(公告)号：US20230235186A1

公开(公告)日：2023-07-27

申请号：US18102389

申请日：2023-01-27

Applicant: University of Connecticut

Inventor： Douglas H. Adamson ,  Feiyang Chen ,  Elizabeth Brown

IPC: C09D11/023 ,  C08K3/04 ,  C08K3/38 ,  C09D11/38 ,  C09D11/52

CPC classification number: C09D11/023 ,  C08K3/042 ,  C08K3/38 ,  C09D11/38 ,  C09D11/52 ,  C08K2003/385

Abstract: The present disclosure provides advantageous sheet stabilized emulsion based inks, and improved methods for fabricating and using such inks. More particularly, the present disclosure provides improved methods for fabricating conductive inks derived from water-in-oil emulsions stabilized by sheets exfoliated from layered materials (e.g., substantially pristine and non-oxidized graphite or hexagonal boron nitride), and related methods of use. A layered material (e.g., substantially pristine and non-oxidized graphite or hexagonal boron nitride) can be exfoliated into individual sheets, and these sheets can be utilized to stabilize water-in-oil emulsions. In certain embodiments, by utilizing long chain alkanes (e.g., hexadecane), one can advantageously fabricate emulsions with high viscosity and stability. In this form, the emulsions can be used as inks, thereby advantageously providing an inexpensive route to printing electrically conducting and/or insulating lines and shapes.

公开(公告)号：US20230225654A1

公开(公告)日：2023-07-20

申请号：US17576370

申请日：2022-01-14

Applicant: Toyota Motor Engineering & Manufacturing North America, Inc. ,  University of Connecticut Health Center

Inventor： Insoo Kim ,  Hossein Hamidi Shishavan ,  Kia Golzari ,  Muhamed Farooq

IPC: A61B5/18 ,  B60W40/08

CPC classification number: A61B5/18 ,  B60W40/08 ,  B60W2040/0872 ,  B60W2540/22 ,  B60W2540/221

Abstract: In accordance with one embodiment of the present disclosure, a method includes generating a plurality of icons, wherein each icon has a target frequency unique from each other, receiving brain activity data based on an epoch, generating a reference signal based on the epoch, calculating correlation coefficients between the brain activity data and the reference signal, wherein the correlation coefficients are calculated in a window that is within ±0.5 Hz of the target frequencies, including endpoints, determining a confidence score based on the correlation coefficients and the epoch, and determining a selected icon among the plurality of icons based on the correlation coefficients in response to the confidence score surpassing a threshold confidence score.