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公开(公告)号：US20170247735A1
公开(公告)日：2017-08-31
申请号：US15511565
申请日：2015-09-30
Applicant: Evolva SA
Inventor： Jens Houghton-Larsen , Katarzyna Krzystanek , Angelika Semmler , Iver Klavs Riishede Hansen , Soren Damkiaer , Gary Liu , Yaoquan Liu , Jorgen Hansen , Sathish Kumar , Muthuswamy Panchapagesa Murali , Nina Nicoline Rasmussen
CPC classification number: C12P33/00 , A23L27/36 , A23V2002/00 , C07H1/06 , C12N9/0014 , C12N9/0042 , C12N9/0071 , C12N9/0073 , C12N9/1051 , C12N9/14 , C12N9/90 , C12N15/00 , C12P19/18 , C12P19/56
Abstract: Methods for recombinant and enzymatic production of mogroside compounds and compositions containing mogroside compounds are provided by this invention.
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公开(公告)号：US20150344920A1
公开(公告)日：2015-12-03
申请号：US14654291
申请日：2013-12-23
Applicant: Evolva SA
Inventor： Jorgen Hansen , Patricia Hoyle , Michael Naesby , Joseph M. Sheridan , Jonathan R. Heal
CPC classification number: C12P17/06 , C12N9/1025 , C12N9/1048 , C12N15/1079 , C12N15/52 , C12P19/44 , C12Y203/00 , C12Y204/00
Abstract: The present disclosure provides methods for identifying anthocyanins with improved stability, color, or hue using a screening method, and producing anthocyanins with improved stability, color, or hue in, for example, host cells comprising one or more heterologous glycosyltransferase nucleic acid molecules and one or more heterologous acyltransferase nucleic acid molecules.
Abstract translation: 本公开提供了使用筛选方法鉴定具有改进的稳定性，颜色或色调的花青素的方法，并且在例如包含一个或多个异源糖基转移酶核酸分子的宿主细胞中产生具有改善的稳定性，颜色或色调的花青素 或更多的异源酰基转移酶核酸分子。
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公开(公告)号：US11091787B2
公开(公告)日：2021-08-17
申请号：US16806812
申请日：2020-03-02
Applicant: Evolva SA
Inventor： Jens Houghton-Larsen , Katarzyna Krzystanek , Angelika Semmler , Iver Klavs Riishede Hansen , Soren Damkiaer , Yaoquan Liu , Jorgen Hansen , Sathish Kumar , Muthuswamy Panchapagesa Murali , Nina Nicoline Rasmussen
IPC: C12P33/00 , C12P19/56 , C12P19/18 , C12N9/14 , C12N9/10 , C12N9/06 , C12N9/90 , C12N9/02 , A23L27/30 , C07H1/06 , C12N15/00
Abstract: Methods for recombinant and enzymatic production of mogroside compounds and compositions containing mogroside compounds are provided by this invention.
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公开(公告)号：US11021727B2
公开(公告)日：2021-06-01
申请号：US16002245
申请日：2018-06-07
Applicant: EVOLVA SA
Inventor： Ernesto Simon , Iben Nordmark Anderson , Michael Dalgaard Mikkelsen , Jorgen Hansen , Veronique Douchin
Abstract: Recombinant microorganisms are disclosed that produce steviol glycosides and have altered expression of one or more endogenous transporter or transcription factor genes, or that overexpress one or more heterologous transporters, leading to increased excretions of steviol glucosides of interest.
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公开(公告)号：US20180327723A1
公开(公告)日：2018-11-15
申请号：US15774134
申请日：2016-11-14
Applicant: Evolva SA
Inventor： Dayal Saran , Jorgen Hansen , Philippe Prochasson , Patrick Roussel , Laura Occhipinti , Alexei Ouspenski , Sumire Honda Malca
CPC classification number: C12N9/1048 , A01N43/16 , A23L29/035 , A61Q13/00 , C12N15/70 , C12P19/44 , C12Y106/02004 , C12Y204/00 , C12Y402/03073
Abstract: The invention relates to methods for producing glycosylated nootkatol. In particular, a recombinant host comprising a gene encoding a UDP-glycosyltransferase polypeptide capable of glycosylating nootkatol is disclosed. Glycosylation of nootkatol detoxifies nootkatol, allowing for greater production of (glycosylated-)nootkatol, a precursor of nootkatone, and therefore greater production of nootkatone. The invention also relates to methods of converting non-toxic, glycosylated nootkatol produced by a recombinant host to nootkatol, wherein the nootkatol can subsequently be converted to large quantities of nootkatone to be used in flavorings, perfumes, and/or insect repellents.
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Patent Agency Ranking
公开(公告)号：US10119154B2
公开(公告)日：2018-11-06
申请号：US14654291
申请日：2013-12-23
Applicant: Evolva SA
Inventor： Jorgen Hansen , Patricia Hoyle , Michael Naesby , Joseph M. Sheridan , Jonathan R. Heal
Abstract: The present disclosure provides methods for identifying anthocyanins with improved stability, color, or hue using a screening method, and producing anthocyanins with improved stability, color, or hue in, for example, host cells comprising one or more heterologous glycosyltransferase nucleic acid molecules and one or more heterologous acyltransferase nucleic acid molecules.
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公开(公告)号：US09932619B2
公开(公告)日：2018-04-03
申请号：US14442694
申请日：2013-12-04
Applicant: Evolva SA
Inventor： Yaoquan Liu , Jorgen Hansen , Jens Houghton-Larsen , Muthuswamy Panchapagesa Murali , Sathish Kumar , Nina Nicoline Rasmussen
IPC: C12P33/20 , C12P19/18 , C12P19/56 , C12N1/00 , C12N9/10 , C12P33/08 , C12N9/02 , C12N9/14 , C12N9/90 , C12P33/00 , C12P33/12 , C12N15/80
CPC classification number: C12P33/20 , C12N9/0071 , C12N9/0073 , C12N9/1048 , C12N9/14 , C12N9/90 , C12N15/80 , C12P19/18 , C12P19/56 , C12P33/00 , C12P33/08 , C12P33/12 , C12Y114/00 , C12Y114/13132 , C12Y303/00 , C12Y504/99033
Abstract: The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention.
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公开(公告)号：US20170321238A1
公开(公告)日：2017-11-09
申请号：US15439660
申请日：2017-02-22
Applicant: Evolva SA
Inventor： Jens Houghton-Larsen , Paula Hicks , Michael Naesby , Thomas Tange Ostergaard , Jorgen Hansen , Michael Mikkelsen Dalgaard , Esben Halkjaer Hansen , Ernesto Simon , Sabina Tavares
IPC: C12P19/56 , C12N15/82 , C12N15/81 , C12N15/63 , C12N9/06 , C12N9/88 , C12N9/10 , C12N9/02 , C12P19/44 , C12N9/90
CPC classification number: C12P19/56 , C12N9/0032 , C12N9/0071 , C12N9/0073 , C12N9/1051 , C12N9/1085 , C12N9/88 , C12N9/90 , C12N15/63 , C12N15/81 , C12N15/8243 , C12P19/44 , Y02P20/52
Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
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公开(公告)号：US20170306376A1
公开(公告)日：2017-10-26
申请号：US15589269
申请日：2017-05-08
Applicant: EVOLVA SA
Inventor： Shriram Raghavan , Jorgen Hansen , Shailendra Sonkar , Sathish Kumar , Kalyan Kumar , Murali Panchapagesa , Esben Hansen , Klavs Riishede Hansen
CPC classification number: C12P19/46 , C12N9/0006 , C12N9/1048 , C12N9/1051
Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a zeaxanthin cleavage dioxygenase alone or in combination with recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce compounds from saffron such as crocetin, crocetin dialdehyde, crocin, or picrocrocin.
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公开(公告)号：US20230407360A1
公开(公告)日：2023-12-21
申请号：US18132027
申请日：2023-04-07
Applicant: EVOLVA SA
Inventor： Jens Houghton-Larsen , Paula Hicks , Michael Naesby , Thomas Tange Ostergaard , Jorgen Hansen , Michael Mikkelsen Dalgaard , Esben Hansen-Halkjaer , Ernesto Simon , Sabina Tavares
IPC: C12P19/56 , C12N9/88 , C12N9/06 , C12N9/02 , C12N9/10 , C12N9/90 , C12N15/81 , C12N15/82 , C12P19/44 , C12N15/63
CPC classification number: C12P19/56 , C12N9/88 , C12N9/0032 , C12N9/0073 , C12N9/0071 , C12N9/1051 , C12N9/1085 , C12N9/90 , C12N15/81 , C12N15/8243 , C12P19/44 , C12N15/63 , Y02P20/52
Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
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