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121 条记录 (耗时 0.051 秒)

    Use of Additives for Enhancing Droplet Operations
    21.
    发明申请
    Use of Additives for Enhancing Droplet Operations 审中-公开
    添加剂用于增强液滴操作

    公开(公告)号：US20110303542A1

    公开(公告)日：2011-12-15

    申请号：US12672564

    申请日：2008-08-08

    申请人： Vijay Srinivasan ,  Michael G. Pollack ,  Vamsee K. Pamula ,  Dwayne Allen

    发明人： Vijay Srinivasan ,  Michael G. Pollack ,  Vamsee K. Pamula ,  Dwayne Allen

    IPC分类号： G01N27/447 ,  B01D57/02

    CPC分类号： B01L3/502792 ,  B01L2200/141 ,  B01L2300/0645 ,  B01L2400/0415 ,  G01N2035/00277

    摘要： The invention relates to a droplet actuator with a substrate comprising electrodes arranged for conducting droplet operations on a droplet operations surface of the substrate; a filler fluid phase in contact with the droplet operations surface at least partially surrounding a droplet phase comprising a droplet arranged on one or more of the electrodes, the droplet comprising: (i) a target substance susceptible to loss from the droplet phase into the filler fluid phase; and (ii) an additive which reduces loss of the target substance to the filler fluid phase relative to a corresponding droplet not comprising the additive. The invention also relates to various compositions and methods.

    摘要翻译： 本发明涉及一种液滴致动器，其具有包括布置用于在基板的液滴操作表面上进行液滴操作的电极的基板; 与液滴操作表面接触的填充流体相，至少部分地围绕包含布置在一个或多个电极上的液滴的液滴相，所述液滴包括：（i）易受从液滴相流入填料中的目标物质 流体相; 和（ii）相对于不包含添加剂的相应液滴，减少目标物质对填料流体相的损失的添加剂。 本发明还涉及各种组合物和方法。

    Droplet Actuator Loading and Target Concentration
    25.
    发明申请
    Droplet Actuator Loading and Target Concentration 有权
    液滴致动器装载和目标浓度

    公开(公告)号：US20100062508A1

    公开(公告)日：2010-03-11

    申请号：US12531835

    申请日：2008-03-24

    申请人： Vamsee K. Pamula ,  Michael G. Pollack ,  Vijay Srinivasan

    发明人： Vamsee K. Pamula ,  Michael G. Pollack ,  Vijay Srinivasan

    IPC分类号： C12N11/00 ,  C12M1/00

    CPC分类号： C25B15/00 ,  B01F13/0071 ,  B01L3/502761 ,  B01L3/502792 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/089 ,  B01L2400/0427 ,  B01L2400/0487 ,  G01N33/5438

    摘要： A droplet actuator and method of providing a droplet comprising an target substance on the droplet actuator, and including discrete flow and continuous flow functionality. Discrete flow function is controlled by electrodes arranged for conducting droplet operations on a substrate surface. The continuous flow function includes a fluid path arranged for flowing a fluid therethrough. The discrete flow and continuous flow functions may be by a barrier, including a second fluid path through the barrier. The continuous flow function may include a capture surface comprising a component having an affinity for the target substance. Methods of the invention may include flowing a fluid comprising the target substance through the fluid path; capturing the target substance on the capture surface; and forming a droplet in the discrete flow region via the second fluid path and the electrodes comprising the captured target substance.

    摘要翻译： 液滴致动器和在液滴致动器上提供包含目标物质的液滴的方法，并且包括离散流动和连续流动功能。 离散流动功能由布置用于在基板表面上进行液滴操作的电极控制。 连续流动功能包括设置成使流体流过其中的流体路径。 离散的流动和连续流动功能可以是通过屏障，包括通过屏障的第二流体路径。 连续流动功能可以包括包含对目标物质具有亲和性的成分的捕获表面。 本发明的方法可以包括使包含目标物质的流体流过流体路径; 捕获表面上的目标物质; 以及经由所述第二流体路径在所述离散流动区域中形成液滴，并且所述电极包括所捕获的目标物质。

    Method of Detecting an Analyte
    26.
    发明申请
    Method of Detecting an Analyte 有权
    检测分析物的方法

    公开(公告)号：US20090311713A1

    公开(公告)日：2009-12-17

    申请号：US12546253

    申请日：2009-08-24

    申请人： Michael G. Pollack ,  Zhishan Hua ,  Allen E. Eckhardt ,  Prasanna Thwar ,  Vijay Srinivasan ,  Vamsee K. Pamula

    发明人： Michael G. Pollack ,  Zhishan Hua ,  Allen E. Eckhardt ,  Prasanna Thwar ,  Vijay Srinivasan ,  Vamsee K. Pamula

    IPC分类号： C12Q1/68

    CPC分类号： B01L3/502792 ,  B01L3/502753 ,  B01L3/502761 ,  B01L7/525 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/089 ,  B01L2400/0427 ,  B01L2400/043 ,  C12Q1/6848 ,  C12Q2565/629

    摘要： The invention relates to certain novel approaches to reducing or eliminating the movement of contaminants from one droplet to another on a droplet actuator via liquid filler fluid. In one application, a method of detecting an analyte is provided and includes providing in a detection window a droplet including a signal-producing substance indicative of the presence and/or quantity of an analyte and one or more magnetically responsive beads which may interfere with signal produced by the signal producing substance. The method further includes using a magnetic field for magnetically removing the magnetically responsive beads from the detection window and/or magnetically restricting the magnetically responsive beads from entering the detection window while transporting and/or retaining the droplet in the detection window. The method additionally includes detecting a signal produced by the signal-producing substance.

    摘要翻译： 本发明涉及在液滴致动器上通过液体填充液减少或消除污染物从一个液滴到另一个液滴的移动的某些新颖方法。 在一个应用中，提供检测分析物的方法，并且包括在检测窗口中提供包含指示分析物的存在和/或量的信号产生物质的液滴和一个或多个可能干扰信号的磁响应珠子 由信号产生物质产生。 该方法还包括使用磁场来从检测窗口磁性地去除磁响应珠子和/或磁力限制磁响应珠子进入检测窗口，同时在检测窗口中传送和/或保持液滴。 该方法还包括检测由信号产生物质产生的信号。

    Method of Manipulating a Droplet
    28.
    发明申请
    Method of Manipulating a Droplet 审中-公开
    操纵水滴的方法

    公开(公告)号：US20130233712A1

    公开(公告)日：2013-09-12

    申请号：US13870709

    申请日：2013-04-25

    申请人： Vamsee K. Pamula ,  Michael G. Pollack ,  Vijay Srinivasan ,  Philip Paik

    发明人： Vamsee K. Pamula ,  Michael G. Pollack ,  Vijay Srinivasan ,  Philip Paik

    IPC分类号： B01L3/02

    CPC分类号： B01L3/502792 ,  B01L3/0241 ,  B01L3/50273 ,  B01L2200/06 ,  B01L2300/06 ,  B01L2400/0427 ,  B41J2/14

    摘要： A method of manipulating a droplet comprising providing a substrate comprising a surface; an elongated transport electrode disposed on the substrate surface, the elongated transport electrode having a first and a second end and configured to impart a gradient force to the droplet; and one or more wires for providing power to the transport electrode; and providing power to the one or more wires to effect the gradient force and thereby transport the droplet along the length of the elongated transport electrode from the first end to the second end.

    摘要翻译： 一种操纵液滴的方法，包括提供包括表面的基底; 设置在基板表面上的细长输送电极，细长输送电极具有第一和第二端并且被配置为向液滴施加梯度力; 以及用于向输送电极供电的一根或多根线; 并且向所述一个或多个电线提供电力以实现所述梯度力，从而将所述液滴沿着所述细长输送电极的长度从所述第一端输送到所述第二端。