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公开(公告)号：US20130039986A1
公开(公告)日：2013-02-14
申请号：US13582903
申请日：2011-03-04
申请人： David L. Kaplan , Monica A. Serban
发明人： David L. Kaplan , Monica A. Serban
IPC分类号： A61K47/42 , C07K1/00 , A61K9/14 , A61K38/02 , A61K35/00 , A61K31/7088 , A61K39/395 , A61K38/19 , A61K38/43 , A61P31/00 , A61K35/76 , A61P31/12 , C07K1/107 , A61P35/00 , A61P5/00 , C07K14/435 , B82Y5/00
CPC分类号： A61L27/52 , A61K9/5063 , A61L15/26 , A61L15/32 , A61L15/42 , A61L27/18 , A61L27/227 , A61L27/26 , A61L27/50 , A61L27/54 , A61L2300/00 , Y10T428/2982 , C08L77/04
摘要： Disclosed herein are pH-dependent silk fibroin-based ionomeric compositions and colloids, and methods of making the same. The state of the silk fibroin ionomeric compositions is reversible and can transform from a gel-like colloid to a more fluid-like solution, or vice versa, upon an environmental stimulus, e.g., pH. Thus, the silk-based ionomeric compositions and colloids can be applied in various industries, ranging from electronic applications to biomedical applications, such as sensors, gel diodes, absorbent materials, drug delivery systems, tissue implants and contrast agents.
摘要翻译： 本文公开了基于pH的丝心蛋白基离聚物组合物和胶体及其制备方法。 丝素蛋白离聚物组合物的状态是可逆的，并且可以在诸如pH的环境刺激下从凝胶状胶体转化为更流体状的溶液，或反之亦然。 因此，基于丝的离聚物组合物和胶体可以应用于各种行业，从电子应用到生物医学应用，例如传感器，凝胶二极管，吸收材料，药物递送系统，组织植入物和造影剂。
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22.发明申请公开(公告)号：US20120070427A1
公开(公告)日：2012-03-22
申请号：US13320036
申请日：2010-06-01
申请人： David L. Kaplan , Tuna Yucel
发明人： David L. Kaplan , Tuna Yucel
IPC分类号： A61K38/17 , A61K39/395 , A61K38/18 , A61K39/00 , A61K38/43 , A61K35/76 , A61K35/12 , A61K35/34 , A61K35/23 , A61K35/407 , A61K35/28 , A61K35/54 , A61K35/48 , A61P31/00 , A61K35/00
CPC分类号： A61K9/5052 , A61K9/0024 , A61K9/06 , A61K9/5089 , A61K38/00 , A61K47/42
摘要： The present invention provided for a novel process of forming silk fibroin gels, and controlling the rate of β-sheet formation and resulting hydrogelation kinetics, by vortex treatment of silk fibroin solution. In addition, the vortex treatment of the present invention provides a silk fibroin gel that may be reversibly shear-thinned, enabling the use of these approach for precise control of silk self-assembly, both spatially and temporally. Active agents, including biological materials, viable cells or therapeutic agents, can be encapsulated in the hydrogels formed from the processes, and be used as delivery vehicles. Hence, the present invention provide for methods for silk fibroin gelation that are useful for biotechnological applications such as encapsulation and delivery of active agents, cells, and bioactive molecules.
摘要翻译： 本发明提供了一种形成丝素蛋白凝胶的新方法，并且通过涡旋处理丝素蛋白溶液来控制成型速率和形成的水凝胶化动力学。 此外，本发明的涡流处理提供了可逆地剪切变薄的丝素蛋白凝胶，使得能够在空间和时间上精确地控制丝自组装的这些方法。 包括生物材料，活细胞或治疗剂在内的活性剂可以包封在由该方法形成的水凝胶中，并用作递送载体。 因此，本发明提供丝素蛋白凝胶化方法，其可用于生物技术应用如活性剂，细胞和生物活性分子的包封和递送。
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23.发明授权Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials 有权纤维蛋白融合及其在先进的有机/无机复合材料的形成中的应用公开(公告)号：US08129141B2
公开(公告)日：2012-03-06
申请号：US13097538
申请日：2011-04-29
申请人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
发明人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
IPC分类号： C12P1/00
CPC分类号： A61L27/48 , A61L27/446 , A61L27/46 , A61L27/54 , A61L2430/00 , C07K14/43518 , C07K14/51 , C07K14/78 , C07K2319/00
摘要： The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation.
摘要翻译： 要求保护的发明提供了包含纤维蛋白结构域和矿化结构域的融合多肽。 该融合用于形成有机 - 无机复合材料。 这些有机 - 无机复合材料可以根据所使用的纤维蛋白融合结构域的大小从纳米级到大规模构建。 在一个实施方案中，根据材料的目标，复合材料还可以加载其它化合物（例如染料，药物，酶），以进一步增强功能。 这可以在组装材料期间或在矿化步骤期间在材料形成中实现。
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24.发明申请NANOIMPRINTING OF SILK FIBROIN STRUCTURES FOR BIOMEDICAL AND BIOPHOTONIC APPLICATIONS 有权用于生物医学和生物医学应用的丝素纤维结构的纳米生物公开(公告)号：US20120034291A1
公开(公告)日：2012-02-09
申请号：US13201380
申请日：2010-02-12
IPC分类号： A61K9/70 , A61K35/00 , A61K38/43 , A61K31/7088 , B29D11/00 , B32B3/10 , A61K39/395 , A61K38/00 , B82Y5/00 , B82Y40/00
CPC分类号： A61K9/7007 , A61K9/70 , A61K41/00 , A61K47/42 , B82Y10/00 , B82Y20/00 , B82Y30/00 , B82Y40/00 , G01N21/4788 , G01N21/774 , G01N2021/7776 , G02B5/1809 , G02B5/1847 , G02B6/02061 , G02B6/1225 , G02B6/262 , G03F7/0002 , Y10T428/24479
摘要： The present invention provides for photonic nanoimprinted silk fibroin-based materials and methods for making same, comprising embossing silk fibroin-based films with photonic nanometer scale patterns. In addition, the invention provides for processes by which the silk fibroin-based films can be nanoimprinted at room temperature, by locally decreasing the glass sition temperature of the silk film Such nanoimprinting process increases high throughput and improves potential for incorporation of silk-based photonics into biomedical and other optical devices.
摘要翻译： 本发明提供了基于光子纳米压印的丝素蛋白的材料及其制备方法，其包括用丝光纳米尺度图案压花丝素蛋白基膜。 此外，本发明提供了通过局部降低丝膜的玻璃化温度，可以在室温下将丝素蛋白基膜纳米压印的方法。这种纳米压印方法增加了高通量并提高了掺入丝基光子学的潜力 进入生物医学和其他光学器件。
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25.发明申请FIBROUS PROTEIN FUSIONS AND USE THEREOF IN THE FORMATION OF ADVANCED ORGANIC/INORGANIC COMPOSITE MATERIALS 有权纤维蛋白融合及其在先进有机/无机复合材料的形成中的应用公开(公告)号：US20110275788A1
公开(公告)日：2011-11-10
申请号：US13097538
申请日：2011-04-29
申请人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
发明人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
CPC分类号： A61L27/48 , A61L27/446 , A61L27/46 , A61L27/54 , A61L2430/00 , C07K14/43518 , C07K14/51 , C07K14/78 , C07K2319/00
摘要： The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation.
摘要翻译： 要求保护的发明提供了包含纤维蛋白结构域和矿化结构域的融合多肽。 该融合用于形成有机 - 无机复合材料。 这些有机 - 无机复合材料可以根据所使用的纤维蛋白融合结构域的大小从纳米级到大规模构建。 在一个实施方案中，根据材料的目标，复合材料还可以加载其它化合物（例如染料，药物，酶），以进一步增强功能。 这可以在组装材料期间或在矿化步骤期间在材料形成中实现。
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26.发明授权Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials 有权纤维蛋白融合及其在先进的有机/无机复合材料的形成中的应用公开(公告)号：US07960509B2
公开(公告)日：2011-06-14
申请号：US11794934
申请日：2006-01-17
申请人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
发明人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
IPC分类号： C07K14/00
CPC分类号： A61L27/48 , A61L27/446 , A61L27/46 , A61L27/54 , A61L2430/00 , C07K14/43518 , C07K14/51 , C07K14/78 , C07K2319/00
摘要： The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein domain used. The composites can also be loaded with other compounds (e.g. dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the materials or during the mineralization step in materials formation.
摘要翻译： 要求保护的发明提供了包含纤维蛋白结构域和矿化结构域的融合多肽。 该融合用于形成有机 - 无机复合材料。 这些有机 - 无机复合材料可以根据所使用的纤维蛋白结构域的大小从纳米级到大规模构建。 根据材料的目标，复合材料还可以加载其它化合物（例如染料，药物，酶），以进一步增强功能。 这可以在组装材料期间或在矿化步骤期间在材料形成中实现。
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27.发明授权User interface and user control in a power aggregation system for distributed electric resources 有权用于分布式电力资源的电力聚合系统中的用户界面和用户控制公开(公告)号：US07949435B2
公开(公告)日：2011-05-24
申请号：US11836756
申请日：2007-08-09
CPC分类号： B60L11/1811 , B60L11/184 , B60L11/1842 , B60L2230/34 , B60L2240/622 , B60L2270/34 , G06Q40/04 , G06Q50/06 , Y02E60/721 , Y02T10/7005 , Y02T10/7088 , Y02T10/7291 , Y02T90/121 , Y02T90/127 , Y02T90/128 , Y02T90/14 , Y02T90/16 , Y02T90/162 , Y02T90/163 , Y02T90/169 , Y04S10/126 , Y04S10/58 , Y04S30/14 , Y04S50/00
摘要： Systems and methods are described for a power aggregation system. In one implementation, a service establishes individual Internet connections to numerous electric resources intermittently connected to the power grid, such as electric vehicles. The Internet connection may be made over the same wire that connects the resource to the power grid. The service optimizes power flows to suit the needs of each resource and each resource owner, while aggregating flows across numerous resources to suit the needs of the power grid. The service can bring vast numbers of electric vehicle batteries online as a new, dynamically aggregated power resource for the power grid. Electric vehicle owners can participate in an electricity trading economy regardless of where they plug into the power grid.
摘要翻译： 为功率聚合系统描述了系统和方法。 在一个实现中，服务建立与间歇地连接到诸如电动车辆的电网的许多电力资源的单独的互联网连接。 互联网连接可以通过将资源连接到电网的相同电线进行。 该服务优化电力流量，以适应每个资源和每个资源所有者的需求，同时整合多个资源的流量以适应电网的需求。 该服务可以将大量电动汽车电池作为电力网络的新的，动态聚合的电力资源在线。 电动车辆所有者可以参与电力交易经济，无论他们在哪里插入电网。
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公开(公告)号：US20110046686A1
公开(公告)日：2011-02-24
申请号：US12866256
申请日：2009-02-06
申请人： David L. Kaplan , Hyeon Joo Kim , Gerard Kugel
发明人： David L. Kaplan , Hyeon Joo Kim , Gerard Kugel
CPC分类号： A61F2/2846 , A61F2002/2817 , A61F2310/00293 , A61F2310/00365 , A61L27/46 , A61L27/54 , A61L2300/414 , A61L2300/602 , A61L2300/64 , A61L2430/02 , C08L89/00
摘要： Described herein are methods and compositions comprising a mixture of silk polymer and hydroxyapatite. The methods described herein can be used to prepare a mixture of silk polymer and hydroxyapatite and further provide mixtures that can be molded into a desired shape. Also encompassed herein are compositions comprising a mixture of silk polymer and hydroxyapatite having a desired shape, which can further be implanted, for example, to facilitate bone healing or tooth structure or support. Such compositions can also include agents, such as therapeutic agents, or cells.
摘要翻译： 本文描述了包含丝聚合物和羟基磷灰石的混合物的方法和组合物。 本文所述的方法可用于制备丝聚合物和羟基磷灰石的混合物，并进一步提供可模塑成所需形状的混合物。 本文还包括包含丝状聚合物和具有所需形状的羟基磷灰石的混合物的组合物，其可以进一步植入，例如以促进骨愈合或牙齿结构或支撑。 这样的组合物还可以包括试剂，例如治疗剂或细胞。
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29.发明申请CONNECTION LOCATOR IN A POWER AGGREGATION SYSTEM FOR DISTRIBUTED ELECTRIC RESOURCES 审中-公开用于分布式电力资源的电力分配系统中的连接定位器公开(公告)号：US20110025556A1
公开(公告)日：2011-02-03
申请号：US12826282
申请日：2010-06-29
CPC分类号： B60L3/12 , B60L53/14 , B60L53/305 , B60L53/63 , B60L53/64 , B60L53/65 , B60L53/665 , B60L55/00 , B60L2240/622 , B60L2240/72 , B60L2240/80 , B60L2250/16 , B60L2260/52 , B60L2260/54 , B60L2260/58 , B60L2270/32 , G06Q30/04 , H02J3/008 , H02J3/38 , H04L41/12 , H04L67/12 , H04L67/18 , H04W4/023 , H04W64/00 , Y02D70/122 , Y02D70/1242 , Y02D70/142 , Y02D70/146 , Y02D70/164 , Y02D70/166 , Y02E60/721 , Y02T10/7005 , Y02T10/7088 , Y02T10/7291 , Y02T90/121 , Y02T90/128 , Y02T90/14 , Y02T90/16 , Y02T90/162 , Y02T90/163 , Y02T90/169 , Y04S10/126 , Y04S30/14 , Y04S50/10 , Y04S50/12 , Y04S50/16 , Y10T307/696
摘要： Systems and methods are described for a power aggregation system. In one implementation, a service establishes individual Internet connections to numerous electric resources intermittently connected to the power grid, such as electric vehicles. The Internet connection may be made over the same wire that connects the resource to the power grid. The service optimizes power flows to suit the needs of each resource and each resource owner, while aggregating flows across numerous resources to suit the needs of the power grid. The service can bring vast numbers of electric vehicle batteries online as a new, dynamically aggregated power resource for the power grid. Electric vehicle owners can participate in an electricity trading economy regardless of where they plug into the power grid.
摘要翻译： 为功率聚合系统描述了系统和方法。 在一个实现中，服务建立与间歇地连接到诸如电动车辆的电网的许多电力资源的单独的互联网连接。 互联网连接可以通过将资源连接到电网的相同电线进行。 该服务优化电力流量，以适应每个资源和每个资源所有者的需求，同时整合多个资源的流量以适应电网的需求。 该服务可以将大量电动汽车电池作为电力网络的新的，动态聚合的电力资源在线。 电动车辆所有者可以参与电力交易经济，无论他们在哪里插入电网。
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公开(公告)号：US20100191328A1
公开(公告)日：2010-07-29
申请号：US12528634
申请日：2008-02-27
申请人： David L. Kaplan , Fiorenzo Omenetto , Jeffrey K. Marchant , Noorjahan Panjwani , Brian Lawrence
发明人： David L. Kaplan , Fiorenzo Omenetto , Jeffrey K. Marchant , Noorjahan Panjwani , Brian Lawrence
CPC分类号： A61L27/3604 , A61L27/225 , A61L27/227 , A61L27/3804 , A61L27/3839 , A61L27/3891 , A61L27/56 , A61L2300/412 , C12N5/0068 , C12N5/0621 , C12N2533/50 , G01N33/5044
摘要： This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.
摘要翻译： 本发明涉及一种薄片组织层，其包括含有组织特异性细胞的开槽丝素蛋白底物。 丝素蛋白底物提供了控制和培养细胞和细胞外基质发育的极好手段。 可以使用多个薄片组织层来产生组织工程化器官，例如组织工程角膜。 组织工程化器官是非免疫原性和生物相容性的。
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