公开(公告)号：US09738858B2

公开(公告)日：2017-08-22

申请号：US14901850

申请日：2014-06-26

申请人： BASF SE

发明人： Frederic Bauer ,  Rainer Eskuchen ,  Juergen Tropsch

IPC分类号： C11D1/825 ,  C11D3/22 ,  C07H1/00 ,  C07H3/02 ,  C07H3/04 ,  C07H3/06 ,  B08B3/04 ,  C07H15/04 ,  C11D1/66 ,  C11D3/20 ,  C07C31/125

CPC分类号： C11D3/225 ,  C07C31/125 ,  C07H15/04 ,  C11D1/662 ,  C11D3/2017

摘要： The current invention is directed towards mixtures of compounds, comprising (A) in the range of from 93 to 97% by weight compound of general formula (I) (B) in the range of from 3 to 6.5% by weight compound of general formula (II) (C) in the range of from 0.2 to 0.5% by weight compound of general formula (III) wherein the integers are defined as follows: R1 is —(CH2)nCH3, R2 is —(CH2)n+2CH3, R3 is —(CH2)n+1CH(CH3)2, R4 is —(CH2)n−1CH(CH3)2 G1 selected from monosaccharides with 4 to 6 carbon atoms, x in the range of from 1.1 to 10, n is a number in the range of from 1 to 4.

公开(公告)号：US09695208B2

公开(公告)日：2017-07-04

申请号：US13703007

申请日：2011-04-08

申请人： Xinshan Ye ,  Fan Yang ,  Xiujing Zheng

发明人： Xinshan Ye ,  Fan Yang ,  Xiujing Zheng

IPC分类号： C07H15/10 ,  C07H15/04 ,  C07H13/00 ,  A61K47/48 ,  C07K1/107 ,  C07K2/00 ,  A61K39/00

CPC分类号： C07H13/00 ,  A61K39/0011 ,  A61K47/48092 ,  A61K47/48284 ,  A61K47/549 ,  A61K47/643 ,  A61K2039/585 ,  A61K2039/6081 ,  C07H15/04 ,  C07H15/10 ,  C07K1/1077

摘要： N-acyl modified sialic acid (α-(2→6))-D-aminopyranose derivatives, their synthesis methods and uses are disclosed. Sialic acid (α-(2→6))-D-aminopyranose derivatives represented by formula 1 are synthesized by using D-aminogalactose (glucose) and sialic acid as raw materials, which are coupled with carrier proteins or polypeptides to obtain glycoprotein (glycopeptide) conjugates. Acetyl is replaced by derivative acyl in the structures of said compounds, therefore the compounds show good activity in antitumor vaccines.

公开(公告)号：US20170174718A1

公开(公告)日：2017-06-22

申请号：US15382872

申请日：2016-12-19

申请人： Ardelyx, Inc.

发明人： Jason Gustaf LEWIS ,  Michael Robert LEADBETTER ,  Jeremy CALDWELL ,  Dean DRAGOLI ,  Noah BELL ,  Jeffrey W. JACOBS ,  Patricia FINN ,  Rakesh JAIN ,  Tao CHEN ,  Matthew SIEGEL

IPC分类号： C07H15/26 ,  C07D213/38 ,  A61K31/4427 ,  C07D405/12 ,  A61K31/443 ,  A61K31/444 ,  C07D213/30 ,  C07D405/04 ,  A61K31/4433 ,  A61K31/4439 ,  C07D413/12 ,  A61K31/553 ,  A61K31/496 ,  A61K31/706 ,  C07H15/04 ,  C07H15/18 ,  C07D401/12 ,  A61K31/5377 ,  C07H15/234 ,  A61K31/4436 ,  C07D409/12 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/4425 ,  A61K31/551 ,  C07D471/04 ,  C07B59/00 ,  C07D213/81 ,  C07D213/80 ,  C07D487/08 ,  A61K45/06 ,  A61K31/4418

CPC分类号： C07H15/26 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/553 ,  A61K31/706 ,  A61K45/06 ,  C07B59/002 ,  C07B2200/05 ,  C07D213/30 ,  C07D213/38 ,  C07D213/80 ,  C07D213/81 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04 ,  C07D487/08 ,  C07H15/04 ,  C07H15/18 ,  C07H15/234

摘要： The invention relates to non-systemic TGR5 agonist useful in the treatment of chemotherapy-induced diarrhea, diabetes, Type II diabetes, gestational diabetes, impaired fasting glucose, impaired glucose tolerance, insulin resistance, hyperglycemia, obesity, metabolic syndrome, ulcerative colitis, Crohn's disease, disorders associated with parenteral nutrition especially during short bowel syndrome, and irritable bowel syndrome (IBS), and other TGR5 associated diseases and disorders, having the Formula: where R1, R2, R2′, R3, R4, X1, X2, X3, X4, Q, and n are described herein.

公开(公告)号：US09677052B2

公开(公告)日：2017-06-13

申请号：US14707718

申请日：2015-05-08

申请人： Thomas J. Silhavy ,  Marcin Grabowicz ,  Daniel Kahne ,  Matthew Lebar ,  Dorothee Andres

发明人： Thomas J. Silhavy ,  Marcin Grabowicz ,  Daniel Kahne ,  Matthew Lebar ,  Dorothee Andres

IPC分类号： C12N9/00 ,  C07H13/06 ,  C12P21/00 ,  A61K39/39 ,  C07H15/04 ,  C07K4/00 ,  A61K39/00

CPC分类号： A61K39/39 ,  A61K2039/55516 ,  A61K2039/55572 ,  A61K2039/55583 ,  A61K2039/55594 ,  C07H13/06 ,  C07H15/04 ,  C07K4/00 ,  C12N9/00 ,  C12N9/93 ,  C12N15/04 ,  C12P21/005

摘要： The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure describes genetic engineering of E. coli to create mutant O-antigen ligase, as well as novel lipopolysaccharide molecules resulting from that genetic engineering. Methods for using those novel molecules are also described.

公开(公告)号：US09650405B2

公开(公告)日：2017-05-16

申请号：US13902879

申请日：2013-05-27

申请人： Polytechnic Institute of New York University

发明人： Richard A. Gross ,  Thavasi Rengathavasi ,  Amanda Koh ,  Yifeng Peng

IPC分类号： A01N43/16 ,  A01N43/90 ,  A01N25/30 ,  A61Q1/00 ,  C12P19/44 ,  A61K31/739 ,  C07H15/04 ,  A61Q9/02 ,  A61Q1/06 ,  A61Q5/12 ,  C11D3/22 ,  A61K8/60 ,  A61Q19/00 ,  A61K31/7028 ,  A61Q11/00 ,  A61Q1/10 ,  A61Q5/02 ,  A61Q19/10 ,  A61Q17/00

CPC分类号： C07H15/04 ,  A01N25/30 ,  A61K8/602 ,  A61K31/7028 ,  A61K2800/10 ,  A61Q1/00 ,  A61Q1/06 ,  A61Q1/10 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q9/02 ,  A61Q11/00 ,  A61Q17/005 ,  A61Q19/00 ,  A61Q19/10 ,  C11D3/22 ,  A01N27/00 ,  A01N65/00 ,  A01N65/36

摘要： A method for the development of a library of modified sophorolipids using a wide-range of chemical and enzyme catalyst tools to identify modified sophorolipids that can be used in pure form, as mixtures with other modified sophorolipids, as mixtures with natural sophorolipids, as mixtures with modified and natural sophorolipids, and as mixtures with other compounds known by one skilled in the art for use in the dispersion, solubilization or emulsification of various oil types and nutraceuticals, and modified sophorolipids for use in dispersion, solubilization or emulsification processes.

公开(公告)号：US20170121360A1

公开(公告)日：2017-05-04

申请号：US15316123

申请日：2015-06-03

申请人： Nanoscience for life GmbH & CoKG ,  GEA Westfalia Separator Group GmbH

发明人： Ulrich Dietz ,  Steffen Hruschka

IPC分类号： C07H1/06 ,  C07H15/04

CPC分类号： C07H1/06 ,  C07H15/04 ,  C11B1/025 ,  C11B1/10

摘要： The present invention relates to an apparatus and method for separating glycoglycerolipids and also glycoglycerolipids and glycosphingolipids from a lipid phase that contains glycoglycerolipids and acyl glycerides or glycoglycerolipids and glycosphingolipids and acyl glycerides, in mild conditions with no hydrolysis and while at the same time effectively depleting the lipid phase of said glycoglycerolipids, glycoglycerolipids and glycosphingolipids and their accompanying substances using an aqueous extraction process.

公开(公告)号：US20170102349A1

公开(公告)日：2017-04-13

申请号：US15314817

申请日：2015-06-01

申请人： GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION

发明人： Suri Saranathan Iyer ,  Abasaheb Dhawane ,  Yun He ,  Xiaohu Zhang ,  Hieu Dinh ,  Mugdha Vasireddi ,  Joyce Sweeney

IPC分类号： G01N27/327 ,  C07H15/203 ,  C12Q1/40 ,  C07H3/04

CPC分类号： G01N27/3275 ,  C07H3/04 ,  C07H15/04 ,  C07H15/18 ,  C07H15/203 ,  C07H17/075 ,  C12Q1/34 ,  C12Q1/40 ,  C12Y302/01018 ,  G01N27/307 ,  G01N27/3272 ,  G01N2333/11 ,  G01N2333/924

摘要： Disclosed are compositions and methods for the electrochemical detection of enzymes, such as enzymes that are indicative of disease, disorders, or pathogens, such as viruses, bacteria, and fungi, or other disorders. These methods can be used in point-of-care diagnostic assays for the detection of disease, disorder, or pathogen (e.g., to identify the strain of pathogen infecting a patient in a healthcare setting). The electrochemical methods described herein can also be used to assess the susceptibility of a pathogen to an antipathogen drug. Also provided are probes suitable for use in conjunction with the methods described herein.

公开(公告)号：US20170101388A1

公开(公告)日：2017-04-13

申请号：US15383885

申请日：2016-12-19

申请人： XUANZHU PHARMA CO., LTD.

发明人： Frank Wu

IPC分类号： C07D309/10 ,  C07H15/04 ,  C07C49/327 ,  C07D307/94 ,  C07D407/12 ,  C07D305/14 ,  C07D307/935 ,  C07H23/00 ,  C07C49/35

CPC分类号： C07D309/10 ,  C07C49/327 ,  C07C49/35 ,  C07C2602/50 ,  C07D305/14 ,  C07D307/77 ,  C07D307/935 ,  C07D307/94 ,  C07D311/96 ,  C07D407/12 ,  C07H15/04 ,  C07H23/00

摘要： The present invention involves a compound represented by general formula (I), a derivative thereof and a use thereof: wherein R1, R2, R3, R4, R5a, R5b, R5c and X are defined as in the description.

公开(公告)号：US20170022241A1

公开(公告)日：2017-01-26

申请号：US15303039

申请日：2015-04-08

申请人： CALIXAR

发明人： Julien DAUVERGNE

IPC分类号： C07H15/26 ,  C07K14/00 ,  C07K14/705 ,  C07K1/14 ,  C07H15/24

CPC分类号： C07H15/26 ,  B01D11/0288 ,  C07H13/04 ,  C07H13/12 ,  C07H15/04 ,  C07H15/24 ,  C07K1/145 ,  C07K14/00 ,  C07K14/70571

摘要： Amphiphilic calixarene glycoside compounds, the preparation of such compounds, and the use of such compounds for selectively extracting, solubilizing and stabilizing membrane proteins.

摘要翻译： 两亲性杯芳烃糖苷化合物，这些化合物的制备，以及这些化合物用于选择性提取，增溶和稳定膜蛋白的用途。

公开(公告)号：US20170002653A1

公开(公告)日：2017-01-05

申请号：US15266451

申请日：2016-09-15

申请人： Saudi Arabian Oil Company ,  Cornell University

发明人： Mazen Y. Kanj ,  Mohammad Harunar Rashid ,  Emmanuel Giannelis

IPC分类号： E21B49/00 ,  C01B31/02 ,  C07C231/02 ,  C09K11/06 ,  B82Y20/00

CPC分类号： C09K11/65 ,  B82Y20/00 ,  B82Y40/00 ,  C01B32/15 ,  C07C215/08 ,  C07C227/18 ,  C07C231/02 ,  C07C235/74 ,  C07H15/04 ,  C09K9/02 ,  C09K11/06 ,  C09K2208/10 ,  C09K2211/10 ,  E21B47/1015 ,  E21B49/00 ,  E21B49/008 ,  Y10S977/773 ,  Y10S977/774 ,  Y10S977/896 ,  Y10S977/95 ,  Y10T428/2982

摘要： The present invention relates to carbon-based fluorescent nano-agent tracers for analysis of oil reservoirs. The carbon-based fluorescent nano-agents may be used in the analysis of the porosity of a formation. The nanoagents are suitable for injection into a petroleum reservoir and may be recovered from the reservoir for the determination of hydrocarbon flow rates and retention times.