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公开(公告)号：US09879292B2
公开(公告)日：2018-01-30
申请号：US15433270
申请日：2017-02-15
发明人： Robert Winnicki , Marc Donsky , Mingyang Sun , Richard Peet
IPC分类号： C12M1/00 , C12M3/00 , C12P17/00 , C12P17/06 , C12M1/40 , C12M1/34 , C12M1/36 , C12N9/02 , C07C29/80 , C07C37/01 , C07C37/74
CPC分类号： C12P17/06 , C07C29/80 , C07C37/01 , C07C37/74 , C12M21/18 , C12M29/00 , C12M29/04 , C12M41/12 , C12M41/26 , C12M41/30 , C12M41/32 , C12M41/40 , C12M41/48 , C12M47/10 , C12N9/0004 , C12P7/22 , C12P7/42 , C12Y121/03 , C12Y121/03007 , C12Y121/03008
摘要： The present invention provides an apparatus and methods for producing tetrahydrocannabinolic acid (THCA), cannabichromenic acid (CBCA) and cannabichromenic acid (CBCA) in different ratios. The apparatus comprises: (i) a bioreactor comprising (a) an automated supply system configured to deliver a first automated supply of cannabigerolic acid (CBGA), a cannabinoid acid synthase, and a reaction mixture; and (b) a second automated system to cease the reaction; (ii) a controller configured to modify a property of the reaction mixture to produce the desired products; and (iii) an extractor configured to recover the tetrahydrocannabinolic acid (THCA), cannabichromenic acid (CBCA) or cannabidiolic acid (CBDA) and cannabichromenic acid.
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公开(公告)号：US09861609B2
公开(公告)日：2018-01-09
申请号：US15242189
申请日：2016-08-19
发明人： Robert Winnicki , Marc Donsky , Mingyang Sun , Richard Peet
IPC分类号： C12N1/20 , C12N1/16 , A61K31/352 , C12M1/40 , C12M1/34 , C12P17/06 , C12P7/42 , C12M1/36 , A61K38/00
CPC分类号： C12P7/22 , A01H6/28 , A61K31/352 , C12M21/18 , C12M41/30 , C12M41/48 , C12N9/0004 , C12N9/1029 , C12P7/04 , C12P7/26 , C12P7/42 , C12P7/62 , C12P17/06 , C12Y121/03007 , C12Y121/03008 , C12Y203/01206 , C12Y205/01102
摘要： The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase. Also described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.
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23.发明申请公开(公告)号：US20170233780A1
公开(公告)日：2017-08-17
申请号：US15514706
申请日：2015-09-28
申请人： BASF SE
发明人： Michael BREUER , Ralf PELZER
IPC分类号： C12P17/06 , C07D311/92
CPC分类号： C12P17/06 , C07D311/92 , C12N9/90 , C12Y504/99017
摘要： The present invention relates to a novel process for cyclizing geranyllinalool using the squalene-hopene cyclase from Zymomonas mobilis (Zm-SHC) or a cyclase with at least 80% sequence identity to the Zm-SHC, and cyclization products obtained in this process.
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公开(公告)号：US20170233779A1
公开(公告)日：2017-08-17
申请号：US15438291
申请日：2017-02-21
发明人： Jonathan E. Page , Steve Gagne
CPC分类号： C12P17/06 , C12N9/1025 , C12N15/52 , C12N15/70 , C12N15/8243 , C12P7/22 , C12P7/42 , C12Y203/01206 , C12Y404/01026 , Y02P20/52
摘要： Nucleic acid molecules encoding polypeptides having polyketide synthase activity have been identified and characterized. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
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公开(公告)号：US20170081685A1
公开(公告)日：2017-03-23
申请号：US15372788
申请日：2016-12-08
申请人： Codexis, Inc.
发明人： Lynne Gilson , Steven J. Collier , Joly Sukumaran , Wan Lin Yeo , Oscar Alvizo , Ee Ling Teo , Robert J. Wilson , Junye Xu
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.
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公开(公告)号：US09598707B2
公开(公告)日：2017-03-21
申请号：US13784877
申请日：2013-03-05
IPC分类号： C12P33/20 , C12P17/06 , C12P17/12 , C12P7/22 , C12P19/02 , C12N5/00 , C12N5/04 , C12P17/18 , C12P19/46 , C12P17/04
CPC分类号： C12P7/22 , C12N5/0025 , C12N5/04 , C12P17/04 , C12P17/06 , C12P17/188 , C12P19/46 , Y02A40/14
摘要： A method to increase the production of products of interest in plant material including plant cultures, such as, for example, cell suspension cultures, root cultures, and hairy root cultures is provided. In one embodiment, the method is to contacting the plant material with a precursor or xenobiotic when producing a product of interest from a plant. In another embodiment the plant material is also contacted with a trapping agent. The process may also provide for contacting an elicitor of the product of interest with the plant material. An embodiment provides for contacting an elicitor, precursor and trapping agent with the plant material. The ability to produce novel compounds such as glucosides and glucuronides is provided.
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公开(公告)号：US09567600B2
公开(公告)日：2017-02-14
申请号：US14010008
申请日：2013-08-26
发明人： Aidyn Mouradov , German Spangenberg
IPC分类号： C12N15/82 , C07K14/415 , C12N9/02 , C12N9/00 , C12P17/06
CPC分类号： C12N15/8243 , C07K14/415 , C12N9/0071 , C12N9/93 , C12N15/825 , C12P17/06 , Y02P20/52
摘要： The present invention relates to nucleic acids encoding flavonoid biosynthetic enzymes, flavonoid-regulating transcription factors and a flavonoid-specific membrane transporter in plants, and the use thereof for the modification of flavonoid biosynthesis in plants. The present invention also relates to constructs and vectors including such nucleic acids, and related polypeptides. More particularly, the protein involved in flavonoid biosynthesis is selected from the group consisting of TRANSPARENT TESTA 12 (TT12), TRANSPARENT TESTA GLABRA 1 (TTG1), TRANSPARENT TESTA 2 (TT2), TRANSPARENT TESTA 8 (TT8), Ieucoanthocyanidin dioxygenase (LDOX), cinnamate-4-hydroxylase (C4H), 4-coumaroyl:CoA-ligase (4CL); and functionally active fragments and variants thereof.
摘要翻译： 本发明涉及植物中黄酮生物合成酶，类黄酮调节转录因子和类黄酮特异性膜转运蛋白的核酸及其在植物中修饰黄酮生物合成的用途。 本发明还涉及包括这种核酸的构建体和载体以及相关多肽。 更具体地，参与类黄酮生物合成的蛋白质选自透明TESTA 12（TT12），透明TESTA GLABRA 1（TTG1），透明TESTA 2（TT2），透明TESTA 8（TT8），异核花色素双加氧酶（LDOX） ，肉桂酸-4-羟化酶（C4H），4-香豆酰基：CoA连接酶（4CL）; 和功能活性片段及其变体。
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28.发明授权公开(公告)号：US09526715B1
公开(公告)日：2016-12-27
申请号：US15171517
申请日：2016-06-02
发明人： Robert Winnicki , Marc Donsky
CPC分类号： C12P7/22 , A01H6/28 , A61K31/352 , C12M21/18 , C12M41/30 , C12M41/48 , C12N9/0004 , C12N9/1029 , C12P7/04 , C12P7/26 , C12P7/42 , C12P7/62 , C12P17/06 , C12Y121/03007 , C12Y121/03008 , C12Y203/01206 , C12Y205/01102
摘要： The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase. Also described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.
摘要翻译： 还描述了通过使THCA合酶与大麻素前体接触并修饰反应混合物的至少一种性质来影响相对于第二种大麻素形成的量形成的第一大麻素的量的生产大麻素和大麻类似物的系统。
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公开(公告)号：US20160355854A1
公开(公告)日：2016-12-08
申请号：US15242189
申请日：2016-08-19
发明人： Robert WINNICKI , Marc DONSKY , Mingyang SUN , Richard PEET
CPC分类号： C12P7/22 , A01H6/28 , A61K31/352 , C12M21/18 , C12M41/30 , C12M41/48 , C12N9/0004 , C12N9/1029 , C12P7/04 , C12P7/26 , C12P7/42 , C12P7/62 , C12P17/06 , C12Y121/03007 , C12Y121/03008 , C12Y203/01206 , C12Y205/01102
摘要： The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase. Also described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.
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公开(公告)号：US20160318893A1
公开(公告)日：2016-11-03
申请号：US15103838
申请日：2014-12-19
发明人： Björn Hamberger , Eirini Pateraki , Birger Lindberg MØLLERø , Morten NØRHOLM , Morten Thrane Nielsen , Johan Andersen-Ranberg , Carl Jörg Bohlmann , Phillipp Zerbe
IPC分类号： C07D311/92 , C12N9/88 , C12P17/06
CPC分类号： C07D311/92 , C07B2200/07 , C12N9/88 , C12N9/90 , C12N15/8243 , C12P17/06 , C12Y402/03 , C12Y505/01
摘要： The present invention relates to a method for manufacturing enantiomerically pure (13R)-manoyl oxide, said method comprising the steps of contacting geranylgeranyl diphosphate (GGPP) with a class II diterpene synthase to obtain labd-13-en-8,15-diol diphosphate (LPP), and then contacting the LPP with a class I diterpene synthase to obtain (13R)-manoyl oxide. The invention further relates to (13R)-manoyl oxide obtained by the method of the invention.
摘要翻译： 本发明涉及一种制备对映异构纯的（13R） - 马来酰氧化物的方法，所述方法包括以下步骤：将香叶基香叶基二磷酸酯（GGPP）与二级二萜合酶接触，得到实验部分13-en-8,15-二醇二磷酸酯 （LPP），然后使LPP与I类二萜合酶接触，得到（13R） - 马来酰氧基。 本发明还涉及通过本发明的方法获得的（13R） - 马来酰氧基氧化物。
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