公开(公告)号：US20090174936A1

公开(公告)日：2009-07-09

申请号：US12365779

申请日：2009-02-04

Applicant: ARTUR G. OLSZAK

Inventor： ARTUR G. OLSZAK

IPC: G02B21/18

CPC classification number: G02B21/002 ,  G01N21/253 ,  G01N2201/0407

Abstract: A microscope array for simultaneously imaging multiple objects. A preferred embodiment of a method according to the invention includes arranging the objects into an array, providing a microscope array having a plurality of imaging elements with respective fields of view arranged into a corresponding array such that the imaging elements are optically aligned respectively with the objects, and simultaneously imaging the objects with the microscope array to produce respective images of the objects. The invention also provides for scanning while imaging, and for stepping and repeating the imaging process.

Abstract translation: 用于同时成像多个物体的显微镜阵列。 根据本发明的方法的优选实施例包括将物体布置成阵列，提供具有多个成像元件的显微镜阵列，其具有排列成相应阵列的各个视场，使得成像元件分别与物体 并且同时用显微镜阵列成像物体以产生物体的各个图像。 本发明还提供了成像时的扫描，以及步进和重复成像过程。

公开(公告)号：US20070206192A1

公开(公告)日：2007-09-06

申请号：US11363938

申请日：2006-03-01

Applicant: Pavel Fomitchov ,  Eugene Barash ,  Ahmad Yekta ,  Joseph Masino

Inventor： Pavel Fomitchov ,  Eugene Barash ,  Ahmad Yekta ,  Joseph Masino

IPC: G01N21/25

CPC classification number: G01N21/6458 ,  G01N21/47 ,  G01N2201/0407 ,  G01N2201/1042 ,  G02B21/0048 ,  G02B21/0076 ,  G02B21/367

Abstract: A system and method for multimode imaging of at least one sample is disclosed. The system includes at least one light source; an optical system selected responsive to a mode of operation of the imaging system; and a detector capable of selective reading of pixels. The at least one sample is moved elative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving. The method includes the steps of (1) selecting a mode of operation for the imaging system; (2) transmitting light from at least one light source through an optical system selected in response to the mode of operation for the imaging system; (3) moving the at least one sample relative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving; and (4) selectively reading pixels with a detector.

Abstract translation: 公开了一种用于至少一个样品的多模成像的系统和方法。 该系统包括至少一个光源; 响应于成像系统的操作模式选择的光学系统; 以及能够选择性地读取像素的检测器。 使用选自步骤样品移动和连续样品移动的样品移动技术将至少一个样品移动到光学系统。 该方法包括以下步骤：（1）选择成像系统的操作模式; （2）从至少一个光源透射通过响应于成像系统的操作模式选择的光学系统的光; （3）使用选自步骤样品移动和连续样品移动的样本移动技术来移动所述至少一个样品相对于所述光学系统; 和（4）用检测器选择性地读取像素。

公开(公告)号：US20070009383A1

公开(公告)日：2007-01-11

申请号：US11174957

申请日：2005-07-05

Applicant: William Bedingham ,  Peter Ludowise ,  Barry Robole

Inventor： William Bedingham ,  Peter Ludowise ,  Barry Robole

IPC: G01N35/00

CPC classification number: F16K99/003 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/025 ,  B01L2300/021 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/004 ,  F16K2099/0084 ,  G01N21/0332 ,  G01N21/07 ,  G01N21/359 ,  G01N21/6428 ,  G01N21/6452 ,  G01N35/00069 ,  G01N35/1097 ,  G01N2021/0325 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2035/00267 ,  G01N2035/00415 ,  G01N2035/0474 ,  G01N2201/0407 ,  G01N2201/0415 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0833 ,  Y10T436/11 ,  Y10T436/111666

Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.

Abstract translation: 描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。 例如，系统包括数据采集装置和耦合到数据采集装置的检测装置。 检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。 该装置还包括多个可移除的光学模块，其被光学配置为激发物种并捕获由不同波长的物质发射的荧光。 耦合到多个可移除光学模块的光纤束将来自光学模块的荧光传送到单个检测器。 此外，该装置可以通过利用激光加热阀来定位和选择性地打开阀分离腔来控制盘中的流体流动。

公开(公告)号：US20060202133A1

公开(公告)日：2006-09-14

申请号：US11345262

申请日：2006-02-01

Applicant: Gyeong-sik Ok ,  Su-hyeon Kim ,  Jin-tae Kim ,  Kwang-wook Oh

Inventor： Gyeong-sik Ok ,  Su-hyeon Kim ,  Jin-tae Kim ,  Kwang-wook Oh

IPC: G01J1/58 ,  F21V9/16

CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N21/05 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/0346 ,  G01N2021/3174 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0407 ,  G01N2201/0461 ,  G01N2201/0612 ,  G01N2201/0627 ,  G01N2201/0631 ,  G01N2201/0806 ,  G01N2201/0833

Abstract: A multi-channel fluorescence measuring optical system and a multi-channel fluorescence sample analyzer using the optical system are provided. The multi-channel fluorescence measuring optical system, which irradiates light onto a plurality of sample channels and detecting fluorescence radiated from samples, includes: a light source; an integrator for giving the light irradiated from the light source a uniform intensity distribution; a sample holder having a plurality of sample channels on which the samples are mounted, wherein the samples are exited by the light emitted from the integrator; and a beam splitter between the integrator and the sample holder for dividing the incident light in a predetermined ratio. Since the light intensities of fluorescence images are detected using optical fiber bundles and photodiodes, the manufacturing cost can be greatly reduced, and the optical system can be miniaturized.

Abstract translation: 提供多通道荧光测量光学系统和使用该光学系统的多通道荧光样品分析仪。 多通道荧光测量光学系统，其将光照射到多个样品通道上并检测从样品辐射的荧光，包括：光源; 用于给从光源照射的光均匀的强度分布的积分器; 具有多个样品通道的样品架，样品安装在样品通道上，其中采样由积分器发出的光退出; 以及在积分器和样品保持器之间的分束器，用于以预定比例分割入射光。 由于使用光纤束和光电二极管检测荧光图像的光强度，因此可以大大降低制造成本，并且可以使光学系统小型化。

公开(公告)号：US06238911B1

公开(公告)日：2001-05-29

申请号：US09340019

申请日：1999-06-28

Applicant: Takashi Kasahara

Inventor： Takashi Kasahara

IPC: C12M120

CPC classification number: B01L3/50853 ,  C12M23/12 ,  C12M41/36 ,  G01N21/253 ,  G01N2201/0407 ,  G02B21/34

Abstract: The present invention provides a culture vessel and microscope that allows a wide area of favorable observation of the sample in the plural wells even when a negative refractive power is generated in the culture medium, wherein a ring-shaped opening, a condenser lens, a lens array, a well plate, an objective lens and a phase contrast plate are disposed in this order viewed from the light source side with a construction to place a phase contrast film of the phase contrast plate in a conjugated relation to the projection pupil position or projection pupil of the objective lens, and the culture vessel is constructed of the lens array and well plate with a relative disposition in which the optical axis of each lens is coaxial with the center line of the confronting each well; the aperture of the ring-shaped opening being smaller than the aperture of the ring-shaped opening that is used when the culture vessel is not disposed in the optical path.

Abstract translation: 本发明提供了一种培养容器和显微镜，即使在培养基中产生负折射力时，也可以在多个孔中对样品进行良好的观察的广泛区域，其中环形开口，聚光透镜，透镜 阵列，阱板，物镜和相位差板以从光源侧观察的顺序设置，以使相位差板的相位相对于投影光瞳位置或投影的共轭关系 物镜的瞳孔，培养容器由透镜阵列和孔板构成，其相对配置为每个透镜的光轴与面对的每个孔的中心线同轴; 环形开口的孔径小于当培养容器未设置在光路中时使用的环形开口的孔。

公开(公告)号：US5526451A

公开(公告)日：1996-06-11

申请号：US324560

申请日：1994-10-18

Applicant: Jerry E. Cahill ,  David H. Tracy

Inventor： Jerry E. Cahill ,  David H. Tracy

IPC: G01N21/25 ,  G02B6/32 ,  G02B6/36 ,  G02B6/42 ,  G02B6/10 ,  G01J1/00

CPC classification number: G02B6/3604 ,  G01N21/253 ,  G01N2201/0407 ,  G01N2201/084 ,  G02B6/32 ,  G02B6/4214

Abstract: In a spectrophotometer, each of a plurality of source optical fibers is selectively receptive of source radiation and carries the radiation to a corresponding selected liquid sample cell. A corresponding return optical fiber returns transmitted radiation from the sample to a polychromator. For selecting a sample, a switching member holds exposed ends of the optical fibers on a circle coaxial with an axle for rotating to selected positions. Respective optical trains in the instrument direct radiation into and out of the selected pair of fibers. The diameter of a source aperture, the spacing of the aperture from the radiation source, and the source area define a source etendue. The optical fibers have a fiber etendue substantially the same as the source etendue.

公开(公告)号：US4988630A

公开(公告)日：1991-01-29

申请号：US42764

申请日：1987-04-27

Applicant: Fang-Chung Chen ,  Michael L. Franklin

Inventor： Fang-Chung Chen ,  Michael L. Franklin

IPC: G01N21/25 ,  G01N33/543

CPC classification number: G01N21/253 ,  G01N33/54313 ,  G01N2021/825 ,  G01N2201/0407 ,  Y10S435/808 ,  Y10S436/807

Abstract: There is described a unique instrument system employing a laser, having a polarized and collimated beam of radiation, which is split into a multitude of primary and secondary beams containing the same desirable properties of high collimation and monochromaticity. The secondary beams are used to measure simultaneously multiple antigen-antibody (Ag-Ab) agglutinations reactions involving latex particles.

Abstract translation: 描述了使用具有偏振和准直辐射束的激光器的独特的仪器系统，其被分成包含具有高准直和单色性的相同期望特性的多个主光束和次光束。 次级束用于同时测量涉及胶乳颗粒的多种抗原 - 抗体（Ag-Ab）凝集反应。

公开(公告)号：US20150362431A1

公开(公告)日：2015-12-17

申请号：US14761048

申请日：2014-01-16

Applicant: MAST GROUP LIMITED

Inventor： Ken JIN WONG ,  David Hugh WILLIAMS ,  Iain MCELARNEY ,  Elizabeth GILLIES

IPC: G01N21/64 ,  G01N35/04 ,  G01N33/487 ,  G01N35/00

CPC classification number: G01N21/6428 ,  B01L3/5027 ,  B01L3/545 ,  B01L2300/021 ,  B01L2300/0803 ,  G01J3/46 ,  G01J5/605 ,  G01J2003/466 ,  G01N33/487 ,  G01N35/00 ,  G01N35/00871 ,  G01N35/04 ,  G01N2021/6439 ,  G01N2035/00158 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00752 ,  G01N2035/00851 ,  G01N2035/0441 ,  G01N2201/024 ,  G01N2201/0256 ,  G01N2201/0407

Abstract: A system for conducting an assay comprises a power source (16), a controller (13) for controlling the assay and a plurality of assay units (14) operatively connected to one another such that the controller can communicate with the assay units and the system is capable of conducting the assay. An assay device comprises a substantially circular body (24) having a plurality of chambers in fluid connection such that fluid can pass between said chambers and a central hub (200) having a sample inlet (202) disposed therein for receiving a sample.

Abstract translation: 用于进行测定的系统包括电源（16），用于控制测定的控制器（13）和可操作地彼此连接的多个测定单元（14），使得控制器可以与测定单元和系统 能够进行测定。 测定装置包括具有流体连接的多个腔室的基本上圆形的本体（24），使得流体可以在所述室之间通过，并且具有设置在其中的用于接收样品的样品入口（202）的中心毂（200）。

公开(公告)号：US20150219555A1

公开(公告)日：2015-08-06

申请号：US14616062

申请日：2015-02-06

Applicant: Valerio PRUNERI ,  Pedro Antonio MARTÍNEZ CORDERO ,  Marc JOFRE CRUANYES

Inventor： Valerio PRUNERI ,  Pedro Antonio MARTÍNEZ CORDERO ,  Marc JOFRE CRUANYES

IPC: G01N21/47 ,  G01N21/84

CPC classification number: G01N21/47 ,  G01N21/4738 ,  G01N21/534 ,  G01N21/57 ,  G01N2021/555 ,  G01N2021/556 ,  G01N2201/0407

Abstract: Apparatus for measuring light scattering of a sample comprising a light beam source, means for collimating the beam and making it impinge on the sample in a perpendicular direction, at least one light sensor, and at least one spatial filter between the sample and the optical sensor, provided with two apertures, means for measuring the total power reaching the sensor and means for measuring the power of beams with a low k vector after the beam traverses the filter. The invention provides thus a simplified, portable and compact device for measuring different parameters like haze, turbidity, etc. can be built, for any sample and without the need of changing detectors.

Abstract translation: 用于测量包括光束源的样品的光散射的装置，用于准直光束并使其沿垂直方向撞击在样品上的装置，至少一个光传感器以及样品和光学传感器之间的至少一个空间滤光器 设置有两个孔，用于测量到达传感器的总功率的装置和用于在光束穿过滤光器之后用低k矢量测量光束的功率的装置。 因此，本发明提供了一种用于测量诸如雾度，浊度等不同参数的简化，便携和紧凑的装置，可用于任何样品并且不需要改变检测器。

公开(公告)号：US07928408B2

公开(公告)日：2011-04-19

申请号：US11345262

申请日：2006-02-01

Applicant: Gyeong-sik Ok ,  Su-hyeon Kim ,  Jin-tae Kim ,  Kwang-wook Oh

Inventor： Gyeong-sik Ok ,  Su-hyeon Kim ,  Jin-tae Kim ,  Kwang-wook Oh

IPC: G01N21/64

CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N21/05 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/0346 ,  G01N2021/3174 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0407 ,  G01N2201/0461 ,  G01N2201/0612 ,  G01N2201/0627 ,  G01N2201/0631 ,  G01N2201/0806 ,  G01N2201/0833

Abstract: A multi-channel fluorescence measuring optical system and a multi-channel fluorescence sample analyzer using the optical system are provided. The multi-channel fluorescence measuring optical system, which irradiates light onto a plurality of sample channels and detecting fluorescence radiated from samples, includes: a light source; an integrator for giving the light irradiated from the light source a uniform intensity distribution; a sample holder having a plurality of sample channels on which the samples are mounted, wherein the samples are exited by the light emitted from the integrator; and a beam splitter between the integrator and the sample holder for dividing the incident light in a predetermined ratio. Since the light intensities of fluorescence images are detected using optical fiber bundles and photodiodes, the manufacturing cost can be greatly reduced, and the optical system can be miniaturized.

Abstract translation: 提供多通道荧光测量光学系统和使用该光学系统的多通道荧光样品分析仪。 多通道荧光测量光学系统，其将光照射到多个样品通道上并检测从样品辐射的荧光，包括：光源; 用于给从光源照射的光均匀的强度分布的积分器; 具有多个样品通道的样品架，样品安装在样品通道上，其中采样由积分器发出的光退出; 以及在积分器和样品保持器之间的分束器，用于以预定比例分割入射光。 由于使用光纤束和光电二极管检测荧光图像的光强度，因此可以大大降低制造成本，并且可以使光学系统小型化。